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| 1 | Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates显示文摘Dear Editor,Omicron(B.1.1.529),is a heavily mutated and highly contagious SARS-CoV-2 variant,which is currently causing large outbreaks in many countries.Protection provided by current vaccines is substantially reduced against Omicron.1,2 Moreover,many immunocompromised individuals cannot effectively be protected by vaccines.3 Hence,antiviral therapies will be essential to protect the most vulnerable individuals from severe COVID-19. | Denisa Bojkova Marek Widera Sandra Ciesek Mark N.Wass Martin Michaelis Jindrich Cinatl Jr | 2022 | Cell Research2022，32，3： | 10 |
| 2 | Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system:more than just receptor cooperation?显示文摘Toll-like receptor 4(TLR4) and protease-activated receptor 2(PAR2) play pivotal roles in the mammalian innate immune response.Notably,in addition to their involvement in detection of invading pathogens,PAR2 and TLR4 modulate the levels of cell death-induced sterile inflammation by activating pro-or anti-inflammatory downstream signaling cascades.Within the central nervous system,there is emerging evidence that both receptors are involved in synaptic transmission and brain plasticity.Furthermore,due to their prominent role in mediating neuroinflammation,PAR2 and TLR4 are associated with development and progression of neurodegenerative disorders including but not limited to Alzheimer's disease,Parkinson's disease and multiple sclerosis.In this article,we summarise the current knowledge on the cooperation between PAR2 and TLR4,discuss the potential cross-talk levels and highlight the impact of the cross-coupling on neuroinflammation. | Darius Widera Rocío Martínez Aguilar Graeme S.Cottrell | 2019 | Neural Regeneration Research2019，14，7： | 3 |
| 3 | TLR2 and TLR4-mediated inflammation in Alzheimer's disease: self-defense or sabotage?显示文摘Alzheimer's disease(AD) is an irreversible disease that leads to neurodegeneration.The underpinning mechanisms of neuronal cell death are a matter of ongoing debate regarding the impact of accumulation of the amyloid beta(Aβ)peptide and post-translation modifications of the tau protein.However,a growing area of research and one that may provide a more rigorous account of the early changes seen in Alzheimer's brains is inflammation. | Mark L.Dallas Darius Widera | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 4 | Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome显示文摘 | Christian Widera Shashi K. Gupta Johan M. Lorenzen Claudia Bang Johann Bauersachs Kerstin Bethmann Tibor Kempf Kai C. Wollert Thomas Thum | 2011 | Journal of Molecular and Cellular Cardiology2011，，： | 2 |
| 5 | MCP-1 induces migration of adult neural stem cells 显示文摘 | Widera D Holtkamp W Entschladen F | 2004 | Eur J Cell Biol2004，83，8： | 1 |
| 6 | MCP-1 induces migration of adult neural stem cells显示文摘 | Widera D Holtamp W Entschladen F | 2004 | Eur J Cell Biol2004，83，8： | 1 |
| 7 | MCP-1 induces migration of adult neural stem cells 显示文摘 | Widera D Holtkamp W Entschladen F | 2004 | Eur J Cell Biol2004，83，8： | 1 |
| 8 | effect of delivery parameters on immunization to ovalbumin following intraeutaneous administration by a coated microneedle array patch system显示文摘 | Widera G Johnson J Kim L | 2006 | Vaccine2006，24，10： | 1 |
| 9 | Increased DNA vaccine delivery and immunogenicity by electroporation in vivo显示文摘 | WIDERA G AUSTIN M RABUSSAY D | 2000 | J Immunol2000，164，9： | 1 |
| 10 | Dynamic Burst Pressure Simulation of Cylindrical Shells 显示文摘 | CHENG Cunjiang WIDERA G E O | 2009 | Journal of Pressure Vessel Technology2009，131，6： | 1 |
| 11 | Circulating concen-trations of follistatin-like 1 in healthy individuals and patientswith acute coronary syndrome as assessed by an immunolumino-metric sandwich assay显示文摘 | Widera C Horn-Wichmann R Kempf T | 2009 | Clin Chem2009，55，： | 1 |
| 12 | Development of a Simplified Theoretical Model for Dynamic Burst Time and Pressure of a Cylindrical Shell 显示文摘 | CHENG Cunjiang WIDERA G E O | 2009 | The Open O- cean Engineering Journal2009，2，： | 1 |
| 13 | Signaling via NF-kappaB in the nervous system 显示文摘 | Kaltschmidt B Widera D Kahsehmidt C | 2005 | Biochim Biophys Acta2005，1745，3： | 1 |
| 14 | Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome显示文摘 | Widera C Gupta SK Lorenzen JM | 2011 | J Molecul Cellul Cardiol2011，51，5： | 1 |
| 15 | Signaling via NF-kappa B in the nervous system显示文摘 | Kaltschmidt B Widera D Kaltschmidt C | 2005 | Biochim Biophys Acta2005，1745，5： | 1 |
| 16 | Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling显示文摘 | Widera D Mikenberg I Elvers M | 2006 | BMC Neurosci2006，7，： | 1 |
| 17 | Adjustment of the GRACE score by growth differentiation factor 15 ena- bles a more accurate appreciation of risk in non-ST-eleva- tion acute coronary syndrome 显示文摘 | Widera C Pencina MJ Meisner A | 2011 | Eur Heart J2011，33，： | 1 |
| 18 | Medical applications of electroporation显示文摘 | DEV S B RABUSSAY D P WIDERA G | 2000 | Ieee T Plasma Sci2000，28，1： | 1 |
| 19 | On the use of the upper-bound method for load determination in H-beam rolling显示文摘 | ZHANG Wenzhi ZHU Chunqing WIDERA G E O | 1996 | Journal of Materials Processing Technology1996，56，14： | 1 |
| 20 | Biomarker and stable carbon isotope systematics of fossil wood from the second Lusatian lignite seam of the Lubstow deposit (Poland) 显示文摘 | Bechtel A Widera M Sachsenhofer R F | 2007 | Organic Geochemistry2007，38，： | 1 |
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