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| 1 | Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage显示文摘证据正在增加精子 DNA 的正直可能也与培植失败和周期性的流产(RM ) 有关。调查这,在有在 vitro 授精,与 RM 诊断的 16 个女人和七位最近的父亲(控制) 列在后面的周期性的培植失败(RIF ) 的 35 个女人的搭挡的精子 DNA 破碎被检验。精子由测试和终端 deoxynucleotidyl transferase dUTP 刻痕结束标记的精子染色质分散(SCD )(TUNEL ) 是检验密度前和密度以后的 centrifugation 试金。在在三之间的搭挡或精子集中,活动性或形态学组织的任何一个的年龄没有重要差别。而且,在 DNA 破碎由也测量了的精子没有明显的差别测试。不管多么虽然平均在所有的精子 DNA 破碎组织当由 SCD 测试测量了时,在准备精子是统计上更低的,这没从 TUNEL 试金与结果被看见。这些结果不支持精子 DNA 破碎是 RIF 或 RM 的一个重要原因的假设,否则测试的那精子 DNA 正直在如此的病人有价值。它也在从精子 DNA 破碎测试解释数据加亮测试方法论和精子准备方法之间的重要差别。 | Carol Coughlan Helen Clarke Rachel Cutting Jane Saxton Sarah Waite William Ledger Tinchiu Li Allan A Pacey | 2015 | Asian Journal of Andrology2015，17，4： | 17 |
| 2 | Bisphenol A exposure alters release of immune and developmental modulators and expression of estrogen receptors in human fetal lung fibroblasts显示文摘Bisphenol A(BPA) has been shown to exert biological effects through estrogen receptor(ER)-dependent and ER-independent mechanisms. Recent studies suggest that prenatal exposure to BPA may increase the risk of childhood asthma. To investigate the underlying mechanisms in the actions of BPA, human fetal lung fibroblasts(h FLFs) were exposed to varying doses of BPA in culture for 24 hr. Effects of BPA on localization and uptake of BPA,cell viability, release of immune and developmental modulators, cellular localization and expression of ERα, ERβ and G-protein coupled estrogen receptor 30(GPR30), and effects of ERs antagonists on BPA-induced changes in endothelin-1(ET-1) release were examined.BPA at 0.01–100 μmol/L caused no changes in cell viability after 24 hr of exposure. h FLFs expresses all three ERs. BPA had no effects on either cellular distribution or protein expression of ERα, however, at 100 μmol/L(or 23 μmol/L intracellular BPA) increased ERβprotein levels in the cytoplasmic fractions and GPR 30 protein levels in the nuclear fractions.These paralleled with increased release of growth differentiation factor-15, decreased phosphorylation of nuclear factor kappa B p65 at serine 536, and decreased release of ET-1,interleukin-6, and interferon gamma-induced protein 10. ERs antagonists had no effects on BPA-induced decrease in ET-1 release. These data suggest that BPA at 100 μmol/L altered the release of immune and developmental modulators in h FLFs, which may negatively influence fetal lung development, maturation, and susceptibility to environmental stressors, although the role of BPA in childhood asthma remains to be confirmed in in vivo studies. | Laziyan Mahemuti Qixuan Chen Melanie C. Coughlan Min Zhang Maria Florian Ryan J Mailloux Xu-Liang Cao Kylie A. Scoggan William G. Willmore Xiaolei Jin | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
| 3 | Fabrication of Noble metal-semiconductor hybrid nanostructures using phase transfer显示文摘 | Tanushree Bala Ajay Singh Ambarish Sanyal Catriona O'Sullivan Fathima Laffir Claudia Coughlan Kevin M. Ryan | 2013 | Nano Research2013，6，2： | 3 |
| 4 | Does hypertriglyceridemia increase the risk of CAD?显示文摘 | COUGHLAN B J SORRENTIO M J | 2001 | Post Graduate Med2001，108，2： | 2 |
| 5 | Optimal Restocking Fees and Information Provision in an Integrated Demand-Supply Model of Product Returns显示文摘 | Jeffrey D. Shulman Anne T. Coughlan R. Canan Savaskan | 2009 | Manufacturing & Service Operations Management2009，，4： | 2 |
| 6 | Reaction of sulfur dioxide limestone and the grain model显示文摘 | Hartman M Coughlan R W | 1976 | AIChE j1976，，22： | 2 |
| 7 | Dysfunctional mitochondria contain endogenous high-affinity human Toll like receptor 4 (TLR4) ligands and induce TLR4 mediated in flammatory reactions 显示文摘 | Nicholas SA Coughlan K Yasinska I | 2011 | Int J Bioehem Cell Biol2011，43，4： | 1 |
| 8 | The estimation of filtering rate from the clearance of suspensions显示文摘 | COUGHLAN J | 1969 | Mar Biol1969，2，4： | 1 |
| 9 | The servicescape as an antecedent to service quality and behavioral intentions显示文摘 | Daire Hooper Joseph Coughlan Michael R. Mullen | 2013 | Journal of Services Marketing2013，，4： | 1 |
| 10 | Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy显示文摘 | Lindblom R Higgins G Coughlan M | 2015 | Rev Diabet Stud2015，12，12： | 1 |
| 11 | Glial nitric oxide and is-chemia显示文摘 | Gibson CL Coughlan TC Murphy SP | 2005 | Glia2005，50，4： | 1 |
| 12 | Development of a technical innovation audit 显示文摘 | Chiesa V Coughlan P Voss C A | 1996 | Journal of Production Innovation Management1996，，13： | 1 |
| 13 | The hydrogenation of benzene over nickel-supported Y zeolites Part 1 A kinetic approach 显示文摘 | COUGHLAN B KEANE M A | 1991 | Zeolites1991，11，： | 1 |
| 14 | Patellofemoral contact forces and pressures during intramedullary tibial nailing显示文摘 | Devitt AT Coughlan KA Ward T | | 0，，02： | 1 |
| 15 | Mitochondrial dysfunction and mitophagy:the beginning and end to diabetic nephropathy显示文摘 | Higgins GC Coughlan MT | 2014 | Br J Pharmacol2014，171，8： | 1 |
| 16 | Oxidative stress as a major cul- prit in kidney disease in diabetes显示文摘 | Forbes JM Coughlan MT Cooper ME | 2008 | Diabetes2008，57，6： | 1 |
| 17 | Statistical edge detection: Learning and evaluating edge cues显示文摘 | Konishi S Yuile AL Coughlan JM | 2003 | IEEE Transactions on Pattern Analysis and Machine Intelligence2003，25，1： | 1 |
| 18 | Immunogenicity of recombinant BCG producing the GRA1 antigen from toxoplasma gondii显示文摘 | Supply P Sutton P Coughlan SN | 1999 | Vaccine1999，17，： | 1 |
| 19 | The hydrogenation of benzene over nickel-supported Y zeolites Part 2 A mechanistic approach 显示文摘 | COUGHLAN B KEANE M A | 1991 | Zeolites1991，11，： | 1 |
| 20 | A study of electrically conductive adhesives as a manufacturing solder alternative显示文摘 | F. M. Coughlan H. J. Lewis | 2006 | Journal of Electronic Materials2006，，5： | 1 |
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