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| 1 | 20世纪重大自然灾害评析显示文摘人类在科学技术上取得了辉煌成绩的同时,在认识自然和改造自然方面也得到了教训和新的认识、这一教训主要是来自自然灾害。根据收集到的全球自然灾害有关数据,对20世纪全球主要自然灾害特征和分布特点进行了分析,并对其成因提出了看法。 | 王润 姜彤 Lorenz King Marco Gemmer Anja Holl | 2000 | 自然灾害学报2000，9，4： | 37 |
| 2 | Calcium-Dependent Protein Kinase CPK21 Functions in Abiotic Stress Response in Arabidopsis thaliana显示文摘钙依赖者蛋白质 kinases (CDPK ) 包括察觉到领域和 kinase 受动器领域的钙在一个分子以内在被联合的植物 serine/threonine 蛋白质 kinases 的一个家庭。到目前为止,在不能生活的应力发信号的生物功能仅仅为很少 CDPK isoforms 被报导了,而为这些 CDPK 的内在的生物化学的机制主要仍然是未知的。这里,我们证明从 Arabidopsis thaliana 的 CPK21 生物化学地响应 hyperosmotic 应力在 vivo 被激活。cpk21 的 Loss-of-function 幼苗对 hyperosmotic 应力更容忍,变异的植物关于标记基因表示和代谢物累积显示出增加的压力回答。在互补在 cpk21 异种背景衬里的转基因的 Arabidopsis,在哪个任何一个 CPK21 野类型,或带氨基酸的替换的全身的酶变体稳定地被表示,压力 responsitivity 被 CPK21 然而并非与 kinase 恢复不活跃的变体。生物化学的描述在 planta,综合并且净化的 CPK21 蛋白质表明在钙绑定领域以内,与 C 终端 EF3 主题和 EF4 主题相比的 N 终端 EF1 主题和 EF2 主题在他们对调整钙的 kinase 活动的贡献不同,为 N 终端 EF 手对建议一个关键角色。我们的数据为在不能生活的应力发信号作出贡献的 CPK21 提供证据并且建议 N 终端 EF 手对是控制 CPK21 的特性的一个察觉到钙的决定因素函数。 | Sandra Franz Britta Ehlert Anja Liese Joachim Kurth Anne-Claire Cazale Tina Romeis | 2011 | Molecular Plant2011，4，1： | 27 |
| 3 | Plasma Membrane H^+-ATPase Regulation in the Center of Plant Physiology显示文摘血浆膜(下午) H +-ATPase 是在植物房间膜的重要离子泵。由渗出从房间的质子并且产生一个膜潜力,这泵给与能量 PM,它是为生长的一个前提。autoinhibitory 终端域的修正激活下午 H +-ATPase 活动, andon 这 basisit 被假设了这些规章的终点是为激活或禁止质子抽的生理的因素的目标。在这评论,我们在进化、生理的上下文集中于 PM H +-ATPase 的 posttranslational 规定和泵的地方规定。新兴的图画是调整植物生长的多重信号防碍 PM H +-ATPase 的 posttranslational 规定。 | Janus Falhof Jesper Torbol Pedersen Anja Thoe Fuglsang Michael Palmgren | 2016 | Molecular Plant2016，9，3： | 27 |
| 4 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 5 | Helicobacter pylori virulence genes显示文摘Helicobacter pylori(H.pylori)is one of the most important human pathogens,infecting approximately half of the global population.Despite its high prevalence,only a subset of H.pylori infected individuals develop serious gastroduodenal pathology.The pathogenesis of H.pylori infection and disease outcome is thus thought to be mediated by an intricate interplay between host,environmental and bacterial virulence factors.H.pylori has adapted to the harsh milieu of the human stomach through possession of various virulence genes that enable survival of the bacteria in the acidic environment,movement towards the gastric epithelium,and attachment to gastric epithelial cells.These virulence factors enable successful colonization of the gastric mucosa and sustain persistent H.pylori infection,causing chronic inflammation and tissue damage,which may eventually lead to the development of peptic ulcers and gastric cancer.Numerous studies have focused on the prevalence and role of putative H.pylori virulence genes in disease pathogenesis.While several virulence factors with various functions have been identified,disease associations appear to be less evident,especially among different study populations.This review presents key findings on the most important H.pylori virulence genes,including several bacterial adhesins and toxins,in children and adults,and focuses on their prevalence,clinical significance and potential relationships. | Anja Sterbenc Erika Jarc Mario Poljak Matjaz Homan | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 6 | Impact of crystalline and amorphous iron-and aluminum hydroxides on mechanisms of phosphate adsorption and desorption显示文摘Fourier-transform infrared(FT-IR) spectroscopic experiments were carried out during phosphate adsorption on highly crystalline gibbsite, poorly crystalline 2-line-ferrihydrite and amorphous iron–aluminum–hydroxide mixtures in the molar ratio 1:0, 10:1, 5:1, 1:1, 1:5, 1:10 and 0:1. The OH stretching vibrational bands were utilized to analyze changes in structural and surface OH groups during adsorption, because the position of characteristic P\O vibrational bands can shift depending on reaction conditions, pH or adsorbed phosphate content.Adsorption and desorption kinetics were studied at pH6 and different initial phosphate concentrations to achieve varying phosphate coverage on the mineral surfaces. For gibbsite the formation of AlHPO_4 and Al_2HPO_4 can be assumed, while for ferrihydrite, a FeHPO_4 or Fe_2PO_4 complex and the precipitation of FePO_4 with longer equilibration time were proposed.Fe_2HPO_4 or a Fe_2PO_4 surface complex was deduced for Fe-hydroxides, an AlH_2PO_4 surface complex was identified for Al-hydroxide, and both displayed either hydrogen bonds to neighboring hydroxyl groups or hydrogen bonds to outer-sphere complexes. Fe:Al-hydroxide mixtures with high Al ratios showed a low phosphate desorption rate, while ferrihydrite and the Fe:Al-hydroxide mixtures with high Fe ratios had almost negligible desorption rates. It was concluded that within the weakly associated amorphous FeO(OH) materials, FePO_4 precipitated, which was bound by outer-sphere hydrogen bonds. With high Al ratios, desorption increased, which indicated weaker phosphate binding of both inner-sphere and outer-sphere complexes and hence, either no or minor quantities of precipitate. Ferrihydrite showed a more rigid structure and a lower extent of precipitation compared to amorphous Fe-hydroxide. | Stella Gypser Florian Hirsch Anja M.Schleicher Dirk Freese | 2018 | Journal of Environmental Sciences2018，30，8： | 14 |
| 7 | 阳离子蛋白衍生物助剂在染色莫代尔织物皂洗中的应用显示文摘将阳离子蛋白衍生物助剂WLS-20应用到活性染料染色莫代尔织物皂洗中,研究WLS-20在活性染料染色莫代尔织物皂洗中的应用效果,对比经WLS-20皂洗处理和未经该助剂处理织物的耐摩擦色牢度、耐洗色牢度、润湿性、透气性、抗皱性。结果表明,经WLS-20助剂防沾处理,皂洗时白布沾色明显减少,染色织物耐摩擦色牢度、耐洗色牢度和润湿性均有所提高,透气性和抗皱性均无明显变化,从而为有效利用废弃物,开发绿色环保助剂提供一条新途径。 | 刘元军 赵晓明 拓晓 Anja Huber | 2015 | 丝绸2015，52，11： | 11 |
| 8 | 3-D打印:一种个性化制备复杂支架和组织工程植入物的多功能快速成型技术(英文)显示文摘目的对3-D打印技术构建的个性化生物支架和组织工程结构物的近期研究进展进行综述。方法广泛查阅近期采用3-D打印技术制备个性化生物支架和组织工程结构物的相关文献,并对作者课题组采用3-D打印技术用于组织工程领域的近期研究工作进行总结。结果相较于仅适用于特定生物材料的快速成型法,3-D打印技术适用于几乎所有膏状生物材料,为构建生物支架、多相支架甚至是包含活细胞的组织工程结构物提供了更多的可能和选择。结论 3-D打印技术是一种越来越重要的快速成型技术,该技术保证了生物材料的广泛选择应用,并使得直接打印敏感生物物质(如生长因子和细胞)成为可能。 | 罗永祥 Ashwini Rahul Akkineni Anja Lode Michael Gelinsky | 2014 | 中国修复重建外科杂志2014，28，3： | 10 |
| 9 | Energy harvesting textiles for a rainy day:woven piezoelectrics based on melt-spun PVDF microfibres with a conducting core显示文摘Recent advances in ubiquitous low-power electronics call for the development of light-weight and flexible energy sources.The textile format is highly attractive for unobtrusive harvesting of energy from e.g.,biomechanical movements.Here,we report the manufacture and characterisation of fully textile piezoelectric generators that can operate under wet conditions.We use a weaving loom to realise textile bands with yarns of melt-spun piezoelectric microfibres,that consist of a conducting core surrounded byβ-phase poly(vinylidene fluoride)(PVDF),in the warp direction.The core-sheath constitution of the piezoelectric microfibres results in a—for electronic textiles—unique architecture.The inner electrode is fully shielded from the outer electrode(made up of conducting yarns that are integrated in the weft direction)which prevents shorting under wet conditions.As a result,and in contrast to other energy harvesting textiles,we are able to demonstrate piezoelectric fabrics that do not only continue to function when in contact with water,but show enhanced performance.The piezoelectric bands generate an output of several volts at strains below one percent.We show that integration into the shoulder strap of a laptop case permits the continuous generation of four microwatts of power during a brisk walk.This promising performance,combined with the fact that our solution uses scalable materials and well-established industrial manufacturing methods,opens up the possibility to develop wearable electronics that are powered by piezoelectric textiles. | Anja Lund Karin Rundqvist Erik Nilsson Liyang Yu Bengt Hagstrom Christian Muller | 2018 | npj Flexible Electronics2018，2，1： | 10 |
| 10 | MicroRNA-regulated viral vectors for gene therapy显示文摘Safe and effective gene therapy approaches require targeted tissue-specific transfer of a therapeutic transgene.Besides traditional approaches, such as transcriptional and transductional targeting, micro RNA-dependent posttranscriptional suppression of transgene expression has been emerging as powerful new technology to increase the specificity of vector-mediated transgene expression. Micro RNAs are small non-coding RNAs and often expressed in a tissue-, lineage-, activation- or differentiation-specific pattern. They typically regulate gene expression by binding to imperfectly complementary sequences in the 3' untranslated region(UTR) of the m RNA. To control exogenous transgene expression, tandem repeats of artificial micro RNA target sites are usually incorporated into the 3' UTR of the transgene expression cassette, leading to subsequent degradation of transgene m RNA in cel s expressing the corresponding micro RNA. This targeting strategy, first shown for lentiviral vectors in antigen presenting cells, has now been used for tissue-specific expression of vector-encoded therapeutic transgenes, to reduce immune response against the transgene, to control virus tropism for oncolytic virotherapy, to increase safety of live attenuated virus vaccines and to identify and select cell subsets for pluripotent stem cell therapies, respectively. This review provides an introduction into the technical mechanism underlying micro RNA-regulation, highlights new developments in this field and gives an overview of applications of micro RNA-regulated viral vectors for cardiac, suicide gene cancer and hematopoietic stem cell therapy, as well as for treatment of neurological and eye diseases. | Anja Geisler Henry Fechner | 2016 | World Journal of Experimental Medicine2016，6，2： | 9 |
| 11 | Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers- Review显示文摘Venous thromboembolism event(VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis(CAT), preferably with low molecular weight heparins(LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers. | Hanno Riess Piet Habbel Anja Jühling Marianne Sinn Uwe Pelzer | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 9 |
| 12 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 13 | MEF13 Requires MORF3 and MORF8 for RNA Editing at Eight Targets in Mitochondrial mRNAs in Arabidopsis thaliana显示文摘在植物线粒体和质体编辑地点的 RNA 被 pentatricopeptide 探讨有 E 或 E 和 DYW 领域的重复(PPR ) 蛋白质,它认出编辑核苷酸在上游的一个特定的核苷酸主题。另外,一些地点为编辑的有效 RNA 要求 MORF 蛋白质。这里,我们分配新奇 E 包含域的 PPR 蛋白质, MEF13 为在 Arabidopsis thaliana 在八个地点编辑被要求。在改变编辑水平在的生态型 C24 的 SNP 仅仅,八个目标地点之一被印射的 genomic 定位。为 MEF13 的基因的他们变异的等位基因在一张变异的植物人口的一幅快照屏幕被识别。根本 MEF13 的八个目标地点,编辑层次在 morf3 和 morf8 异种被减少,但是在仅仅在 morf1 异种的一个地点,建议特定的 MEF13-MORF 相互作用被要求。酵母二混血儿的分析与有 MORF3 蛋白质的 MORF1 和弱接触检测 MEF13 的稳固的连接。酵母三混血儿(Y3H ) 分析证明 MORF8 的存在提高在 MEF13 和 MORF3 之间的连接,建议 MORF3-MORF8 heteromer 可以稳定地或短暂地形成与 MEF13 建立相互作用。 | Franziska Glass Barbara Hartel Anja Zehrmann Daniil Verbitskiy Mizuki Takenaka | 2015 | Molecular Plant2015，8，10： | 8 |
| 14 | 玻璃纤维膨体花式纱的性能研究显示文摘为了改善玻璃纤维膨体纱的织造性能,将玻璃纤维膨体纱加工成玻璃纤维膨体花式纱。以断裂强力、断裂伸长率和条干均匀率为评价指标,优化出最佳的玻璃纤维膨体花式纱制备工艺。然后,研究了玻璃纤维膨体花式纱的形态结构、导热系数及热防护性能。结果表明:速比为1.0,捻度为80捻/m时,玻璃纤维膨体花式纱的性能最佳;膨体花式纱具备良好的蓬松性及热防护性能,其导热系数为0.1 W/(m·K),是一种性能良好的保温材料。 | 刘元军 赵晓明 李卫斌 拓晓 Anja Huber | 2015 | 丝绸2015，52，12： | 8 |
| 15 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 16 | Involvement of sweet pepper Ca LOX2 in jasmonate-dependent induced defence against Western flower thrips显示文摘Insect herbivory can seriously hinder plant performance and reduce crop yield. Thrips are minute cell-content-feeding insects that are important vectors of viral plant pathogens, and are serious crop pests. We investigated the role of a sweet pepper (Capsicum annuum) lipoxygenase gene, CaLOX2, in the defense of pepper plants against Western flower thrips (Frankliniella occidentalis). This was done through a combination of in-silico, transcrip-tional, behavioral andchemicalanalyses.Our datashowthat CaLOX2 is involved in jasmonic acid (JA) biosynthesis and mediates plant resistance. Expression of the JA-related marker genes, CaLOX2 and CaPIN II, was induced by thrips feeding. Silencing of CaLOX2 in pepper plants through virus-induced gene silencing (VIGS) resulted in low levels of CaLOX2 transcripts, as well as significant reduction in the accumulation of JA, and its derivatives, upon thrips feeding compared to control plants. CaLOX2-silenced pepper plants exhibited enhanced susceptibility to thrips. This indicates that CaLOX2 mediates JA-dependent signaling, resulting in defenseagainstthrips. Furthermore,exogenous application of JA to pepper plants increased plant resistance to thrips, constrained thrips population development and made plants less attractive to thrips. Thus, a multidisciplinary approach shows that an intact lipoxygenase pathway mediates various components of sweet pepper defense against F. occidentalis. | Sandeep J Sarde Klaas Bouwmeester Jhon Venegas-Molina Anja David Wilhelm Boland Marcel Dicke | 2019 | Journal of Integrative Plant Biology2019，61，10： | 6 |
| 17 | OMEGAlap条并卷机技术为精梳准备带来质的飞跃显示文摘条并卷机OMEGAlap E 35——Rieter(立达)全新的精梳准备设备采用创新的Ω形状成卷技术,此工艺可生产更均匀的棉卷品质,产量可提高50%。 | Bert Rusch Anja Knick | 2007 | 纺织导报2007，，3： | 5 |
| 18 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 19 | Effect of exogenous fibrolytic enzymes on performance and blood profile in early and mid-lactation Holstein cows显示文摘The supplementation of exogenous fibrolytic enzymes(EFE) to dairy cows diets could be a strategy to improve fiber degradation in the rumen which is especially important for the early lactating cows characterized by a high milk energy output and an insufficient energy intake. The objective of this study was to examine the effects of a fibrolytic enzyme product(Roxazyme G2 Liquid, 3.8 and 3.9 mL/kg total mixed ration [TMR] DM) supplemented to a TMR on production performance and blood parameters of dairy cows during early(trial 1) and mid-lactation(trail 2). In addition, rumination activity was measured in trial 2. The nutrient digestibility of the experimental TMR was obtained by using wethers. In the digestibility trial, EFE was supplemented at a rate of 4.4 m L/kg Roxazyme G2 Liquid TMR-DM. The TMR contained 60% forage and 40% concentrate(DM basis). Twenty eight 50 ± 16 days in milk(DIM)and twenty six 136 ± 26 DIM Holstein cows were used in two 8-wk completely randomized trails,stratified by parity and milk yield level. One milliliter of the enzyme product contained primarily cellulase and xylanase activities(8,000 units endo-1,4-? glucanase, 18,000 units endo-1,3(4)-? glucanase and 26,000 units 1,4-? xylanase). No differences in digestibility of DM, OM, CP, NDF and ADF were observed(P >0.05) between the control and the EFE supplemented TMR. Addition of EFE to the TMR fed to early(trial 1) and mid-lactation cows(trial 2) did not affect daily dry matter intake(DMI), milk yield,4% fat-corrected milk, energy-corrected milk(ECM), concentration of milk fat, protein, fat-protein-quotients, somatic cell score, energy balance, and gross feed efficiency of early and mid-lactation cows(P >0.05). Mid-lactation cows(trial 2) fed with TMR enzyme showed a tendency of a slightly higher ECM yield(P = 0.09). The tested blood parameters were not affected by treatment in trials 1 and 2(P >0.05).Exogenous fibrolytic enzymes supplementation did not alter daily time spent ruminating in trial 2(P =0.44). In conclusion, under the conditions of this study, no positive effects of enzyme supplementation on dairy performance and health status of dairy cows during early and mid-lactation were observed. | Anja Peters Ulrich Meyer Sven Danicke | 2015 | Animal Nutrition2015，，3： | 5 |
| 20 | Toxoplasma gondii : from animals to humans显示文摘 | Astrid M Tenter Anja R Heckeroth Louis M Weiss | 2000 | International Journal for Parasitology2000，，12： | 4 |
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