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| 1 | 颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明显示文摘背景抗栓药的使用,包括抗凝药、抗血小板药和溶栓药,在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的,但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会,涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定,目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索,并对符合标准的研究进行了评价。结果利用GRADE方法学,委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。 | Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. Wartenberg Cindy L. Zerfoss 杨一萍 谢丽丽 宁小金 季宇腾 柯开富 | 2016 | 国际脑血管病杂志2016，24，11： | 24 |
| 2 | Neutrophils in chronic inflammatory diseases显示文摘Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide.Chronic inflammation is characterized by persistent,low-grade inflammation and is increased in the aging population.Neutrophils are normally the first responders to acute inflammation and contribute to the resolution of inflammation.However,in chronic inflammation,the role of neutrophils is less well understood and has been described as either beneficial or detrimental,causing tissue damage and enhancing the immune response.Emerging evidence suggests that neutrophils are important players in several chronic diseases,such as atherosclerosis,diabetes mellitus,nonalcoholic fatty liver disease and autoimmune disorders.This review will highlight the interaction of neutrophils with other cells in the context of chronic inflammation,the contribution of neutrophils to selected chronic inflammatory diseases,and possible future therapeutic strategies. | Andrea Herrero-Cervera Oliver Soehnlein Ellinor Kenne | 2022 | Cellular & Molecular Immunology2022，19，2： | 7 |
| 3 | 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society显示文摘 | Craig T. January L. Samuel Wann Joseph S. Alpert Hugh Calkins Joaquin E. Cigarroa Joseph C. Cleveland Jamie B. Conti Patrick T. Ellinor Michael D. Ezekowitz Michael E. Field Katherine T. Murray Ralph L. Sacco William G. Stevenson Patrick J. Tchou Cynthia | 2014 | Circulation2014，，23： | 4 |
| 4 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 5 | 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society显示文摘 | Craig T. January L. Samuel Wann Joseph S. Alpert Hugh Calkins Joaquin E. Cigarroa Joseph C. Cleveland Jamie B. Conti Patrick T. Ellinor Michael D. Ezekowitz Michael E. Field Katherine T. Murray Ralph L. Sacco William G. Stevenson Patrick J. Tchou Cynthia | 2014 | Circulation2014，，23： | 2 |
| 6 | Endosymbiotic pathogen-inhibitory gut bacteria in three Indian Major Carps under polyculture system: A step toward making a probiotics consortium显示文摘The gastrointestinal(GI)microbiome in fish plays significant roles in health and disease resistance.This investigation was accomplished to enumerate,characterize and identify the potential probiotic bacteria from three Indian Major Carps(IMCs),viz.,rohu(Labeo rohita),catla(Catla catla)and mrigal(Cirrhinus mrigala)using culture dependent methods.Altogether,105 pathogen-inhibitory bacteria(out of 1216 isolates)were detected from three IMCs by double layer assay.16S rRNA partial gene sequence analyses and BLAST search in the NCBI GenBank unveiled that 94.29%of the pathogen inhibitory bacteria were bacilli(99 strains)and Bacillus licheniformis by far the most common(28%).The primarily selected 27 pathogen-inhibitory strains(cumulative inhibition score≥13)produced extracellular enzymes,while 15 of them produced all the six exo-enzymes studied(amylase,protease,lipase,cellulase,phytase and xylanase).Gut stability of the strains became apparent by their ability to grow in fish mucus and tolerance to diluted bile-juice.Finally,14 strains were noticed asγ-hemolytic and susceptible to the commonly used antibiotics.Further,intra-peritoneal injection withγ-hemolytic strains did not induce any pathological signs or mortalities in fish,and thus were considered as safe.These 14γ-hemolytic isolates were represented by the genus Bacillus(13)and Stenotrophomonas(1),which might form probiotic consortia for prospective use in carp culture. | Koushik Ghosh Anjan Mukherjee Dipanjan Dutta Sudeshna Banerjee Eva Marie Breines Ellinor Hareide Einar Ringø | 2021 | Aquaculture and Fisheries2021，6，2： | 2 |
| 7 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 8 | Discordant atrial natriuretic peptide and brain natriuretic peptide levels in lone atrial fibrillation显示文摘 | Patrick T. Ellinor Adrian F. Low Kristen K. Patton Marisa A. Shea Calum A. MacRae | 2005 | Journal of the American College of Cardiology2005，，1： | 2 |
| 9 | Potassium channel gene mutations rarely cause atrial fibrillation显示文摘 | Ellinor PT Petrov-Kibdrativ VI Zakharova E | 2006 | BMC Med Genel2006，7，： | 1 |
| 10 | Discordant atrial natriuretic peptide and brain natriuretic peptide levels in lone atrial fibrillation 显示文摘 | Ellinor P T Low A F Patton K K | 2005 | J Am Coll Cardiol2005，45，1： | 1 |
| 11 | Common variants in KCNN3 are associated with lone atrial fibrillation 显示文摘 | Ellinor PT Lunetta KL Glazer N | 2010 | Nat Genet2010，42，3： | 1 |
| 12 | Discordant atrial natriurefic peptide and brain natriuretic peptide levels in lone atrial fibrillation 显示文摘 | Ellinor P Low A Patton K | 2005 | J Am Coll Cardio2005，45，1： | 1 |
| 13 | Genome-wide association studies of atrial fibrillation: past, present, and future 显示文摘 | Sinner MF Ellinor PT Meitinger T | 2011 | Cardiovasc Res2011，89，4： | 1 |
| 14 | Mutant desmocollin-2 cau- ses arrhythmogenic fight ventrieular cardiomyopathy 显示文摘 | Heuser A Plovie ER Ellinor PT | 2006 | Am J Hum Genet2006，79，6： | 1 |
| 15 | Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy显示文摘 | Heuser A Plovie ER Ellinor PT | 2006 | AmJ Hum Genet2006，79，6： | 1 |
| 16 | Structure and Function of gC1q-R: a Multiligand Binding Cellular Protein显示文摘 | Berhane Ghebrehiwet Ellinor I.B. Peerschke | 1998 | Immunobiology1998，，2： | 1 |
| 17 | Discordant atrial natriuretie peptide and brain natriuretic peptide levels in lone atrial fibrillation显示文摘 | Ellinor PT Low AF Patton KK | 2005 | J Am Coll Cardiol2005，45，1： | 1 |
| 18 | Utility of aminoterminal pro-brain natriuretic peptide, galectin-3 and apelin for the evaluation of patients with acute heart failure显示文摘 | Van Kimmenade RR Januzzi JL Jr Ellinor PT | 2006 | J Am Coil Cardiol2006，48，： | 1 |
| 19 | Common variants in KC- NN3 are associated with lone atrial fibrillation 显示文摘 | Ellinor PT Lunetta KL Glazer NL | 2010 | Nat Genet2010，42，3： | 1 |
| 20 | Discordant atrial natriuretic peptide and brain natriuretic peptide leves in lone atrial fibrillation显示文摘 | Ellinor PT Low AF Patton KK | 2005 | J Am Coll Cardiol2005，45，1： | 1 |
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