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| 1 | DUF221 proteins are a family of osmosensitive calciumpermeable cation channels conserved across eukaryotes显示文摘 | Congcong Hou Wang Tian Thomas Klelst Kai He Veder Garcia Fenglin Bai Yanli Hao Sheng Luan Legong Li | 2014 | Cell Research2014，24，5： | 22 |
| 2 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 3 | 100 GHz silicon–organic hybrid modulator显示文摘Electro-optic modulation at frequencies of 100 GHz and beyond is important for photonic-electronic signal processing at the highest speeds.To date,however,only a small number of devices exist that can operate up to this frequency.In this study,we demonstrate that this frequency range can be addressed by nanophotonic,silicon-based modulators.We exploit the ultrafast Pockels effect by using the silicon–organic hybrid(SOH)platform,which combines highly nonlinear organic molecules with silicon waveguides.Until now,the bandwidth of these devices was limited by the losses of the radiofrequency(RF)signal and the RC(resistor-capacitor)time constant of the silicon structure.The RF losses are overcome by using a device as short as 500 μm,and the RC time constant is decreased by using a highly conductive electron accumulation layer and an improved gate insulator.Using this method,we demonstrate for the first time an integrated silicon modulator with a 3dB bandwidth at an operating frequency beyond 100 GHz.Our results clearly indicate that the RC time constant is not a fundamental speed limitation of SOH devices at these frequencies.Our device has a voltage–length product of only V_(π)L=11 V mm,which compares favorably with the best silicon-photonic modulators available today.Using cladding materials with stronger nonlinearities,the voltage–length product is expected to improve by more than an order of magnitude. | Luca Alloatti Robert Palmer Sebastian Diebold Kai Philipp Pahl Baoquan Chen Raluca Dinu Maryse Fournier Jean-Marc Fedeli Thomas Zwick Wolfgang Freude Christian Koos Juerg Leuthold | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 4 | Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome显示文摘 | Christian Widera Shashi K. Gupta Johan M. Lorenzen Claudia Bang Johann Bauersachs Kerstin Bethmann Tibor Kempf Kai C. Wollert Thomas Thum | 2011 | Journal of Molecular and Cellular Cardiology2011，，： | 2 |
| 5 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 6 | Myocardial Scar Visualized by Cardiovascular Magnetic Resonance Imaging Predicts Major Adverse Events in Patients With Hypertrophic Cardiomyopathy显示文摘 | Oliver Bruder Anja Wagner Christoph J. Jensen Steffen Schneider Peter Ong Eva-Maria Kispert Kai Nassenstein Thomas Schlosser Georg V. Sabin Udo Sechtem Heiko Mahrholdt | 2010 | Journal of the American College of Cardiology2010，，11： | 2 |
| 7 | Acute appendicitis–advances and controversies显示文摘Being one of the most common causes of the acute abdomen,acute appendicitis(AA)forms the bread and butter of any general surgeon’s practice.With the recent advancements in AA’s management,much controversy in diagnostic algorithms,possible differential diagnoses,and weighing the management options has been generated,with no absolute consensus in the literature.Since Alvarado described his eponymous clinical scoring system in 1986 to stratify AA risk,there has been a burgeoning of additional scores for guiding downstream management and mortality assessment.Furthermore,advancing literature on the role of antibiotics,variations in appendicectomy,and its adjuncts have expanded the surgeon’s repertoire of management options.Owing to the varied presentation,diagnostic tools,and management of AA have also been proposed in special groups such as pregnant patients,the elderly,and the immunocompromised.This article seeks to raise the critical debates about what is currently known about the above aspects of AA and explore the latest controversies in the field.Considering the ever-evolving coronavirus disease 2019 situation worldwide,we also discuss the pandemic’s repercussions on patients and how surgeons’practices have evolved in the context of AA. | Thomas Zheng Jie Teng Xuan Rong Thong Kai Yuan Lau Sunder Balasubramaniam Vishal G Shelat | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 8 | Expression and subcellular localization of Spred proteins in mouse and human tissues显示文摘 | Catherine M. Engelhardt Karin Bundschu Marlies Messerschmitt Thomas Renné Ulrich Walter Matthias Reinhard Kai Schuh | 2004 | Histochemistry and Cell Biology2004，，6： | 1 |
| 9 | Correlation of the solubility of low-volatile organic compounds in near-and supercritical fluids显示文摘 | Thomas Kraska Kai O Leonhard Dirk Tuma | 2002 | Journal of Supercritical Fluids2002，23，： | 1 |
| 10 | First Scale - Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15 - Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient 显示文摘 | Thomas N Michael B Kai D | 2005 | Org Process Res Dev2005，9，： | 1 |
| 11 | Incidence and clinical course of thrombus formation on atrial septal defect and patient foramen ovale closure devices in 1,000 consecutive patients显示文摘 | Ulrike Krumsdorf Stefan Ostermayer Kai Billinger Thomas Trepels Elisabeth Zadan Kathrin Horvath Horst Sievert | 2004 | Journal of the American College of Cardiology2004，，2： | 1 |
| 12 | Rapid charge transport in dye-sensitized solar cells made from vertically aligned single-crystal rutile TiO2 nanowires 显示文摘 | Feng Xinjian Zhu Kai Frank Arthur J Grimes Craig A Mallouk Thomas E | 2012 | Angewandte Chemie International Edition2012，51，11： | 1 |
| 13 | Narcotrend? and Bispectral Index? Monitor Are Superior to Classic Electroencephalographic Parameters for the Assessment of Anesthetic States during Propofol-Remifentanil Anesthesia显示文摘 | Gunter N. Schmidt Petra Bischoff Thomas Standl Kai Jensen Moritz Voigt Jochen Schulte Esch | 2003 | Anesthesiology2003，，5： | 1 |
| 14 | Systematic Analysis of Functional and Structural Changes After Coronary Microembolization: A Cardiac Magnetic Resonance Imaging Study显示文摘 | Frank Breuckmann Kai Nassenstein Christina Bucher Ina Konietzka Gernot Kaiser Thomas Konorza Christoph Naber Andreas Skyschally Petra Gres Gerd Heusch Raimund Erbel J?rg Barkhausen | 2009 | JACC: Cardiovascular Imaging2009，，2： | 1 |
| 15 | Online monitoring of biofilm growth and activity using a combined multi-channel impedimetric and amperometric sensor显示文摘 | Leonardo Pires Kai Sachsenheimer Tanja Kleintschek Ansgar Waldbaur Thomas Schwartz Bastian E. Rapp | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 16 | Multi-detector row CT of left ventricular function with dedicated analysis software versus MR imaging: initial experience 显示文摘 | Kai U Matthias G David M Eva M Thomas W Walter H | 2004 | Radiology2004，230，2： | 1 |
| 17 | Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology显示文摘 | Tetyana Yevsa Thomas Ebensen Barbara Fuchs Beata Zygmunt Rimma Libanova Roy Gross Kai Schulze Carlos A. Guzmán | 2012 | Environmental Microbiology2012，，1： | 1 |
| 18 | Estrogen receptor α supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells显示文摘 | Marie Brinckmann Elena Kaschina Wassim Altarche-Xifró Caterina Curato Melanie Timm Aleksandra Grzesiak Jun Dong Kai Kappert Ulrich Kintscher Thomas Unger Jun Li | 2009 | Journal of Molecular and Cellular Cardiology2009，，1： | 1 |
| 19 | Growth-Differentiation Factor-15 for Risk Stratification in Patients With Stable and Unstable Coronary Heart Disease: Results From the AtheroGene Study显示文摘 | Tibor Kempf Jan-Malte Sinning Anja Quint Christoph Bickel Christoph Sinning Philipp S. Wild Renate Schnabel Edith Lubos Hans J. Rupprecht Thomas Münzel Helmut Drexler Stefan Blankenberg Kai C. Wollert | 2009 | Circulation: Cardiovascular Genetics2009，，3： | 1 |
| 20 | Myocardial Scar Visualized by Cardiovascular Magnetic Resonance Imaging Predicts Major Adverse Events in Patients With Hypertrophic Cardiomyopathy显示文摘 | Oliver Bruder Anja Wagner Christoph J. Jensen Steffen Schneider Peter Ong Eva-Maria Kispert Kai Nassenstein Thomas Schlosser Georg V. Sabin Udo Sechtem Heiko Mahrholdt | 2010 | Journal of the American College of Cardiology2010，，11： | 1 |
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