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| 1 | Interstitial cells of Cajal, the Maestro in health and disease显示文摘Interstitial cells of Cajal (ICC) are important players in the symphony of gut motility. They have a very signif icant physiological role orchestrating the normal peristaltic activity of the digestive system. They are the pacemaker cells in gastrointestinal (GI) muscles. Absence, reduction in number or altered integrity of the ICC network may have a dramatic effect on GI system motility. More understanding of ICC physiology will foster advances in physiology of gut motility which will help in a future breakthrough in the pharmacological interventions to restore normal motor function of GI tract. This mini review describes what is known about the physiologic function and role of ICCs in GI system motility and in a variety of GI system motility disorders. | Randa M Mostafa Yasser M Moustafa Hosam Hamdy | 2010 | World Journal of Gastroenterology2010，16，26： | 56 |
| 2 | Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients显示文摘AIM To investigate the prospective importance of serum micro(mi)RNAs(mi R-125 b, mi R-138 b, mi R-1269, mi R-214-5p, mi R-494, mi R375 and mi R-145) as early biomarkers for the diagnosis of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS Two-hundred and fifty HCV4 a patients, 224 HCV4 aHCC patients, and 84 healthy controls were enrolled in the study. Expression levels of mi R214-5p, mi R-125 b, mi R-1269 and mi R-375 were quantified using quantitative real-time PCR.RESULTS Expression of the selected mi RNAs in serum wassignificantly lower in HCC patients than in the healthy controls, except for mi R-1269 and mi R-494. There was a significant difference between HCC and HCV patients, in particular for HCC and late stage fibrosis, rather than HCV patients and early fibrosis. It is obvious that mi R-1269 was significantly upregulated in HCC cases compared to hepatic fibrosis cases. Each mi RNA can show HCC progression. Multivariate logistic regression analysis indicated that the tested panel of mi RNAs(mi R214-5p, mi R-125 b, mi R-1269 and mi R-375) represent accurate and specific indictors of HCC development.CONCLUSION This study presents a panel of mi RNAs with strong power as putative diagnostic and prognostic biomarkers for HCV-induced HCC. Moreover, mi R-214-5p and mi R-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to HCC. | Moustafa Nouh Elemeery Ahmed Noah Badr Marwa Anwar Mohamed Doaa Ahmed Ghareeb | 2017 | World Journal of Gastroenterology2017，23，21： | 20 |
| 3 | Aetiology and risk factors of ischaemic cholangiopathy after liver transplantation显示文摘Liver transplantation(LT)is the best treatment for endstage hepatic failure,with an excellent survival rates over the last decade.Biliary complications after LT pose a major challenge especially with the increasing number of procured organs after circulatory death.Ischaemic cholangiopathy(IC)is a set of disorders characterized by multiple diffuse strictures affecting the graft biliary system in the absence of hepatic artery thrombosis or stenosis.It commonly presents with cholestasis and cholangitis resulting in higher readmission rates,longer length of stay,repeated therapeutic interventions,and eventually re-transplantation with consequent effects on the patient’s quality of life and increased health care costs.The pathogenesis of IC is unclear and exhibits a higher prevalence with prolonged ischaemia time,donation after circulatory death(DCD),rejection,and cytomegalovirus infection.The majority of IC occurs within 12 mo after LT.Prolonged warm ischaemic times predispose to a profound injury with a subsequently higher prevalence of IC.Biliary complications and IC rates are between 16%and 29%in DCD grafts com-pared to between 3%and 17%in donation after brain death(DBD)grafts.The majority of ischaemic biliary lesions occur within 30 d in DCD compared to 90 d in DBD grafts following transplantation.However,there are many other risk factors for IC that should be considered.The benefits of DCD in expanding the donor pool are hindered by the higher incidence of IC with increased rates of re-transplantation.Careful donor selection and procurement might help to optimize the utilization of DCD grafts. | Moustafa Mabrouk Mourad Abdullah Algarni Christos Liossis Simon R Bramhall | 2014 | World Journal of Gastroenterology2014，20，20： | 16 |
| 4 | 倾斜旋转型三维隔震装置的力学模型和竖向性能试验研究显示文摘基于铅芯橡胶隔震支座的变形及耗能力学性能特点,设计开发出一种新型的倾斜旋转型三维隔震装置,给出了三维隔震装置的组成构造和力学性能设计方法,提出了三维隔震装置的变形机理,推导了三维隔震装置的刚度和阻尼的理论计算公式。设计了倾斜旋转型三维支座的模型支座系统,并完成了竖向压缩力学性能试验。试验结果表明该倾斜旋转型三维隔震装置构造合理、传力机制明确,在竖向变形状态下具有良好的阻尼耗能性能;试验得到的支座刚度和理论计算刚度一致性较好。 | 刘文光 余宏宝 IMAM MOUSTAFA I. 何文福 | 2017 | 振动与冲击2017，36，9： | 15 |
| 5 | Multitarget therapeutic strategies for Alzheimer's disease显示文摘Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well. | Mostafa M.Ibrahim Moustafa T.Gabr | 2019 | Neural Regeneration Research2019，14，3： | 8 |
| 6 | 浙江花岗岩中斜长石钾交代产生的条纹长石(英文)显示文摘对研究区内花岗岩类的60个薄片进行了岩相学研究.研究的目的是确定区内岩石中普遍存在的矿物组成及结构类型. 碱性长石花岗岩为中粒,块状,白到粉色,主要由碱性长石和石英组成,含镁铁质矿物如黑云母、白云母等,含副矿物磷灰石、褐帘石和锆石.碱性长石占岩石组成的绝大部分,包括微斜长石和微条纹长石.斜长石晶体一般具钠长石—卡斯巴双晶,无条带. 正常花岗岩通常比碱性长石花岗岩稍暗,中—粗粒,一般为半自形粒状或花岗结构.长石和镁铁质矿物都以半自形晶体出现,而石英则通常为灰色玻璃质,充填于其他矿物颗粒之间. 对碱性斜长花岗岩和正常花岗岩所做的化学分析显示,这些过铝质岩石呈高Si、Al、Na和K含量的特征.其中碱性斜长花岗岩的氧化物含量为:SiO2 76.61%,TiO20.15%,Al2O3 12.81%,Fe2O3 0.67%,FeO0.5%,MnO0.01%,MgO0.19%,CaO0.18%,Na2O3.82%,K2O4.46%,P2O5 0.01%.正常花岗岩中氧化物含量为:SiO2 73.76%,TiO2 0.12%,Al2O3 13.93%,Fe2O3 0.77,FeO0.58%,MnO0.03%,MgO0.16%,CaO0.31%,Na2O3.04%,K2O3.64%,P2O5 0.02%. 关于花岗岩类中钾长石的成因有2种观点.一种认为形成于岩浆的结晶作用,钾长石或是缓慢长大,或是在成核作用后快速长大;另一种观点则认为钾长石是钾交代成因的.岩浆成? | Moustafa El Omella 巩恩普 孙旭东 Abdalghni Saleh | 2003 | 地质与资源2003，12，3： | 7 |
| 7 | Pancreatitis: Preventing catastrophic haemorrhage显示文摘Pancreatitis represents nearly 3% of acute admissions to general surgery in United Kingdom hospitals and has a mortality of around 1%-7% which increases to around 10%-18% in patients with severe pancreatitis. Patients at greatest risk were those identified to have infected pancreatic necrosis and/or organ failure. This review seeks to highlight the potential vascular complications associated with pancreatitis that despite being relatively uncommon are associated with mortality in the region of 34%-52%. We examine the current evidence base to determine the most appropriate method by which to image and treat pseudo-aneurysms that arise as the result of acute and chronic inflammation of pancreas. We identify how early recognition of the presence of a pseudo-aneurysm can facilitate expedited care in an expert centre of a complex pathology that may require angiographic, percutaneous, endoscopic or surgical intervention to prevent catastrophic haemorrhage. | Richard PT Evans Moustafa Mabrouk Mourad Gunraj Pall Simon G Fisher Simon R Bramhall | 2017 | World Journal of Gastroenterology2017，23，30： | 6 |
| 8 | Toward an operating speed profile model for rural two-lane roads in Egypt显示文摘The geometric design, especially the horizontal and vertical alignments, of rural two-lane highway facilities is considered one of the most important factors affecting the quality of traffic service and safety. A consistent highway geometric design is defined to be one that conforms to the driver's expectations. In order to calculate the main measures of design consistency, an accurate operating speed profile model for road alignment is needed.Studies have shown that operating speed models are country dependent due to varying demographics, driver attitudes, habits, etc. This paper develops a speed profile model for two-lane rural roads in Egypt. This includes the development of operating speed models for horizontal curves and tangents, as well as the study of the characteristics and relationships between acceleration and deceleration rates before and after horizontal curves. The study uses a desert rural two-lane, two-way road sections that connect the city of Sohag with the city of Hurghada, in Upper Egypt. All geometric characteristics were obtained from highway authority. Speed data regarding individual drivers traveling on selected two-lane rural road sections were sampled using an on-board GPS system. The study confirms the finding in previous research that curvature is the most important factor in determining the speed on horizontal curves. Moreover, tangent length is the most important factor in determining operating speeds at tangents. The acceleration and deceleration characteristics were derived to gain an understanding of the behavior of individual vehicles traveling through curves of varying radii and lengths as well as preceding tangent length. Several operating speed models were developed for tangents and curves as well as for acceleration and deceleration rates. Incredibly effective, these models can be used for design consistency evaluations. | Ibrahim H.Hashim Talaat A.Abdel-Wahed Yasser Moustafa | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，1： | 5 |
| 9 | Characterization of HULC, a Novel Gene With Striking Up-Regulation in Hepatocellular Carcinoma, as Noncoding RNA显示文摘 | Katrin Panzitt Marisa M.O. Tschernatsch Christian Guelly Tarek Moustafa Martin Stradner Heimo M. Strohmaier Charles R. Buck Helmut Denk Renée Schroeder Michael Trauner Kurt Zatloukal | 2007 | Gastroenterology2007，，1： | 4 |
| 10 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 11 | Analysis of Unsteady Flow over Offshore Wind Turbines in Combination with Different types of Foundations显示文摘Environmental effects have an important influence on Offshore Wind Turbine (OWT) power generation efficiency and the structural stability of such turbines. In this study, we use an in-house Boundary Element (BEM)-panMARE code-to simulate the unsteady flow behavior of a full OWT with various combinations of aerodynamic and hydrodynamic loads in the time domain. This code is implemented to simulate potential flows for different applications and is based on a three-dimensional first-order panel method. Three different OWT configurations consisting of a generic 5 MW NREL rotor with three different types of foundations (Monopile, Tripod, and Jacket) are investigated. These three configurations are analyzed using the RANSE solver which is carried out using ANSYS CFX for validating the corresponding results. The simulations are performed under the same environmental atmospheric wind shear and rotor angular velocity, and the wave properties are wave height of 4 m and wave period of 7.16 s. In the present work, wave environmental effects were investigated firstly for the two solvers, and good agreement is achieved. Moreover, pressure distribution in each OWT case is presented, including detailed information about local flow fields. The time history of the forces at inflow direction and its moments around the mudline at each OWT part are presented in a dimensionless form with respect to the mean value of the last three loads and the moment amplitudes obtained from the BEM code, where the contribution of rotor force is lower in the tripod case and higher in the jacket case and the calculated hydrodynamic load that effect on jacket foundation type is lower than other two cases. | Israa Alesbe Moustafa Abdel-Maksoud Sattar Aljabair | 2017 | Journal of Marine Science and Application2017，16，2： | 3 |
| 12 | MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes显示文摘BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(T2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among T2DM patients is important to reduce the morbidity and mortality of this disease.MicroRNA(miRNA)is considered a key player in HCC and T2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic tool.AIM To investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic patients.METHODS Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,RT-qPCR was used to validate significantly altered miRNAs between the two groups.Candidate miRNAs were tested in serum samples of 200 T2DM patients,270 LC patients,200 HCC patients,and 225 healthy control subjects.Additionally,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+T2DM).RESULTS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive T2DM patients.Two miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC patients.Analysis of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic patients.The study recommends further research to shed light on a possible role of c-Met in T2DM-associated HCC via the miRNA regulatory pathway. | Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa Ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa Ahmed Noah Badr Doaa Ahmed Ghareeb Cheol-Ho Pan | 2019 | World Journal of Gastroenterology2019，25，42： | 3 |
| 13 | 辽宁排山楼金矿围岩的岩石学特征(英文)显示文摘Standard laboratory procedures and remote sensing techniques were employed in the characterization of gold bearing rocks of the Paishanlou area. Results indicate that, the rocks were formed in an alteration complex of medium temperature and pressure. The area was under intense polymetamorphism (ductile shearing, and hydrothermal metamorphism), which occurred along the deformation zone stretching from Jinzhou to Fuxin. The area bears some propylitic, phyllic (or sericitic) and argillic alteration styles. Gold minerals are contained in fine grained pyrite in silicified zones, and associated with metamorphosed Precambrian rocks. The host rock is composed of gneiss, mylonite and trondhjemite granite, and has a distinctive gold lead geochemical affinity. | Malogo J. M. Kongola 王恩德 于明旭 Moustafa El Omella | 2004 | 地质与资源2004，13，2： | 3 |
| 14 | 铁对粉末冶金法制备铝基复合材料微观组织和力学性能及磁学性能的影响(英文)显示文摘研究铁对粉末冶金法制备铝基复合材料微观组织、力学性能及磁学性能的影响。利用机械混合制备含0,5%,10%和15%Fe(质量分数)的铝基复合材料。Al-Fe混合粉末经压制后在真空炉中600°C烧结1 h。XRD结果表明:在含有5%和10%Fe的试样中只有Fe和Al的衍射峰,而含有15%Fe的试样中则存在Al和Al13Fe4的衍射峰。实验结果表明:随着Fe含量的增加,材料的致密度和导热性变差。复合材料中的Fe可以提高其强度和硬度。材料的强化机制包括基体的晶粒细化,Fe颗粒的均匀分布以及Al13Fe4金属间化合物的形成。含有5%Fe试样的磁化强度为0.3816×10-3A·m2/g,对于含有10%Fe的试样,其磁化强度增加至0.6597×10-3A·m2/g,而对于含有15%Fe试样,其磁化强度降低至0.0702×10-3A·m2/g。这是由于在高铁试样中形成了反磁性的Al13Fe4金属间化合物导致磁化强度降低。 | A.FATHY Omyma EL-KADY Moustafa M.M.MOHAMMED | 2015 | Transactions of Nonferrous Metals Society of China2015，25，1： | 3 |
| 15 | Giant mesenteric fibromatosis:Report of a case and review of the literature显示文摘Mesenteric fibromatosis poses a diagnostic and therapeutic challenge.This paper presents a 35-year-old female complaining of vague abdominal pain of 2 mo duration.Her computed tomography scan and magnetic resonance imaging revealed a pelvi-abdominal heterogenous mass with significant displacement of the small bowel and urinary bladder.She underwent surgical excision of the mass with resection and anastomosis of the involved loop of the small intestine.Histological examination confirmed mesenteric fibromatosis without infiltration of the bowel.The patient remained well during the 6 mo follow-up. | Mohammed Khalid Mirza Gari Salman Yousuf Guraya Amir Mounir Hussein Moustafa Mahmoud Nafady Hego | 2012 | World Journal of Gastrointestinal Surgery2012，4，3： | 3 |
| 16 | Telomeric 1p36.3 deletion and Ki‐67 expression in B‐Non‐Hodgkin’s Lymphoma patients associated with chronic hepatitis C virus infection显示文摘 | E. Mosad M. Said Abd El‐Rahman Allam H. M. Moustafa A. Eliaw Mohammed A. M. El kebeer S. S. Abdel‐Moneim | 2014 | J Viral Hepat2014，，12： | 2 |
| 17 | Hemodynamic Factors and Perfusion Abnormalities in Early Neurological Deterioration显示文摘 | Josef A. Alawneh Ramez Reda Moustafa Jean-Claude Baron | 2009 | Stroke2009，，6： | 2 |
| 18 | Ultrafine Fraction and Aerosol Attached Activity Size Distribution of Radon Progeny in Living Room显示文摘 | Amer Mohamed Mohamed Moustafa lotfy Abd EI-Hady Mona Moustafa Mahmoud Mostafa Yuness Abd El Fatah | 2012 | Journal of Physical Science and Application2012，2，7： | 2 |
| 19 | Enhancing IoT anomaly detection performance for federated learning显示文摘Federated Learning (FL) with mobile computing and the Internet of Things (IoT) is an effective cooperative learning approach. However, several technical challenges still need to be addressed. For instance, dividing the training process among several devices may impact the performance of Machine Learning (ML) algorithms, often significantly degrading prediction accuracy compared to centralized learning. One of the primary reasons for such performance degradation is that each device can access only a small fraction of data (that it generates), which limits the efficacy of the local ML model constructed on that device. The performance degradation could be exacerbated when the participating devices produce different classes of events, which is known as the class balance problem. Moreover, if the participating devices are of different types, each device may never observe the same types of events, which leads to the device heterogeneity problem. In this study, we investigate how data augmentation can be applied to address these challenges and improving detection performance in an anomaly detection task using IoT datasets. Our extensive experimental results with three publicly accessible IoT datasets show the performance improvement of up to 22.9% with the approach of data augmentation, compared to the baseline (without relying on data augmentation). In particular, stratified random sampling and uniform random sampling show the best improvement in detection performance with only a modest increase in computation time, whereas the data augmentation scheme using Generative Adversarial Networks is the most time-consuming with limited performance benefits. | Brett Weinger Jinoh Kim Alex Sim Makiya Nakashima Nour Moustafa K.John Wu | 2022 | Digital Communications and Networks2022，8，3： | 2 |
| 20 | Optimal control of overhead cranes显示文摘 | Al-Garni A Z Moustafa K A F Nizami S S A K J | 1995 | Control Engineering Practice1995，3，9： | 2 |
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