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| 1 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 2 | In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing显示文摘Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and hospitals.Despite the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound healing.Therefore,more efficient and easy-to-use treatment modalities are needed.In this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the wounds.In vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any sutures.The scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in vitro.Histological analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine wounds.The introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities. | Kristo Nuutila Mohamadmahdi Samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha | 2022 | Bioactive Materials2022，7，2： | 3 |
| 3 | Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition显示文摘 | Karl Quint Manuel Tonigold Pietro Di Fazio Roberta Montalbano Susanne Lingelbach Felix Rückert Beate Alinger Matthias Ocker Daniel Neureiter | 2012 | International Journal of Oncology2012，，6： | 2 |
| 4 | MR imaging of hepatic focal nodular hyperplasia: characterization and distinction from primary rnallgnant hepatic rumors显示文摘 | Mattison Gr Glazer GM Quint LE | 1987 | A JR1987，148，4： | 1 |
| 5 | ASPEN:A micro simulation model of the e- conomy显示文摘 | BASU N PRYOR R QUINT T | 1998 | Computational Economics1998，12，3： | 1 |
| 6 | Con- struction and characterization of deletion mutants of pseudor- abies virus:a new generation of 'live' vaccines显示文摘 | QUINT W GIELKENS A VAN OIRSCHOT J | 1987 | J Gen Vir- ol1987，68，2： | 1 |
| 7 | Intraoperative US versus intraoperative MR imaging for guidance during intracranial neurosurgery显示文摘 | Rubin J M Quint D J | 2000 | Radiology2000，215，3： | 1 |
| 8 | Stereotactic navigation for placement ofpedicle screws in the thoracic spine显示文摘 | Youkilis AS Quint DJ McGillicuddy JE | 2001 | Neurosurgery2001，48，4： | 1 |
| 9 | Lung cancer: Reproducibility of quantitative measurements for evaluating 2--fluoro-2-deoxy-D- glucose uptake at PET显示文摘 | Minn H Zasadny KR Quint LE | 1995 | Radiology1995，196，1： | 1 |
| 10 | The PINOID protein kinase regulates organ development in Arabidopsis by enhancing polar auxin transport显示文摘 | BENJAMINS R QUINT A WEIJERS D | 2001 | Development2001，128，20： | 1 |
| 11 | Diagnostic maxillofacial coional images reformatted from helically acquired thin - section axial CT data 显示文摘 | Rosenthal E Quint DJ Johns M | 2000 | AJR2000，175，4： | 1 |
| 12 | Duodenal neoplasms:predictive value of CT for determining malignancy and tumor resectability显示文摘 | Kazerooni EA Quint LE Francis IR | 1992 | AJR1992，159，2： | 1 |
| 13 | MR imaging of hepatic focal nodular hyperplasia:characterization and distinction from primary malignant hepatic tumors显示文摘 | Mattison GR Glazer GM Quint LE | 1987 | AJR1987，148，4： | 1 |
| 14 | Stereotactic navigation for placement of pedicle screws in the thoracic spine显示文摘 | Youkilis AS Quint DJ McGillicuddy JE | 2001 | Neurosurgery2001，48，4： | 1 |
| 15 | Reduction of irradiated small bowel volume and accurate patient positioning by use of a bellyboard device in pelvic radiotherapy of gynecological cancer patients显示文摘 | Olofsen-van Acht M van den Berg H Quint S | 2001 | Radiother Oncol2001，59，1： | 1 |
| 16 | 'Anatometabolic' tumor imaging: fusion of FI PET with CT or MRI to localize loci or increased activity 显示文摘 | Wahl RL Quint LE Cieslak RD | 1993 | J Nucl Med1993，34，11： | 1 |
| 17 | Human pap-illomavirus genotype attribution in invasive cervical can-cer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L | | 0，，11： | 1 |
| 18 | The biology and life- cycle of human papillomaviruses 显示文摘 | Doorbar J Quint W Banks L | 2012 | Vaccine2012，305，： | 1 |
| 19 | Immediate spinal cord decomp ression for cervical spinal cord injury 显示文摘 | Papadopoulos SM Selden NR Quint DJ | 2002 | J Trauma2002，52，2： | 1 |
| 20 | Emergency magnetic resonance imaging of cervical spinal cord injuries: clinical correlation and prognosis显示文摘 | Selden NR Quint D Patel N | 1999 | Neurosurgery1999，44，4： | 1 |
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