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| 1 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 2 | Involvement of cholangiocyte proliferation in biliary fibrosis显示文摘Cholangiocytes are the epithelial cells that line the biliary tree.In the adult liver,they are a mitotically dormant cell population,unless ductular reaction is triggered by injury.The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type,which are termed cholangiopathies(i.e.primary biliary cirrhosis,primary sclerosing cholangitis and biliary atresia).In our article,we provide background information on the morphological and functional heterogeneity of cholangiocytes,summarize what is currently known about their proliferative processes,and briefly describe the diseases that target these cells.In addition,we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis,and propose directions for future studies. | Sally Priester Candace Wise Shannon S Glaser | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 10 |
| 3 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 4 | Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis显示文摘干细胞(hPSC ) 人口着急地在基本研究并且在基于房间的治疗应用为质量控制被需要的为孤立人的 pluripotent 的快速、可靠的方法。用 lectin 数组,我们分析了从 26 件 hPSC 样品和 22 件区分的房间样品提取的 glycoproteins,并且与是足够的把 hPSCs 与许多 non-pluripotent 房间类型区分开来的特殊有约束力的签名识别了 lectins 的一个小组。这些特定的 biomarkers 被所有 12 人的胚胎的干细胞和检验的 14 件人的导致的 pluripotent 干细胞样品分享,不管起源,文化条件,体的房间类型 reprogrammed,或使用的 reprogramming 方法的实验室。我们演示了由检测有调停 lectin 的染色的一张区分的房间人口由荧光显微镜学和流动 cytometry,并且由充实并且清除跟随了的在内的 hPSCs 有约束力的特定的 lectin 的一个实际应用程序从用调停 lectin 的房间分离的混合房间人口的可行 hPSCs。全球基因表示分析显示出特定的 fucosyltransferases 和 sialyltransferases 的联系 pluripotency 的微分表示,它可以在蛋白质 glycosylation 和 lectin 绑定位于这些差别下面。一起拿,我们的结果证明蛋白质 glycosylation 在 pluripotent 和 non-pluripotent 房间之间更加不同,并且证明 lectins 可以被用作 biomarkers 从混合房间人口在干细胞人口并且为可行 hPSCs 的移动监视 pluripotency。 | Yu-ChiehWang MasatoNakagawa IbonGaritaonandia IleanaSlavin GulsahAltun Robert MLacharite Kristopher LNazor Ha TTran Candace LLynch Trevor RLeonardo YingLiu Suzanne EPeterson Louise CLaurent ShinyaYamanaka Jeanne FLoring | 2011 | Cell Research2011，21，11： | 5 |
| 5 | Phylogenetically Distinct Cellulose Synthase Genes Support Secondary Wall Thickening in Arabidopsis Shoot Trichomes and Cotton Fiber显示文摘Through exploring potential analogies between cotton seed trichomes (or cotton fiber) and arabidopsis shoot trichomes we discovered that CesAs from either the primary or secondary wall phylogenetic clades can support secondary wall thickening. CesA genes that typically support primary wall synthesis, AtCesA1,2,3,5, and 6, underpin expansion and secondary wall thickening of arabidopsis shoot trichomes. In contrast, apparent orthologs of CesA genes that support secondary wall synthesis in arabidopsis xylem, AtCesA4,7, and 8, are up-regulated for cotton fiber secondary wall deposition. These conclusions arose from: (a) analyzing the expression of CesA genes in arabidopsis shoot trichomes; (b) observing birefringent secondary walls in arabidopsis shoot trichomes with mutations in AtCesA4, 7, or 8; (c) assaying up-regulated genes during different stages of cotton fiber development; and (d) comparing genes that were co-expressed with primary or secondary wall CesAs in arabidopsis with genes upregulated in arabidopsis trichomes, arabidopsis secondary xylem, or cotton fiber during primary or secondary wall deposition. Cumulatively, the data show that: (a) the xylem of arabidopsis provides the best model for secondary wall cellulose synthesis in cotton fiber; and (b) CesA genes within a 'cell wall toolbox' are used in diverse ways for the construction of particular specialized cell walls. | Lissete Betancur Bir Singh Ryan A.Rapp Jonathan F.Wendel M. David Marks Alison W.Roberts Candace H.Haigler | 2010 | Journal of Integrative Plant Biology2010，52，2： | 4 |
| 6 | Perturbation of Wood Cellulose Synthesis Causes Pleiotropic Effects in Transgenic Aspen显示文摘在树上的纤维素生合成的基因操作可以提供新奇卓见进树的生长和发展。探索这可能性,一棵白杨的 overexpression 第二等的联系墙的纤维素 synthase (PtdCesA8 ) 基因在转基因的白杨(Populus tremuloides L.) 被尝试并且出人意料地象它的内长的对应物一样导致了 transgene 的 silencing。转基因的白杨植物的主要的轴快速停止成长,并且弱树枝采用了一个哭泣的生长习惯。而且,转基因的植物开始开发了更小的叶子和一个不太广泛的根系统。几乎没象 10% 纤维素一样包含的转基因的白杨植物的第二等的木部(木头) 使正常化与典型地在正常白杨木头发现的 41% 纤维素相比弄干重量。在纤维素的这巨大的减小被木质素(35%) 和非有纤维质的多糖(55%) 的比例的增加在控制植物与 22% 木质素和 36% 非有纤维质的多糖相比伴随。生产的转基因的茎典型崩溃或改变了第二等的墙形态学并且极大地包含了的不规则的木部容器减少了水晶的纤维素的数量。这些结果在维持要求在树上建立垂直生长习惯的力量和结构的正直在第二等的木部以内表明第二等的墙纤维素的基本角色。 | Chandrashekhar R Joshi Shivegowda Thammannagowda Takeshi Fujino Ji-Qing Gou Utku Avci Candace H. Haigler Lisa M. McDonnell Shawn D. Mansfield Bemnet Mengesha Nicholas C. Carpita Darby Harris Seth DeBolt Gary F. Peter | 2011 | Molecular Plant2011，4，2： | 4 |
| 7 | The evolution of trust in information technology alliances显示文摘 | Candace E. Ybarra Thomas A. Turk | 2009 | Journal of High Technology Management Research2009，，1： | 2 |
| 8 | Moral Responsibility and Respect for Autonomy:Meeting the Communitarian Challenge显示文摘 | GAUTHIER CANDACE CUMMINS | 2000 | Kennedy Institute of Ethics Joumal2000，10，： | 2 |
| 9 | Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B显示文摘 | Grace Lai-Hung Wong Henry Lik-Yuen Chan Catherine Ka-Yan Wong Calvin Leung Candace Yim Chan Patricia Po-Lai Ho Vivian Chi-Yee Chung Zhan Cham-Yan Chan Yee-Kit Tse Angel Mei-Ling Chim Tina Kit-Ting Lau Vincent Wai-Sun Wong | 2014 | Journal of Hepatology2014，，2： | 2 |
| 10 | Impact of dysphagia on quality of life after treatment of head-and-neck cancer显示文摘 | Nam P. Nguyen Cheryl Frank Candace C. Moltz Paul Vos Herbert J. Smith Ulf Karlsson Suresh Dutta Allan Midyett Jessica Barloon Sabah Sallah | 2005 | International Journal of Radiation Oncology Biology Physics2005，，3： | 1 |
| 11 | Osmium isotope geochemistry of a tropical estuary 显示文摘 | Peucker-Ehrenbrink Martin Candace E Bernhard | 2001 | Goeochimica et Cosmochimica Acta2001，，： | 1 |
| 12 | Some Thoughts about the Think- aloud Protocols显示文摘 | Candace Seguinot | 1996 | Target1996，，1： | 1 |
| 13 | Cytokines, Obesity, and Cancer: New Insights on Mechanisms Linking Obesity to Cancer Risk and Progression显示文摘 | Candace A. Gilbert Joyce M. Slingerland | 2013 | Annual Review of Medicine2013，，： | 1 |
| 14 | Use Of a polymerase chain reaction assay with Eperythrozoon wenyoni in cattle 显示文摘 | Jennifer M Vandervoort D V M Candace Bourne | 2001 | J Am Vet Med Assoc2001，219，： | 1 |
| 15 | Living on the Edge 显示文摘 | Bob Mekereher Candace Fu | 2006 | Annals of Tourism Research2006，33，2： | 1 |
| 16 | XND1, a member of the NAC domain family in Arabidopsis thaliana, negatively regulates lignocellulose synthesis and programmed cell death in xylem显示文摘 | ChengsongZhao UtkuAvci Emily H.Grant Candace H.Haigler Eric P.Beers | 2007 | The Plant Journal2007，，3： | 1 |
| 17 | 'Making all the difference in the world': How physicians can help HIV-- seropositive patients become more involved in their health eare显示文摘 | Barbara Gerbert Candace Love | 1999 | AIDS PATIENT CARE and STDs1999，13，1： | 1 |
| 18 | High - performance lithium battery anodes using silicon nanowires nature nanotechnology 显示文摘 | I CANDACE K CHAN HAILIN PENG et at | 2007 | published online2007，，12： | 1 |
| 19 | A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses显示文摘 | Samuli Ripatti Emmi Tikkanen Marju Orho-Melander Aki S Havulinna Kaisa Silander Amitabh Sharma Candace Guiducci Markus Perola Antti Jula Juha Sinisalo Marja-Liisa Lokki Markku S Nieminen Olle Melander Veikko Salomaa Leena Peltonen Sekar Kathiresan | 2010 | The Lancet . 2010 (9750)2010，，： | 1 |
| 20 | Young-ybarra technology R&D alliances and firm value 显示文摘 | John Neill D Glenn Pfeiffer M Candace E | 2001 | Journal of High Technology Management Research2001，，12： | 1 |
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