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| 1 | 坎地沙坦在炎症过程中抑制氧化应激反应机制的研究显示文摘目的探讨坎地沙坦(Cand esartan,CAN)是否具有不依赖血管紧张素1型受体(anti-inflammation viaindependent,AT1R)的抗炎作用及其可能的机制。方法以人肾小管上皮细胞为研究对象,观察CAN对肿瘤坏死因子(TNF-α)诱导炎症趋化因子的影响及CAN对TNF-α所诱导ROS的作用。采用RT-PCR方法测定相关分子mRNA表达,Western blotting和ELISA方法测定相关分子蛋白含量。结果 CAN能有效抑制TNF-α诱导炎症趋化因子MCP-1、RANTES mRNA和蛋白表达,且能抑制TNF-α诱导的NF-αB磷酸化。CAN还具有类是抗氧化应激物N乙酰半胱氨酸(NCA)的作用,抑制TNF-α诱导的ROS产生。结论 CAN能抑制TNF-α诱导肾小管上皮细胞发生炎症反应,其机制与CAN的直接抗氧化作用有关。 | 余莹 李长明 周沛然 傅兰君 Lance Dworkin 余晨 | 2010 | 同济大学学报(医学版)2010，31，3： | 6 |
| 2 | Entamoeba histolytica/Entamoeba dispar infections in human immunodeficiency virus-infected patients in the United States显示文摘 | Lowther SA Dworkin MS Hanson DL | 2000 | Clin Infect Dis2000，30，： | 2 |
| 3 | Induction of myocardial insulin-like growth factor-1 gene expression in left ventricular hypertrophy 显示文摘 | Donohue TJ Dworkin LD Lango MN | 1994 | Circulation1994，89，： | 1 |
| 4 | Treatment of postherpetic neuralgia 显示文摘 | Kanazi GE Johnson RW Dworkine RH | 2000 | Drugs2000，59，5： | 1 |
| 5 | Pain and its persistence in herpes zoster显示文摘 | Dworkin R H Portenoy R K | 1996 | Pain1996，67，23： | 1 |
| 6 | Pharmacologic management of neuropathic pain: evidence - based recommendations 显示文摘 | DWORKIN R H O'CONNOR A B BACKONJA M | 2007 | Pain2007，132，3： | 1 |
| 7 | Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations显示文摘 | Sandra D. Comer James P. Zacny Robert H. Dworkin Dennis C. Turk George E. Bigelow Richard W. Foltin Donald R. Jasinski Edward M. Sellers Edgar H. Adams Robert Balster Laurie B. Burke Igor Cerny Robert D. Colucci Edward Cone Penney Cowan John T. Farrar J. | 2012 | Pain2012，，： | 1 |
| 8 | Prevalence of temporomandibular disorder subtypes,psychologic distress,and psychosocial dysfunction in Asian patients显示文摘 | Yap AU Dworkin SF Chua EK | 2003 | J Orofac Pain2003，17，1： | 1 |
| 9 | Prospects for the prevention of postherpetic neuralgia in herpes zoster patients 显示文摘 | Dworkin GH Perkins FM Nagasako EM | 2000 | Clin J Pare2000，16，2： | 1 |
| 10 | The role of sympathetic nerveblocks in herpes zoster and postherpetic neuralgia显示文摘 | Wu CL Marsh A Dworkin RH | | 0，，02： | 1 |
| 11 | Di- agnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia 显示文摘 | DWORKIN RH GNANN JW JR OAKLANDER AL | 2008 | J pain2008，9990，1： | 1 |
| 12 | IgA nephropathy : markers of progression and clues to pathogenesis 显示文摘 | Rifai A Dworkin LD | 2008 | Kidney Int2008，73，12： | 1 |
| 13 | the Trouble with the Tribunals显示文摘 | Ronald Dworkin | 2002 | in: N-Y Review of Books Vol 492002，，： | 1 |
| 14 | Abnormalities of blood selenium and glutathione peroxidase activity in patients with acquired immunodeficiency syndrome and AIDS-related complex显示文摘 | DWORKIN B M ROSENTHAL W S WORMSER G P | 1988 | Biol Trace Elem Res1988，15，： | 1 |
| 15 | Recom- mendations for the management of herpes zoster 显示文摘 | DWORKIN RH JOHNSON RW BREUER J | 2007 | Clin Infect Dis2007，44，1： | 1 |
| 16 | Preserving renal function in adults with hypertension and diabetes,A Lonsensus Approach显示文摘 | Bacris GL Williams M Dworkin L | 2000 | Am J Kidney Dis2000，36，3： | 1 |
| 17 | Ion channel targets and treatment efficacy in neuropathic pain显示文摘 | Markman JD Dworkin RH | 2006 | J Pain2006，7，11： | 1 |
| 18 | A high-risk method forstudying psychosocial antecedents of chronic pain: the prospective investigation of herpes zoster 显示文摘 | Dworkin RH Hartstein G Rosner HL | 1992 | J Abnorm Psychol1992，101，： | 1 |
| 19 | Prevalence of tem-poromandibular disorder subtypes, psychologic distress,and psychosocial dysfunction in Asian patients显示文摘 | Yap AU Dworkin SF Chua EK | 2003 | J Oro-fac Pain2003，17，1： | 1 |
| 20 | Reliability,Validity,clinical utility of the research diagnostic crpressio,non - spe-cific physical symptoms and graded chronic pain 显示文摘 | Dworkin SF Sherman J Mancl L | 2002 | J OrfacPain2002，16，3： | 1 |
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