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| 1 | 美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用显示文摘经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine M.Sturgeon教授和Eleftherios P.Diaman-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。 | 鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund Mads Holten-Andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋 梁红艳 姜晓峰 田亚平 薛丽 林文涛 顾兵 潘世扬 沈文梅 郑磊 李江 | 2012 | 临床检验杂志2012，30，2： | 32 |
| 2 | Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets显示文摘Metastatic occurrence is the principal cause of death in breast cancer patients. The high osteotropism makes breast cancer the most common primary tumor type associated with metastatic bone disease. The peculiar clinical aspects associated with metastases limited to the skeletal system suggest considering these cases as a distinctive subset of metastatic patients with a better prognosis. Because bone is frequently the first metastatic site in disease relapse, it is feasible that the next improvement in therapeutic options for bone metastatic disease could be associated with an improvement of survival expectation and quality of life in breast cancer patients. Study of the molecular basis of bone remodeling and breast cancer osteotropism has allowed identification of several therapeutic candidates involved in formation and progression of bone metastases. These targets are frequently the determinants of positive feedback between the tumor and bone cells whose clinical outcome is osteolytic lesions. In this review, we discuss the physiopathologic features underlying targeted therapeutic strategies aimed at interfering with the aberrant bone remodeling associated with breast cancer metastases. | Nadia Rucci Patrizia Sanità Simona Delle Monache Edoardo Alesse Adriano Angelucci | 2014 | World Journal of Clinical Oncology2014，5，3： | 18 |
| 3 | Participation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation显示文摘老鼠蛋白质 DE 是一个雄激素依赖者充满半胱氨酸的能分泌的蛋白质(松脆) 由近似附睾区域综合了。DE,也作为 CRISP-1 知道,在反应 acrosome 的精子的赤道的片断上是局部性的并且通过绑定参予配偶子熔化到鸡蛋互补地点。有 DE 的老鼠的免疫禁止富饶和精子熔化能力,建议 DE 代表一个好附睾避孕药目标。Recombinant 整理碎片和合成的肽表明 DE 经由 anevolutionarily 保存的主题的一个 12-amino 酸区域绑在卵,签名 2 (S2 ) 。松脆的其它的能力与他们的 S2 氨基酸序列被相关绑在老鼠卵。尽管阴囊的蛋白质 Tpx-1 (CRISP-2 ) 能够到啮齿类动物卵的绑定,人的附睾的 AEG 相关的蛋白质(ARP ) 和 helothermine (从蜥蜴口水) 不。S2 区域在 Tpx-1 介绍了仅仅二替换并且四在 ARPand helothermine,与 DE S2 相比,建议这氨基酸定序为鸡蛋是相关的相互作用。有 Tpx-1 和 anti-Tpx-1 的研究在卵通过绑定在配偶子熔化揭示了这蛋白质的参予到互补地点。在比赛研究, DE dose-dependently 减少了 Tpx-1 的绑定,显示那两个松脆的份额卵互补地点。当认出仅仅相应蛋白质时,那 anti-DE 和 anti-Tpx-1 禁止精子鸡蛋熔化,建议在这些之间的功能的合作相应对松脆保证授精成功。这些结果增加我们配偶子熔化的分子的机制的理解并且贡献调整方法的新、更安全的富饶的发展。 | Debora J. Cohen Vanina G. Da Ros Dolores Busso Diego A. Ellerman Julieta A. Maldera Nadia Goldweic Patricia S. Cuasnicti | 2007 | Asian Journal of Andrology2007，9，4： | 16 |
| 4 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 5 | 骨科手术患者术后早期进食的效果观察显示文摘目的观察骨科手术患者在椎管内麻醉或全麻术后早期进食的效果。方法选择在本院骨科住院并在椎管内麻醉或全麻下接受手术的手术患者52例,按照病房单位分为实验组30例和对照组22例。实验组遵医嘱,告知患者麻醉清醒后感到饥饿即可进食(不必经过排气),对照组术后6~8h后进食。比较两组患者的首次排气时间、首次进食量、首次进食症状和住院时间。结果实验组患者术后首次排气时间早于对照组;首次进食后实验组患者无恶心、呕吐、腹胀发生,且口渴和饥饿的发生率低于对照组患者,出院时间明显早于对照组患者,两组比较,差异具有统计学意义(均P<0.05);两组患者在首次进食量方面比较,差异无统计学意义(P>0.05)。结论骨科非脊柱手术患者术后早期进食是可行的,有利于患者尽早排气,减少进食并发症和缩短住院时间。 | 刘妍 孙昕 NADIA MOHEBATI | 2017 | 现代临床护理2017，16，2： | 14 |
| 6 | Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery显示文摘Pomegranate fruit peel is rich in bioactive plant natural products,such as hydrolyzable tannins and anthocyanins.Despite their documented roles in human nutrition and fruit quality,genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain.Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform.Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies (TAs) (>200 bp).Candidate genes for hydrolyzable tannin,anthocyanin,flavonoid,terpenoid and fatty acid biosynthesis and/or regulation were identified.Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts.In addition,115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers.The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate.This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis,identifying genes controlling important agronomic traits,and discovering molecular markers in non-model specialty crop species. | Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian | 2011 | Journal of Integrative Plant Biology2011，53，10： | 12 |
| 7 | Al-Cu-Zr和Al-Cu-Zr-Ti-V合金中Al_3Zr析出相的析出行为(英文)显示文摘利用透射电子显微技术研究Al-Cu-Zr和Al-Cu-Zr-Ti-V合金中Al3Zr的沉淀析出行为。亚稳态的Al3Zr沉淀相在枝晶中心均匀形核并获得均匀分布。然而,在枝晶边缘区域的析出复杂,观察到由许多球形Al3Zr析出颗粒组成的螺旋状和条状的形貌。条状的沉淀团簇沿100铝方向优先排列,这可能与Al2Cu的亚稳态θ′和稳态θ析出相相关。添加铜有利于Al3Zr沉淀相从L12→D023的结构转变。 | 贾志宏 Jean-Philippe COUZINIé Nadia CHERDOUDI Ivan GUILLOT LarsRNBERG Petter SHOLT Stig BRUSETHAUG Bruno BARLAS5 Denis MASSINON | 2012 | Transactions of Nonferrous Metals Society of China2012，22，8： | 9 |
| 8 | Alginate oligosaccharides preparation, biological activities and their application in livestock and poultry显示文摘Alginate oligosaccharides(AOS), belonging to the class of functional marine oligosaccharides, are low-molecular polymers linked by β-1,4-mannuronic acid(M) and α-1,4-guluronic acid(G), which could be classically obtained by enzymatic hydrolysis of alginate. With low viscosity and good water solubility, as well as anti-oxidant, immune regulation, anti-bacterial and antiinflammatory activities, AOS have been widely used in medical science and functional food, green agriculture and other fields. As new bio-feed additives, AOS have broad potential applications in animal husbandry. In this review, the sources of alginate, chemical structure and preparation methods of AOS, and their biological activities and application in livestock and poultry are summarized. We expect this review could contribute to lay a foundation of application and further research for AOS in livestock and poultry. | LIU Ming LIU Lei ZHANG Hong-fu YI Bao Nadia EVERAERT | 2021 | Journal of Integrative Agriculture2021，20，1： | 9 |
| 9 | MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning(non-alcoholic steatohepatitis) and eventually fibrosis.The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries.Obesity,visceral adiposity,insulin resistance,and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD.Furthermore,different factors,including genetic background,epigenetic mechanisms and environmental factors,such as diet and physical exercise,contribute to NAFLD development and progression.Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD.In NAFLD,microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction.In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease. | Nadia Panera Daniela Gnani Annalisa Crudele Sara Ceccarelli Valerio Nobili Anna Alisi | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 10 | Pathophysiology and biology of peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis represents a devastating form of cancer progression with a very poor prognosis.Its complex pathogenesis is represented by a dynamic process comprising several steps.To the best of our knowledge pathogenesis can be partly explained by 3 major molecular pathways: (1) dissemination from the primary tumor;(2) primary tumor of peritoneum;and (3) independent origins of the primary tumor and peritoneal implants.These are not mutually exclusive and combinations of different mechanisms could occur inside a single case.There are still several aspects which need explanation by future studies.A comprehensive understanding of molecular events involved in peritoneal carcinomatosis is of paramount importance and should be systematically pursued not only to identify novel strategies for the prevention of the condition,but also to obtain therapeutic advances,through the identification of surrogate markers of prognosis and development of future molecular targeted therapies. | Shigeki Kusamura Dario Baratti Nadia Zaffaroni Raffaella Villa Barbara Laterza Maria Rosaria Balestra Marcello Deraco | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 8 |
| 11 | Does antecolic reconstruction decrease delayed gastric emptying after pancreatoduodenectomy?显示文摘Delayed gastric emptying(DGE) is a frequent complication after pylorus-preserving pancreatoduodenectomy(PpPD).Kawai and colleagues proposed pylorus-resecting pancreatoduodenectomy(PrPD) with antecolic gastrojejunal anastomosis to obviate DGE occurring after PpPD.Here we debate the reported differences in the prevalence of DGE in antecolic and retrocolic gastro/duodeno-jejunostomies after PrPD and PpPD,respectively.We concluded that the route of the gastro/duodeno-jejunal anastomosis with respect to the transverse colon;i.e.,antecolic route or retrocolic route,is not responsible for the differences in prevalence of DGE after pancreatoduodenectomy(PD) and that the impact of the reconstructive method on DGE is related mostly to the angulation or torsion of the gastro/duodeno-jejunostomy.We report a prevalence of 8.9% grade A DGE and 1.1% grade C DGE in a series of 89 subtotal stomach-preserving PDs with Roux-en Y retrocolic reconstruction with anastomosis of the isolated Roux limb to the stomach and single Roux limb to both the pancreatic stump and hepatic duct.Retrocolic anastomosis of the isolated first jejunal loop to the gastric remnant allows outflow of the gastric contents by gravity through a 'straight route'. | Nadia Peparini Piero Chirletti | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 12 | Medicinal plant products targeting quorum sensing for combating bacterial infections显示文摘Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances. | Abdelhakim Bouyahya Nadia Dakka Abdeslam Et-Touys Jamal Abrini Youssef Bakri | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 7 |
| 13 | Effect of infliximab on small bowel stenoses in patients with Crohn's disease显示文摘AIM: To assess prospectively small bowel stenoses in Crohn's disease (CD) patients treated with infliximab using Small Intestine Contrast Ultrasonography (SICUS). METHODS: Twenty patients (M 12, age, 42.7 ± 11.8 years), 15 of whom showed obstructive symptoms indicating the presence of small bowel stenosis, and 5 without stenosis, were treated with infliximab (5 mg/kg at wk 0, 2, 6 and 5 mg/kg every 8 wk thereafter) for steroid refractoriness, fistulizing disease, or to avoid high-risk surgery. SICUS was performed at the induction phase and at regular time intervals during the follow-up period of 34.7 ± 16.1 mo (range 7-58). Small bowel stenoses were detected by SICUS, endoscopy and MRI. RESULTS: In no case was progression of stenoses or the appearance of new ones seen. Of the 15 patients with stenosis, 5 stopped treatment after the induction phase (2 for no response, 3 for drug intolerance, one of whom showed complete regression of one stenosis). Among the remaining 10 patients, a complete regression of 8 stenoses (1 stenosis in 5 patients and 3 stenoses in one patient) was observed after 6-22 infliximab infusions. CONCLUSION: In patients with CD treated with infliximab we observed: (a) No progression of small bowel stenosis and no appearance of new ones, (b) Complete regression of 1/22 stenosis after the induction phase and of 8/15 (53.3%) stenosis after 6-22 infusionsduring maintenance therapy. | Nadia Pallotta Fausto Barberani Naima Abdulkadir Hassan Danila Guagnozzi Giuseppina Vincoli Enrico Corazziari | 2008 | World Journal of Gastroenterology2008，14，12： | 7 |
| 14 | Relationship between antral distension and postprandial symptoms in functional dyspepsia显示文摘AIM: To investigate in patients with functional dyspepsia (FD) after an every-day meal whether (1) gastrointestinal (GI) and extra-GI symptoms had any relation with the degree of antral volume, (2) the onset of postprandial symptoms was associated with, and may predict, delayed gastric emptying. METHODS: In 94 symptomatic FD patients, antral volume variations and gastric emptying were assessed with ultrasonography after a 1050 kcal meal. Symptoms were evaluated with a standardized questionnaire. The association of GI and extra-GI symptoms with antral volumes and gastric emptying were estimated with logistic regression analysis. RESULTS: Forty percent of patients did not report any symptoms after a meal. Compared to the healthy controls, the antrum was more distended in patients throughout the entire observation period and 37 (39.4%) patients had delayed gastric emptying. Only postprandial drowsiness was associated with antral volume variations (AOR = 1.42; P < 0.001) and with delayed gastric emptying (AOR = 3.59; P < 0.03). CONCLUSION: In FD patients, GI symptoms are neither associated with antral distension nor with gastric emptying. Drowsiness is associated with antral distension and delayed gastric emptying. The onset of drowsiness is preceded by an increment of antral distension and the duration of the symptom appears to be related to the persistence of antral distension. | Nadia Pallotta Patrizio Pezzotti Enrico Corazziari | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 15 | Characterization of lipid parameters in diabetic and non-diabetic atherosclerotic patients显示文摘背景 &在类脂化合物侧面不安和糖尿病之间的 ObjectiveThe 关系联系了复杂并发症长是兴趣的一个区域。Dyslipidemia 在糖尿病的病人是心血管的病态和死亡的一个有势力预言者。现在的学习的目的是在百和 76 个个人(45-75 年年龄) 参予了的糖尿病、非糖尿病的动脉粥样硬化患者 patients.MethodsFive 调查在老化和类脂化合物侧面之间的关系这研究。在这些之中, 192 正在有糖尿病 mellitus 和动脉粥样硬化的历史。个人们在健康的底上被分类(正常、非糖尿病的动脉粥样硬化,糖尿病的动脉粥样硬化) 并且年龄(45-55 年, 56-65 年,和 66-75 年) 。所有参加者受到象详细历史一样的过程,为 fasting 血糖的生物化学的分析,血红素 A1c,全部的胆固醇(TC ) , triglycerides (TG ) ,低密度的脂蛋白 --(LDL ) ,很低密度的脂蛋白(VLDL ) 和高密度的脂蛋白(HDL ) 。所有这些参数在所有三个年龄组的糖尿病、非糖尿病的动脉粥样硬化患者病人之间被比较。TC/HDL 和 LDL/HDL 也是有的 calculated.ResultsDiabetic 动脉粥样硬化患者个人(男性和女性) 与非糖尿病的动脉粥样硬化患者和正常控制个人相比的 HDL 的 TC, TG, LDL, VLDL 和底层高级。在所有三个年龄组之中,脂蛋白反常被观察比男性在女性更经常。在与年龄相比的糖尿病的动脉粥样硬化患者题目 TC/HDL 和 LDL/HDL 比率有重要增加,性别随两性的年龄的增加匹配非糖尿病的动脉粥样硬化患者和 dyslipidemia 增加的正常 control.ConclusionsDegree。女性是对糖尿病的 dyslipidemia 敏感的更多并且因此有与增加年龄开发动脉粥样硬化的更多的风险。 | Fatima Ali Hassan Jamil Sanam Saiqa Anwar Nadia Wajid | 2015 | Journal of Geriatric Cardiology2015，12，1： | 6 |
| 16 | Nuclear magnetic resonance based metabolomics and liverdiseases:Recent advances and future clinical applications显示文摘Metabolomics is defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification.It is an'omics'technique that is situated downstream of genomics,transcriptomics and proteomics.Metabolomics is recognized as a promising technique in the field of systems biology for the evaluation of global metabolic changes.During the last decade,metabolomics approaches have become widely used in the study of liver diseases for the detection of early biomarkers and altered metabolic pathways.It is a powerful technique to improve our pathophysiological knowledge of various liver diseases.It can be a useful tool to help clinicians in the diagnostic process especially to distinguish malignant and non-malignant liver disease as well as to determine the etiology or severity of the liver disease.It can also assess therapeutic response or predict drug induced liver injury.Nevertheless,the usefulness of metabolomics is often not understood by clinicians,especially the concept of metabolomics profiling or fingerprinting.In the present work,after a concise description of the different techniques and processes used in metabolomics,we will review the main research on this subject by focusing specifically on in vitro proton nuclear magnetic resonance spectroscopy based metabolomics approaches in human studies.We will first consider the clinical point of view enlighten physicians on this new approach and emphasis its future use in clinical'routine'. | Roland Amathieu Mohamed Nawfal Triba Corentine Goossens Nadia Bouchemal Pierre Nahon Philippe Savarin Laurence Le Moyec | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 17 | Temporomandibular joint damage in K/BxN arthritic mice显示文摘Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood. | Sabine Kuchler-Bopp Alexandre Mariotte Marion Strub Chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence Fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel Fabien Bornert | 2020 | International Journal of Oral Science2020，12，1： | 6 |
| 18 | Archaea and the human gut:New beginning of an old story显示文摘Methanogenic archaea are known as human gut inhabitants since more than 30 years ago through the detection of methane in the breath and isolation of two methanogenic species belonging to the order Methanobacteriales,Methanobrevibacter smithii and Methanosphaera stadtmanae.During the last decade,diversity of archaea encountered in the human gastrointestinal tract(GIT)has been extended by sequence identification and culturing of new strains.Here we provide an updated census of the archaeal diversity associatedwith the human GIT and their possible role in the gut physiology and health.We particularly focus on the still poorly characterized 7th order of methanogens,the Methanomassiliicoccales,associated to aged population.While also largely distributed in non-GIT environments,our actual knowledge on this novel order of methanogens has been mainly revealed through GIT inhabitants.They enlarge the number of final electron acceptors of the gut metabolites to mono-di-and trimethylamine.Trimethylamine is exclusively a microbiota-derived product of nutrients(lecithin,choline,TMAO,L-carnitine)from normal diet,from which seems originate two diseases,trimethylaminuria(or Fish-Odor Syndrome)and cardiovascular disease through the proatherogenic property of its oxidized liver-derived form.This therefore supports interest on these methanogenic species and its use as archaebiotics,a term coined from the notion of archaea-derived probiotics. | Nadia Gaci Guillaume Borrel William Tottey Paul William O’Toole Jean-Fran?ois Brugère | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 19 | Fast-tracking regenerative medicine for traumatic brain injury显示文摘Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death.Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect.In this review,we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation,edema,and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants.Although these studies of stand-alone treatments have yielded some positive results,more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy.Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts.The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan | 2020 | Neural Regeneration Research2020，15，7： | 5 |
| 20 | Clinical outcome of pediatric collagenous gastritis: Case series and review of literature显示文摘Collagenous gastritis (CG) is characterized by patchy subepithelial collagen bands. Effective treatment and the clinical and histological outcome of CG in children are poorly defined. The aim of this study is to summarize the published literature on the clinical outcome and response to therapy of pediatric CG including two new cases. We performed a search in Pubmed, OVID for related terms; articles including management and clinical and/or endo-histologic follow up information were included and abstracted. Reported findings were pooled in a dedicated database including the corresponding data extracted from chart review in our patients with CG. Twenty-four patients were included (17 females) with a mean age of 11.7 years. The clinical presentation included iron deficiency anemia and dyspepsia. The reported duration of follow up (in 18 patients) ranged between 0.2-14 years. Despite most subjects presenting with anemia including one requiring blood transfusion, oral iron therapy was only documented in 12 patients. Other treatment modalities were antisecretory measures in 13 patients; proton pump inhibitors (12), or histamine-2 blockers (3), sucralfate (5), prednisolone (6), oral budesonide in 3 patients where one received it in fish oil and triple therapy (3). Three (13%) patients showed no clinical improvement despite therapy; conversely 19 out of 22 were reported with improved symptoms including 8 with complete symptom resolution. Spontaneous clinical resolution without antisecretory, anti-inflammatory or gastroprotective agents was noted in 5 patients (4 received only supplemental iron). Follow up endohistopathologic data (17 patients) included persistent collagen band and stable Mononuclear cell infiltrate in 12 patients with histopathologic improvement in 5 patients. Neither collagen band thickness nor mononuclear cell infiltrate correlated with clinical course. Intestinal metaplasia and endocrine cell hyperplasia were reported (1) raising the concern of long term malignant transformation. In summary, CG in children is a chronic disease, typically with a variable clinical response and an indolent course that is distinct from the adult phenotype. Long term therapy usually inclused iron supplementation but cannot be standardized, given the chronicity of the disease, variability of response and potential for adverse events. | Nadia Mazen Hijaz Seth Steven Septer James Degaetano Thomas Mario Attard | 2013 | World Journal of Gastroenterology2013，19，9： | 5 |
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