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| 1 | 盾构隧道开挖对邻近桩基影响数值分析显示文摘经与离心试验结果对比分析,验证了应用数值模拟研究盾构隧道开挖对邻近桩基影响是可靠的。通过采用Mohr-Coulomb弹塑性屈服准则,建立三维有限元数值模型,研究软土地区盾构隧道开挖对邻近桩基的影响规律。数值模拟结果表明,开挖导致群桩中前排桩变形及内力均大于后排桩,且同排桩水平位移、弯矩和轴力沿桩身分布几乎重合;与同位置单桩相比,群桩中各桩水平位移稍大,而沉降则更小;前排桩最大弯矩与同位置单桩相差不大,而后排桩最大弯矩稍大于同位置单桩,前、后排桩最大轴力均大于同位置单桩。 | 朱逢斌 杨平 ONG C W | 2008 | 岩土工程学报2008，30，2： | 117 |
| 2 | g-C_3N_4界面改性:掺杂金属硫化物构建新型异质结光催化剂的能源转换展望(英文)显示文摘光催化技术不仅可以将太阳能转化为化学能,还可以直接降解和矿化有机污染物的特性,因而成为最具吸引力和前景的技术之一,被广泛应用于解决环境和能源问题.但是目前,太阳能燃料的最高转化效率为5%,无法满足商业化要求(≥10%).各种光催化材料被探索研究以进一步提高光催化效率.但目前广泛使用的材料都有不同的缺点.比如最常用的金属氧化物(TiO2)由于禁带较宽,仅能利用太阳光中的紫外光,限制了其对光的使用效率;贵金属化合物虽性能优异但成本较高,不宜规模化应用;硫化物或非金属单质一般容易发生光腐蚀,稳定性较差;非金属化合物或聚合物中光生电子和空穴复合率高,活性较低.最近几年,类石墨相氮化碳(g-C_3N_4)以其优异的热稳定性以及化学稳定性,能带结构易调控和前驱体价格低廉等特点而成为目前研究的热点,在光解水制氢产氧、污染物降解、光催化CO_2还原、抗菌和有机官能团选择性转换等领域受到广泛的应用.然而,传统热缩聚法合成的g-C_3N_4光催化剂比表面积小、电荷复合率高、禁带宽度稍微大、光生载流子传输慢,抑制了其光催化活性.为了进一步提高g-C_3N_4的光催化活性,出现了多种改性方法.纳米异质结由于能展现出单组分纳米材料或体相异质结所不具备的独特性质,更能促进光生电子和空穴快速转移,提供更多的光生电子或使光生电子具有更强的还原性而成为研究的热点.从2009年以来,基于g-C_3N_4的异质结结构以其优异的光催化性能吸引了世界各国科学家的关注.本文综述了过渡金属硫化物(TMS)/g-C_3N_4纳米复合材料的最近研究进展,包括:(1)纯g-C_3N_4的制备,(2)g-C_3N_4的改性方法,(3)TMS/g-C_3N_4异质结光催化剂的设计原则,以及(4)能量转换方面的应用.并从以下几个方面对金属硫化物异质结体系的特性和转移机理进行了介绍:(1) I-型异质结,(2)Ⅱ-型异质结,(3) p-n型异质结,(4)肖特基异质结和(5) Z-型异质结.此外,还系统地介绍了g-C_3N_4基异质结光催化剂在光解水、CO_2还原、固氮和污染物降解等方面的应用.最后,本文分析了目前g-C_3N_4光催化剂异质结领域面临的问题和挑战,展望了未来的发展趋势. | 任亦杰 曾德乾 Wee-Jun Ong | 2019 | Chinese Journal of Catalysis2019，40，3： | 27 |
| 3 | A comprehensive survey of augmented reality assembly research显示文摘 | X. Wang S. K. Ong A. Y. C. Nee | 2016 | Advances in Manufacturing2016，4，1： | 23 |
| 4 | 菊花倍半萜烯内酯诱导人鼻咽癌细胞毒性和凋亡的研究显示文摘目的 评价菊花倍半萜烯内酯类化合物 (SL s)对鼻咽癌的抗肿瘤作用。方法 采用 SL s的活性成分parthenolide (PN)为受试物作用于人鼻咽癌高分化细胞株 CNE1,检测细胞毒性和诱导性凋亡指标 ,进行时间 -效应和剂量 -效应作用观察。结果 10~ 10 0 μm ol/ L 的 PN作用 6~ 36 h后与阴性对照组比较 ,CNE1细胞乳酸脱氢酶 (L DH)漏出率明显增加、细胞计数减少、细胞增殖抑制率升高 (P<0 .0 5 ) ;细胞出现凋亡特征形态学改变 ,TU NEL阳性细胞、Sub G1亚群细胞百分数增加 ,细胞失贴壁率明显增高 (P<0 .0 5 ) ;上述指标与 PN剂量存在明显相关 (P<0 .0 5 )和时间循序变化。结论 PN可通过对人鼻咽癌细胞毒性作用和诱导细胞凋亡发挥其抗肿瘤作用 ,提示 | 林忠宁 林育纯 SHEN Han-ming YANG Cheng-feng Ong Choon-Nam | 2002 | 中草药2002，33，10： | 23 |
| 5 | Complications of endoscopic retrograde cholangiography in the post-MRCP era: A tertiary center experience显示文摘AIM: To evaluate our experience in endoscopic retrograde cholangio-pancreatography (ERCP) in terms of fulfilling the ASGE guidelines in indications, positive findings,and complications in the post-magnetic resonance cholangiopancreatography (MRCP) era.METHODS: Between November 2001 and February 2003, consecutive ERCP cases were prospectively evaluated with regard to the indications, findings, cannulation techniques,devices used during the procedure, sedation given,duration of procedure, and complications. These data were entered in a database for subsequent processing and analysis.RESULTS: Of 336 cases, 21.4% were diagnostic and 78.6% therapeutic ERCP. The indications for ERCP fulfilled the ASGE guidelines in 323 cases (96.1%). Suspected bile duct stone was the most frequent indication (26.8%), and this was followed by cholangitis (24.4%), dilated common bile duct (14.9%), and cholestatic jaundice (13.4%).Cannulation success rate was 94%. Biliary sphincterotomy was performed in 175 (52.1%) patients. Repeated ERCP was performed on 31.5% of the patients. Overall, the complication rate was 9.8% with 0.3% being procedurerelated mortality. The complications were pancreatitis (5.4%), bleeding (0.8%), cholangitis (2.4%) and others (1.5%). No significant difference was observed between the complication rate and the type of ERCP performed.CONCLUSION: Our study showed that post-ERCP complication rate was comparable with the other large prospective studies and there was no difference in the complication between the diagnostic and therapeutic ERCP. | Tze-Zen Ong Jen-Lock Khor Dede-Sutedja Selamat Khay-Guan Yeoh Khek-Yu Ho | 2005 | World Journal of Gastroenterology2005，11，33： | 21 |
| 6 | Contrast-enhanced 3D ultrasound in the radiofrequency ablation of liver tumors显示文摘Liver metastases and hepatocellular carcinomas are two of the most common causes of cancer deaths in the world.Radiofrequency ablation(RFA) is a well recognized,effective and minimally invasive means of treating malignant hepatic tumors.This article describes the use of contrast-enhanced 3D ultrasound(CE-3DUS) in the staging,targeting and follow-up of patients with liver tumors undergoing RFA.In particular,its value in the management of large hepatic lesions will be illustrated.Current limitations of CE-3DUS and future developments in the technique will also be discussed.In summary,CE-3DUS is useful in the RFA of liver tumors with improved detection and display of occult lesions and recurrence,in the assessment of lesional geometry and orientation for a more accurate planning and guidance of multiple RFA needle electrodes in large tumors and in the evaluation of residual or recurrent disease within the immediate and/or subsequent follow-up periods. | Edward Leen Senthil Kumar Shahid A Khan Gavin Low Keh Oon Ong Paul Tait Mike Averkiou | 2009 | World Journal of Gastroenterology2009，15，3： | 19 |
| 7 | 广义负二项分布对钉螺分布的拟合显示文摘目的介绍并应用广义负二项分布研究湖北钉螺的分布规律,为定量化研究提供理论依据。方法随机抽取安徽省池州市贵池区秋浦河沿岸的4块滩地作为研究现场,2005年调查4块滩地的钉螺数据,2006年从中再随机抽取2块滩地进行调查。通过全局最大似然法分别拟合广义负二项分布和负二项分布,比较同一季节不同滩地和不同季节同一滩地的分布拟合结果。结果不同季节、不同滩地的钉螺密度是不同的,但其分布形状均是相似的正偏态分布,广义负二项分布能成功地拟合所有的钉螺数据。不同季节同一滩地间的广义负二项分布参数的变化不一致,同一季节不同滩地广义负二项分布的参数估计结果即使在钉螺密度相近的情况下也不相近,钉螺生存环境的微小差异可以通过广义负二项分布的参数灵敏反映。结论广义负二项分布比负二项分布能更好地反映钉螺分布的复杂性,其将在钉螺的定量化研究领域以及家庭聚集性疾病、寄生虫病和定量生态学的研究中具有重要意义。 | 张志杰 彭文祥 Ong Senghuat 周艺彪 庄建林 姜庆五 陈更新 | 2008 | 中国卫生统计2008，25，1： | 17 |
| 8 | 马占相思的日光合作用和日碳固定总量研究(英文)显示文摘马占相思(Acacia mangium)是一种具有较高经济价值和生态效益的热带速生树种。为了研究其光合作用对一天内光强、温度等环境因子变化的响应,揭示其迅速生长的生理生态机制,在叶片水平上测量了马占相思在24h内的净光合速率(Pn)、蒸腾速率、气孔导度(Gs)、胞间CO2浓度(Gi)、每日固定碳的总量、夜间消耗碳的总量以及日问光合系统Ⅱ光化学效率(Fv/Fm)的变化。结果显示:其净光合速率在正午降低了14.5%;其较高的蒸腾速率和气孔导度有助于保持叶片日间较高的碳固定速率;光合系统Ⅱ对于高光强和高温有较强的忍受度;每日固定碳的总量为502 mmol CO2·m-2,夜间碳的损失为54 mmol CO2·m-2。研究结果在一定程度上揭示了马占相思在热带高光强和高温条件下迅速生长的生理机制。 | 余华 Bee Lian ONG | 2003 | 植物生态学报2003，27，5： | 17 |
| 9 | 精液中硒含量与精子质量和精子DNA氧化损伤的关系显示文摘目的 探讨血清和精液中硒浓度与精子质量和精子DNA氧化损伤的关系。方法 用原子吸收光谱检测血清和精液中硒浓度 ,按WHO规范方法检测精液量、精子数、每次射出精子总数、活力和活动精子百分率及精子畸形率 ,用高压液相色谱 光电检测系统和高压液相色谱 紫外线检测器同时检测人精子DNA 8 羟基脱氧核糖鸟苷 (8 OHdG)和脱氧核糖鸟苷 (dG)水平。结果 已孕组精液硒平均浓度 (0 74μmol/L)明显高于不孕组 (0 5 6 μmol/L) ,而两组间血清硒平均浓度差异无显著性。已孕组精液量、精子数和每次射出精子总数的平均值 (3 91ml、46 4× 10 9/L和 16 8 0× 10 6)明显高于不孕组 (2 79ml、36 5× 10 9/L和 10 2 0× 10 6) ,两组间精子活力、活动精子百分率和精子畸形率的平均值差异无显著性。精液硒浓度与精子数、每次射出精子总数、精子活力、活动精子百分率之间呈明显的正相关 ,而血清硒浓度与精子质量均无明显相关关系。精子DNA 8 OHdG水平与精液硒浓度呈明显负相关 ,而与血清硒浓度无明显相关关系。结论 精液硒浓度与人类精子质量和精子DNA 8 OHdG有关 。 | 徐德祥 Ong Choonnam Shen Hanming Chua Laiha Chia Seneng | 2001 | 中华预防医学杂志2001，35，6： | 16 |
| 10 | Self-assembly of nitrogen-doped TiO2 with exposed {001} facets on a graphene scaffold as photo-active hybrid nanostructures for reduction of carbon dioxide to methane显示文摘明确的锐钛矿 TiO 的定制的合成 < 潜水艇 class= “ a-plus-plus ” > 2 -based 晶体与暴露 { 001 } 方面刺激了由于他们的科学、工艺的重要性世界范围的连续研究兴趣。此处,锐钛矿做氮的 TiO <潜水艇class=“ a-plus-plus ”> 2 ( N-TiO <潜水艇class=“ a-plus-plus ”> 2 ) nanoparticles 与暴露{ 001 }方面在 graphene ( GR )上扔了表( N-TiO <潜水艇class=“ a-plus-plus ”> 2 -001/GR)第一次被综合经由一步舞 solvothermal 用 NH 的合成线路<潜水艇class=“ a-plus-plus ”> 4 F 作为控制形态学的代理人。试验性的结果例示那 GR 一致地被锐钛矿 N-TiO 盖住 < 潜水艇 class= “ a-plus-plus ” > 2 nanoparticles (1017 nm ) ,暴露 { 001 } 方面。百分比暴露 { 001 } 在 N-TiO 的方面 < 潜水艇 class= “ a-plus-plus ” > 2 -001/GR nanocomposites 被计算是 ca。35% 。另外,在吸收边的红移动和在可见轻范围的强壮的吸收由于 Ti-O-C 契约的形成被观察,导致从 3.23 ~ 2.9 eV 的乐队差距的成功的变窄。同样准备的光催化剂的 photocatalytic 活动为公司被评估<潜水艇class=“ a-plus-plus ”>生产 CH 的 2 减小<潜水艇class=“ a-plus-plus ”> 4 面对在周围的温度和气压用下面的水蒸汽一低力量 15 W 节省精力的日光灯作为可见到最通常采用的高力量的氙 lampswhich 的轻 sourcein 对比经济地并且实际上显示了这个过程可行。在所有学习光催化剂之中, N-TiO < 潜水艇 class= “ a-plus-plus ” > 2 -001/GR nanocomposites 展出了最大的 CH < 潜水艇 class= “ a-plus-plus ” > 3.70 摩尔的 4 产量?? | Wee-Jun Ong Lling-Lling Tan Siang-Piao Chai Siek-Ting Yong Abdul Rahman Mohamed | 2014 | Nano Research2014，7，10： | 16 |
| 11 | Preliminary experience with drug-coated balloon angioplasty in primary percutaneous coronary intervention显示文摘We evaluated the clinical feasibility of using drugcoated balloon(DCB) angioplasty in patients undergoingprimary percutaneous coronary intervention(PPCI). Between January 2010 to September 2014,89 STelevation myocardial infarction patients(83% male,mean age 59 ± 14 years) with a total of 89 coronary lesions were treated with DCB during PPCI. Clinical outcomes are reported at 30 d follow-up. Left anterior descending artery was the most common target vessel for PCI(37%). Twenty-eight percent of the patients had underlying diabetes mellitus. Mean left ventricular ejection fraction was 44% ± 11%. DCB-only PCI was the predominant approach(96%) with the remaining 4% of patients receiving bail-out stenting. Thrombolysis in Myocardial Infarction(TIMI) 3 flow was successfully restored in 98% of patients. An average of 1.2 ± 0.5 DCB were used per patient,with mean DCB diameter of 2.6 ± 0.5 mm and average length of 23.2 ± 10.2 mm. At 30-d follow-up,there were 4 deaths(4.5%). No patients experienced abrupt closure of the infarctrelated artery and there was no reported target-lesion failure. Our preliminary experience showed that DCB angioplasty in PPCI was feasible and associated with a high rate of TIMI 3 flow and low 30-d ischaemic event. | Hee Hwa Ho Julian Tan Yau Wei Ooi Kwok Kong Loh Than Htike Aung Nwe Tun Yin Dasdo Antonius Sinaga Fahim Haider Jafary Paul Jau Lueng Ong | 2015 | World Journal of Cardiology2015，7，6： | 14 |
| 12 | 尖锐心肌的梗塞: 在在新加坡的年轻成年人的临床的特征和结果显示文摘 AIM: To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS: Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS: The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6±1.2 mmol/L, 3.8±1.1 mmol/L and 0.93±0.25 mmol/L respectively. The mean left ventricular function was 44%±10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION: Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI. | Chun Pong Wong Seet Yoong Loh Kwok Kong Loh Paul Jau Lueng Ong David Foo Hee Hwa Ho | 2012 | World Journal of Cardiology2012，4，6： | 13 |
| 13 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 14 | Lycopene and male infertility显示文摘反应的氧种类(ROS ) 的过多的数量引起氧化应力的一个状态,它导致精子膜类脂化合物 peroxidation, DNA 损坏和 apoptosis,导致减少的精子生存能力和活动性。ROS 的提高的层次是自发的男因素不孕的一个主要原因,它是今天的一个逐渐地普通的问题。Lycopene,所有类胡萝卜素的大多数有势力汗衫氧 quencher,因为它的抗氧化剂性质,是为男不孕的一种可能的处理选择。由反应与并且抵销自由激进分子, lycopene 能减少氧化应力的发生并且这样,减少将不那样被施加在精子身上的损坏。lycopene 可以在睾丸经由 nonoxidative 机制有另外的有益的效果,这被要求,例如差距连接通讯,基因表示的调整,房间周期和 immunoenhancement 的规定。在人和动物上进行的各种各样的 lycopene 补充研究在减轻男 infertility— 显示出有希望的结果;当精子计数和生存能力,和一般免疫被增加时,类脂化合物 peroxidation 和 DNA 损坏被减少。这些参数的改进在氧化应力显示减小,并且这样精子对氧化损坏不太脆弱,它增加使肥沃的一个正常精子的机会卵。人的试用每天与 lycopene 的 4-8 mg 的补充在精子参数和怀孕率报导改进 3-12 月了。然而,进一步详细说明了,广泛的研究仍然被要求为男不孕作为一个处理决定剂量和 lycopene 的实用性。 | Damayanthi Durairajanayagam Ashok Agarwal Chloe Ong Pallavi Prashast | 2014 | Asian Journal of Andrology2014，16，3： | 13 |
| 15 | Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?显示文摘Alcohol consumption is the principal factor in thepathogenesis of chronic liver diseases.Alcoholic liver disease(ALD)is defined by histological lesions on the liver that can range from simple hepatic steatosis to more advanced stages such as alcoholic steatohepatitis,cirrhosis,hepatocellular carcinoma and liver failure.As one of the oldest forms of liver injury known to humans,ALD is still a leading cause of liver-related morbidity and mortality and the burden is exerting on medical systems with hospitalization and management costs rising constantly worldwide.Although the biological mechanisms,including increasing of acetaldehyde,oxidative stress with induction of cytochrome p4502E1,inflammatory cytokine release,abnormal lipid metabolism and induction of hepatocyte apoptosis,by which chronic alcohol consumption triggers serious complex progression of ALD is well established,there is no universally accepted therapy to prevent or reverse.In this article,we have briefly reviewed the pathogenesis of ALD and the molecular targets for development of novel therapies.This review is focused on current therapeutic strategies for ALD,including lifestyle modification with nutrition supplements,available pharmacological drugs and new agents that are under development,liver transplantation,application of complementary medicines,and their combination.The relevant molecular mechanisms of each conventional medication and natural agent have been reviewed according to current available knowledge in the literature.We also summarized efficacy vs safety on conventional and herbal medicines which are specifically used for the prevention and treatment of ALD.Through a system review,this article highlighted that the combination of pharmaceutical drugs with naturally occurring agents may offer an optimal management for ALD and its complications.It is worthwhile to conduct large-scale,multiple centre clinical trials to further prove the safety and benefits for the integrative therapy on ALD. | Moon-Sun Kim Madeleine Ong Xianqin Qu | 2016 | World Journal of Gastroenterology2016，22，1： | 13 |
| 16 | Poor performance of the modified early warning score for predicting mortality in critically ill patients presenting to an emergency department显示文摘BACKGROUND:This study was undertaken to validate the use of the modified early warning score(MEWS) as a predictor of patient mortality and intensive care unit(ICU)/ high dependency(HD)admission in an Asian population.METHODS:The MEWS was applied to a retrospective cohort of 1 024 critically ill patients presenting to a large Asian tertiary emergency department(ED) between November 2006 and December2007.Individual MEWS was calculated based on vital signs parameters on arrival at ED.Outcomes of mortality and ICU/HD admission were obtained from hospital records.The ability of the composite MEWS and its individual components to predict mortality within 30 days from ED visit was assessed.Sensitivity,specificity,positive and negative predictive values were derived and compared with values from other cohorts.A MEWS of ≥4 was chosen as the cut-off value for poor prognosis based on previous studies.RESULTS:A total of 311(30.4%) critically ill patients were presented with a MEWS ≥4.Their mean age was 61.4 years(SD 18.1) with a male to female ratio of 1.10.Of the 311 patients,53(17%)died within 30 days,64(20.6%) were admitted to ICU and 86(27.7%) were admitted to HD.The area under the receiver operating characteristic curve was 0.71 with a sensitivity of 53.0%and a specificity of 72.1%in addition to a positive predictive value(PPV) of 17.0%and a negative predictive value(NPV)of 93.4%(MEWS cut-off of ≥4) for predicting mortality.CONCLUSION:The composite MEWS did not perform well in predicting poor patient outcomes for critically ill patients presenting to an ED. | Le Onn Ho Huihua Li Nur Shahidah Zhi Xiong Koh Papia Sultana Marcus Eng Hock Ong | 2013 | World Journal of Emergency Medicine2013，4，4： | 12 |
| 17 | Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats显示文摘AIM To investigate protective effects and molecular mechanisms of green tea polyphenols(GTP) on nonalcoholic fatty liver disease(NAFLD) in Zucker fatty(ZF) rats.METHODS Male ZF rats were fed a high-fat diet(HFD) for 2 wk then treated with GTP(200 mg/kg) or saline(5 m L/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase(ALT) and aspartate aminotransferase(AST), inflammatory cytokines and hepatic triglyceride and liver histology. Immunoblotting was used to detect phosphorylation of AMP-activated protein kinase(AMPK) acetyl-Co A carboxylase(ACC), and sterol regulatory element-binding protein 1c(SREBP1c). RESULTS Genetically obese ZF rats on a HFD presented with metabolic features of hepatic pathological changes comparable to human with NAFLD. GTP intervention decreased weight gain(10.1%, P = 0.052) and significantly lowered visceral fat(31.0%, P < 0.01). Compared with ZF-controls, GTP treatment significantly reduced fasting serum insulin, glucose and lipids levels. Reduction in serum ALT and AST levels(both P < 0.01) were observed in GTP-treated ZF rats. GTP treatment also attenuated the elevated TNFα and IL-6 in the circulation. The increased hepatic TG accumulation and cytoplasmic lipid droplet were attenuated by GTP treatment, associated with significantly increased expression of AMPK-Thr172(P < 0.05) and phosphorylated ACC and SREBP1c(both P < 0.05), indicating diminished hepatic lipogenesis and triglycerides out flux from liver in GTP treated rats. CONCLUSION The protective effects of GTP against HFD-induced NAFLD in genetically obese ZF rats are positively correlated to reduction in hepatic lipogenesis through upregulating the AMPK pathway. | Yi Tan Jane Kim Jing Cheng Madeleine Ong Wei-Guo Lao Xing-Liang Jin Yi-Guang Lin Linda Xiao Xue-Qiong Zhu Xian-Qin Qu | 2017 | World Journal of Gastroenterology2017，23，21： | 11 |
| 18 | Unravelling charge carrier dynamics in protonated g-C3N4 interfaced with carbon nanodots as co-catalysts toward enhanced photocatalytic CO2 reduction: A combined experimental and first-principles DFT study显示文摘在这个工作,我们表明了没有金属的 zerodimensional/ 的成功的构造二维的碳 nanodot (CND )-hybridized protonated g-C 3 N 4(pCN )(CND/pCN ) 借助于静电的吸引力的异质接面光催化剂。我们试验性地发现有 4.4 nm 的一条平均直径的 CND 在用电子显微镜学分析的 pCN 的表面上是一致地分布式的。有 3 wt.% 的一个 CND 内容的 CND/pCN-3 样品在可见、模仿的太阳的光下面在 CO 2 光致还原过程显示出最高催化的活动。这个过程导致在可见光的活动的 10 h 被发现是 29.23 和 58.82 摩尔 ? 以后, CH 4 和公司的全部的数量由 CND/pCN-3 光催化剂产生了的 CH 4 和公司的进化 ? 挠潲獳氭湩敫 ? 牧灡敨敮 ?????? ?? 吗?? | Wee-Jun Ong Lutfi Kurnianditia Putri Yoong-Chuen Tan Lling-Lling Tan Neng Li Yun Hau Ng Xiaoming Wen Siang-Piao Chai | 2017 | Nano Research2017，10，5： | 11 |
| 19 | An electrostatic spectral neighbor analysis potential for lithium nitride显示文摘Machine-learned interatomic potentials based on local environment descriptors represent a transformative leap over traditional potentials based on rigid functional forms in terms of prediction accuracy.However,a challenge in their application to ionic systems is the treatment of long-ranged electrostatics.Here,we present a highly accurate electrostatic Spectral Neighbor Analysis Potential(eSNAP)for ionicα-Li3N,a prototypical lithium superionic conductor of interest as a solid electrolyte or coating for rechargeable lithium-ion batteries.We show that the optimized eSNAP model substantially outperforms traditional Coulomb–Buckingham potential in the prediction of energies and forces,as well as various properties,such as lattice constants,elastic constants,and phonon dispersion curves.We also demonstrate the application of eSNAP in long-time,large-scale Li diffusion studies in Li3N,providing atomistic insights into measures of concerted ionic motion(e.g.,the Haven ratio)and grain boundary diffusion.This work aims at providing an approach to developing quantum-accurate force fields for multi-component ionic systems under the SNAP formalism,enabling large-scale atomistic simulations for such systems. | Zhi Deng Chi Chen Xiang-Guo Li Shyue Ping Ong | 2019 | npj Computational Materials2019，，1： | 11 |
| 20 | Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions显示文摘MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. | Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew | 2020 | Neural Regeneration Research2020，15，4： | 11 |
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