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| 1 | Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel. | Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth | 2010 | World Journal of Cardiology2010，2，7： | 36 |
| 2 | Progress in Brucella vaccine development显示文摘Brucella spp。是 zoonotic,容许的细胞内部的病原体,它原因动物和人的疾病。在胎儿的流产的动物疾病结果;在人,它与起伏的发烧表明像流感的症状,与象感染的普通复杂并发症的骨关节炎。为人的普鲁斯病病人的抗菌素政体可以持续几个月并且不总是是完全有效的。当为人没有疫苗时,几支准许的实时 Brucella 疫苗为在家畜的使用是可得到的。这些动物疫苗的表演依赖于免疫的宿主种,剂量,和线路。最新设计了实时疫苗,缺乏明确的毒力因素,保留低剩余毒力,是高度保护的,并且可以某天代替当前使用的动物疫苗。这些也有可能的人的应用。而且由于他们在动物模型的提高的安全和功效,为普鲁斯病的子单元疫苗在家畜和人为他们的申请显示出大诺言。这评论总结普鲁斯病疫苗开发的进步并且给出候选人疫苗的概述。 | Xinghong YAN Jerod A. SKYBERG Ling CAO Beata CLAPP Theresa THORNBURG David W. PASCUAL | 2013 | Frontiers in Biology2013，8，1： | 27 |
| 3 | Biliary cysts:Etiology,diagnosis and management显示文摘Biliary cysts(BC) are rare dilatations of different parts of a biliary tract.They account for approximately 1% of all benign biliary diseases.BC occur the most frequently in Asian and female populations.They are an important problem for pediatricians,gastroenterologists,radiologists and surgeons.Clinical presentation and management depend on the BC type.Cholangiocarcinoma is the most serious and dangerous BC complication.The other complications associated with BC involve cholelithiasis and hepatolithiasis,cholangitis,acute and chronic pancreatitis,portal hypertension,liver fibrosis and secondary liver cirrhosis and spontaneous cyst perforation.Different BC classifications have been described in the literature.Todani classification dividing BC into five types is the most useful in clinical practice.The early diagnosis and proper treatment are very important,because BC are associated with a risk of carcinogenesis.A malignancy risk increases with the age.Radiological investigations(ultrasonography,computed tomography,endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography) play an important role in BC diagnostics.Currently,prenatal diagnosis using ultrasonography is possible.It allows to differentiate biliary disorders in fetals and to perform the early surgical treatment that improves results.In most patients,total cyst excision with Roux-Y hepaticojejunostomy is the treatment of choice.Surgical treat-ment of BC is associated with high success rate and low morbidity and mortality.The early treatment is associated with a lower number of complications.Patients following BC surgery require permanent and careful postoperative observation using laboratory and imaging investigations because of possibility of biliary anastomosis stricture and biliary cancer in tissue remnant. | Beata Jabońska | 2012 | World Journal of Gastroenterology2012，18，35： | 26 |
| 4 | Iatrogenic bile duct injuries:Etiology,diagnosis and management显示文摘Iatrogenic bile duct injuries (IBDI) remain an important problem in gastrointestinal surgery. They are most frequently caused by laparoscopic cholecystectomy which is one of the commonest surgical procedures in the world. The early and proper diagnosis of IBDI is very important for surgeons and gastroenterologists, because unrecognized IBDI lead to serious complications such as biliary cirrhosis, hepatic failure and death. Laboratory and radiological investigations play an important role in the diagnosis of biliary injuries. There are many classifications of IBDI. The most popular and simple classification of IBDI is the Bismuth scale. Endoscopic techniques are recommended for initial treatment of IBDI. When endoscopic treatment is not effective, surgical management is considered. Different surgical reconstructions are performed in patients with IBDI. According to the literature, Roux- en-Y hepaticojejunostomy is the most frequent surgical reconstruction and recommended by most authors. In the opinion of some authors, a more physiological and equally effective type of reconstruction is end- to-end ductal anastomosis. Long term results are the most important in the assessment of the effectiveness of IBDI treatment. There are a few classifications for the long term results in patients treated for IBDI; the Terblanche scale, based on clinical biliary symptoms, is regarded as the most useful classification. Proper diagnosis and treatment of IBDI may avoid many serious complications and improve quality of life. | Beata Jab■ońska Pawe■ Lampe | 2009 | World Journal of Gastroenterology2009，15，33： | 17 |
| 5 | Bacteriophages and Lysins in Biofilm Control显示文摘To formulate the optimal strategy of combatting bacterial biofilms,in this review we update current knowledge on the growing problem of biofilm formation and its resistance to antibiotics which has spurred the search for new strategies to deal with this complication.Based on recent findings,the role of bacteriophages in the prevention and elimination of biofilm-related infections has been emphasized.In vitro,ex vivo and in vivo biofilm treatment models with single bacteriophages or phage cocktails have been compared.A combined use of bacteriophages with antibiotics in vitro or in vivo confirms earlier reports of the synergistic effect of these agents in improving biofilm removal.Furthermore,studies on the application of phage-derived lysins in vitro,ex vivo or in vivo against biofilm-related infections are encouraging.The strategy of combined use of phage and antibiotics seems to be different from using lysins and antibiotics.These findings suggest that phages and lysins alone or in combination with antibiotics may be an efficient weapon against biofilm formation in vivo and ex vivo,which could be useful in formulating novel strategies to combat bacterial infections.Those findings proved to be relevant in the prevention and destruction of biofilms occurring during urinary tract infections,orthopedic implant-related infections,periodontal and peri-implant infections.In conclusion,it appears that most efficient strategy of eliminating biofilms involves phages or lysins in combination with antibiotics,but the optimal scheme of their administration requires further studies. | Marzanna Lusiak-Szelachowska Beata Weber-Dabrowska Andrzej Gorski | 2020 | Virologica Sinica2020，35，2： | 11 |
| 6 | Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation显示文摘AIM: To investigate the indications and outcomes of liver transplantation for hepatic epithelioid hemangioendothelioma(HEHE). METHODS: Between 1989 and August 2013, in the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, 1306 orthotopic liver transplantations(OLTx) were performed, including 72 retransplantations. Unresectable HEHE was an indication for OLTx in 10 patients(0.8% of primary OLTx), the mean age of the patients was 40.5 ± 13.3 years(range 23-65 years), and the male-to-female ratio was 2:8. Kaplan-Meier survival analysis in HEHE, hepatocellular carcinoma(HCC), and other OLTx recipients groups was performed. The differences in mortality were compared using the χ2 test. A P-value < 0.05 indicated statistical significance.RESULTS: No concomitant liver disease was found in any patient. There was no neoadjuvant chemotherapy or radiotherapy. Liver function test results were normal in most of the patients. The levels of alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9 were normal. In immunohistochemical staining, the neoplastic cells were positive for factor Ⅷ-related antigen, CD31, and CD34, which are endothelial cell markers, and negative for cytokeratin 19, cytokeratin 7, and HepPar-1. Nine patients were alive without tumor recurrence. One patient died 2 mo after OLTx due to septic complications. No morbidity was observed. Maximum follow-up was 11.4 years, with a minimum of 1 mo. The cumulative survival rate at the end of followup in HEHE patients was 87.5% compared with 54.3% in the HCC group and 76.3% in the other OLTx recipients group(χ2 test = 1.784, df = 2, P = 0.409).CONCLUSION: Unresectable HEHE, without extrahepatic metastases is an excellent indication for liver transplantation. Long-term survival is very good and much better than in HCC patients and the entire group of OLTx patients. | Piotr Remiszewski Ewa Szczerba Piotr Kalinowski Beata Gierej Krzysztof Dudek Mariusz Grodzicki Marcin Kotulski Rafa Paluszkiewicz Waldemar Patkowski Krzysztof Zieniewicz Marek Krawczyk | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 7 | Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota-Key players in the pathogenesis of celiac disease显示文摘Celiac disease(CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens(HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy. Although gluten is the main external trigger activating both innate and adaptive(specific) immunity, its presence in the intestinal lumen does not fully explain CD pathogenesis. It has been hypothesized that an early disruption of the gut barrier in genetically susceptible individuals, which would result in an increased intestinal permeability, could precede the onset of gluten-induced immune events. The intestinal barrier is a complex functional structure, whose functioning is dependent on intestinal microbiotahomeostasis, epithelial layer integrity, and the gutassociated lymphoid tissue with its intraepithelial lymphocytes(IELs). The aim of this paper was to review the current literature and summarize the role of the gut microbiota, epithelial cells and their intercellular junctions, and IELs in CD development. | Bozena Cukrowska Agnieszka Sowińska Joanna Beata Bierla Elzbieta Czarnowska Anna Rybak Urszula Grzybowska-Chlebowczyk | 2017 | World Journal of Gastroenterology2017，23，42： | 7 |
| 8 | Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation显示文摘BackgroundMedication 坚持是有收到口头的 anticoagulations (OAC ) 的 atrial 纤维性颤动(AF ) 的病人的全面照顾的不可分的部分治疗。有 AF 的许多病人是老的并且可以受不了认知缺陷的某形式。这研究被进行调查认知缺陷是否在包含的 AF patients.MethodsThe 学习影响坚持的水平到 anticoagulation 治疗 111 个 AF 病人(吝啬的年龄, 73.5 ±8.3 年) 与 OAC 对待。认知功能用微型心理州的考试(MMSE ) 被估计。坚持的水平被 8 条款 Morisky 药坚持规模(MMAS-8 ) 估计。从 0 ~ 8 在 MMAS-8 范围上得分,与分数 <6 思考低坚持, 6 到 <8 中等坚持,和 AF 病人的 8 高 adherence.Results46.9% 有低坚持, 18.8% 有的中等坚持,和 33.3% 有的高坚持到 OAC。有更低的坚持的病人是比有中等或高的坚持的那些老的(76.6 ±8.7 对 71.3 ±6.4 对 71.1 ±6.7 年) 并且获得的低 MMSE 分数,显示的认知混乱或痴呆(MMSE = 22.3 ±4.2 ) 。有中等或高的坚持的病人获得了高 MMSE 测试结果(27.5 ±1.7 和 27.5 ±3.6 ) 。根据枪兵等级关联,到有 OAC 的治疗的更坏的坚持被老年决定(r S =− 0.372 ) 并且更低的 MMSE 分数(r S = 0.717 ) 。根据 multivariate 回归分析,认知功能的水平是坚持的一个重要独立预言者(b = 1.139 ).ConclusionsCognitive 缺陷是对在有 AF 的老病人的药理学治疗的依从的一个独立决定因素。出乎对认知功能的评价之外,更低的坚持与病人的年龄有关。 | Beata Jankowska-Polanska Lomper Katarzyna Alberska Lidia Jaroch Joanna Krzysztof Dudek Uchmanowicz Izabella | 2016 | Journal of Geriatric Cardiology2016，13，7： | 6 |
| 9 | 水平管道水力输送粗粒物料的阻力损失研究显示文摘以深海采矿固液两相流管道输送工艺为应用背景,通过建立管道水力输送模拟系统,研究了不同粒径、不同体积浓度、不同输送速度条件下粗颗粒在水平管道中的阻力损失的变化规律。试验结果表明:颗粒浓度越高,输送速度越大,阻力损失越大。阻力损失与各参数的主要关系有:在保持其他条件不变的情况下,阻力损失与浓度或速度呈指数关系;颗粒运动状态对阻力的变化率有一定的影响。基于试验数据并结合理论分析,提出了阻力损失计算公式。 | 叶坚 夏建新 Malczewska Beata | 2011 | 金属矿山2011，40，7： | 6 |
| 10 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 11 | 南极Lambert,Mellor和Fisher冰川的物质平衡及Amery冰架底部物质通量的估算显示文摘利用现场观测与遥感数据对Lambert,Mellor和Fisher冰川的物质平衡及其在Amery冰架的底部融化与冻结状况进行了估算.结果表明,澳大利亚组织的Lambert冰川盆地(LGB)考察路线的上游地区,Lambert与Mellor冰川分别为(3.9±2.1)和(2.1±2.4)Gt·a-1的正平衡,而Fisher冰川基本处于平衡状态.上游地区总的正平衡为(5.9±4.9)Gt·a-1.考察路线以下,3条冰川均处于负平衡,总的负平衡为(-8.5±5.8)Gt·a-1.整个Lambert,Mellor和Fisher冰川均接近于平衡状态.3条冰川总净平衡为(-2.6±6.5)Gt·a-1.前人认为GL线(1970年代初澳大利亚在LGB建立的冰川运动观测点的连线)以上的内陆盆地处于显著正平衡,可能是因为过高地估算了总积累量,并低估了穿过GL线的冰通量.靠近Amery冰架南端着地线,冰架底部的平均融化速率为(-23.0±3.5)m冰·a-1,向下游方向快速减小,并在距冰架最南端约300km处过渡为底部冻结.沿3条冰川在Amery冰架的冰流带(flowband),冻结速率约介于(0.5±0.1)^(1.5±0.2)m冰·a-1.由于冰流带底部的融化,流入冰架的内陆冰损失了大约80%±5%.3条冰流带底部总融化和总冻结分别为(50.3±7.5)和(7.0±1.1)Gt冰·a-1,这要比前人通过模拟和海洋观测估算的整个Amery冰架底部总融化和总冻结还要大很多. | 温家洪 Kenneth C.Jezek Beata M.Csathó Ute C.Herzfeld Katy L.Farness Philippe Huybrechts | 2007 | 中国科学(D辑)2007，37，9： | 4 |
| 12 | Complete Oxidation of Methane over Palladium Supported on Alumina Modified with Calcium,Lanthanum,and Cerium Ions显示文摘The activity and thermal stability of Pd/Al_2O_3 and Pd/(Al_2O_3+MO_x)(M=Ca,La,Ce) palladium catalysts in the reaction of complete oxidation of methane are presented in this study.The catalyst supports were prepared by sol-gel method and they were dried either conventionally or with supercritical carbon dioxide.Then they were impregnated with palladium nitrate solution.The catalysts with unmodified alumina had a high surface area.The activity and thermal stability of the alumina- supported catalyst was also very high.The introduction of calcium,lanthanum,or cerium oxide into alumina support caused a decrease of the surface area in the way dependent on the support precursor drying method.These modifiers decreased the activity of palladium catalysts,and they required higher temperatures for the complete oxidation of methane than unmodified Pd/Al_2O_3.The improvement of the palladium activity by lanthanum and cerium support modifier was observed only at low temperatures of the reaction. | Beata Stasinska Wojciech Gac Theophilos Ioannides Andrzej Machocki | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 4 |
| 13 | Modeling of Thermal Properties of Thermal Insulation Layered with Transparent,Opaque and Reflective Film显示文摘The popular and effective food preservation technology based on refrigeration is not sufficient for high-quality products while undergoing logistic operations(transport and retail). One of the basic factors that affects the quality of chilled and frozen food products during storage and transport is packaging. A protective function of packaging strongly depends on the material used and its composition. There are different kinds of thermal insulation used for food packaging. One of them, proposed by the authors is a multilayer structure of insulation made of rectangular air cells. The insulation can be prepared by means of plastic film featuring various properties. The paper presents how to improve an effective material designed for food freezing and transport aiming to enhance its thermal resistance through the application of different transparency, reflectivity and emissivity of the film. Mathematical model based on heat exchange equations, including conduction, convection and radiation throughout a number of parallel internal sheets of film of multilayer structures was proposed. Thermal properties depending on different transparency, reflectivity and emissivity of the film were analyzed. The model was verified experimentally showing its compatibility and obtaining a significant influence of thermal resistance according to the type of film used to make air structures, the number and thickness of its layers as well as the gaps between internal folds. For multi-layer insulation designed for the insulation of packed frozen food in the shape of a rectangle, it was recommended to apply film transmittance as small as possible for the internal parts of the structure. | GRABOWSKA Beata KASPERSKI Jacek | 2018 | Journal of Thermal Science2018，27，5： | 4 |
| 14 | Hepatectomy for bile duct injuries: When is it necessary?显示文摘Iatrogenic bile duct injuries(IBDI)are still a challenge for surgeons.The most frequently,they are caused by laparoscopic cholecystectomy which is one of the commonest surgical procedure in the world.Endoscopic techniques are recommended as initial treatment of IBDI.When endoscopic treatment is not effective,surgery is considered.Different surgical biliary reconstructions are performed in most patients in IBDI.Roux-Y hepaticojejunostomy is the commonest biliary reconstruction for IBDI.In some patients with complex IBDI,hepatectomy is required.Recently,Liet al analyzed the factors that had led to hepatectomy for patients with IBDI after laparoscopic cholecystectomy(LC).Authors concluded that hepatectomy might be necessary to manage early or late complications after LC.The study showed that proximal IBDI(involving hepatic confluence)and IBDI associated with vascular injuries were the two independent risk factors of hepatectomy in this series.Authors distinguished two main groups of patients that require liver resection in IBDI:those with an injury-induced liver necrosis necessitating early intervention,and those in whom liver resection is indicated for treatment of liver atrophy following long-term cholangitis.In this commentary,indications for hepatectomy in patients with IBDI are discussed.Complex biliovascular injuries as indications for hepatectomy are presented.Short-and long-term results in patients following liver resection for IBDI are also discussed.Hepatectomy is not a standard procedure in surgical treatment of IBDI,but in some complex injuries it should be considered. | Beata Jablońska | 2013 | World Journal of Gastroenterology2013，19，38： | 4 |
| 15 | 在线教学:我们将教育转移到在线环境的改革中究竟取得了哪些经验?显示文摘琼斯国际大学通过了地区的鉴定认可——这是第一所通过美国地区鉴定机构鉴定认可的完全虚拟大学——从而在学术界引发了热烈的讨论。他们把对有关学术人员与教师角色的变化的关注用来作为反对人们狂热追逐新教学机会的依据这篇论文以琼斯国际大学五年来活生生的在线教学的实际例证为基础 ,来检验当我们决定采用通过计算机网络实施教育活动时 ,教学活动本身、教师的角色。 | Beata Krupa 董秀华 | 2001 | 开放教育研究2001，7，4： | 4 |
| 16 | 以 Ni/ZSM-5 为催化剂制备纳米碳质材料( 英文)显示文摘以ZSM-5分子筛为模板担载金属镍(Ni/ZSM-5)为催化剂,在不同质量分数Ni和温度下进行气相化学沉积过程得到氢气和纳米碳质材料(碳纳米管、纳米炭纤维)。氢气和纳米碳质材料的产率随Ni质量分数增加和反应温度升高而显著地增加,但当Ni含量为8%时产率却减小。纳米碳质材料的形貌与反应温度密切相关。在较高温度下可沉积出碳纳米管,在较低温度下则可得到纳米炭纤维。随着反应时间的延长Ni/ZSM-5的催化活性降低。 | Justyna Majewska Beata Michalkiewicz | 2014 | 新型炭材料2014，29，2： | 4 |
| 17 | Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis显示文摘AIM:To evaluate the clinical significance of-765G/C and-1195G/A cyclooxygenase-2 (COX-2) gene polymorphisms in patients with pancreatic cancer (PC).METHODS:The study included 201 patients:85 with PC and 116 healthy controls.-765G/C and-1195G/A COX-2 gene polymorphisms were studied in DNA isolated from blood samples.The associations of the analyzed genotypes and clinical data at diagnosis were evaluated.RESULTS:We found an increased frequency of the homozygous-1195AA COX-2 genotype in patients with PC (53.7%) compared with the control group (21%) (P < 0.01).In contrast,the distribution of genotypeand allele frequencies of the-765G/C COX-2 polymorphism in the PC patients were not different from those in control groups.A correlation between presence of homozygous-1195AA COX-2 genotype and tumor size > 3 cm was observed (P < 0.05).Analyzed polymorphisms were unrelated to the patients' sex and age,nor to the presence of regional or distant metastases.CONCLUSION:These preliminary results indicate that the-1195G/A COX-2 polymorphism may play an important role in PC prognosis and carcinogenesis. | Renata Talar-Wojnarowska Anita Gasiorowska Marek Olakowski Pawel Lampe Beata Smolarz Hanna Romanowicz-Makowska Ewa Malecka-Panas | 2011 | World Journal of Gastroenterology2011，17，36： | 4 |
| 18 | A Highly Efficient Agrobacterium-Mediated Method for Transient Gene Expression and Functional Studies in Multiple Plant Species显示文摘Although the use of stable transformation technology has led to great insight into gene function,its application in high-throughput studies remains arduous.Agro-infiltration have been widely used in species such as Nicotiana benthamiana for the rapid detection of gene expression and protein interaction analysis,but this technique does not work efficiently in other plant species,including Arabidopsis thaliana.As an efficient high-throughput transient expression system is currently lacking in the model plant species A.thaliana,we developed a method that is characterized by high efficiency,reproducibility,and suitability for transient expression of a variety of functional proteins in A.thaliana and 7 other plant species,including Brassica oleracea,Capsella rubella,Thellungiella salsuginea,Thellungiella halophila,Solanum tuberosum,Capsicum annuum,and N.benthamiana.Efficiency of this method was independently verified in three independent research facilities,pointing to the robustness of this technique.Furthermore,in addition to demonstrating the utility of this technique in a range of species,we also present a case study employing this method to assess protein–protein interactions in the sucrose biosynthesis pathway in Arabidopsis. | Youjun Zhang Moxian Chen Beata Siemiatkowska Mitchell Rey Toleco Yue Jing Vivien Strotmann Jianghua Zhang Yvonne Stahl Alisdair R.Fernie | 2020 | Plant Communications2020，1，5： | 4 |
| 19 | Mass budgets of the Lambert, Mellor and Fisher Glaciers and basal fluxes beneath their flowbands on Amery Ice Shelf显示文摘We used in situ measurements and remote-sensing data sets to evaluate the mass budgets of the Lambert, Mellor and Fisher Glaciers and the basal melting and freezing rates beneath their flowbands on the Amery Ice Shelf. Our findings show the Lambert and Mellor Glaciers upstream of the ANARE Lambert Glacier Basin (LGB) traverse may have positive imbalances of 3.9±2.1 Gt a-1 and 2.1±2.4 Gt a-1, respectively, while the Fisher Glacier is approximately in balance. The upstream region as a whole has a positive imbalance of 5.9±4.9 Gt a-1. The three same glaciers downstream of the ANARE LGB traverse line are in negative imbalance, where the whole downstream region has a negative imbalance of -8.5±5.8 Gt a-1. Overall the mass budgets of the Lambert, Mellor, and Fisher Glaciers are close to bal-ance, and the collective three-glacier system is also nearly in balance with a mass budget of -2.6±6.5 Gt a-1. The significant positive imbalances for the interior basin upstream of the ice-movement stations established in the early 1970s (GL line) reported previously are possibly due to an overestimate of the total accumulation and an underestimate of the ice flux through the GL line. The mean melting rate is -23.0±3.5 m ice a-1 near the southern grounding line, which decreases rapidly downstream, and transitions to refreezing at around 300 km from the southern extremity of the Amery Ice Shelf. Freezing rates along the flowbands are around 0.5±0.1 to 1.5±0.2 m ice a-1. The per-centage of ice lost from the interior by basal melting beneath the flowbands is about 80%±5%. The total basal melting and refreezing beneath the three flowbands is 50.3±7.5 Gt ice a-1 and 7.0±1.1 Gt ice a-1, respectively. We find a much larger total basal melting and net melting than the results for the whole Amery Ice Shelf derived from previous modeling and oceanographic measurements. | Kenneth C. JEZEK Beata M. CSATHó Ute C. HERZFELD Katy L. FARNESS Philippe HUYBRECHTS | 2007 | Science China Earth Sciences2007，50，11： | 4 |
| 20 | Pancreatic intraductal papillary mucinous neoplasms:Current diagnosis and management显示文摘Intraductal papillary mucinous neoplasms(IPMNs)represent approximately 1%of all pancreatic neoplasms and 25%of cystic neoplasms.They are divided into three types:main duct-IPMN(MD-IPPMN),branch duct-IPMN(BD-IPMN),and mixed type-IPMN.In this review,diagnostics,including clinical presentation and radiological investigations,were described.Magnetic resonance imaging is the most useful for most IPMNs.Management depends on the type and radiological features of IPMNs.Surgery is recommended for MD-IPMN.For BD-IPMN,management involves surgery or surveillance depending on the tumor size,cyst growth rate,solid components,main duct dilatation,high-grade dysplasia in cytology,the presence of symptoms(jaundice,new-onset diabetes,pancreatitis),and CA 19.9 serum level.The patient’s age and comorbidities should also be taken into consideration.Currently,there are different guidelines regarding the diagnosis and management of IPMNs.In this review,the following guidelines were presented:Sendai International Association of Pancreatology guidelines(2006),American Gastroenterological Association guidelines,revised international consensus Fukuoka guidelines(2012),revised international consensus Fukuoka guidelines(2017),and European evidence-based guidelines according to the European Study Group on Cystic Tumours of the Pancreas(2018).The Verona Evidence-Based Meeting 2020 was also presented and discussed. | Beata Jabłońska PawełSzmigiel Sławomir Mrowiec | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
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