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| 1 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 2 | 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions显示文摘 | Glenn N. Levine Eric R. Bates James C. Blankenship Steven R. Bailey John A. Bittl Bojan Cercek Charles E. Chambers Stephen G. Ellis Robert A. Guyton Steven M. Hollenberg Umesh N. Khot Richard A. Lange Laura Mauri Roxana Mehran Issam D. Moussa Debabrata Mu | 2011 | Circulation2011，，23： | 3 |
| 3 | Benzimidazolium Functionalized Polysulfone-based Anion Exchange Membranes with Improved Alkaline Stability显示文摘The stability of anion exchange membranes(AEMs) is an important feature of alkaline exchange membrane fuel cells(AEMFCs), which has been extensively studied. However it remains a real challenge due to the harsh working condition. Herein, we developed a novel type of polysulfone-based AEMs with three modified 1,2-dimethylbenzimidazoliums containing different substitutes at C4-and C7-position. The results showed that the introduction of the substitutes could obviously improve the dimensional and alkaline stabilities of the corresponding membranes. The swelling ratios of resultant AEMs were all lower than 10% after water immersion. The membrane with 4,7-dimethoxy-1,2-dimethylbenzimidazolium group exhibited the highest alkaline stability. Only 9.2% loss of hydroxide conductivity was observed after treating the membrane in 1 mol·L^(-1) KOH solution at 80 °C for 336 h. Furthermore, the density functional theory(DFT) study on the three functional group models showed that the substitutes at C4-and C7-position affected the lowest unoccupied molecular orbital(LUMO) energies of the different 1,2-dimethylbenzimidazolium groups. | Yu Pan Ting-Yun Wang Xiao-Ming Yan Xiao-Wei Xu Qi-Dong Zhang Bao-Lin Zhao Issam El Hamouti Ce Hao Gao-Hong He | 2018 | Chinese Journal of Polymer Science2018，36，1： | 2 |
| 4 | Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM):A Molecular Assessment显示文摘Objective To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity. Methods Female Wistar rats were randomly assigned to control (3 groups, 6 rats in each) and treatment groups (3 groups, 6 rats in each). They were subjected to subcutaneous injections of DM (at doses of 0.003, 0.03, and 0.3 mg/kg bw/d) after 30, 45, and 60 d, respectively. Results Significant alterations were recorded in liver parenchyma induced by hepatic vacuolization, fragmented chromatin in nuclei, dilatation of sinusoids and congestions. Lesions within proximal and distal tubules were observed in the kidneys. Tissue congestions and severe alterations within glomeruli were visible. DM as a pyrethroid insecticide induced significant increase (P≤0.05) of plasma MDA concentrations after 45 d. A significant increase (P≤0.05) in plasma ALT (after 45 and 60 d) and AST (after 60 d) concentrations was recorded as compared to controls. During the whole experimental period the toxic agent provoked significant DNA damages (P≤0.05), especially in the dominance of classes 3 and 4 of obtained comet. Conclusion DM even at a very low dose displays harmful effects by disrupting hepatic and renal function and causing DNA damages in puberscent female rats. Low doses of DM are hepatotoxic and nephrotoxic. | CHARGUI Issam GRISSA Intissar BENSASSI Fatma HRIRA Mohamed Yahia HAOUEM Samir HAOUAS Zohra BENCHEIKH Hassen | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 5 | Decline and dieback of cork oak(Quercus suber L.)forests in the Mediterranean basin:a case study of Kroumirie,Northwest Tunisia显示文摘Assessing the vulnerability of forest ecosystems in the climate change context is a challenging task as the mechanisms that determine this vulnerability cannot be directly observed.Based on the ecological interrelationships between forests and climate,the present review focused on providing current information about vulnerability assessments of cork oak(Quercus suber L.)forests in the Mediterranean basin,especially,in the Kroumirie region(northwest Tunisia),currently under historic extreme drought conditions.From comparing recent findings in this region,we synthesized data on cork oak decline and mortality collected during the historic drought years 1988–1995 period.Climate change impacts cork forest decline,with special interest shown in elevated temperatures and drought;cork oak forest regeneration,and the adaptation of the Kroumirie forest to climate change,are reviewed herein.The studied region has been influenced largely by frequent prolonged drought periods,especially from 1988 to 1995.Droughts were found to consistently have a more detrimental impact on the growth and mortality rates of cork oak populations.Cork oak mortality was recorded for up to 63,622 trees.In the future,more research studies and observational data will be needed,which could represent an important key to understand ecosystem processes,and to facilitate the development of better models that project climate change impacts and vulnerability.The study is useful for researchers and forestry decision makers to develop the appropriate strategies to restore and protect ecosystems,and to help anticipate potential future droughts and climate change. | Issam Touhami E.Chirino H.Aouinti A.El Khorchani M.T.Elaieb A.Khaldi Z.Nasr | 2020 | Journal of Forestry Research2020，31，5： | 2 |
| 6 | Guidelines for the prevention of intravascular catheter-related infections显示文摘 | Naomi P. O’Grady Mary Alexander Lillian A. Burns E. Patchen Dellinger Jeffrey Garland Stephen O. Heard Pamela A. Lipsett Henry Masur Leonard A. Mermel Michele L. Pearson Issam I. Raad Adrienne G. Randolph Mark E. Rupp Sanjay Saint | 2011 | AJIC: American Journal of Infection Control2011，，4： | 2 |
| 7 | Chitosan polymer as bioactive coating and film against Aspergillus niger contamination显示文摘 | ISSAM S T ADELE M G ADELE C P | 2005 | Journal of Food Science2005，70，2： | 1 |
| 8 | Drill flank wear estimation using supervised vector quantization neural networks显示文摘 | Issam Abu-Mahfouz | 2005 | Neural Computing and Applications2005，14，3： | 1 |
| 9 | BRAINSTEM CAVERNOUS MALFORMATIONS显示文摘 | Bradley A. Gross H. Hunt Batjer Issam A. Awad Bernard R. Bendok | 2009 | Neurosurgery2009，，5： | 1 |
| 10 | The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) Trial显示文摘 | James A. Goldstein Kavitha M. Chinnaiyan Aiden Abidov Stephan Achenbach Daniel S. Berman Sean W. Hayes Udo Hoffmann John R. Lesser Issam A. Mikati Brian J. O’Neil Leslee J. Shaw Michael Y.H. Shen Uma S. Valeti Gilbert L. Raff | 2011 | Journal of the American College of Cardiology2011，，14： | 1 |
| 11 | Evaluating surrogates for disinfection by-products显示文摘 | Issam N Najm Nancy L Patania Joseph G Jacangelo | 1994 | American Water Works Association Journal1994，86，6： | 1 |
| 12 | Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters显示文摘 | Andrew J. Hope Patricia E. Lindsay Issam El Naqa James R. Alaly Milos Vicic Jeffrey D. Bradley Joseph O. Deasy | 2006 | International Journal of Radiation Oncology Biology Physics2006，，1： | 1 |
| 13 | Products of Toeplitz Operators on the Bergman Space显示文摘 | Issam Louhichi Elizabeth Strouse Lova Zakariasy | 2006 | Integral Equations and Operator Theory2006，，4： | 1 |
| 14 | Correlation of sauter mean diameter and critical heat flux for spray cooling of small surfaces 显示文摘 | Kurt A Estes Issam Mudawar | 1995 | Inter- national Journal of Heat and Mass Transfer1995，38，16： | 1 |
| 15 | The view-based approach to dynamic inter-organizational workflow cooperation显示文摘 | Issam Chebbi Schahram Dustdar Samir Tata | 2005 | Data & Knowledge Engineering2005，，2： | 1 |
| 16 | The Influence of Mind Mapping on Eighth Graders' Science Achievement显示文摘 | Issam Abi-E1-Mona | | School Science and Mathe- matics0，108，7： | 1 |
| 17 | Efficacy and safety of EMR to completely remove Barrett’s esophagus: experience in 41 patients显示文摘 | Henning Gerke Junaid Siddiqui Issam Nasr Daniel M. Van Handel Chris S. Jensen | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 18 | What is the Role of NSAIDs in Pre-emp- tive Analgesia 显示文摘 | Andrew O Issam A | 2003 | Drugs2003，63，24： | 1 |
| 19 | Theoretical and experimental study of the effects of spray inclination on two-phase spray cooling and critical heat flux 显示文摘 | Milan Visaria Issam Mudawar | 2008 | International Journal of Heat and Mass Transfer2008，51，： | 1 |
| 20 | Pre-clinical studies of toxin-specific Nanobodies: Evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming显示文摘 | Issam Hmila Bernard Cosyns Hayfa Tounsi Bram Roosens Vicky Caveliers Rahma Ben Abderrazek Samir Boubaker Serge Muyldermans Mohamed El Ayeb Balkiss Bouhaouala-Zahar Tony Lahoutte | 2012 | Toxicology and Applied Pharmacology2012，，： | 1 |
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