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| 1 | TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype显示文摘AIM To evaluate the impact of the Glu167Lys(E167K) transmembrane 6 superfamily member 2(TM6SF2) variant on the biochemical and morphologic expression of liver lesions in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) co-infected patients.METHODS The study comprised 167 consecutive patients with HIV/HCV coinfection and biopsy-proven chronic hepatitis. A pathologist graded liver fibrosis and necroinflammation using the Ishak scoring system, and steatosis using Kleiner's scoring system. Patients were genotyped for TM6SF2 E167K(rs58542926) by real-time Polymerase chain reaction. The 167 patients, 35 therapy-naive and 132 receiving ART, were prevalently males(73.6%), the median age was 40.7 years and the immunological condition good(median CD4+ cells/mm3 = 505.5).RESULTS The 17 patients with the TM6SF2 E167 K variant, compared with the 150 with TM6SF2-E/E, showed higher AST(P = 0.02) and alanine aminotransferase(P = 0.02) and higher fibrosis score(3.1 ± 2.0 vs 2.3 ± 1.5, P = 0.05). In a multivariate analysis, TM6SF2 E167 K was independently associated with severe fibrosis. The same analysis showed that HCV-genotype 3, present in 42.2% of patients was an independent predictor of severe steatosis. The association of TM6SF2 E167 K with severe steatosis, absent for the whole group of 167 patients, was re-evaluated separately for HCVgenotype 3 and non-3 patients: No factor was independently associated with severe steatosis in the HCV-genotype-3 subgroup, whereas an independent association was observed between severe steatosis and TM6SF2 E167 K in non-3 HCV genotypes. No association between the TM6SF2 E167 K variant and severe liver necroinflammation was observed.CONCLUSION In HIV/HCV coinfection the TM6SF2 E167 K variant is an independent predictor of severe fibrosis, but appears to be independently associated with severe steatosis only for patients with a non-3 HCV genotype. | Caterina Sagnelli Marco Merli Caterina Uberti-Foppa Hamid Hasson Anna Grandone Grazia Cirillo Stefania Salpietro Carmine Minichini Mario Starace Emanuela Messina Patrizia Morelli Emanuele Miraglia Del Giudice Adriano Lazzarin Nicola Coppola Evangelista Sagnelli | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 2 | 太阳能制冷的应用现状显示文摘太阳能制冷是一种有前景的环保制冷技术,它能满足全球空间制冷日益增长的需求。太阳能制冷可以通过多种技术途径来实现,其中有两种主要的商用太阳能制冷方式:由光伏(PV)驱动的蒸气压缩制冷机(光电制冷)和由太阳能集热器收集热量驱动的制冷机(光热制冷),两者的系统效率值相差不大。经济分析表明,光伏(PV)系统的投资成本最低,是其他系统的50%。太阳能制冷技术可以减少化石燃料的使用,从而对环境产生非常积极的影响,并且此技术已经成熟,可以与传统制冷技术竞争。 | Renato LAZZARIN 王云鹏(翻译) 张晓宁(翻译) 赵国君(翻译) | 2021 | 制冷技术2021，41，2： | 3 |
| 3 | Factors influencing liver fibrosis and necroinflammation in HIV/HCV coinfection and HCV monoinfection显示文摘 | C. Sagnelli C. Uberti-Foppa G. Pasquale S. Pascalis N. Coppola L. Albarello C. Doglioni A. Lazzarin E. Sagnelli | 2013 | Infection2013，，5： | 2 |
| 4 | Anti-hepatitis C virus treatment may prevent the progression of liver fibrosis in non-responder human immunodeficiency virus/hepatitis C virus coinfected patients显示文摘 | Caterina Sagnelli Caterina Uberti-Foppa Laura Galli Giuseppe Pasquale Nicola Coppola Luca Albarello Carlo Doglioni Adriano Lazzarin Evangelista Sagnelli | 2013 | Brazilian Journal of Infectious Diseases2013，，： | 2 |
| 5 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 6 | Fatigue strength of Al7075 notched plates based on the local SED averaged over a control volume显示文摘When pointed V-notches weaken structural components,local stresses are singular and their intensities are expressed in terms of the notch stress intensity factors(NSIFs).These parameters have been widely used for fatigue assessments of welded structures under high cycle fatigue and sharp notches in plates made of brittle materials subjected to static loading.Fine meshes are required to capture the asymptotic stress distributions ahead of the notch tip and evaluate the relevant NSIFs.On the other hand,when the aim is to determine the local Strain Energy Density(SED)averaged in a control volume embracing the point of stress singularity,refined meshes are,not at all,necessary.The SED can be evaluated from nodal displacements and regular coarse meshes provide accurate values for the averaged local SED.In the present contribution,the link between the SED and the NSIFs is discussed by considering some typical welded joints and sharp V-notches.The procedure based on the SED has been also proofed to be useful for determining theoretical stress concentration factors of blunt notches and holes.In the second part of this work an application of the strain energy density to the fatigue assessment of Al7075 notched plates is presented.The experimental data are taken from the recent literature and refer to notched specimens subjected to different shot peening treatments aimed to increase the notch fatigue strength with respect to the parent material. | BERTO Filippo LAZZARIN Paolo | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，1： | 2 |
| 7 | Chemical dehumidification by liquid desiccants:theory and experiment显示文摘 | Lazzarin R M Gasparella A Longo G A | 1999 | International Journal of Refrigeration1999，22，： | 1 |
| 8 | Experimental measurements and numerical modeling of a green roof 显示文摘 | Lazzarin R M Castellotti F Busato F | 2005 | Energy and Buildings2005，37，12： | 1 |
| 9 | A control strategy for parallel operation of single-phase voltage source inverters: analysis,design and experimental results显示文摘 | Lazzarin T B Bauer G A T Barbi I | 2013 | IEEE Transactions on Industrial Electronics2013，60，6： | 1 |
| 10 | A finite-volume-energy based approach to predict the static and fatigue behavior of components with V-shaped notches显示文摘 | LAZZARIN P ZAMBARDI R | 2001 | International Journal of Fracture2001，112，3： | 1 |
| 11 | An altemative to steroids for prevention of respiratory distress syndrome (RDS):Multieenter controlled study to compare ambroxol and betametha-sone显示文摘 | Luerti M Lazzarin A Corbella E Zavattini G | 1987 | J Perinat Med1987，15，3： | 1 |
| 12 | Hysteroscopic netroplasty improves gestational outcome in women with recurrent spontaneous abortion显示文摘 | Valli E Vaquero E Lazzarin N | 2004 | J Am Assoc Gynecol Laparosc2004，11，2： | 1 |
| 13 | J-integral evaluation for U-and V-blunt notches under Mede I loading and materials obeying a power hardening law显示文摘 | Betro F Lazzarin P Matvienko Yu G | 2007 | Springer Science and Business Media2007，146，： | 1 |
| 14 | A unified approach to the evaluation of linear elastic fields in the neighborhood of cracks and notches 显示文摘 | Lazzarin P Tovo R | 1996 | International Journal of Fracture1996，78，： | 1 |
| 15 | Ammonia- water absorption machines for refrigeration: theoreticaland real performances 显示文摘 | LAZZARIN R M GASPARELLA A LONGO G A | 1996 | International Journal of Refrigeration1996，19，4： | 1 |
| 16 | Chemical dehumidification by liquid desiccants:theory and experiment显示文摘 | Lazzarin R M Gasparella A Longo G A | 1999 | International Journal of Refrigeration1999，22，4： | 1 |
| 17 | Developments of some explicit formulas useful to describe elastic stress field ahead of the notches 显示文摘 | Filippi S Lazzarin P Tovo R | 2002 | International Journal of Solids and Structures2002，39，： | 1 |
| 18 | Primary mediastinal B-cell lymphoma with sclerosis an aggressive tumor with distinctive clinical and pathologic feactures显示文摘 | Lazzarin M Orlandi E | 1993 | J Clin Oncol1993，11，： | 1 |
| 19 | Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia显示文摘 | LAZZARIN A CLOTET B COOPER D | 2003 | N Engl J Med2003，348，22： | 1 |
| 20 | Local strain energy density and fatigue strength of welded joints under uniaxial and multiaxial loading显示文摘 | LAZZARIN P LIVIERIP BERTO F | | 0，，7： | 1 |
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