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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Capillary column gas chromatography of environmental polycyclic aromatic compounds 显示文摘 | Lee L Milton Daniel Vassilaros L Douglasr W L | 1982 | Intern J Environ Anal Chem1982，11，： | 1 |
| 3 | Plants transformed with a tobacco mosaic virus nonstructural gene sequence are resistant to the virus显示文摘 | DANIEL B GOLEMBOSKI GEORGE P LOMONOSSOFF MILTON Z | 1990 | PNAS1990，87，： | 1 |
| 4 | SPET–CT in thyroid cancer: a systematic review显示文摘 | Ka Kit Wong Daniel J. Wale Lorraine M. Fig Milton D. Gross | 2014 | Clinical and Translational Imaging2014，，： | 1 |
| 5 | Capillary column gas chromatography of environmental polycyclic aromatic compounds显示文摘 | Milton L L Daniel L Vassilaros W | 1982 | Intern J Enviro Anal Chem1982，11，34： | 1 |
| 6 | The REMATCH trial: rationale, design, and end points显示文摘 | Eric A Rose Alan J Moskowitz Milton Packer Josephine A Sollano Deborah L Williams Anita R Tierney Daniel F Heitjan Paul Meier Deborah Davis Ascheim Ronald G Levitan Alan D Weinberg Lynne Warner Stevenson Peter A Shapiro Ronald M Lazar John T Watson Daniel | 1999 | The Annals of Thoracic Surgery1999，，3： | 1 |
| 7 | Intra-puff CO and CO 2 measurements of cigarettes with iron oxide cigarette paper using quantum cascade laser spectroscopy显示文摘 | Danielle R. Crawford Milton E. Parrish Diane L. Gee Charles N. Harward | 2006 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2006，，1： | 1 |
| 8 | Cambial tissue culture and subsequent shoot regeneration 显示文摘 | Kyung H H Daniel E K Milton P G | 1993 | Plant Cell Reports1993，12，4： | 1 |
| 9 | Capillary Column Gas Chromatograph of Polycyclclic Aromatic Compounds 显示文摘 | Milton L Lee Daniel L Vassilaros Douglas W Later | 1982 | Intern J Environ Anal Chem1982，11，： | 1 |
| 10 | Pulmonary Carcinoid显示文摘 | Gershon Fink Tali Krelbaum Alon Yellin Daniel Bendayan Milton Saute Mendel Glazer Mordechai R. Kramer | 2001 | Chest2001，，6： | 1 |
| 11 | Single-Dose Intravenous Toxicity Study of IRDye 800CW in Sprague-Dawley Rats显示文摘 | Milton V. Marshall Daniel Draney Eva M. Sevick-Muraca D. Michael Olive | 2010 | Molecular Imaging and Biology2010，，6： | 1 |
| 12 | How Long After Drug Ingestion Is Activated Charcoal Still Effective?显示文摘 | Robert Green Robert Grierson Daniel S. Sitar Milton Tenenbein | 2001 | Clinical Toxicology2001，，6： | 1 |
| 13 | High readmission rates after surgery for chronic pancreatitis显示文摘 | Alexander V. Fisher Jeffrey M. Sutton Gregory C. Wilson Dennis J. Hanseman Daniel E. Abbott Milton T. Smith Nathan Schmulewitz Kyran A. Choe Jiang Wang Jeffrey J. Sussman Syed A. Ahmad | 2014 | Surgery2014，，： | 1 |
| 14 | Capillary Column Gas Chromatography of Environmental Polycyclie Aromatic Compounds显示文摘 | Milton L L Daniel L V Douglas W L | | Intern J Environ Anal Chem0，982，11： | 1 |
| 15 | Endocrine disruption in crustaceans due to pollutants: A review 显示文摘 | Enrique M Rodrguez Daniel A Medesani Milton Fingerman | 2007 | Comparative Biochemistry and Physiology2007，146，2： | 1 |
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