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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013，，6： | 10 |
| 3 | National Park vegetation mapping using multitemporal Landsat 7 data and a decision tree classifier显示文摘 | Eric C. Brown de Colstoun Michael H. Story Craig Thompson Kathy Commisso Timothy G. Smith James R. Irons | 2003 | Remote Sensing of Environment2003，，3： | 2 |
| 4 | Serious infections in patients with inflammatory bowel disease receiving anti‐tumor‐necrosis‐factor‐alpha therapy: An Australian and New Zealand experience显示文摘 | Ian CLawrance Graham LRadford‐Smith Peter ABampton Jane MAndrews Pok‐KernTan AnthonyCroft Richard BGearry Timothy H JFlorin | 2010 | Journal of Gastroenterology and Hepatology2010，，11： | 2 |
| 5 | A Pooled Analysis of Advanced Colorectal Neoplasia Diagnoses After Colonoscopic Polypectomy显示文摘 | María Elena Martínez John A. Baron David A. Lieberman Arthur Schatzkin Elaine Lanza Sidney J. Winawer Ann G. Zauber Ruiyun Jiang Dennis J. Ahnen John H. Bond Timothy R. Church Douglas J. Robertson Stephanie A. Smith–Warner Elizabeth T. Jacobs David S. Alb | 2009 | Gastroenterology2009，，3： | 2 |
| 6 | Exome Resequencing Identifies Potential Tumor‐Suppressor Genes that Predispose to Colorectal Cancer显示文摘 | Christopher G. Smith Marc Naven Rebecca Harris James Colley Hannah West Ning Li Yuan Liu Richard Adams Timothy S. Maughan Laura Nichols Richard Kaplan Michael J. Wagner Howard L. McLeod Jeremy P. Cheadle | 2013 | Human Mutation2013，，7： | 2 |
| 7 | Blast wave propagation in city streets -an overview显示文摘 | Peter D Smith Timothy A Rose | 2006 | Structural Safety and Reliability2006，，8： | 1 |
| 8 | Lactated Ringer’s Solution Reduces Systemic Inflammation Compared With Saline in Patients With Acute Pancreatitis显示文摘 | Bechien U. Wu James Q. Hwang Timothy H. Gardner Kathryn Repas Ryan Delee Song Yu Benjamin Smith Peter A. Banks Darwin L. Conwell | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 9 | Formal Dysphagia Screening Protocols Prevent Pneumonia显示文摘 | Judith A. Hinchey Timothy Shephard Karen Furie Don Smith David Wang Sarah Tonn | 2005 | Stroke2005，，9： | 1 |
| 10 | Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep显示文摘 | Susan K. Murphy Brad A. Freking Timothy P.L. Smith Kreg Leymaster Catherine M. Nolan Andrew A. Wylie Heather K. Evans Randy L. Jirtle | 2005 | Mammalian Genome2005，，3： | 1 |
| 11 | Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat显示文摘 | S. E. Hemby Conchita Co Timothy R. Koves James E. Smith Steven I. Dworkin | 1997 | Psychopharmacology1997，，1： | 1 |
| 12 | Measurements of left ventricular dimensions using real-time acquisition in cardiac magnetic resonance imaging: comparison with conventional gradient echo imaging显示文摘 | Sven Plein William H. T. Smith John P. Ridgway Andrea Kassner David J. Beacock Timothy N. Bloomer Mohan U. Sivananthan | 2001 | Magma: Magnetic Resonance Materials in Physics Biology and Medicine2001，，2： | 1 |
| 13 | Onset of action of a lozenge containing flurbiprofen 8.75<ce:hsp sp='0.25'/>mg: A randomized, double-blind, placebo-controlled trial with a new method for measuring onset of analgesic activity显示文摘 | Bernard Schachtel Sue Aspley Adrian Shephard Timothy Shea Gary Smith Kathleen Sanner Laurie Savino Jeanne Rezuke Emily Schachtel | 2013 | Pain2013，，： | 1 |
| 14 | Cholecystokinin Mediates Progression and Metastasis of Pancreatic Cancer Associated with Dietary Fat显示文摘 | Gail L. Matters Timothy K. Cooper Christopher O. McGovern Evan L. Gilius Jiangang Liao Brian M. Barth Mark Kester Jill P. Smith | 2014 | Digestive Diseases and Sciences2014，，6： | 1 |
| 15 | The Posterior Shearing Tibial Plateau Fracture: Treatment and Results via a Posterior Approach显示文摘 | Timothy Bhattacharyya L Pearce McCarty Mitchell B Harris Suzanne M Morrison John J Wixted Mark S Vrahas R Malcolm Smith | 2005 | Journal of Orthopaedic Trauma2005，，： | 1 |
| 16 | A porcine BAC library with tenfold genome coverage: a resource for physical and genetic map integration显示文摘 | Scott C. Fahrenkrug Gary A. Rohrer Brad A. Freking Timothy P.L. Smith Kazutoyo Osoegawa Chung Li Shu Joseph J. Catanese Pieter J. de Jong | 2001 | Mammalian Genome2001，，6： | 1 |
| 17 | Formal Dysphagia Screening Protocols Prevent Pneumonia显示文摘 | Judith A. Hinchey Timothy Shephard Karen Furie Don Smith David Wang Sarah Tonn | 2005 | Stroke2005，，9： | 1 |
| 18 | Toward a Theory of International Service: Marketing Intangibles in a World of Nations 显示文摘 | Terry Clark Daniel Rajaratnam Timothy Smith | 1996 | Journal of International Marketing1996，4，2： | 1 |
| 19 | State-space model generation for flexible aircraft显示文摘 | TIMOTHY A SMITH JAMES W HAKANSON SATISH S NAIR | 2004 | Journal of Aircraft2004，41，6： | 1 |
| 20 | An electrokinetic study on a synthetic adsorbent of crystalline calcium silicate hydrate and its mechanism of endotoxin removal 显示文摘 | Qun Wang John P Zhang Timothy R Smith | 2005 | Colloids and Surfaces B: Biointerfaces2005，，44： | 1 |
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