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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) Trial显示文摘 | James A. Goldstein Kavitha M. Chinnaiyan Aiden Abidov Stephan Achenbach Daniel S. Berman Sean W. Hayes Udo Hoffmann John R. Lesser Issam A. Mikati Brian J. O’Neil Leslee J. Shaw Michael Y.H. Shen Uma S. Valeti Gilbert L. Raff | 2011 | Journal of the American College of Cardiology2011，，14： | 1 |
| 3 | The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir显示文摘 | Bo Qin Bettina Budeus Liang Cao Chunchen Wu Yun Wang Xiaoyong Zhang Simon Rayner Daniel Hoffmann Mengji Lu Xinwen Chen | 2013 | Antiviral Research2013，，2： | 1 |
| 4 | Feasibility study and control values of transient elastography in healthy children显示文摘 | Guido Engelmann Caroline Gebhardt Daniel Wenning Elke Wühl Georg F Hoffmann Buket Selmi Juergen Grulich-Henn Jens Peter Schenk Ulrike Teufel | 2012 | European Journal of Pediatrics2012，，2： | 1 |
| 5 | Pericardial Fat Is Associated With Prevalent Atrial Fibrillation: The Framingham Heart Study显示文摘 | George Thanassoulis Joseph M. Massaro Christopher J. O?Donnell Udo Hoffmann Daniel Levy Patrick T. Ellinor Thomas J. Wang Renate B. Schnabel Ramachandran S. Vasan Caroline S. Fox Emelia J. Benjamin | 2010 | Circulation: Arrhythmia and Electrophysiology2010，，4： | 1 |
| 6 | Fabrication characterization and modelling of electrostatic micro-generator- s 显示文摘 | Hoffmann Daniel Folkmer Bernd Manolil Yiannos | 2009 | Journal of Micromeehanics and Microengineering2009，19，： | 1 |
| 7 | Shock Efficacy of Subcutaneous Implantable Cardioverter-Defibrillator for Prevention of Sudden Cardiac Death: Initial Multicenter Experience显示文摘 | Ali Aydin Friederike Hartel Michael Schlüter Christian Butter Julia K?be Martin Seifert Nils Gosau Boris Hoffmann Matthias Hoffmann Eik Vettorazzi Iris Wilke Karl Wegscheider Hermann Reichenspurner Lars Eckardt Daniel Steven Stephan Willems | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，5： | 1 |
| 8 | Inference of Global HIV-1 Sequence Patterns and Preliminary FeatureAnalysis显示文摘The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to Produce Error Reduction) to multiple sequence alignments of Env sequences from four classes of compiled datasets, we generated four sets of signature patterns. We found that these patterns were able to distinguish southeastern Asian from non- southeastern Asian sequences with 97.5% accuracy, Chinese from non-Chinese sequences with 98.3% accuracy, African from non-African sequences with 88.4% accuracy, and southern African from non-southern African sequences with 91.2% accuracy. These patterns showed different associations with subtypes and with amino acid positions. In addition, some signature patterns were characteristic of the geographic area from which the sample was taken. Amino acid features corresponding to the phylogenetic clustering of HIV-1 sequences were consistent with some of the deduced patterns. Using a combination of patterns inferred from subtypes B, C, and all subtypes chimeric with CRF01_AE worldwide, we found that signature patterns of subtype C were extremely common in some sampled countries (for example, Zambia in southern Africa), which may hint at the origin of this HIV-1 subtype and the need to pay special attention to this area of Africa. Signature patterns of subtype B sequences were associated with different countries. Even more, there are distinct patterns at single position 21 with glycine, leucine and isoleucine corresponding to subtype C, B and all possible recombination forms chimeric with CRF01_AE, which also indicate distinct geographic features. Our method widens the scope of inference of signature from geographic, genetic, and genomic viewpoints. These findings may provide a valuable reference for epidemiological research or vaccine design. | Yan Wang Reda Rawi Daniel Hoffmann Binlian Sun Rongge Yang | 2013 | Virologica Sinica2013，28，4： | 1 |
| 9 | Fusing MEMS technology with lab-on-chip: nanoliter-scale silicon microcavity arrays for digital DNA quantification and multiplex testing显示文摘We report on the development of a microfluidic multiplexing technology for highly parallelized sample analysis via quantitative polymerase chain reaction(PCR)in an array of 96 nanoliter-scale microcavities made from silicon.This PCR array technology features fully automatable aliquoting microfluidics,a robust sample compartmentalization up to temperatures of 95°C,and an application-specific prestorage of reagents within the 25nl microcavities.The here presented hybrid silicon–polymer microfluidic chip allows both a rapid thermal cycling of the liquid compartments and a real-time fluorescence read-out for a tracking of the individual amplification reactions taking place inside the microcavities.We demonstrate that the technology provides very low reagent carryover of prestored reagents<6×10^(−2) and a cross talk rate<1×10^(−3) per PCR cycle,which facilitate a multi-targeted sample analysis via geometric multiplexing.Furthermore,we apply this PCR array technology to introduce a novel digital PCR-based DNA quantification method:by taking the assay-specific amplification characteristics like the limit of detection into account,the method allows for an absolute gene target quantification by means of a statistical analysis of the amplification results. | Daniel Podbiel Franz Laermer Roland Zengerle Jochen Hoffmann | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 10 | Neck Circumference as a Novel Measure of Cardiometabolic Risk: The Framingham Heart Study显示文摘 | Sarah Rosner Preis Joseph M. Massaro Udo Hoffmann Ralph B. D?Agostino Daniel Levy Sander J. Robins James B. Meigs Ramachandran S. Vasan Christopher J. O?Donnell Caroline S. Fox | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，8： | 1 |
| 11 | A comparative ultrastructural study of blood cells from nine insect orders显示文摘 | Dr. Michel Brehélin Daniel Zachary Jules A. Hoffmann | 1978 | Cell and Tissue Research1978，，1： | 1 |
| 12 | Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation显示文摘 | Sarah–Fee Katz André Lechel Anna C. Obenauf Yvonne Begus–Nahrmann Johann M. Kraus Eva M. Hoffmann Johanna Duda Parisa Eshraghi Daniel Hartmann Birgit Liss Peter Schirmacher Hans A. Kestler Michael R. Speicher K. Lenhard Rudolph | 2012 | Gastroenterology2012，，5： | 1 |
| 13 | Feasibility study and control values of transient elastography in healthy children显示文摘 | Guido Engelmann Caroline Gebhardt Daniel Wenning Elke Wühl Georg F Hoffmann Buket Selmi Juergen Grulich-Henn Jens Peter Schenk Ulrike Teufel | 2012 | European Journal of Pediatrics2012，，2： | 1 |
| 14 | The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) Trial显示文摘 | James A. Goldstein Kavitha M. Chinnaiyan Aiden Abidov Stephan Achenbach Daniel S. Berman Sean W. Hayes Udo Hoffmann John R. Lesser Issam A. Mikati Brian J. O’Neil Leslee J. Shaw Michael Y.H. Shen Uma S. Valeti Gilbert L. Raff | 2011 | Journal of the American College of Cardiology2011，，14： | 1 |
| 15 | Acute skin alterations following ultraviolet radiation investigated by optical coherence tomography and histology显示文摘 | Thilo Gambichler Stefanie Boms Markus Stücker Georg Moussa Alexander Kreuter Michael Sand Daniel Sand Peter Altmeyer Klaus Hoffmann | 2005 | Archives of Dermatological Research2005，，5： | 1 |
| 16 | Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis显示文摘 | Philippe Georgel Silvia Naitza Christine Kappler Dominique Ferrandon Daniel Zachary Candace Swimmer Casey Kopczynski Geoffrey Duyk Jean-Marc Reichhart Jules A. Hoffmann | 2001 | Developmental Cell2001，，4： | 1 |
| 17 | Imprinted Zac1 in neural stem cells显示文摘Neural stem cells(NSCs) and imprinted genes play an important role in brain development. On historical grounds, these two determinants have been largely studied independently of each other. Recent evidence suggests, however, that NSCs can reset select genomic imprints to prevent precocious depletion of the stem cell reservoir. Moreover, imprinted genes like the transcriptional regulator Zac1 can fine tune neuronal vs astroglial differentiation of NSCs. Zac1 binds in a sequence-specific manner to pro-neuronal and imprinted genes to confer transcriptional regulation and furthermore coregulates members of the p53-family in NSCs. At the genome scale, Zac1 is a central hub of an imprinted gene network comprising genes with animportant role for NSC quiescence, proliferation and differentiation. Overall, transcriptional, epigenomic, and genomic mechanisms seem to coordinate the functional relationships of NSCs and imprinted genes from development to maturation, and possibly aging. | Guillaume Daniel Udo Schmidt-Edelkraut Dietmar Spengler Anke Hoffmann | 2015 | World Journal of Stem Cells2015，7，2： | 1 |
| 18 | Ground-based spectral reflectance measurements for evaluating the efficacy of aerially- applied glyphosate treatments显示文摘 | Huihui Zhang Yubin Lan Ronald Lacey W. Clint Hoffmann Daniel E. Martin Brad Fritz Juan Lopez | 2010 | Biosystems Engineering2010，，1： | 1 |
| 19 | Human aldehyde dehydrogenase-catalyzed oxidation of ethylene glycol ether aldehydes显示文摘 | Aaron Gross Ta Ren Ong Rainer Grant Todd Hoffmann Daniel D. Gregory Lakshmaiah Sreerama | 2008 | Chemico-Biological Interactions2008，，： | 1 |
| 20 | In Situ Electrochemical Electron Microscopy Study of Oxygen Evolution Activity of Doped Manganite Perovskites显示文摘 | Stephanie Raabe Daniel Mierwaldt Jim Ciston Matthé Uijttewaal Helge Stein J?rg Hoffmann Yimei Zhu Peter Bl?chl Christian Jooss | 2012 | Adv. Funct. Mater2012，，16： | 1 |
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