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| 1 | Improved spontaneous erectile function in men with mild-tomoderate arteriogenic erectile dysfunction treated with a nightly dose of sildenafil for one year: a randomized trial显示文摘瞄准:为了测试假设,那 sildenafil (为一年夜里的 50 mg ) 能与 mild-to-moderate arteriogenic 在人改进自发的可勃起的功能(EF ) 可勃起的机能障碍(编辑) 对 erectogenic 处理应答。方法:在未来的开标签的试用,有编辑的 112 个人被使随机化到 sildenafil 夜里的 50 mg 或 sildenafil 需要 for12 月的 50 或 100 mg,由一个月和 6 月的非药物治疗的时期列在后面。非使随机化,有编辑的 non-medicatedmen 也被估计。可勃起的功能(IIEFEF ) 和山峰的国际索引的 EF 领域阴茎多孔的动脉的收缩速度(PSV ) 被用来测量功效。结果:在 sildenafil 处理和一个随后的非药物治疗的月以后, IIEF EF 在 48 中的 29 个是正常的(60.4% , 95% 信心间隔[CI ] :45.3-74.2%) 夜里的组对 4 of49 (8.2% , 95% CI:2.3-19.6%) 同样需要的组。PSV 由 11.2 cm/s 改善了(95% CI:4.7-21.4;P= 0.012 ) 在夜里的组,但是仅仅由 3.4 cm/s (-5.1-14.7;P = 0.435 ) 在同样需要的 group.IIEF, EF 在 18 中的 1 个使正常化(5.6% , 95% CI:0.1-27.3%) 非药物治疗的人和 PSV 稍微拒绝了。在处理,正常的仍然是的 IIEF EF 和 PSV 以后的六个月在大多数被稳定(28/29, 97%) 开始使正常化的夜里的组人。结论:为一年夜里的 Sildenafil 导致了在处理的结束以后坚持了很好的编辑回归,以便 spontaneousEF 在大多数人在 IIEF 上作为正常被描绘。从这开标签的、使随机化的试用的结果在双窗帘下面保证确认,控制安慰剂的条件。 | Frank Sommer Theodor Klotz Udo Engelmann | 2007 | Asian Journal of Andrology2007，9，1： | 12 |
| 2 | Role of nuclear factor kappa B in central nervous system regeneration显示文摘Activation of nuclear factor kappa B(NF-κB) is a hallmark of various central nervous system(CNS) pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, promotes neuronal survival under a range of conditions, i.e., for ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of NF-κB triggers a growth-permissive program which contributes to neural tissue inflammation, scar formation, and the expression of axonal growth inhibitors. Intriguingly, inhibition of such inducible NF-κB in the neuro-glial compartment, i.e., by genetic ablation of RelA or overexpression of a transdominant negative mutant of its upstream regulator IκBα, significantly enhances functional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of the NF-κB subunit p50, which lacks transcriptional activator function and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that NF-κB orchestrates a multicellular program in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of neuronal circuits. Considering these subunit-specific functions, interference with the NF-κB pathway might hold clinical potentials to improve functional restoration following traumatic CNS injury. | Christian Engelmann Falk Weih Ronny Haenold | 2014 | Neural Regeneration Research2014，9，7： | 8 |
| 3 | Detection of neurone-specific enolase in long-term cultures of human corneal endothelium显示文摘 | M. B?hnke Katrin Vogelberg Katrin Engelmann | 1998 | Graefe’s Archive for Clinical and Experimental Ophthalmology1998，，7： | 2 |
| 4 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 5 | ESPEN Guidelines on Enteral Nutrition: Gastroenterology显示文摘 | H. Lochs C. Dejong F. Hammarqvist X. Hebuterne M. Leon-Sanz T. Schütz W. van Gemert A. van Gossum L. Valentini H. Lübke S. Bischoff N. Engelmann P. Thul | 2006 | Clinical Nutrition2006，，2： | 2 |
| 6 | Behavioural impact of intraseptally released vasopressin and oxytocin in rats显示文摘 | ENGELMANN M WOTJAK CT EBNER K | 2000 | Exp-Physiol2000，85，： | 1 |
| 7 | Intravascular tissue factor pathway-a model for rapid initiation of coagulation within the blood vessel显示文摘 | Engelmann B Luther T Muller I | 2003 | Thrombosis and Haemostasis2003，89，1： | 1 |
| 8 | Influence of micromixing on the free-radical polymerization in a discontinuous process显示文摘 | Engelmann U Schmidt-Naake G | 1994 | Macromolecular Theory and Simulations1994，3，5： | 1 |
| 9 | Development of cryopreservation for oil palm somatic embryos using an improved process显示文摘 | Dumet D Engelmann F Chabrillange N and Duval Y | 1993 | Ol e agineux1993，48，： | 1 |
| 10 | Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus显示文摘 | Pamp SJ Frees D Engelmann S | 2006 | J Bacteriol2006，188，13： | 1 |
| 11 | Feasibility study and control values of transient elastography in healthy chil- dren 显示文摘 | Engelmann G Gebhardt C Wenning D | 2012 | Eur J Pediatr2012，171，2： | 1 |
| 12 | Soluble CD40 in the serum of healthy donors, patients with chronic renal failure, haemodialysis and chronic ambulatory peritoneal dialysis (CAPD) patients显示文摘 | Schwabe RF Engelmann H Hess S | 1999 | Clin Exp Immunol1999，117，1： | 1 |
| 13 | Computer-aided diagnosis in chest radiography: results of large-scale observer tests at the 1996-2001 RSNA scientific assemblies显示文摘 | MacMahon H Engelmann R | 2003 | Radiographics2003，23，1： | 1 |
| 14 | Neural responses of goldfish lateral line afferents to vortex motions 显示文摘 | CHAGNAUD B P BLECKMANN H ENGELMANN J | 2006 | J Exp Biol2006，209，2： | 1 |
| 15 | Protective role ofintracoronary vasoactive intestinal peptide in ischemnic and reperfused myocardium 显示文摘 | Kalfm R Maulik N Engelmann MR | 1994 | J Pharmcol Exp Ther1994，268，： | 1 |
| 16 | Ambroxol improves the broncho-spasmolytic activity of clenbuterol in the guinea-pig显示文摘 | Pairet M Engelmann P Von Nicolai H | 1997 | Jpharm pharmacol1997，49，： | 1 |
| 17 | Computer-aided diagnosis in chest radiography:results of large-scale observer tests at the 1996-2001 RSNA scientific assemblies显示文摘 | ABE H MACMAHON H ENGELMANN R | 2003 | Radiographics2003，23，1： | 1 |
| 18 | Comparative evaluation of three antifungal susceptibility test methods for Candida albicans isolates and correlation wiiith response to fluconazole therapy 显示文摘 | Ruhnke M Schmidt-westhausen A Engelmann E | 1996 | J Clin Microbiol1996，34，： | 1 |
| 19 | Effect of various sugars and polyols on the tolerance to desiccation and freezing of oil palm polyembryonic cultures显示文摘 | Dumet D Engelmann F Chabrillange N Dussert S Duval Y | 1994 | Seed Science P esearch1994，4，： | 1 |
| 20 | Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias:a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group显示文摘 | Groschel S Schlenk RF Engelmann J | | 0，，01： | 1 |
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