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| 1 | Protective effect of ascorbic acid on cyclophosphamide induced testicular gametogenic and androgenic disorders in male rats显示文摘Aim:To study the detrimental effects of cyclophosphamide on the testicular androgenic and gametogenic activities through endocrine inhibiton and/or induction of oxidative stress in male albino rats and to evaluate the protective effect of ascorbic acid.Methods:The testicular△^5,3β-hydroxysteroid dehydrogenase(HSD),17β-HSD,peroxidase and catalase activities along with the levels of malondialdehyde(MDA)and conjugated dienes in testicular tissue were measured for the evaluation of testicular oxidative stress.The plasma testosterone(T)level was measured by immunoassay7.Various germ cells at stage VⅡof spermatogenic cycle were quantified from testicular stained sections.Results:Cyclophosphamide treatment results in a significant inhibition in the testicular△^5,3β-HSDand17β-HSDactivities,a decrease in plasma T level and a diminution in the coumts of various gern cells,Moreover,this treatment was also associated with a significant inhibition of the peroxidase and catalase activities along with high levels of MDA and conjugated dienes in the testis.All these changes were reversed by ascorbic acid co-administration.Conclusion:Cyclophosphamide treatment at the dosage used caused testicular gametogenic and androgenic disor-ders as well as induced testicular oxidative stress that can be reversed by ascorbic acid co-administration. | Ujjal Baran Das Mousumi Mallick Jogendra Mohan Debnath Debidas Ghosh | 2002 | Asian Journal of Andrology2002，4，3： | 27 |
| 2 | Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update显示文摘More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding,the transjugular intrahepatic portosystemic shunt(TIPS)procedure continues to remain a focus of intense clinical and biomedical research.By the impressive reduction in portal pressure achieved by this intervention,coupled with its minimally invasive nature,TIPS has gained increasing acceptance in the treatment of complications of portal hypertension.The early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic encephalopathy.Moreover,the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions,which was occasionally severe.While the incidence of shunt dysfunction has markedly reduced with the advent of covered stents,hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after TIPS.It has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after TIPS.The past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax,portal hypertensive gastropathy,ectopic varices,hepatorenal and hepatopulmonary syndromes,non-tumoral portal vein thrombosis and chylous ascites.It has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and mortality.The current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis. | Sasidharan Rajesh Tom George Cyriac Abby Philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan Philip Augustine | 2020 | World Journal of Gastroenterology2020，26，37： | 26 |
| 3 | Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats显示文摘Aim:To investigate the effect of arsenic on spermatogenesis.Methods:Mature(4 months old)Wistar rats were intraperitoneally administered sodium arsenite at doses of 4,5 or 6mg·kg^-1·day^-1 for 26 days.Different varieties of germ cells at stage Ⅶ seminiferous epithelium cycle,namely,type A spermatogonia(ASg),preleptotene spermatocytes(pLSc),midpachytene spermatocytes(mPSc) and step 7 spermatids(7Sd) were quantitatively evaluated, along with radioimmunoassay of plasma follicle-stimulating hormone(FSH),lutuneizing hormone(LH),testosterone and assessment of the epididymal sperm count.Results:In the 5 and 6 mg/kg groups,there were significant dosedependent decreases in the accessory sex organ weights,epididymal sperm count and plasma concentrations of LH,FSH and testosterone with massive degeneration of all the germ cells at stage Ⅶ,The changes were insignificant in the 4 mg/kg group.Conclusion:Arsenite has a suppressive influence on spermatogenesis and gonadotrophin and testosterone release in rats. | Mahitosh Sarkar Gargi Ray Chaudhuri Aloke Chattopadhyay Narendra Mohan Biswas | 2003 | Asian Journal of Andrology2003，5，1： | 24 |
| 4 | Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region显示文摘Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials. | Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu Yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino | 2017 | World Journal of Gastroenterology2017，23，45： | 14 |
| 5 | Epidural anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and biliary calculi显示文摘AIM: To evaluate the efficacy of thoracic epidural analgesia for extracorporeal shock wave lithotripsy (ESWL). METHODS: ESWL is an effective, non-invasive technique for the treatment of difficult pancreatic and large bile duct calculi. The procedure is often painful and requires large doses of analgesics. Many different anesthetic techniques have been used. Patients with either large bile duct calculi or pancreatic duct calculi which could not be extracted by routine endoscopic methods were selected. Thoracic epidural anesthesia (TEA) was routinely used in all the subjects unless contraindicated. Bupivacaine 0.25% with or without clonidine was used to block the segments D6 to D12. The dose was calculated depending on the age, height and weight of the patient. It was usually 1-2 mL per segment blocked.RESULTS: Ninety eight percent of the 1509 patients underwent ESWL under TEA. The subjects selected were within American Society of Anesthesiologists grade Ⅰ to Ⅲ. ESWL using EA permitted successful elimination of bile duct or pancreatic calculi with minimal morbidity. The procedure time was shorter in patients with TEA than in those who underwent ESWL under total intravenous anesthesia. CONCLUSION: Almost all patients undergoing ESWL with EA had effective blocks with a single catheter insertion and local anesthetic injection. | Santosh Darisetty Manu Tandan Duvvuru Nageshwar Reddy Rama Kotla Rajesh Gupta Mohan Ramchandani Sandeep Lakhtakia Guduru Venkat Rao Rupa Banerjee | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 13 |
| 6 | Pseudoaneurysm of profunda femoris artery following dynamic hip screw fixation for intertrochanteric femoral fracture显示文摘动态新潮的螺丝钉固定是为 intertrochanteric 的内部固定的一个通常执行的过程大腿骨的破裂。跟随起作用的固定的动脉的损害是一个稀罕却严肃的事件。我们在场与一个动态新潮的螺丝钉在 intertrochanteric 骨折的内部固定以后开发了 profunda femoris 动脉的 pseudoaneurysm 的一个病人。诊断被 angiographic 学习证实,它被卷 embolization 成功地对待。 | Shailendra Singh Sumit Arora Ankit Thora Ram Mohan, Sumit Sural Anti Dhal | 2013 | Chinese Journal of Traumatology2013，16，4： | 13 |
| 7 | Deceptive jamming suppression in multistatic radar based on coherent clustering显示文摘This paper proposes a suppression method of the deceptive false target(FT) produced by digital radio frequency memory(DRFM) in a multistatic radar system. The simulated deceptive false targets from DRFM cannot be easily discriminated and suppressed with traditional radar systems. Therefore, multistatic radar has attracted considerable interest as it provides improved performance against deception jamming due to several separated receivers. This paper first investigates the received signal model in the presence of multiple false targets in all receivers of the multistatic radar. Then, obtain the propagation time delays of the false targets based on the cross-correlation test of the received signals in different receivers. In doing so, local-density-based spatial clustering of applications with noise(LDBSCAN) is proposed to discriminate the FTs from the physical targets(PTs) after compensating the FTs time delays, where the FTs are approximately coincident with one position, while PTs possess small dispersion.Numerical simulations are carried out to demonstrate the feasibility and validness of the proposed method. | ABDALLA Ahmed AHMED Mohaned Giess Shokrallah ZHAO Yuan XIONG Ying TANG Bin | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 12 |
| 8 | Sorting radar signal from symmetry clustering perspective显示文摘The main function of electronic support measure system is to detect threating signals in order to take countermeasures against them. To accomplish this objective, a process of associating each interleaved pulse with its emitter must be done. This process is termed sorting or de-interleaving. A novel point symmetry based radar sorting(PSBRS) algorithm is addressed. In order to deal with all kinds of radar signals, the symmetry measure distance is used to cluster pulses instead of the conventional Euclidean distance. The reference points of the symmetrical clusters are initialized by the alternative fuzzy c-means(AFCM) algorithm to ameliorate the effects of noise and the false sorting. Besides,the density filtering(DF) algorithm is proposed to discard the noise pulses or clutter. The performance of the algorithm is evaluated under the effects of noise and missing pulses. It has been observed that the PSBRS algorithm can cope with a large number of noise pulses and it is completely independent of missing pulses.Finally, PSBRS is compared with some benchmark algorithms,and the simulation results reveal the feasibility and efficiency of the algorithm. | Mohaned Giess Shokrallah Ahmed Bin Tang | 2017 | Journal of Systems Engineering and Electronics2017，28，4： | 10 |
| 9 | Species diversity, regeneration and dominance as influenced by canopy gaps and their characteristics in tropical evergreen forests of Western Ghats, India显示文摘Canopy gaps play a significant role in maintaining structure and composition of tropical forests. This study was carried out in tropical evergreen forests of central Western Ghats in India to understand the influence of canopy gap size and the relationship of gap regime attributes to diversity measures and regeneration. The average gap size in the study area was found to be 396 m2 and around half of gaps were 4–8 years old. Gaps created by natural single tree fall were smaller in size but significantly higher in number. Diversity and regeneration of woody species were compared with canopy gaps and intact vegetation. Species richness and diversity was higher in gaps than in intact vegetation. Macaranga peltata, a shade intolerant species dominated gaps while intact vegetation was dominated by shade tolerant Kingiodendron pinnatum.Gap size significantly influenced species diversity and regeneration. Gap area and age were significantly and negatively correlated with diversity measures but positively correlated with regeneration. Among all the attributes of gaps, regeneration was significantly positively correlated with light intensity. Gaps maintained species diversity and favored regeneration of woody species. In addition to gap size and age, other gap ecological attributes also affected species diversity and regeneration. | Guddappa Mahalingappa Devagiri Anil Kumar Khaple Siddagangaiah Mohan Puttanaik Venkateshamurthy Sanjay Tomar Arkalgud Nagaraja Arunkumar Geeta Joshi | 2016 | Journal of Forestry Research2016，27，4： | 9 |
| 10 | 射电频率干扰的消减显示文摘一直以来,射电天文装备不断得到升级和发展,以使其具有更好的观测性能,包括提高数据记录的时间和频率分辨率以及获得更高的接收和记录带宽等.然而与之形成矛盾的是:国际电信联盟(International Telecommunication Union,ITU)仅为射电天文分配了非常有限的频谱资源,导致的后果是射电观测设备不可避免地受到日益增强的非天文信号的影响,后者的来源主要是人类的通信活动和日常生活,这就构成了通常射电天文中所说的射频干扰(Radio Frequency Interference,RFI).射频干扰会降低数据质量甚至导致数据无效,对科学结果的影响越来越严重.对RFI消减的需求进行分析,总结了RFI的特性、抑制和消减的技术和方案,并介绍了一些有代表性的射电望远镜(或阵列)中采用的RFI消减方法;还分析比较了4种常用方案,即预防、预检测、预相关和后相关的优势和不足.对RFI进行准确的识别和标记是减少数据损失从而有效提高数据质量的关键,也是发展RFI消减技术的最终目的.通过研究不难发现,上述4种方案的组合运用将具有更高的实用价值.近几年来,随着高速数字信号处理和高性能计算的迅速发展,依赖大量计算的实时模式下的预检测以及离线模式下从大型望远镜阵列所产生的大规模干涉相关数据中检测RFI已经成为可能. | 安涛 陈骁 MOHAN Prashanth 劳保强 | 2017 | 天文学报2017，58，5： | 9 |
| 11 | 乘用车两车侧面碰撞变形侵入量影响因素研究显示文摘选取美国福特汽车公司第5代Taurus轿车侧面变形侵入量为研究目标,分析其侧向速度变化为定值(28km/h)时的变量(两车质量比、主要吸能结构相对位置、撞击车接近速度和接触面积等侧面碰撞因素)与侧面变形侵入量的函数关系。为了确保侧面碰撞因素的有效性,对比分析了在美国联邦碰撞法规FMVSS规定的碰撞条件下的US-NCAP实验值和模拟值,验证了目标车Taurus侧面碰撞有限元模型和其他一系列乘用车前面碰撞有限元模型的正确性。结合真实世界事故统计分析数据,分析了变形侵入量对乘员损伤等级的影响。 | 唐友名 曹立波 Mohan Pradeep Kan Steve | 2009 | 中国机械工程2009，，24： | 9 |
| 12 | Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats显示文摘Type-A procyanidine polyphenols(TAPP)are reported to have immunomodulatory and anti-inflammatory potential in vitro.The objective of present work is to evaluate potential of TAPP extracted from Cinnamon(Cinnamomum zeylanicum)bark in animal models of inflammation and rheumatoid arthritis in rats.Carrageenan-induced rat paw edema(CPE)and adjuvant induced established arthritis(AIA),in rats were used as the experimental models for inflammation and arthritis respectively.Analgesic activity was evaluated in Randall–Selitto assay in AIA rats.TAPP showed significant anti-inflammatory effect at dose of 4,8 and 25 mg/kg,p.o.but not at 2 mg/kg,p.o.dose in CPE model.The dose of 8 mg/kg,p.o.was selected for the evaluation of anti-arthritic activity in AIA model.TAPP(8 mg/kg,p.o.,daily from day-12 to day-21)treatment in established arthritic rats showed significant reversal of changes induced in AIA with respect to body weight drop(cachexia),ankle diameter,arthritic score,serum C-reactive protein(CRP)levels.Moreover,TAPP was found to be non-ulcerogenic as compared to AIA control rats.However,TAPP did not show analgesic effect on AIA-induced pain as seen in Randall–Selitto assay.In conclusion,TAPP showed disease-modifying potential in animal models of inflammation and arthritis in rats.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Sachin Vetal Subhash L.Bodhankar Vishwaraman Mohan Prasad A.Thakurdesai | 2013 | Food Science and Human Wellness2013，2，2： | 8 |
| 13 | A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley显示文摘瞄准:为了系统地检验风险因素的关联的程度,例如年龄,与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法:所有情况(n = 51 ) 并且控制(n = 150 ) 是克什米尔山谷的永久居民。基因改变在 Tp53 肿瘤的前 ons 5-8 被决定压制或在 45 个 ESCC 盒子之中的基因组织学地由 PCR-SSCP 分析证实了。为单个癌症盒子的数据(n = 45 ) 并且住院病人控制(n = 150 ) 与非癌症,疾病在癌症的家庭历史上包括了信息,与病人的年龄组一起的三十个占优势的普通饮食的风险因素。在到从这些参数的万物有灵论的数据的 p53 前 ons 的基因损害的关联被 Chi 平方测试与健康控制一起产生到所有 45 个组织学地证实的 ESCC 盒子。结果:(77.8%) 45 中的 35 个组织学地描绘了与 45 正常样品中的 1 个对比的有的类似的体细胞突变从一样的耐心的显示出的细菌线变化从邻近的区域获得了的肿瘤样品。 SSCP 分析表明了改变在 6 上在前被发现的那很普通的 p53 基因(77.7%),那没与个人和 clinicopathological 参数的年龄相关,但是与癌症的家庭历史显示出重要词语索引( P<0.05 )( CD = 58 ),在消费的一个未知地点,和饮食的习惯建议细菌线倾向局部地种芥属蔬菜“ Hakh ”( CD = 19.5 ),红 chillies ( CD = 20.2 ),热咸苏打茶( CD = 2.37 )并且本地烤的面包( CD = 1.1 )。结论:我们的学习建议那体的染色体变化特别在 6 Tp53 基因上的前,在人种上的食道的癌症病人之中,克什米尔山谷的同质的人口是仔细与到各种各样的普通饮食的风险因素,特别热的咸茶,肉,烤的面包和“ Hakh ”的继续的暴露有关,那富于 nitrosoamines 和家庭癌症历史。 | Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar Ahmad Wani Ishfaq Ahmad Mohan Lal Bhat | 2006 | World Journal of Gastroenterology2006，12，25： | 8 |
| 14 | Per oral cholangiopancreatoscopy in pancreatico biliary diseases- Expert consensus statements显示文摘AIM: To provide consensus statements on the use of per-oral cholangiopancreatoscopy(POCPS).METHODS: A workgroup of experts in endoscopic retrograde cholangiopancreatography(ERCP), endosonography, and POCPS generated consensus statements summarizing the utility of POCPS in pancreaticobiliary disease. Recommendation grades used validated evidence ratings of publications from an extensive literature review.RESULTS: Six consensus statements were generated:(1) POCPS is now an important additional tool during ERCP;(2) in patients with indeterminate biliary strictures, POCS and POCS-guided targeted biopsy are useful for establishing a definitive diagnosis;(3) POCS and POCS-guided lithotripsy are recommended for treatment of difficult common bile duct stones when standard techniques fail;(4) in patients with main duct intraductal papillary mucinous neoplasms(IPMN) POPS may be used to assess extent of tumor to assist surgicalresection;(5) in difficult pancreatic ductal stones,POPS-guided lithotripsy may be useful in fragmentation and extraction of stones; and(6) additional indications for POCPS include selective guidewire placement,unexplained hemobilia, assessing intraductal biliary ablation therapy, and extracting migrated stents. CONCLUSION: POCPS is important in association with ERCP, particularly for diagnosis of indeterminate biliary strictures and for intra-ductal lithotripsy when other techniques failed, and may be useful for preoperative assessment of extent of main duct IPMN, for extraction of difficult pancreatic stones, and for unusua indications involving selective guidewire placement,assessing unexplained hemobilia or intraductal biliary ablation therapy, and extracting migrated stents. | Mohan Ramchandani Duvvur Nageshwar Reddy Sundeep Lakhtakia Manu Tandan Amit Maydeo Thoguluva Seshadri Chandrashekhar Ajay Kumar Randhir Sud Rungsun Rerknimitr Dadang Makmun Christopher Khor | 2015 | World Journal of Gastroenterology2015，21，15： | 8 |
| 15 | An alternative treatment process for upgrade of petroleum refinery wastewater using electrocoagulation显示文摘An electrocoagulation treatment process was developed for treatment and upgrade of petroleum refinery effluent (wastewater), instead of the conventional methods, which can consume higher amounts of chemicals and produce larger amounts of sludge. The effect of the operation parameters, such as current density, initial pH, anode material, anode dissolution, energy consumption and electrolysis time, on treatment efficiency was investigated. The experimental results showed that the effluent can be effectively treated under optimal conditions. Fourier transform infrared (FTIR) analysis of the effluent, and scanning electron microscopy (SEM) coupled with energy dispersive analysis of X-rays (EDAX) of the sludge produced, revealed that the unwanted pollutants can be eliminated. The electrocoagulation treatment process was assessed by using the removal efficiency of chemical oxygen demand (COD), total suspended solids (TSS), and the general physicochemical characteristics of wastewater, and the results showed that the electrocoagulation is an efficient process for recycling of petroleum wastewater; it is faster and provides better quality of treated water than the conventional methods. | Dhorgham Skban Ibrahim Mohan Lathalakshmi Appusamy Muthukrishnaraj Natesan Balasubramanian | 2013 | Petroleum Science2013，10，3： | 8 |
| 16 | Recent advances in catalytic combustion of AP-based composite solid propellants显示文摘Composite solid propellants(CSPs) have widely been used as main energy source for propelling the rockets in both space and military applications. Internal ballistic parameters of rockets like characteristic exhaust velocity, specific impulse, thrust, burning rate etc., are measured to assess and control the performance of rocket motors. The burn rate of solid propellants has been considered as most vital parameter for design of solid rocket motors to meet specific mission requirements. The burning rate of solid propellants can be tailored by using different constituents, extent of oxidizer loading and its particle size and more commonly by incorporating suitable combustion catalysts. Various metal oxides(MOs),complexes, metal powders and metal alloys have shown positive catalytic behaviour during the combustion of CSPs. These are usually solid-state catalysts that play multiple roles in combustion of CSPs such as reduction in activation energy, enhancement of rate of reaction, modification of sequences in reaction-phase, influence on condensed-phase combustion and participation in combustion process in gas-phase reactions. The application of nanoscale catalysts in CSPs has increased considerably in recent past due to their superior catalytic properties as compared to their bulk-sized counterparts. A large surface-to-volume ratio and quantum size effect of nanocatalysts are considered to be plausible reasons for improving the combustion characteristics of propellants. Several efforts have been made to produce nanoscale combustion catalysts for advanced propellant formulations to improve their energetics. The work done so far is largely scattered. In this review, an effort has been made to introduce various combustion catalysts having at least a metallic entity. Recent developments of nanoscale combustion catalysts with their specific merits are discussed. The combustion chemistry of a typical CSP is briefly discussed for providing a better understanding on role of combustion catalysts in burning rate enhancement. Available information on different types of combustion nanocatalysts is also presented with critical comments. | Narendra Yadav Prem Kumar Srivastava Mohan Varma | 2021 | Defence Technology(防务技术)2021，17，3： | 8 |
| 17 | IGCT——更高功率处理能力的正确选择显示文摘IGCT被视为大功率应用的理想开关器件,其主要优势不仅体现在高可靠性上,同时,其低损耗使得系统损耗较低。在三电平拓扑中,IGCT与目前最高水平的IGBT在器件损耗方面的对比结果为IGCT的较低。由于IGCT器件是基于晶闸管特性,系统中独立的箝位电路设计是必须的,以实现其与续流二极管配合工作时的高可靠性。文中不仅提到了对故障现象的特别考虑,重点介绍了外围电路设计和故障电流保护策略,而且介绍了IGCT目前最新的研发成果。在朝更大功率容量方向发展方面,IGCT器件具有很大的潜力。 | Thomas Stiasny Vasileios Kappatos Thomas Setz Sven Klaka Makan Chen Madhan Mohan | 2015 | 大功率变流技术2015，0，6： | 8 |
| 18 | Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development显示文摘The importance of the thyroid hormone axis in the regulation of skeletal growth and maintenance has been well established from clinical studies involving patients with mutations in proteins that regulate synthesis and/or actions of thyroid hormone.Data from genetic mouse models involving disruption and overexpression of components of the thyroid hormone axis also provide direct support for a key role for thyroid hormone in the regulation of bone metabolism.Thyroid hormone regulates proliferation and/or differentiated actions of multiple cell types in bone including chondrocytes,osteoblasts and osteoclasts.Thyroid hormone effects on the target cells are mediated via ligand-inducible nuclear receptors/transcription factors,thyroid hormone receptor(TR) α and β,of which TRα seems to be critically important in regulating bone cell functions.In terms of mechanisms for thyroid hormone action,studies suggest that thyroid hormone regulates a number of key growth factor signaling pathways including insulin-like growth factor-I,parathyroid hormone related protein,fibroblast growth factor,Indian hedgehog and Wnt to influence skeletal growth.In this review we describe findings from various genetic mouse models and clinical mutations of thyroid hormone signaling related mutations in humans that pertain to the role and mechanism of action of thyroid hormone in the regulation of skeletal growth and maintenance. | Ha-Young Kim Subburaman Mohan | 2013 | Bone Research2013，1，2： | 7 |
| 19 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 20 | Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography -angiography in myopia显示文摘Background:To examine the retinal structure–vascular-function relationship using optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)in myopia.Methods:This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment abnormalities.All eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti;Optovue.Individual macular retinal layer thicknesses and flow areas and vessel densities were measured on OCT and OCTA,respectively.Linear correlations were made between the macular layer thicknesses,flow areas and vessel densities with axial length,spherical equivalent and visual acuity.Results:The participants’mean ages were 33.34±14.45 years,mean spherical equivalent refractions were−7.17±5.71 D and axial lengths were 25.95±2.41 mm.There were significant positive correlations of foveal angle(r=0.757,p=0.001),inner retinal(r=0.764,p=0.001)and outer plexiform layer(r=0.771,p=0.001)thickness on OCT and vessel densities in deep capillary plexus(r=0.313,p=0.003)on OCTA with axial length and negative correlations with spherical equivalents and visual acuity.Significant negative correlations of outer nuclear layer(r=−0.560,p=0.03)and photoreceptor outer segment layer thickness(r=−0.856,p<0.001)were noted on OCT with axial length and positive correlations with spherical equivalents and visual acuity.Conclusion:The lateral retinal stretching in myopia could possibly explain the correlation between retinal layer thickness,vascular density and visual acuity in these eyes.Further research is required to investigate this. | Ramesh Venkatesh Shivani Sinha Deepika Gangadharaiah Santosh G.K.Gadde Ashwin Mohan Rohit Shetty Naresh Kumar Yadav | 2019 | Eye and Vision2019，6，1： | 7 |
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