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| 1 | Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal显示文摘Chronic atrophic gastritis (CAG) is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue (non-metaplastic atrophy) or by glandular structures inappropriate for location (metaplastic atrophy).Epidemiological data suggest that CAG is associated with two different types of tumors:Intestinal-type gastric cancer (GC) and type Ⅰ gastric carcinoid (TⅠGC).The pathophysiological mechanisms which lead to the development of these gastric tumors are different.It is accepted that a multistep process initiating from Helicobacter pylori-related chronic inflammation of the gastric mucosa progresses to CAG,intestinal metaplasia,dysplasia and,finally,leads to the development of GC.The TⅠGC is a gastrin-dependent tumor and the chronic elevation of gastrin,which is associated with CAG,stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of TⅠGC.Thus,several events occur in the gastric mucosa before the development of intestinal-type GC and/or TⅠGC and these take several years.Knowledge of CAG incidence from superficial gastritis,its prevalence in different clinical settings and possible risk factors associated with the progression of this condition to gastric neoplasias are important issues.This editorial intends to provide a brief review of the main studies regarding incidence and prevalence of CAG and risk factors for the development of gastric neoplasias. | Lucy Vannella Edith Lahner Bruno Annibale | 2012 | World Journal of Gastroenterology2012，18，12： | 73 |
| 2 | Treatment of Helicobacter pylori infection in atrophic gastritis显示文摘Helicobacter pylori(Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis(AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection. AG is reportedly linked to an increased risk for gastric cancer, particularly when extensive intestinal metaplasia is present. Active or past Hp infection may be detected by conventional methods in about two-thirds of AG patients. By immunoblotting of sera against Hp whole-cell protein lysates, a previous exposure to Hp infection is detected in all AG patients. According to guidelines, AG patients with Hp positivity should receive eradication treatment. The goals of treatment are as follows:(1) Cure of infection, resolution of inflammation and normalization of gastric functions;(2) possible reversal of atrophic and metaplastic changes of the gastric mucosa; and(3) prevention of gastric cancer. An ideal antibiotic regimen for Hp should achieve eradication rates of approximately 90%, and complex multidrug regimens are required to reach this goal. Amongst the factors associated with treatment failure are high bacterial load, high gastric acidity, Hp strain, smoking, low compliance, overweight, and increasing antibiotic resistance. AG, when involving the corporal mucosa, is linked to reduced gastric acid secretion. At a non-acidic intra-gastric p H, the efficacy of the common treatment regimens combining proton pump inhibitors with one or more antibiotics may not be the same as that observed in patients with Hp gastritis in an acid-producing stomach. Although the efficacy of these therapeutic regimens has been thoroughly tested in subjects with Hp infection, there is a paucity of evidence in the subgroupof patients with AG. Bismuth-based therapy may be an attractive treatment in the specific setting of AG, and specific studies on the efficacy of bismuth-based therapies are needed in patients with AG. | Edith Lahner Marilia Carabotti Bruno Annibale | 2018 | World Journal of Gastroenterology2018，24，22： | 57 |
| 3 | A 60-year journey of mycorrhizal research in China:Past,present and future directions显示文摘The significance of mycorrhizas(fungal roots in 90% of land plants) in plant nutrient acquisition and growth,element biogeo-chemical cycling and maintaining of terrestrial ecosystem structures has been globally established for more than 120 years.Great progress in mycorrhizal research in the past 60 years(1950-2009,1981-2009 in particular) has also been made across China,particularly in the mainland,Hong Kong and Taiwan.For instance,a total of 20 new and ~120 records of arbuscular mycorrhizal(AM) fungal species,30 new and ~800 records of ectomycorrhizal(EM) fungal species,a dozen of new and ~100 records of orchid mycorrhizal(OM) fungal species have been isolated by morphological observation and/or molecular identification in China since the 1950s.Great accomplishment has also been made in the following area,including fungal species richness and genetic structure,relationships between species composition and plant taxa,effects of mycorrhizal fungi on plant nutrient uptake and growth,resistances to pathogens and interactions with other soil microorganisms,potential of mycorrhizal fungi in phytoremediation and/or land reclamation,alterations of enzymatic activities in mycorrhizal plants,and elevated CO2 and O3 on root colonization and species diversity.Unfortunately,the international community cannot easily appreciate almost all Chinese mycorrhizal studies since the vast majority of them have been published in Chinese and/or in China-based journals.The aim of this review is to make a comprehensive exposure of the past and present China's major mycorrhizal research to the whole world,and then to suggest potential directions for the enhancement of future mycorrhizal research within and/or between the Chinese and international mycorrhizal community. | HE XinHua1,2,3*,DUAN YingHua2,CHEN YingLong4 & XU MingGang2 1School of Life Sciences,Yunnan Normal University,Kunming 650092,China 2Key Laboratory of Crop Nutrition and Fertilization,Ministry of Agriculture of China,Institute of Agricultural Resources and Regional Planning,Chinese Academy of Agricultural Sciences,Beijing 100081,China 3Centre for Ecosystem Management,School of Natural Resources,Edith Cowan University,Joondalup,WA 6027 State Centre of Excellence for Ecohydrology,School of Plant Biology,University of Western Australia,Crawley,WA 6009,Australia 4School of Earth and Environment,University of Western Australia,Crawley,WA 6009,Australia | 2010 | Science China(Life Sciences)2010，53，12： | 23 |
| 4 | Depression in patients with irritable bowel syndrome in Jos,Nigeria显示文摘AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions. | Nimzing G Ladep Taiwo J Obindo Moses D Audu Edith N Okeke Abraham O Malu | 2006 | World Journal of Gastroenterology2006，12，48： | 22 |
| 5 | Calcineurin B-like interacting protein kinase OsCIPK23 functions in pollination and drought stress responses in rice (Oryza sativa L.)显示文摘Drought is very harmful to grain yield due to its adverse effect on reproduction, especially on pollination process in rice. However, the molecular basis of such an effect still remains largely unknown. Here, we report the role of a member of CBL (Calcineurin B-Like) Interacting Protein Kinase (CIPK) family, OsCIPK23, in pollination and stress responses in rice. Molecular analyses revealed that it is mainly expressed in pistil and anther but up-regulated by pollination, as well as by treatments of various abiotic stresses and phytohormones. RNA interference-mediated suppression of OsCIPK23 expression significantly reduced seed set and conferred a hypersensitive response to drought stress, indicating its possible roles in pollination and drought stress. In consistent, overexpression of OsCIPK23 induced the expression of several drought tolerance related genes. Taken together, these results indicate that OsCIPK23 is a multistress induced gene and likely mediates a signaling pathway commonly shared by both pollination and drought stress responses in rice. | Wenqiang Yang Zhaosheng Kong Edith Omo-Ikerodah Wenying Xu Qun Li Yongbiao Xue | 2008 | Journal of Genetics and Genomics2008，35，9： | 21 |
| 6 | Pernicious anemia: New insights from a gastroenterological point of view显示文摘Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B12 defi ciency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damage are increased fasting gastrin and decreased pepsinogen .Without performing Schilling's test,intrinsic factor deficiency may not be proven, andintrinsic factor and parietal cell antibodies are useful surrogate markers of PA, with 73% sensitivity and 100% specificity. PA is mainly considered a disease of the elderly, but younger patients represent about 15% of patients. PA patients may seek medical advice due to symptoms related to anemia, such as weakness and asthenia. Less commonly, the disease is suspected to be caused by dyspepsia. PA is frequently associated with autoimmune thyroid disease (40%) and other autoimmune disorders, such as diabetes mellitus (10%), as part of the autoimmune polyendocrine syndrome. PA is the end-stage of ABG. Longstanding Helicobacter pylori infection probably plays a role in many patients with PA, in whom the active infectious process has been gradually replaced by an autoimmune disease that terminates in a burned-out infection and the irreversible destruction of the gastricbody mucosa. Human leucocyte antigen-DR genotypes suggest a role for genetic susceptibility in PA. PA patients should be managed by cobalamin replacement treatment and monitoring for onset of iron defi ciency. Moreover, they should be advised about possible gastrointestinal long-term consequences, such as gastric cancer and carcinoids. | Edith Lahner Bruno Annibale | 2009 | World Journal of Gastroenterology2009，15，41： | 13 |
| 7 | 普瑞巴林治疗糖尿病周围神经痛的疗效、安全性和耐受性显示文摘目的:通过分析7项普瑞巴林治疗糖尿病周围神经病(DPN)的临床研究,评估普瑞巴林在其有效剂量范围内的疗效、安全性和耐受性;评估每日两次给药(BID)和每日三次给药(TID)的疗效差异; | Roy Freeman Edith Durso-Decruz Birol Emir | 2011 | 中国新药杂志2011，20，6： | 10 |
| 8 | Metabolic complications in liver transplant recipients显示文摘The metabolic syndrome(MS), which includes obesity,dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease(CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1.78. On the other hand, non-alcoholic fatty liver disease(NAFLD), considered as the manifestation of the MS in the liver, is now the second leading reason for liver transplantation in the United States after hepatitis C and alcohol. NAFLD has a high rate of recurrence in the liver graft and a direct relation with the worsening of other metabolic disorders, such as insulin resistance or diabetes mellitus. Consequently, it is vitally important to identify and treat as soon as possible such modifiable factors as hypertension, overweight, hyperlipidaemia or diabetes in transplanted patients to thus minimise the impact on patient survival. Additionally, steroid-free regimens are favoured, with minimal immunosuppression to limit the possible effects on the development of the MS. | Miguel Jiménez-Pérez Rocío González-Grande Edith Omonte Guzmán Víctor Amo Trillo Juan Miguel Rodrigo López | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 9 | Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing显示文摘AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one family.CONCLUSION: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population. | Janos Papp Marietta E Kovacs Edith Olah | 2007 | World Journal of Gastroenterology2007，13，19： | 9 |
| 10 | 基因组和转录组学分析WHOⅡ/Ⅲ级大脑弥漫性胶质瘤的分子分型有助于患者的预后分层显示文摘将大脑胶质瘤在组织学分类和临床病理上分出Ⅱ级和Ⅲ级,这对WHO而言是一个重大的挑战。本文作者设想利用大规模基因组和转录组学分析是否能分出更为明确的不同预后类型。作者基于微阵列的基因组和转录组方法分析了137例原发大脑胶质瘤,病例来自一个前瞻性的德国胶质瘤网( German Glioma Network),其中包括61例WHO II级和76例WHO III级的肿瘤患者。用综合生物信息学分析确定分子亚型,然后将其与组织学、分子生物标记和患者预后相联系,分子生物标志物包括异柠檬酸脱氢酶1或2( IDH1/2),1p/19q联合缺失和端粒酶逆转录酶(TERT)基因启动子突变。通过基因组分析将其分为5个的胶质瘤组,包括3个IDH1/2突变型和2个IDH1/2野生型。通过表达谱分析发现8个不同的转录组(5个IDH1/2突变型,3个IDH1/2野生型),它们与基因组只有部分关联。结合DNA为基础的分子分层和临床预后划分为3个主要预后组,他们有着特异的基因组突变。 IDH1/2突变和1p/19q染色体联合缺失的患者预后最好。 IDH1/2野生型胶质瘤和类似胶质母细胞瘤基因组变异[包括7q染色体获得(+7q),10q染色体缺失(-10q),TERT启动子突变和癌基因扩增]的患者预后最差。IDH1/2突变但1p/19q染色体正常的患者(主要是星形细胞瘤)和IDH1/2野生型,但没有+7q/-10q 基因型及 TERT启动子突变的胶质瘤患者处于中间位的生存期。这种分子分层将患者分为不同的预后组比组织学分类更好。加入基因组分类的基因表达谱分析并不能更进一步促进预后分层。 | Michael W Ruthild G Edith W 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，7： | 9 |
| 11 | Spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism显示文摘We report an unusual case of spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma in an adult,non-pregnant woman.Her condition was triggered by unrecognized primary hypothyroidism,which regressed after thyroid hormone replacement therapy.This case highlights the need for clinicians and radiologists to familiarize themselves with the clinical and imaging features detected in case of these complications of primary hypothyroidism,which are not well known in the medical and radiological profession.Such improved knowledge will help avoid delays in diagnosis,progression to lifethreatening complications,and unnecessary surgery. | Rene Epunza Kanza Sylvain Gagnon Helene Villeneuve David Laverdiere Isabelle Rousseau Edith Bordeleau Michel Berube | 2013 | World Journal of Radiology2013，5，1： | 8 |
| 12 | Gender influence on defecographic abnormalities in patients with posterior pelvic floor disorders显示文摘AIM:To compare defecographic abnormalities in symptomatic men and women and to analyze differences between men and age-and symptom-matched women.METHODS:Sixty-six men(mean age:55.4 years,range:20-81 years) who complained of constipation and/or fecal incontinence and/or pelvic pain underwent defecography after intake of a barium meal.Radiographs were analyzed for the diagnosis of rectocele,enterocele,intussusception and perineal descent.They were compared with age-and symptom-matched women(n = 198) who underwent defecography during the same period.RESULTS:Normal defecography was observed in 22.7% of men vs 5.5% of women(P < 0.001).Defecography in men compared with women showed 4.5%vs 44.4%(P < 0.001) rectocele,and 10.6% vs 29.8%(P < 0.001) enterocele,respectively.No difference was observed for the diagnosis of intussusception(57.6% vs 44.9%).Perineal descent at rest was more frequent in women(P < 0.005).CONCLUSION:For the same complaint,diagnosis of defecographic abnormalities was different in men than in women:rectocele,enterocele and perineal descent at rest were observed less frequently in men than in women. | Céline Savoye-Collet Guillaume Savoye Edith Koning Anne-Marie Leroi Jean-Nicolas Dacher | 2010 | World Journal of Gastroenterology2010，16，4： | 8 |
| 13 | A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity显示文摘Arylamine N-acetyltransferase(NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins. | Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 7 |
| 14 | Helicobacter pylori infection and drugs malabsorption显示文摘Drug absorption represents an important factor affecting the efficacy of oral drug treatment.Gastric secretion and motility seem to be critical for drug absorption.A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori(H.pylori)infection has been proposed.Associations have been reported between poor bioavailability of l-thyroxine and l-dopa and H.pylori infection.According to the Maastricht Florence Consensus Report on the management of H.pylori infection,H.pylori treatment improves the bioavailability of both these drugs,whereas the direct clinical benefits to patients still await to be established.Less strong seems the association between H.pylori infection and other drugs malabsorption,such as delavirdine and ketoconazole.The exact mechanisms forming the basis of the relationship between H.pylori infection and impaired drugs absorption and/or bioavailability are not fully elucidated.H.pylori infection may trigger a chronic inflammation of the gastric mucosa,and impaired gastric acid secretion often follows.The reduction of acid secretion closely relates with the wideness and the severity of the damage and may affect drug absorption.This minireview focuses on the evidence of H.pylori infection associated with impaired drug absorption. | Edith Lahner Camilla Virili Maria Giulia Santaguida Bruno Annibale Marco Centanni | 2014 | World Journal of Gastroenterology2014，20，30： | 6 |
| 15 | Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis显示文摘AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG. | Bruno Annibale Edith Lahner Riccardo Negrini Flavia Baccini Cesare Bordi Bruno Monarca Gianfranco Delle Fave | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 16 | Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis显示文摘AIM: To investigate the role of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,T&T-IS protocol,TWIST protocol). The target variable was the presence of thyroid disease. RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. The increase of sensitivity of the TWIST protocol was statistically signifi cant compared to T&T-IS. CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status. | Edith Lahner Marco Intraligi Massimo Buscema Marco Centanni Lucy Vannella Enzo Grossi Bruno Annibale | 2008 | World Journal of Gastroenterology2008，14，4： | 6 |
| 17 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 18 | Protein-Repairing Methionine Sulfoxide Reductases in Photosynthetic Organisms: Gene Organization, Reduction Mechanisms, and Physiological Roles显示文摘到蛋氨酸 sulfoxide (MetSO ) 的蛋氨酸氧化被蛋氨酸 sulfoxide 的二种类型颠倒 reductases (MSR ) , A 和 B,对 MetSO 的 S-diastereomers 和 R-diastereomers 特定分别地。MSR 基因从细菌在大多数有机体被发现到人。在当前的评论,我们首先从 cyanobacteria 在光合的有机体把 MSR 基因家庭的组织比作更高的工厂。分析表明 MSR 与 cyanobacteria 和所有非光合的有机体相比在更高的工厂,藓苔类的植物,和水藻组成复杂家庭。我们也执行一个分类,基于基因数字和结构,氧化还原作用活跃的半胱氨酸的位置和预言的亚 cellular 本地化。各种各样的催化机制和涉及 MSR 活动的新生的潜在的生理的电子施主然后被描述。从更高的植物可得到的数据表明 MSR 对氧化损坏在蛋白质修理并且在保护通过一个角色在环境限制期间完成必要生理的功能。在非光合的房间在植物和这些基因的已知的角色考虑 MSR 基因的表达式模式, MSR 的另外的函数在特定的发展阶段期间被讨论并且在光合的有机体变老。 | Lionel Tarrago Edith Laugier Pascal Rey | 2009 | Molecular Plant2009，2，2： | 5 |
| 19 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 20 | Adhesion of PBO Fiber in Epoxy Composites显示文摘The high mechanical and thermal performance of poly p-phenylene-2, 6-benzobisoxazole(PBO) fiber provides great potential applications as reinforcement fibers for composites. A composite of PBO fiber and epoxy resin has excellent electrical insulation properties, therefore, it is considered to be the best choice for the reinforcement in high magnetic field coils for pulsed magnetic fields up to 100 T. However, poor adhesion between PBO fiber and matrix is found because of the chemically inactive and/or relatively smooth surface of the reinforcement fiber preventing efficient chemical bonding in the interface, which is a challenging issue to improve mechanical properties. Here, we report the surface modification of PBO fibers by ultraviolet (UV) irradiation, O2 and NH3 plasma, as well as acidic treatments. The interfacial adhesion strength values of all the treatments show the similar level as determined for aramid fibers by pull-out tests, a significant impact on fiber-matrix-adhesion was not achieved. The surface free energy and roughness are increased for both sized and extracted fibers after plasma treatments together with maleic anhydride grafting. The sized fiber shows marginal improvement in adhesion strength and no change in fiber tensile strength because of the barrier effect of the finish. For the extracted fiber, different surface treatments either show no apparent effect or cause reduction in adhesion strength. Atomic force microscopy (AFM) topography analysis of the fracture surfaces proved adhesive failure at the fiber surface. The fiber surface roughness is increased and more surface flaws are induced, which could result in coarse interface structures when the treated fiber surface has no adequate wetting and functional groups. The adhesion failure is further confirmed by similar adhesion strength and compression shear strength values when the fiber was embedded in various epoxy resins with different temperature behavior. The tensile strength of fiber is sensitive to surface treatment conditions as revealed by a bimodal Weibull statistical distribution analysis. Considerable strength reduction occurred, particularly for cases of acidic and plasma treatments, while UV irradiation shows the better ability to retain fiber strength. | MADER Edith MELCHER Steffen 刘建文 高尚林 | 2007 | Journal of Donghua University(English Edition)2007，24，2： | 4 |
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