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| 1 | 拉米夫定治疗慢性乙型肝炎病毒感染的经济效益显示文摘目的 评估慢性乙型肝炎及其并发症的经济负担和拉米夫定治疗的临床效果与经济效益。方法 根据慢性乙型肝炎、代偿性肝硬化、失代偿性肝硬化和肝癌病人的年直接医疗费用、直接非医疗费用以及间接费用计算其经济负担。同时根据亚洲拉米夫定多中心临床研究和 15个国家临床研究的综合数据来计算节省的费用。结果 不同肝病阶段的病人年经济负担不同 ,慢性乙型肝炎为 2 0 478元 ,代偿性肝硬化为 3 63 2 5元 ,失代偿性肝硬化为 3 675 9元 ,肝细胞肝癌为 3 82 69元。拉米夫定治疗 1年后 ,使医疗费用得到部分节省。结论 慢性乙型肝炎病毒感染者经济负担较重 。 | 陈兴宝 陈慧芬 Larry Lacey Gauri B Saal Alison Tan-Mulligan | 2002 | 肝脏2002，7，2： | 27 |
| 2 | Multisensor Data Fusion for High Quality Data Analysis and Processing in Measurement and Instrumentation显示文摘Multisensor data fusion (MDF) is an emerging technology to fuse data from multiple sensors in order to make a more accurate estimation of the environment through measurement and detection. Applications of MDF cross a wide spectrum in military and civilian areas. With the rapid evolution of computers and the proliferation of micro-mechanical/electrical systems sensors,the utilization of MDF is being popularized in research and applications. This paper focuses on application of MDF for high quality data analysis and processing in measurement and instrumentation. A practical,general data fusion scheme was established on the basis of feature extraction and merge of data from multiple sensors. This scheme integrates artificial neural networks for high performance pattern recognition. A number of successful applications in areas of NDI (Non-Destructive Inspection) corrosion detection,food quality and safety characterization,and precision agriculture are described and discussed in order to motivate new applications in these or other areas. This paper gives an overall picture of using the MDF method to increase the accuracy of data analysis and processing in measurement and instrumentation in different areas of applications. | Yan-bo Huang Yu-bin Lan W. C. Hoffmann R. E. Lacey | 2007 | Journal of Bionic Engineering2007，4，1： | 13 |
| 3 | 中国e抗原阳性慢性乙型肝炎抗病毒治疗方案的经济学评价显示文摘目的 对HBeAg阳性慢性乙型肝炎短期和长期的抗病毒治疗方案进行经济学评价。方法 建立包含10个健康状态的Markov模型,估计不同方案治疗HBeAg阳性CHB患者的长期效果和费用,并进行增量分析。结果 与非抗病毒治疗相比,拉米夫定治疗1年是具有高度成本效果的短期治疗方案;拉米夫定治疗必要时换用阿德福韦,或者阿德福韦治疗必要时换用拉米夫定作挽救用药治疗5年,可以更持续地延缓疾病进展。与拉米夫定治疗1年相比,更具成本效果的长期治疗方案则是拉米夫定+阿德福韦,或者阿德福韦+拉米夫定作为挽救用药治疗5年,每单位质量调整生命年的增量费用分别为25 115元和35 577元,分别比国际阈值的中国估计值低55.2%和36.5%。结论 在HBeAg阳性CHB短期治疗方案中,拉米夫定比IFNα、恩替卡韦、聚乙二醇干扰素α-2a和非抗病毒治疗更具成本效果。在长期治疗方案中,拉米夫定+阿德福韦或阿德福韦+拉米夫定挽救治疗均具有成本效果。 | Larry Lacey 卢宪中 Alison Tan | 2007 | 中华肝脏病杂志2007，15，6： | 8 |
| 4 | 包涵体肌炎11例临床及组织病理报告显示文摘目的 探讨包涵体肌炎的诊断标准。方法 分析了 11例包涵体肌炎病人的临床表现、组织化学。碱性刚果红染色 9例 ,电镜检查 2例。结果 全部病人均在 4 2岁后发病 ,表现为远、近端肌肉力弱 ,2例肌电图检查显示肌源性改变 ,11例均有边缘着色性空泡及炎性改变 ,9例有淀粉样蛋白沉积物 ,有胞核或胞质细丝包涵体各 1例。结论 包涵体肌炎的所有诊断指标中 ,无一项有决定性或特征性 ,需要进行综合判断。 | 闵丹琳 Anne Lacey 王鲁宁 沈定国 | 2001 | 中华神经科杂志2001，34，5： | 7 |
| 5 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 6 | Capsule endoscopy in suspected small bowel Crohn's disease:Economic impact of disease diagnosis and treatment显示文摘AIM: To model clinical and economic benef its of capsule endoscopy (CE) compared to ileo-colonoscopy and small bowel follow-through (SBFT) for evaluation of suspected Crohn’s disease (CD). METHODS: Using decision analytic modeling, total and yearly costs of diagnostic work-up for suspected CD were calculated, including procedure-related adverse events, hospitalizations, off ice visits, and medications. The model compared CE to SBFT following ileo-colonoscopy and secondarily compared CE to SBFT for initial evaluation. RESULTS: Aggregate charges for newly diagnosed, medically managed patients are approximately $8295. Patients requiring aggressive medical management costs are $29 508; requiring hospitalization, $49 074. At sensitivity > 98.7% and specifi city of > 86.4%, CE is less costly than SBFT. CONCLUSION: Costs of CE for diagnostic evaluationof suspected CD is comparable to SBFT and may be used immediately following ileo-colonoscopy. | Jonathan A Leighton Ian M Gralnek Randel E Richner Michael J Lacey Frank J Papatheofanis | 2009 | World Journal of Gastroenterology2009，15，45： | 5 |
| 7 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 8 | Change in ecosystem service values in the San Antonio area, Texas显示文摘 | Urs P Kreuter Heather G Harris Marty D Matlock Ronald E Lacey | 2001 | Ecological Economics2001，，3： | 3 |
| 9 | Anal intraepithelial neoplasia: A review of diagnosis and management显示文摘Anal intraepithelial neoplasia(AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus(HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior. A history of HPVmediated genital cancer, which suggests infection with an oncogenic HPV strain, is another risk factor for AIN/anal cancer. Because progression of AIN to anal cancer is known to occur in some individuals over several years, screening for AIN and early anal cancer, as well as treatment of advanced AIN lesions, is reasonable in certain high-risk populations. Although randomized controlled trials evaluating screening and treatment outcomes are lacking, experts support routine screening for AIN in high risk populations. Screening is performed using anal cytological exams, similar to those performed in cervical cancer screening programs, along with direct tissue evaluation and biopsy via high resolution anoscopy. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. Reductions in AIN and anal cancer rates have been shown in studies where high-risk populations were vaccinated against the oncogenic strains of HPV. Currently, the CDC recommends both high-risk and average-risk populations be vaccinated against HPV infection using the quadrivalent or nonavalent vaccines. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations. | Joseph R Roberts Lacey L Siekas Andrew M Kaz | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 3 |
| 10 | Osteoprotegerin (OPG) ligand is a cytokine that regulates osteoclast differentiation and activation显示文摘 | Lacey DL Timms E Tan HL | | 0，，： | 3 |
| 11 | 中国HBeAg阴性慢性乙型肝炎抗病毒治疗方案的经济学评价显示文摘目的从中国医疗系统的角度,对HBeAg阴性慢性乙型肝炎(乙肝)短期和长期抗病毒治疗方案进行经济学评价。方法建立包含10个健康状态的Markov模型,估计不同方案治疗HBeAg阴性慢性乙肝患者的长期效果和费用,并进行增量分析。结果与非抗病毒治疗比较,最具成本效果的短期治疗方案是拉米夫定治疗1年;拉米夫定治疗必要时换用阿德福韦,或阿德福韦治疗必要时换用拉米夫定作为挽救治疗5年,可更持续地延缓疾病进展。与拉米夫定治疗1年比较,最具成本效果的长期治疗方案是拉米夫定+阿德福韦,或阿德福韦+拉米夫定作为挽救治疗5年,每单位质量调整生命年(QALY)的增量费用分别为16 465元和17 884元,分别比国际阈值的中国估值低70.6%和68.1%。结论HBeAg阴性慢性乙肝短期治疗方案中,拉米夫定比恩替卡韦、聚乙二醇干扰素α-2a和非抗病毒治疗更具成本效果;长期治疗方案中,拉米夫定加阿德福韦或阿德福韦加拉米夫定挽救治疗均具有成本效果。 | Larry Lacey 卢宪中 Alison Tan | 2007 | 中华传染病杂志2007，25，8： | 3 |
| 12 | Global Burden of Human Papillomavirus and Related Diseases显示文摘 | David Forman Catherine de Martel Charles J. Lacey Isabelle Soerjomataram Joannie Lortet-Tieulent Laia Bruni Jerome Vignat Jacques Ferlay Freddie Bray Martyn Plummer Silvia Franceschi | 2012 | Vaccine2012，，： | 2 |
| 13 | Plant cuticles shine: advances in wax biosynthesis and export显示文摘 | Ljerka Kunst Lacey Samuels | 2009 | Current Opinion in Plant Biology2009，，6： | 2 |
| 14 | Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography显示文摘Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术,特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时,肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此,我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1,被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ,在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro, nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) , syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加, 10x,与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo,肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要,我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。 | Anil Khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally | 2015 | Nano Research2015，8，12： | 2 |
| 15 | 贺普丁治疗慢性乙型肝炎的成本-效果分析显示文摘该研究运用中国上海慢性乙型肝炎与肝硬化病人的年总成本和直接医疗成本以及葛兰素史克公司NUCB 30 0 9,NUCB 30 10 ,NUCA 30 10临床研究中的血清转换率与肝硬化转归率 ,分析了贺普丁治疗 1年后的四种成本节约模型。结果显示 :模型Ⅰ采用贺普丁治疗所有慢性乙型肝炎病人一年后 ,每一病人节省的卫生保健成本可抵消 4 6 .3%贺普丁年治疗成本 ;模型Ⅱ采用贺普丁治疗ALT水平高于 2倍正常值的慢性乙型肝炎病人 ,每一病人节省的卫生保健成本可抵消 90 .8%贺普丁年治疗成本 ;模型Ⅲ采用贺普丁治疗ALT水平高于 2倍正常值的慢性乙型肝炎 ,每一病人节省的卫生保健成本可抵消 6 2 .2 %贺普丁年直接医疗成本 ;模型Ⅳ采用贺普丁治疗亚州ALT水平高于 2倍正常值的慢性乙型肝炎病人 ,除可抵消贺普丁年治疗成本外 ,每一病人还可净节省 4 2 6 .9元卫生保健成本。由此可见 ,贺普丁治疗慢性乙型肝炎 | 陈兴宝 Alison Tan Lanrry Lacey Saal GB | 2003 | 中国卫生资源2003，6，5： | 2 |
| 16 | Analysis of vegetation indices derived from aerial multispectral and ground hyperspectral data显示文摘Aerial multispectral images are a good source of crop,soil,and ground coverage information.Spectral reflectance indices provide a useful tool for monitoring crop growing status.A series of aerial images were obtained by an airborne MS4100 multispectral imaging system on the cotton and soybean field.Ground hyperspectral data were acquired with a ground-based integration system at the same time.The Normalized Difference Vegetative Index(NDVI),Simple Ratio(SR),and Soil Adjusted Vegetation Index(SAVI)calculated from both systems were analyzed and compared.The information derived from aerial multispectral images has shown the potential to monitor the general growth status of crop field.The vegetation indices derived from both systems were significantly different(p-value was 0.073 atα=0.1 level)at the early growing stage of crops.The correlation coefficients of the image NDVI and ground NDVI were 0.3029 for soybean field and 0.338 for cotton field.SAVI and SR were not correlated. | Huihui Zhang Yubin Lan Ronald Lacey W.C.Hoffmann Yanbo Huang | 2009 | International Journal of Agricultural and Biological Engineering2009，2，3： | 2 |
| 17 | Famotidine, a new H2-receptor antagonist显示文摘 | Dr. J. Lacey Smith Mohamed A. Gamal A. N. Chremos David Y. Graham | 1985 | Digestive Diseases and Sciences1985，，4： | 2 |
| 18 | 真实的虚拟电厂显示文摘当日本启动破坏性地震和海啸后的重建工作时,它不得不面临严重电力短缺的局面。由于福岛第一核电站危机和其他发电设施的问题,该国几乎丧失了4%的基本电力荷载,轮流停电在东京周边很常见,这严重阻碍了该国的制造业。 | Stephen Lacey 哲伦 | 2012 | 资源与人居环境2012，，11： | 2 |
| 19 | Change in ecosystem service values in the San Antonio area, Texas显示文摘 | Urs P Kreuter Heather G Harris Marty D Matlock Ronald E Lacey | 2001 | Ecological Economics2001，，3： | 2 |
| 20 | Secondary Cell Wall Deposition in Developing Secondary Xylem of Poplar显示文摘Although poplar is widely used for genomic and biotechnological manipulations of wood, the cellular basis of wood development in poplar has not been accurately documented at an ultrastructural level. Developing secondary xylem cells from hybrid poplar (Populus deltoides x P. trichocarpa), which were actively making secondary cell walls, were preserved with high pressure freezing/freeze substitution for light and electron microscopy. The distribution of xylans and mannans in the different cell types of developing secondary xylem were detected with immunofluorescence and immuno-gold labeling. While xylans, detected with the monoclonal antibody LM10, had a general distribution across the secondary xylem, mannans were enriched in the S2 secondary cell wall layer of fibers. To observe the cellular structures associated with secondary wall production, cryofixed fibers were examined with transmission electron microscopy during differentiation. There were abundant cortical microtubules and endomembrane activity in cells during the intense phase of secondary cell wall synthesis. Microtubule-associated small membrane compartments were commonly observed, as well as Golgi and secretory vesicles fusing with the plasma membrane. | Minako Kaneda Kim Rensing Lacey Samuels | 2010 | Journal of Integrative Plant Biology2010，52，2： | 2 |
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