|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | 利率和收入差距如何左右住房支付能力?显示文摘最近新成立的“哈佛—清华住房政策学术研究组”由哈佛大学住房研究中心(Joint Center for Housing Studies at Harvard University)和清华大学房地产研究所(Institute of Real Estate Studies at Tsinghua University)联合组建,主要致力于探讨中国当前城市住房市场中的经济、政策和金融问题。哈佛大学住房研究中心执行主任EricBelsky和清华大学房地产研究所所长刘洪玉教授是该研究组的学术顾问,清华大学房地产研究所讲师郑思齐博士与哈佛大学住房研究中心MarkDuda博士担任研究组学术论文的编辑工作。自本期起,《城市开发》将邀请该研究组陆续(隔期)发表对当前中国住房市场和住房政策的评论性文章,突出国际比较和理性分析,敬请关注。 | Mark Duda 郑思齐 | 2006 | 城市开发2006，，10： | 12 |
| 3 | 预期是否在推动房价上涨?显示文摘在短期,除了经济基本面因素外,住房需求还在很大程度上受到市场参与者“近视预期”的驱动,而短期供给不能对需求的变化作出快速的反应,从而导致房价的短期波动。 | 郑思齐 Mark Duda | 2007 | 城市开发2007，，8： | 8 |
| 4 | 由CDSN记录计算出的谱震级和地震辐射能显示文摘用10个数字化台的宽频带数字记录,计算了1986至1989年间发生在欧亚地震带上的18次Ms≥6地震的谱震级和地震辐射能。10个数字化台中有9个属于中国数字化地震台网,1个属于德国格拉芬堡台阵,计算得到的不同周期的谱震级,有的稳定性较好,有的稳定性较差,最大谱震级mi和地震辐射能E稳定性较好,各台之间差异很小。特别是对于震中距较大,射线主要通过下地幔的台站,稳定性更好,而拐角周期的稳定性一般较差。 | 陈培善 Duda,SJ | 1993 | 地震学报1993，15，4： | 7 |
| 5 | Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer显示文摘Metastatic prostate cancer is one of the leading causes of cancer-related death in men.The primary site of metastasis from prostate cancers is the bone.During the last decade,multiple studies have pointed to the role of the stromal cell-derived factor 1 alpha(SDF1α)/CXCR4 axis in the metastatic spread of the disease,but the mechanisms that underlie this effect are still incompletely understood.In this review,we summarize the current understanding of the role of the SDF1α/CXCR4 pathway in bone metastatic prostate cancer.We also discuss the therapeutic potential of disrupting the interaction between prostate tumor cells and bone environment with focus on the SDF1α pathway. | Nisha Gupta Dan G. Duda | 2016 | The Journal of Biomedical Research2016，30，3： | 5 |
| 6 | Doege-Potter syndrome by malignant solitary fibrous tumor of the liver: A case report and review of literature显示文摘BACKGROUND Solitary fibrous tumor of the liver (SFTL) is a rare occurrence with a low number of cases reported in literature. SFTL is usually benign but, 10%-20% cases are reported to be malignant with a tendency to metastasize. The majority of malignant SFTL cases are associated with a paraneoplastic hypoglycaemia defined as Doege-Potter syndrome. Surgery is the best therapeutic treatment, however, long- life follow-up is recommended. CASE SUMMARY A 74-year-old man, was admitted to the emergency department after a syncopal episode with detection of hypoglycaemia resistant to medical treatment. The computed tomography revealed a solid mass measuring 15 cm of the left liver. An open left hepatectomy was performed with complete resection of tumor. Histopathological analyses confirmed a malignant SFTL. CONCLUSION Large series with long-term follow-up have not been published neither have clinical trials been undertaken. Consequently, the methodical long-term followup of surgically treated SFTLs is strongly recommended. | Delvecchio Antonella Duda Loren Conticchio Maria Fiore Felicia Lafranceschina Stefano Riccelli Umberto Cristofano Antonella Pascazio Bianca Colagrande Anna Resta Leonardo Memeo Riccardo | 2019 | World Journal of Gastrointestinal Surgery2019，11，8： | 5 |
| 7 | A numerical study on the generation of a distinct type of nonlinear internal wave packet in the South China Sea显示文摘A distinct type of nonlinear internal-wave packet, with the largest internal solitary wave in the middle of the packet, was regularly observed in the South China Sea during the Asian Seas International Acoustics Experiment in 2001. Data analysis shows that the occurrence of the distinct internal wave packet is closely related with the occurrence of lower-high internal tides; the internal tides are mixed in the experimental area and, thus, there is diurnal inequality between the heights of two neighboring internal tides. Modeling of internal tides and internal solitary waves in a shoaling situation suggests that this type of wave packet can be generated in the South China Sea by the large shoaling of internal solitary waves and internal tides. Both the internal solitary waves and the internal tides come from the direction of Luzon Strait. The initial large internal solitary waves contribute to the occurrence of the largest internal solitary wave in the middle of the packet and the waves behind the largest internal solitary wave, while the shoaling internal tides bring about the nonlinear internal waves in front of the largest internal solitary wave via interaction with the local shelf topography. | 杜涛 严晓海 Timothy DUDA | 2010 | Chinese Journal of Oceanology and Limnology2010，28，3： | 4 |
| 8 | Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature显示文摘BACKGROUND Benign recurrent intrahepatic cholestasis is a genetic disorder with recurrent cholestatic jaundice due to ATP8B1 and ABCB11 gene mutations encoding for hepato-canalicular transporters.Herein,we firstly provide the evidence that a nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygous form is involved in BRIC pathogenesis.CASE SUMMARY A 29-year-old male showed severe jaundice and laboratory tests consistent with intrahepatic cholestasis despite normal gamma-glutamyltranspeptidase.Acute and chronic liver diseases with viral,metabolic and autoimmune etiology were excluded.Normal intra/extra-hepatic bile ducts were demonstrated by magnetic resonance.Liver biopsy showed:Cholestasis in the centrilobular and intermediate zones with bile plugs and intra-hepatocyte pigment,Kupffer’s cell activation/hyperplasia and preserved biliary ducts.Being satisfied benign recurrent intrahepatic cholestasis diagnostic criteria,ATP8B1 and ABCB11 gene analysis was performed.Surprisingly,we found a novel nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygosis.The variant was confirmed by Sanger sequencing following a standard protocol and tested for familial segregation,showing a maternal inheritance.Immunohistochemistry confirmed a significant reduction of mutated gene related protein(familial intrahepatic cholestasis 1).The patient was treated with ursodeoxycholic acid 15 mg/kg per day and colestyramine 8 g daily with total bilirubin decrease and normalization at the 6th and 12th mo.CONCLUSION A genetic abnormality,different from those already known,could be involved in familial intrahepatic cholestatic disorders and/or pro-cholestatic genetic predisposition,thus encouraging further mutation detection in this field. | Mariano Piazzolla Nicola Castellaneta Antonio Novelli Emanuele Agolini Dario Cocciadiferro Leonardo Resta Loren Duda Michele Barone Enzo Ierardi Alfredo Di Leo | 2020 | World Journal of Hepatology2020，12，2： | 3 |
| 9 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 10 | Solution of Inverse Heat Conduction Problem using the Tikhonov Regulariza-tion Method显示文摘It is hard to solve ill-posed problems, as calculated temperatures are very sensitive to errors made while calculating 'measured' temperatures or performing real-time measurements. The errors can create temperature oscillation, which can be the cause of an unstable solution. In order to overcome such difficulties, a variety of techniques have been proposed in literature, including regularization, future time steps and smoothing digital filters. In this paper, the Tikhonov regularization is applied to stabilize the solution of the inverse heat conduction problem. The impact on the inverse solution stability and accuracy is demonstrated. | Piotr Duda | 2017 | Journal of Thermal Science2017，26，1： | 2 |
| 11 | Biomechanical In Vitro Testing of Human Osteoporotic Lumbar Vertebrae Following Prophylactic Kyphoplasty With Different Candidate Materials显示文摘 | Robert Rotter Robert Pflugmacher Frank Kandziora Andreas Ewert Georg Duda Thomas Mittlmeier | 2007 | Spine2007，，13： | 2 |
| 12 | Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue显示文摘 | Ihtzaz Ahmed Malik Federico Moriconi Nadeem Sheikh Naila Naz Sajjad Khan Jozsef Dudas Tümen Mansuroglu Clemens Friedrich Hess Margret Rave-Fr?nk Hans Christiansen Giuliano Ramadori | 2010 | The American Journal of Pathology2010，，4： | 2 |
| 13 | Proximal humeral fractures: how stiff should an implant be?显示文摘 | H. Lill P. Hepp J. Korner J.-P. Kassi A. P. Verheyden C. Josten G. N. Duda | 2003 | Archives of Orthopaedic and Trauma Surgery (-)2003，，2： | 2 |
| 14 | Global spread of dengue virus types: mapping the 70-year history显示文摘 | Jane P. Messina Oliver J. Brady Thomas W. Scott Chenting Zou David M. Pigott Kirsten Duda Samir Bhatt Leah Katzelnick Rosalind E. Howes Katherine E. Battle Cameron P. Simmons Simon I. Hay | 2013 | Trends in Microbiology2013，，： | 2 |
| 15 | The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial det'ects显示文摘 | Jason R Dudas BA Kacey G | 2006 | J Ann Plast Surg2006，56，5： | 1 |
| 16 | Skin--sparing mastectomy and immediate reconstruction: oncologic risks and aesthetic resuits in patients with early--stage breast cancer显示文摘 | Slavin SA Schnitt SJ Duda RB | 1998 | Plast Reconstr Surg1998，102，1： | 1 |
| 17 | Is social acceptance aproblem for noise control and active silencers显示文摘 | Hirschom M Duda J | 2000 | Sound and Vibration2000，34，8： | 1 |
| 18 | Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway显示文摘 | DUDAS M NAGY A LAPING N J | 2004 | Dev Biol2004，266，1： | 1 |
| 19 | Immunohistochemical localization of androgen receptor and aromatase in the ovary of the pregnam pig显示文摘 | Duda M Burek M Galas J | 2004 | Biol Reprod2004，114，3： | 1 |
| 20 | Design, scale up and safe piloting of thymol hydro- genation and menthol racemisation显示文摘 | Dudas J Hanika J | 2009 | Chemical Engineering Research and Design2009，87，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员