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| 1 | 中国人心脏房室腔内径及左右心室功能正常参数的MRI研究显示文摘目的使用MRI测量中国正常成人心脏各房室腔内径及心功能参数。方法共269名正常志愿者,无线矢量心电门控下,采用单次激发半傅立叶快速自旋回波与真实稳态自由进动序列,分别获得标准心脏各长轴及短轴切面二维体层及电影图像。由2名医师独立分析MRI,分别测量心脏各房室腔径线及心功能后处理分析,获得包括射血分数(EF)、舒张末容积(EDV)、收缩末容积(ESV)及心肌质量(CM)等心功能参数。男性与女性相对应参数做非配对的t检验。结果所有志愿者均完成MR扫描,平均扫描时间(15±3)min。心脏各房室腔主要参数为:左心房前后径(2.87±0.77)cm,右心房径(垂直于房间隔,3.61±0.57)cm,左心室舒张末横径(4.97±0.52)cm,右心室舒张末横径(2.65±0.48)cm,心功能主要参数为:左心室EF(60.62±7.08)%、EDV(128.27±32.16)ml、ESV(46.02±15.72)ml、CM(82.97±24.03)g;右心室EF(47.73±6.50)%、EDV(115.37±26.71)ml、ESV(67.7±21.07)m1、CM(48.24±13.42)g。除左心室ESV(P:0.144)、EDV指数(P:0.714)、ESV指数(P=0.113)、心脏指数(P=0.199)及右心室EF值(P=0.296)和ESV指数(P=0.093)男女差异无统计学意义外,其余各指标性别间差异均有统计学意义(P〈0.01)。结论MRI以其高度的可重复性可获得正常中国人心脏形态与功能信息。 | 陆敏杰 赵世华 蒋世良 尹刚 张岩 凌坚 刘琼 韦云青 闫朝武 吕建华 祁晓鸥 程怀兵 马宁 安靖 Renate Jerecic | 2011 | 中华放射学杂志2011，45，10： | 35 |
| 2 | Therapy of gastric mucosa associated lymphoid tissue lymphoma显示文摘Gastric mucosa associated lymphoid tissue (MALT) lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success. | Andrea Morgner Renate Schmelz Christian Thiede Manfred Stolte Stephan Miehlke | 2007 | World Journal of Gastroenterology2007，13，26： | 14 |
| 3 | MR纵向弛豫时间定量成像评价肥厚型心肌病心肌纤维化的初步研究显示文摘目的探讨纵向弛豫时间定量(T1 mapping)成像对肥厚型心肌病(HCM)纤维化的诊断价值。方法按诊断标准人选48例HCM患者和18名健康志愿者,分别行常规延迟强化(LGE)检查与T1 mapping成像,按HCMLGE有无及程度,分为LGE远处正常区、LGE边缘区、LGE区(分为晕状LGE与典型斑片状LGE),分别测量2组心肌对比剂增强后T.值的变化率并进行卡方检验、两两对比及ROC曲线分析。结果健康志愿者T1值变化率与HCM远离LGE区差异无统计学意义(3.98±3.19和3.36±2.77.t=0.98,P〉0.05),与LGE周边区(13.51±5.67)、晕状区(17.70±5.57)、斑片区(36.62±8.03)比较差异有统计学意义(t值分别为15.28、17.13和47.48,P值均〈0.01);远处正常区(3.36±2.77)与LGE周边区、晕状区及斑片区比较差异均有统计学意义(t值分别为19.64、20.76和56.64,P值均〈0.01);LGE周边区与LGE晕状区和斑片区比较差异均有统计学意义(t值分别为6.12和39.90,P值均〈0.01);LGE晕状区与斑片区比较差异有统计学意义(t=25.63,P〈0.01)。ROC曲线提示T1 mapping成像较传统LGE成像有更大的曲线下面积(0.974±0.050和0.751±0.180)。结论HCM纤维化常见,且受累心肌的纤维化程度不一,T1mapping成像能对HCM患者心肌纤维化的严重程度进行评价,能够发现处于纤维化早期的病变。 | 陆敏杰 赵世华 蒋世良 尹刚 赵涛 张岩 凌坚 韦云青 刘琼 陈秀玉 马宁 相里伟 殷小荣 安靖 Renate Jerecic Shah Saurabh Xue Hui | 2013 | 中华放射学杂志2013，47，5： | 14 |
| 4 | 不同清洗方式对义齿白色假丝酵母菌生物膜清除效果的影响显示文摘目的比较不同清洁方式对义齿白色假丝酵母菌生物膜的清除能力。方法制作并消毒树脂片,在其表面培养白色假丝酵母菌生物膜,分别以化学(浸泡)、机械(刷洗)和复合(浸泡与刷洗并用)等方式处理覆有白色假丝酵母菌生物膜的树脂片,再将其浸入新鲜培养液进行残留生物膜的恢复培养,分别在0、6、24h后利用菌落计数进行效果评价。结果机械清除效果与牙膏种类密切相关,单纯的化学处理没有明显的清除作用,保丽净义齿清洁片复合处理清除白色假丝酵母菌生物膜的效果最佳,其处理后的树脂片培养24h仍未检出白色假丝酵母菌。结论不同的义齿清洗方法对附着在义齿表面的白色假丝酵母菌生物膜的清除能力有差异。其中,以保丽净义齿清洁片复合效果最好且能够持续地发挥抑菌作用。 | 李莉娜 Young Kim 舒毅 Renate Lux 田敏 Prasad Adusumilli Zvi Loewy 郭宏 Yu Shao 施文元 沈嵩 黄正蔚 田宇 朱昞 张恺 陈谦明 王敏 吴红崑 周学东 | 2010 | 国际口腔医学杂志2010，37，2： | 10 |
| 5 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 6 | Induction of the AOX1D Isoform of Alternative Oxidase in A. thaliana T-DNA Insertion Lines Lacking Isoform AOX1A Is Insufficient to Optimize Photosynthesis when Treated with Antimycin A显示文摘植物呼吸被二条小径为电子转移描绘到 O2,也就是被连接到 ATP 生产的细胞色素小径(CP ) ,和其他的小径(AP ) ,没有伴随物 ATP,从 ubiquinol 的电子在哪儿,直接经由其他的 oxidase (AOX ) 转到 O2 生产。这条后者小径很好被适合在光过量电子处理,导致优化光合的性能。我们描绘了不表示主要 isoform 的 Arabidopsis thaliana 的 T-DNA-insertion 变异的线, AOX1A。处于标准生长条件,这些植物没由抗霉素 A 通过 CP 显示出电子流动的任何显型,而是限制,它导致 AOX1A 表示在野类型,在 aox1a 大美人异种的叶子导致了 AOX1D 的增加的表情。尽管有在异种的 AOX1D isoform 的增加的存在,抗霉素 A 引起了光合作用的抑制,增加了 ROS,并且当时,最终导致了放大的膜漏和坏死与相比野类型,它被禁止者仅仅在边际地影响。经由 CP 的电子流动什么时候被限制,因此出现 AOX1D 是不能的充分补偿 AOX1A 的损失。抑制的联合学习,联合了到代谢物介绍并且指向了 glycine decarboxylase 建筑群(GDC ) 的 P 蛋白质的表示分析,建议 aox1a 异种试图为 photorespiration 增加他们的能力。然而,给他们的缺乏,在当与抗霉素 A 对待时,任何一个 AOX1D 都不能充分补偿让 AOX1A 的缺乏优化光合作用的表示增加,是吸引人的。我们建议 aox1a 异种能进一步被用来有关对光合的性能和基因表示的 mitochondrial 氧化还原作用的影响证实当前的模型。 | Inga Strodtkotter Kollipara Padmasree Challabathula Dinakar Birgit Speth Pamela S. Niazi Joanna Wojtera Ingo Voss Phuc Thi Do Adriano Nunes-Nesi Alisdair R. Fernie Vera Linke Agepati S. Raghavendra Renate Scheibe | 2009 | Molecular Plant2009，2，2： | 5 |
| 7 | Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection显示文摘Aim Dental biofilms are complex communities composed largely of harmless bacteria. Certain pathogenic species including Streptococcus mutans (S. mutans) can become predominant when host factors such as dietary sucrose intake imbalance the biofilm ecology. Current approaches to control S. mutans infection are not pathogen-specific and eliminate the entire oral community along with any protective benefits provided. Here, we tested the hypothesis that removal of S. mutans from the oral community through targeted antimicrobial therapy achieves protection against subsequent S. mutans colonization. Methodology Controlled amounts of S. mutans were mixed with S. mutans-free saliva, grown into biofilms and visualized by antibody staining and cfu quantization. Two specifically-targeted antimicrobial peptides (STAMPs) against S. mutans were tested for their ability to reduce S. mutans biofilm incorporation upon treatment of the inocula. The resulting biofilms were also evaluated for their ability to resist subsequent exogenous S. mutans colonization. Results S. mutans colonization was considerably reduced (9 ± 0.4 fold reduction, P=0.01) when the surface was preoccupied with saliva-derived biofilms. Furthermore, treatment with S. mutans-specific STAMPs yielded S. mutans-deficient biofilms with significant protection against further S. mutans colonization (5 minutes treatment: 38 ± 13 fold reduction P=0.01; 16 hours treatment: 96 ± 28 fold reduction P=0.07). Conclusion S. mutans infection is reduced by the pre- sence of existing biofilms. Thus maintaining a healthy or 'normal' biofilm through targeted antimicrobial therapy (such as the STAMPs) could represent an effective strategy for the treatment and prevention of S. mutans colonization in the oral cavity and caries progression. | Li-na Li Li-hong Guo Renate Lux Randal Eckert Daniel Yarbrough Jian He Maxwell Anderson Wen-yuan Shi | 2010 | International Journal of Oral Science2010，2，2： | 5 |
| 8 | 呼吸运动适应参数对磁共振冠状动脉成像质量的影响显示文摘目的探讨在全心对比增强磁共振冠状动脉成像中,呼吸运动适应(resp move.adap)参数的使用与否对呼吸平稳患者成像质量的影响。方法应用3.0T磁共振扫描仪对34名志愿者进行全心对比增强检查,其中26名志愿者成功完成检查。应用序贯抽样方案分为A和B两组,每组13名志愿者。A组使用参数resp move.adap,B组不使用该参数。应用两样本U检验及χ2检验对比分析两种方法的成像质量及段落显示率。结果两组图像质量比较差异有统计学意义(U=46.00,P=0.034),右冠状动脉节段显示率差异有统计学意义(χ2=6.385,P=0.012),前降支节段显示率差异有统计学意义(χ2=5.764,P=0.016),回旋支节段显示率差异无统计学意义(χ2=2.229,P=0.135)。组间性别及年龄差异无统计学意义。结论在对比增强全心磁共振冠状动脉成像中,对于呼吸平稳的患者,不使用resp move.adap参数成像的效果优于使用该参数。 | 梁红琴 朱立强 张笑春 金利新 李长英 Renate Jerecic 王新 王健 | 2010 | 中国医学影像技术2010，26，9： | 5 |
| 9 | Contribution of the Alternative Respiratory Pathway to PSII Photoprotection in C3 and C4 Plants显示文摘mitochondrial 选择 oxidase (AOX ) 小径由贡献 photoprotection 在争论的 photosystem II (PSII ) 的机制。AOX 小径由驱散减少通过 malate/oxaloacetate (Mal/OAA ) 从叶绿体出口的等价物的过量保护 photosystems,这通常被认为梭并且因此阻止叶绿体的在减小上。在这研究,用 aox1a Arabidopsis 异种和九其它, C3 和 C4 种种类,我们在 PSII photoprotection 揭示了 AOX 小径的一个另外的行动模型。尽管 AOX 小径在与高光对待的 C3 叶子贡献 PSII photoprotection,当 photorespiration 被压制时,这贡献被观察消失。AOX 小径的混乱或抑制显著地减少了在 C3 的 photorespiration 离开。而且, AOX 小径没对高光作出回应并且在拥有高度活跃的 Mal/OAA 梭的 C4 叶子,但是与小 photorespiration 贡献很少到 PSII photoprotection。这些结果证明 AOX 小径由维持 photorespiration 除去在 C3 植物贡献 PSII photoprotection glycolate 并且经由由 Mal/OAA 梭从叶绿体减少等价物的过量的间接出口。这个新行动模型解释 AOX 小径为什么不在 C4 植物贡献 PSII photoprotection。 | Zi-Shan Zhang Mei-Jun Liu Renate Scheibe Jennifer Selinski Li-Tao Zhang Cheng Yang Xiang-Long Meng Hui-Yuan Gao | 2017 | Molecular Plant2017，10，1： | 4 |
| 10 | Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms显示文摘A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds(EDCs), including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease. | Renate Kopp Irene Ozáez Martínez Jessica Legradi Juliette Legler | 2017 | Journal of Environmental Sciences2017，29，12： | 4 |
| 11 | The Plastid-Localized NAD-Dependent Malate Dehydrogenase Is Crucial for Energy Homeostasis in Developing Arabidopsis thaliana Seeds显示文摘当光合作用不在时, ATP 被 ATP/ADP transporters 进口进叶绿体和非绿的质体或在 glycolysis 期间形成了,要求 NAD+ 的连续新生的后者,由 NADMDH 的 plastidial isoform 供应了。在在 Arabidopsis 的 plNADMDH 基因为 T-DNA 插入异种屏蔽期间,仅仅异质接合的植物能被孤立,同型结合的猛烈异种仅仅在互补以后成长了。这些异质接合的植物显示出其他的改革 NAD+ 酶的更高的抄本层次, NADHGOGAT,并且,显著地,当铵是唯一的 N 来源时,改进了生长。在 situ,杂交并且 GUS 组织化学的染色表明 plNADMDH 特别地充满男、女的配偶体。猛烈 plNADMDH 花粉展览在 vitro 损害了试管生长,它能被增加 NADHGOGAT 的底层克服。在 vivo,猛烈花粉能使肥沃卵房间。异质接合的植物包含的 selfed 的年轻 siliques 相应于 wild-type/heterozygous (绿色) 和同型结合的猛烈异种(白色) 在的绿、白的种子一(1:2 ): 1 比率。同型结合的猛烈种子的胚胎仅仅到达了球状的阶段,绿,并且发展了到微小的起皱的种子。有在本国的倡导者下面的基因的互补救了作为野类型开发的这个缺点,和所有种子。这建议在 plNADMDH 异种的一个堵住的主要生理的过程停止胚胎和内乳开发,因此避免在损害后代吸收投资。 | Jennifer Selinski Nicolas Konig Benedikt Wellmeyer Guy T. Hanke Vera Linke H. Ekkehard Neuhaus Renate Scheibe | 2014 | Molecular Plant2014，7，1： | 4 |
| 12 | Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria显示文摘Dental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods. | Chu-hong Hu Jian He Randal Eckert Xiao-yang Wu Li-na Li Yan Tian Renate Lux Justin A. Shuffer Faina Gelman Janet Mentes Sue Spackman Janet Bauer Maxwell H. Anderson Wen-yuan Shi | 2011 | International Journal of Oral Science2011，3，1： | 3 |
| 13 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 14 | Different modes of foveal regeneration after closure of full-thickness macular holes by(re)vitrectomy and autologous platelet concentrate显示文摘AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells. | Andreas Bringmann Claudia Jochmann Jan Darius Unterlauft Renate Wiedemann Matus Rehak Peter Wiedemann | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 15 | Effect of Chlorophytum Borivilianum Santapau and Fernandes on Sexual Dysfunction in Hyperglycemic Male Rats显示文摘Objective:To investigate the effects of Chlorophytum borivilianum(CB) on sexual dysfunction, loss of body weight,and lack of libido in hyperglycemic rats induced with streptozotocin or alloxan.Methods: Wistar strain male albino rats were divided into five groups of six animals each:the control group(2% polyvinylpyrollidone solution),the streptozotocin control group(50 mg/kg),the alloxan control group(100 mg/kg), the streptozotocin + CB treated group(200 mg/kg),and the alloxan + CB treated group(200 mg/kg... | Mayank Thakur Shilpi Bhargava Werner Praznik Renate Loeppert Vinod K Dixit | 2009 | Chinese Journal of Integrative Medicine2009，15，6： | 3 |
| 16 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 17 | Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis显示文摘Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral bio?lm architecture by acting as a bridge between early Gram-positive and late Gram-negative colonizers that do not otherwise adhere to each other. In this study, we survey a key adherence interaction of F. nucleatum with Porphyromonas gingivalis, and present evidence that multiple fusobacterial adhesins have a role in the attachment of F. nucleatum ATCC 23726 to P. gingivalis in a highly strain-dependent manner. Interaction between these species displayed varying sensitivities to arginine,galactose and lactose. Arginine was found to hamper coaggregation by at least 62% and up to 89% with several P. gingivalis strains and galactose inhibition ranged from no inhibition up to 58% with the same P. gingivalis strains. Lactose consistently inhibited F. nucleatum interaction with these P. gingivalis strains ranging from 40% to 56% decrease in coaggregation. Among the adhesins involved are the previously described Fap2 and surprisingly, Rad D, which was described in an earlier study for its function in attachment of F. nucleatum to Gram-positive species. We also provide evidence for the presence of at least one additional adhesin that is sensitive to arginine but unlike Fap2 and Rad D, is not a member of the autotransporter family type of fusobacterial large outer membrane proteins. The strain-speci?c binding pro?le of multiple fusobacterial adhesins to P. gingivalis highlights the heterogeneity and complexity of interspecies interactions in the oral cavity. | Jane Park Bhumika Shokeen Susan K Haake Renate Lux | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 18 | 使用草酸作为沉淀剂提高腐植酸品质显示文摘用有机溶剂对冷冻干燥的泥炭样品进行索氏提取和使用有机酸使腐植酸沉淀的两种纯化腐植酸的方法已经被探讨。用有机溶剂萃取,能够有效去除可溶性有机杂质(高达12%),而对腐植质没有明显损失和改性。使用有机酸为沉淀剂是为了脱除腐植酸中的卤素和无机酸。本文比较了用上述方法获得腐植酸与用传统方法盐酸沉淀获得腐植酸。 | Guido Meyer Renate Klcking 张彩凤 王丽君 | 2013 | 腐植酸2013，，6： | 2 |
| 19 | Staging of Klatskin tumours (hilar cholangiocarcinomas): comparison of MR cholangiography, MR imaging, and endoscopic retrograde cholangiography显示文摘 | Thomas J. Vogl Wolfram O. Schwarz Matthias Heller Christopher Herzog Stephan Zangos Rainer E. Hintze Peter Neuhaus Renate M. Hammerstingl | 2006 | European Radiology2006，，10： | 2 |
| 20 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，： | 2 |
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