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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | Comparison of gut-associated and nest-associated microbial communities of a fungus-growing termite (Odontotermes yunnanensis)显示文摘 | Yan-Hua Long Lei Xie Ning Liu Xing Yan Ming-Hui Li Mei-Zhen Fan Qian Wang | 2010 | Insect Science2010，17，3： | 11 |
| 3 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 4 | Study of Static Adsorption Capacity of ACF for Xenon at 201 K显示文摘The static adsorption performances of a series of active carbon fiber(ACF)for xenon at 201 K were measured with a model ASAP2010M specific surface area and aperture distribution instrument by changing the working gas of instrument from N 2 to Xenon. Compared with grain active carbon(GAC): (1) the adsorption performance of Viscose based ACF(VACF) adsorbents is better than that of GAC; (2) owing to the difference of aperture distribution, the adsorption performance of ACF with different radicales is different under the same experiment conditions though the specific surface area is similar; (3) there is no definite relationship between adsorption performance and specific surface area; (4) the VACF A2 is the superior xenon adsorbent at the experimental temperature. | WANG Ya long ** , ZHANG Hai tao, WANG Xu hui, ZHANG Li xing, CHEN Li yun, XIE Jin chuan (Northwest Institute of Nuclear Technology, Xian 710024, P. R. China) | 2002 | Chemical Research in Chinese Universities2002，18，2： | 9 |
| 5 | Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury显示文摘 | Hou-Qing Long Guang-Sheng Li Xing Cheng Jing-Hui Xu Fo-Bao Li | 2015 | Chinese Journal of Traumatology2015，18，5： | 8 |
| 6 | Diacylglycerol Compounds from Barks of Betula platyphylla with Inhibitory Activity against Acyltransferase显示文摘Objective To identify the active compounds from the barks of Betula platyphylla for inhibitory on diacylglycerol acyltransferase(DGAT1).Methods Bioassay-guided fractionation resulted in the isolation of DGAT1 inhibitory activity of lupane triterpenes.Results Ten compounds were identified as lupenone(1),lupeol(2),betulinic acid(3),betulinaldehyde(4),betulin(5),3-deoxybetulonic acid(6),glochidonol(7),lup-20/29-ene-1β/3β-diol(8),3α-hydroxy-lup-20(29)-en-23,28-dioic acid(9),and 3α,11α-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid(10).Compounds 3-6,9,and 10 inhibited DGAT1 with IC50 values ranging from(11.2±0.3)to(38.6±1.2)μmol/L.Conclusion Compounds 6,9,and 10 are first isolated from the barks of B.platyphylla.,and compounds 3-6,9,and 10 from the barks of B.platyphylla are responsible for the inhibition on DGAT1. | Nan Zhang Na Li Ya-nan Sun Jia-lin Li Shan-shan Xing Zhen-dong Tuo Long Cui | 2014 | Chinese Herbal Medicines2014，6，2： | 8 |
| 7 | Synthesis and application of a hydrophobic hypercrosslinked polymeric resin for removing VOCs from humid gas stream显示文摘恐水病的亢奋的 crosslinked 聚合树脂 LC-1 被准备并且描绘。LC-1 树脂的性质与商业亢奋的 crosslinked 聚合物 NDA-201 树脂的那些相比。另外, trichloroethylene (TCE ) 的动态吸附被调查到在在 303 K 的干燥、潮湿的条件下面的 LC-1 上, LC-1 拥有的结果表演高恐水病的性质和罐头把 TCE 从气体移开没有高湿度的效果,高效地流。 | Peng Liu Chao Long Hong Ming Qian Ying Li Ai Min Li Quan Xing Zhang | 2009 | Chinese Chemical Letters2009，20，4： | 7 |
| 8 | Two new lignans from Dipteronia dyeriana显示文摘新 sesquilignan, 7 鈥 ? 8 鈥 ? didehydroherpetotriol (1 ) ,和新 lignan glycoside,(+)-isolariciresinol-9 鈥 ?O- 伪 -l-rhamnopyranosyl-(1 鈫 ? 6 )- 尾 -d-glucopyranoside (2 ) ,从 Dipteronia dyeriana 的分支被孤立。他们的结构被分光镜的方法和化学证据阐明。与 39 渭 m ol/L 的 IC50 价值对人的白血球过多症 K562 房间加重 1 项拥有的禁止的活动。 | Rong Guo Min Luo Chun Lin Long Ma Lin Li Zhi Qin Ouyang Yi Ping Zhou Yue Hu Wang Xing Yu Li Ya Na Shi | 2008 | Chinese Chemical Letters2008，19，10： | 7 |
| 9 | Simulated Sensitivity of Ozone Generation to Precursors in Beijing during a High O_(3) Episode显示文摘This study uses the WRF-Chem model combined with the empirical kinetic modeling method(EKMA curve)to study the compound pollution event in Beijing that happened in 13−23 May 2017.Sensitivity tests are conducted to analyze ozone sensitivity to its precursors,and to develop emission reduction measures.The results suggest that the model can accurately simulate the compound pollution process of photochemistry and haze.When VOCs and NOx were reduced by the same proportion,the effect of O_(3)reduction at peak time was more obvious,and the effect during daytime was more significant than at night.The degree of change in ozone was peak time>daytime average.When reducing or increasing the ratio of precursors by 25%at the same time,the effect of reducing 25%VOCs on the average ozone concentration reduction was most significant.The degree of change in ozone decreased with increasing altitude,the location of the ozone maximum change shifted westward,and its range narrowed.As the altitude increases,the VOCs-limited zone decreases,VOCs sensitivity decreases,NOx sensitivity increases.The controlled area changed from near-surface VOCs-limited to high-altitude NOx-limited.Upon examining the EKMA curve,we have found that suburban and urban are sensitive to VOCs.The sensitivity tests indicate that when VOCs in suburban are reduced about 60%,the O_(3)-1h concentration could reach the standard,and when VOCs of the urban decreased by about 50%,the O_(3)-1h concentration could reach the standard.Thus,these findings could provide references for the control of compound air pollution in Beijing. | Meng CUI Xingqin AN Li XING Guohui LI Guiqian TANG Jianjun HE Xin LONG Shuman ZHAO | 2021 | Advances in Atmospheric Sciences2021，38，7： | 7 |
| 10 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 11 | Sequential analysis of dimethyl sulfur compounds in seawater显示文摘为暗淡乙醇硫的化合物,包括的 dimethylsulfide (数据管理系统) , dimethylsulfoniopropionate (DMSP ) 和 dimethylsulfoxide (DMSO ) 的决心的一个顺序的方法,在海水,样品被开发了。在 25 mL 样品的数据管理系统的 2.5 pmol 的检测极限,相应于 0.10 nmol/L,被完成。为暗淡乙醇硫的化合物的恢复在范围 68.6 78.3% 。为数据管理系统, DMSP 和 DMSO 决心的相对标准偏差(R.S.D.s ) 分别地是 3.0, 5.4 和 7.4% 。 | Meng Li Dong Xing Yuan Quan Long Li Xiao Ying Jin | 2007 | Chinese Chemical Letters2007，18，1： | 6 |
| 12 | Role of PLC-PIP2 and cAMP-PKA Signal Pathways in Radiation-induced Immune-suppressing Effect显示文摘Objective The purpose of the present study was to observe the changes in CD4+CD25+Nrp1+Treg cells after irradiation with different doses and explore the possible molecular mechanisms involved. Methods ICR mice and mouse lymphoma cell line(EL-4 cells) was used. The expressions of CD4,CD25,Nrp1,calcineurin and PKC-α were detected by flow cytometry. The expressions of TGF-β1,IL-10,PKA and cAMP were estimated with ELISA. Results At 12 h after irradiation,the expression of Nrp1 increased significantly in 4.0 Gy group,compared with sham-irradiation group(P<0.05) in the spleen and thymus,respectively,when ICR mice received whole-body irradiation(WBI). Meanwhile the synthesis of Interleukin 10(IL-10) and transforming growth factor-β1(TGF-β1) increased significantly after high dose irradiation(HDR)(> or = 1.0 Gy). In addition,the expression of cAMP and PKA protein increased,while PKC-α,calcineurin decreased at 12h in thymus cells after 4.0 Gy X-irradiation. While TGF-β1 was clearly inhibited when the PLC-PIP2 signal pathway was stimulated or the cAMP-PKA signal pathway was blocked after 4.0 Gy X-irradiation,this did not limit the up-regulation of CD4+CD25+Nrp1+Treg cells after ionizing radiation. Conclusion These results indicated that HDR might induce CD4+CD25+Nrp1+Treg cells production and stimulate TGF-β1 secretion by regulating signal molecules in mice. | DONG Juan Cong CHENG Guang Hui SHAN Yu Xing WU Ning SHAO Ming Long LI Peng Wu JIN Shun Zi | 2014 | Biomedical and Environmental Sciences2014，27，1： | 5 |
| 13 | Long-term results of single-procedure catheter ablation for atrial fibrillationin pre-and post-menopausal women显示文摘ObjectivesTo 地址经绝期是否由比较安全和长期的结果为 atrial 纤维性颤动(AF ) 影响导管脱离(CA ) 的结果一在经历了药倔强的 AF 的一个单个 CA 过程的 743 个女病人全部的绝经前、绝经后的 women.MethodsA 单个过程回顾地被分析。在为在绝经前的女人之间的 AF 的 CA 的临床的表示和结果的差别(PreM 组, 94 个病人, 12.7%) 并且绝经后的女人(PostM 组, 649 个病人, 87.3%) 在 PreM 组的 assessed.ResultsThe 病人更年轻(P <0.001 ) 并且不太可能有高血压(P <0.001 ) 并且糖尿病(P = 0.005 ) 比那些在 PostM 组。二个组关于伴随物的比例是类似的僧帽形的阀门流回冠的动脉疾病,左中庭尺寸,和左室的喷射部分。与 AF 脱离有关的复杂并发症的全面的率在两个组是类似的(P = 0.385 ) 。在 43 以后(16-108 ) 后续的月,脱离的成功率在 PreM 组是 54.3% , 54.2% 在 PostM 组织(P = 0.842 ) 。从 atrial tachyarrhythmia 复发的全面自由在两个组是类似的。经绝期没被发现是为 AF 的单个过程的 CA 的长期的结果是的 atrial tachyarrhythmia.ConclusionsThe 的复发的一个独立预兆的因素在绝经前、绝经后的女人类似。结果显示 AF 的 CA 看起来在绝经前的女人同样象在绝经后的女人安全、有效。 | Tao LIN Xing DU Rong BAI Ying-Wei CHEN Rong-Hui YU De-Yong LONG Ri-Bo TANG Cai-Hua SANG Song-Nan LI Chang-Sheng MA Jian-Zeng DONG | 2014 | Journal of Geriatric Cardiology2014，11，2： | 5 |
| 14 | PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4显示文摘 | Wenyong Long Wei Zhao Bo Ning Jing Huang Junjun Chu Linfeng Li Qianquan Ma Changsheng Xing Helen Y. Wang Qing Liu Rong-Fu Wang | 2018 | Journal of Molecular Cell Biology2018，10，2： | 5 |
| 15 | Improved drought tolerance by α-naphthaleneacetic acid-induced ROS accumulation in two soybean cultivars显示文摘Drought is a major abiotic factor limiting agricultural crop production.The objective of this study was to investigate whether a-naphthaleneacetic acid(NAA) confers drought tolerance to soybeans and if such tolerance is correlated with the early reactive oxygen species(ROS) accumulation in leaves.The plants of soybean(Glycine max[L]Merr.) cv.Nannong 99-6and cv.Kefeng 1 were foliar treated with 40 mg L^(-1) NAA at the beginning of bloom and then exposed to water stress for 10 d.We monitored changes in ROS levels,lipid peroxidation and antioxidant system as well as plant biomass during the drought treatment.The results showed that drought stress significantly depressed the growth and yield regardless of spraying NAA.However,drought-stressed plants treated with NAA showed much higher plant biomass and yield than those without NAA.The ROS levels increased in stressed Kefeng 1 but not in stressed Nannong 99-6 2-4 days after the treatment(DAT).During 6-10 DAT,stressed Kefeng 1 had greater increase in the levels of superoxidedismutase(SOD).guaiacol peroxidase(POD),ascorbate peroxidase(APX),monodehydroascorbate reductase(MDHAR),dehydroascorbate reductase(DHAR),glutathione reductase(GR),glutathione peroxidase(GPX),γ-glutamylcysteine synthetase(γ-GCS),reduced ascorbate(AsA),and glutathione(GSH),smaller increase in ROS and malondialdehyde(MDA) as compared with stressed Nannong99-6.Low ROS prevented ROS from directly reacting with membrane lipid during this stage and,consequently,reduced the cell damage.NAA application elevated ROS levels at 4 DAT,and then increased antioxidant capacity and blocked the increase in the MDA and ROS in stressed Nannong 99-6 and Kefeng 1.Overall,the results indicate that NAA application effectively alleviates the adverse effects of drought stress,which is partially attributable to increase in antioxidant ability and decrease in lipid peroxidation induced by the early ROS accumulation triggered by NAA. | XING Xing-hua FANG Chuan-wen LI Long JIANG Hong-qiang ZHOU Qin JIANG Hai-dong WANG Shao-hua | 2016 | Journal of Integrative Agriculture2016，15，8： | 5 |
| 16 | In situ observation of C_(60)(C(COOH)_(2))_(2) interacting with living cells using fluorescence microscopy显示文摘The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this pur- pose, the C60 derivative C60(C(COOH)2)2, a thera- peutic agent for degeneration diseases of central nervous system, was synthesized, purified and characterized. Its interaction with the living cell and penetration of the cellular membrane were in situ studied using the real time imaging technique, and its potential cytotoxicity was also examined by flow cy- tometry. The results indicate that C60(C(COOH)2)2 can easily enter cells, and is mainly located in cytoplasm by fluorescein labeling. Furthermore, C60(C(COOH)2)2 can carry the molecule that cannot cross cellular membranes into cells, because fluo- rescein compound itself cannot enter the cell or ad- here to membrane. At concentrations ranging from 1×10?2 to 1×102 mg/L, C60(C(COOH)2)2 does not show any detectable cytotoxicity. | YE Chang CHEN Chunying CHEN Zhen MENG Huan XING Li JIANG Yaxin YUAN Hui XING Gengmei ZHAO Feng ZHAO Yuliang CHAI Zhifang FANG Xiaohong HAN Dong CHEN Long WANG Chen WEI Taotao | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 17 | Nanocluster PtNiP supported on graphene as an efficient electrocatalyst for methanol oxidation reaction显示文摘In this study,phosphorus doped graphene supported PtNiP nanocluster electrocatalyst(PtNiP/P-graphene)was successfully prepared via a simple hypophosphite-assisted co-reduction method.The improved anchoring force and increased anchoring sites of graphene support result from phosphorus doping as well as size-confined growth effect of NaH_(2)PO_(2) leads to uniform dispersion of ultrafine PtNiP nanoclusters.Doped P also promotes the removal of CO-like intermediate by adjusting Pt electronic structure combining with alloyed Ni via electronic effects.As a result,the as-prepared PtNiP/P-graphene catalyst with more exposed active sites and optimized electronic structure of Pt alloy shows excellent electrocatalytic performances for methanol oxidation reaction(MOR)both in activity and durability in an acidic medium. | Long Yang Guoqiang Li Rongpeng Ma Shuai Hou Jinfa Chang Mingbo Ruan Wenbin Cai Zhao Jin Weilin Xu Guiling Wang Junjie Ge Changpeng Liu Wei Xing | 2021 | Nano Research2021，14，8： | 4 |
| 18 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 19 | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells显示文摘 | Haisong Liu Huan Yang Dicong Zhu Xin Sui Juan Li Zhen Liang Lei Xu Zeyu Chen Anzhi Yao Long Zhang Xi Zhang Xing Yi Meng Liu Shiqing Xu Wenjian Zhang Hua Lin Lan Xie Jinning LOU Yong Zhang Jianzhong Xi Hongkui Deng | 2014 | Cell Research2014，24，10： | 3 |
| 20 | Nematode-Encoded RALF Peptide Mimics Facilitate Parasitism of Plants through the FERONIA Receptor Kinase显示文摘The molecular mechanism by which plants defend against plant root-knot nematodes(RKNs)is largely unknown.The plant receptor kinase FERONIA and its peptide ligands,rapid alkalinization factors(RALFs),regulate plant immune responses and cell expansion,which are two important factors for successful RKN parasitism.In this study,we found that mutation of FERONIA in Arabidopsis thaliana resulted in plants showing low susceptibility to the RKN Meloidogyne incognita.To identify the underlying mechanisms associated with this phenomenon,we identified 18 novel RALF-likes from multiple species of RKNs and showed that two RALF-likes(i.e.,MiRALF1 and MiRALF3)from M.incognita were expressed in the esophageal gland with high expression during the parasitic stages of nematode development.These nematode RALF-likes also possess the typical activities of plant RALFs and can directly bind to the extracellular domain of FERONIA to modulate specific steps of nematode parasitism-related immune responses and cell expansion.Genetically,both MiRALF1/3 and FERONIA are required for RKN parasitism in Arabidopsis and rice.Collectively,our study suggests that nematode-encoded RALFs facilitate parasitism via plant-encoded FERONIA and provides a novel paradigm for studying host-pathogen interactions. | Xin Zhang Huan Peng Sirui Zhu Junjie Xing Xin Li Zhaozhong Zhu Jingyuan Zheng Long Wang Bingqian Wang Jia Chen Zhenhua Ming Ke Yao Jinzhuo Jian Sheng Luan Devin Coleman-Derr Hongdong Liao Yousong Peng Deliang Peng Feng Yu | 2020 | Molecular Plant2020，13，10： | 3 |
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