|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Intestinal barrier in inflammatory bowel disease显示文摘A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms.In this review,we provide an overview about the major components of this protective system as for example an intact epithelium,the synthesis of various antimicrobial peptides(AMPs)and the formation of the mucus layer.We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease.Barrier disturbances including a defective production of AMPs,alterations in thickness or composition of the intestinal mucus layer,alterations of pattern-recognition receptors,defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis. | Lena Antoni Sabine Nuding Jan Wehkamp Eduard F Stange | 2014 | World Journal of Gastroenterology2014，20，5： | 33 |
| 3 | HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV-infection: does it really mean viral replication?显示文摘AIM To analyze the association of HCV-RNA with peripheral blood mononuclear cells (PBMC)and to answer the question whether HCV-RNA positivity in PBMC is due to viral replication,METHODS HCV-RNA was monitored in serumand PBMC preparations from 15 patients with chronic HCV infection before, during and after an IFN-α therapy using a nested RT/ PCRtechnique. In a second approach, PBMC from healthy donors were incubated in HCV positive plasma.RESULTS In the IFN-α responding patients,HCV-RNA disappeared first from total RNApreparations of PBMC and then from serum. In contrast, in relapsing patients, HCV-RNAreappeared first in serum and then in PBMC. A quantitative analysis of the HCV-RNAconcentration in serum was performed before and after transition from detectable to nondetectable HCV-RNA in PBMC-RNA and vice versa. When HCV-RNA was detectable in PBMCpreparations, the HCV concentration in serum was significantly higher than the serum HCV-RNA concentration when HCV-RNA in PBMC was not detectable. Furthermore, at no time during the observation period was HCV specific RNA observed in PBMC, if HCV-RNA in serum was under the detection limit. Incubation of PBMCfrom healthy donors with several dilutions of HCV positive plasma for two hours showed a concentration-dependent PCR-positivity for HCV-RNA in reisolated PBMC.CONCLUSION The detectability of HCV-RNA in total RNA from PBMC seems to depend on the HCV concentration in serum. Contamination or passive adsorption by circulating virus could be the reason for detection of HCV-RNA in PBMCpreparations of chronically infected patients. | Volker Meier Sabine Mihm Perdita Wietzke-Braun Guliano Ramadori | 2001 | World Journal of Gastroenterology2001，7，2： | 29 |
| 4 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 5 | 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells显示文摘以前,导出髓的干细胞(MSC ) 与不确定的脱氧核糖核酸甲基转移酶禁止者 5-azacytidine 对待的老鼠骨头被报导区分 intocardiomyocytes。现在的学习的目的是在从健康骨髓施主获得的人的单音的原子房间调查类似的区别策略的效率。After1-3 段落,文化为 24 h 暴露于到 6 星期进一步的文化跟随的 5-azacytidine (3 mciroM ) 。药处理没导致 myogenic 标记 MyoD 或心脏的 markersNkx2.5 和 GATA-4 的表示并且没在后续期间产出跳动的房间。在补丁夹钳实验,近似 10-15% 对待,未经治疗的房间展出了 L 类型 Ca (2+) 水流。几乎所有房间表面地出现了修正快速或慢的激活动力学的 K (+) 水流。在与匹配时间的控制相比在 6 星期处理以后加倍的 +60 mV 意味着当前的振幅。对待的房间的 Membranecapacitance 比在在处理以后的 controls2 星期内显著地大并且在 6 个星期以后仍然保持高。为 K (+) 隧道 Kv1.1, Kv1.5, Kv2.1, Kv4.3 和 KCNMA1 并且为 Ca (2+) 隧道 Ca (v) 的 mRNAs 的表示层次 1.2 没被 5-azacytidine 影响。在以前显示出禁止 hMSC 的快速或慢慢地激活的 K (+) 水流的集中的 Treatmentwith 钾隧道块 ers tetraethylammonium 和 clofilium 禁止了这些房间的增长。我们的结果建议尽管有进 cardiomyocytes 的 hMSC 的区别的缺席,有 5-azacytidine 的处理在当前的密度引起了深刻变化。 | Bartosz Balanal Cecilia Nicoletti Ihor Zahanich Eva M Graf Torsten Christ Sabine Boxberger Ursula Ravens | 2006 | Cell Research2006，16，12： | 20 |
| 6 | Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update显示文摘Epithelial-to-mesenchymal transition(EMT) represents conversion of an epithelial cell in an elongated cell with mesenchymal phenotype, which can occur in physiologic and pathologic processes such as embryogenesis(type 1 EMT), wound healing and/or fibrosis(type 2 EMT) and malignant tumors(type 3 EMT). The proliferation rate, metastasizing and recurrence capacity, as also the individualized response at chemotherapics, in both epithelial and mesenchymal malignant tumors is known to be influenced by reversible switch between EMT and mesenchymal-to-epithelial transition(MET). Although much research work has already been done in these fields, the specific molecular pathways of EMT, relating to the tumor type and tumor localization, are yet to be elucidated. In this paper, based on the literature and personal experience of the authors, an update in the field of EMT vs MET in epithelial and mesenchymal tumors is presented. The authors tried to present the latest data about the particularities of these processes, and also of the so-called endothelialto-mesenchymal transition, based on tumor location. The EMT-angiogenesis link is discussed as a possible valuable parameter for clinical follow-up and targeted therapeutic oncologic management. The paper begins with presentation of the basic aspects of EMT, its classification and assessment possibilities, and concludes with prognostic and therapeutic perspectives. The particularities of EMT and MET in gastric and colorectal carcinomas, pancreatic cancer, hepatocellular and cholangiocarcinomas, and lung, breast and prostate cancers, respectively in sarcomas and gastrointestinal stromal tumors are presented in detail. | Simona Gurzu Sabin Turdean Attila Kovecsi Anca Otilia Contac Ioan Jung | 2015 | World Journal of Clinical Cases2015，3，5： | 20 |
| 7 | Coronary thrombus in patients undergoing primary PCI for STEMI:Prognostic significance and management显示文摘Acute ST-elevation myocardial infarction(STEMI) usually results from coronary atherosclerotic plaque disruption with superimposed thrombus formation. Detection of coronary thrombi is a poor prognostic indicator,which is mostly proportional to their size and composition. Particularly,intracoronary thrombi impair both epicardial blood flow and myocardial perfusion,by occluding major coronary arteries and causing distal embolization,respectively. Thus,although primary percutaneous coronary intervention is the preferred treatement strategy in STEMI setting,the associated use of adjunctive antithrombotic drugs and/or percutaneous thrombectomy is crucial to optimize therapy of STEMI patients,by improving either angiographical and clinical outcomes. This review article will focus on the prognostic significance of intracoronary thrombi and on current antithrombotic pharmacological and interventional strategies used inthe setting of STEMI to manage thrombotic lesions. | Sabine Vecchio Elisabetta Varani Tania Chechi Marco Balducelli Giuseppe Vecchi Matteo Aquilina Giulia Ricci Lucchi Alessro Dal Monte Massimo Margheri | 2014 | World Journal of Cardiology2014，6，6： | 18 |
| 8 | Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus显示文摘Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus. | Maud Lemoine Aurélie Revaux Claire Francoz Guillaume Ducarme Sabine Brechignac Emmanuel Jacquemin Michèle Uzan Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，42： | 14 |
| 9 | Conserved Functions of Arabidopsis and Rice CC-Type Glutaredoxins in Flower Development and Pathogen Response显示文摘Glutaredoxins (GRX ) 是无所不在的 oxidoreductases 由在各种各样的有机体减少二硫化物响应氧化应力起一个关键作用。在 planta,三个不同 GRX 班根据他们的活跃地点主题被识别了。CPYC 和 CGFS 班在所有有机体被发现,而 CC 类型班为更高的陆地植物是特定的。最近,二 Arabidopsis CC 类型 GRX, ROXY1 和 ROXY2,被显示在花瓣和花药开始和区别施加关键功能。在远地相关的 monocots 分析 CC 类型 GRX 的功能,我们孤立并且描绘 ROXY1 的 OsROXY1 和 OsROXY2two 米饭相当或相同的事物。两基因在植物、繁殖的阶段被表示。尽管米饭花形态学从 eudicots 是不同的, OsROXY1/2 花的表示模式类似于他们的 Arabidopsis 对应物 ROXY1/2。互补实验证明 OsROXY1 和 OsROXY2 罐头充分救 roxy1 花的变异的显型。在 Arabidopsis 的 OsROXY1, OsROXY2,和 ROXY1 的 Overexpression 引起类似的植物、繁殖的植物发展缺点。ROXY1 和它的米饭相当或相同的事物因此在 eudicot 和 monocot 花开发期间施加一个保存函数。惊人地,这些 CC 类型 GRX 的 overexpression 也从 necrotrophic 病原体 Botrytis cinerea 导致氢过氧化物层次和超的增加的累积到感染,揭示在花机关开发和病原体防卫的平衡氧化还原作用过程的重要性。 | ZhenWang Shuping Xing Rainer R Birkenbihl Sabine Zachgo | 2009 | Molecular Plant2009，2，2： | 13 |
| 10 | 中美急诊道路交通伤患者流行病学研究显示文摘目的阐明中美两国综合性医院急诊医学科道路交通伤患者的异同点,为两国在道路交通伤临床、教学和科研方面的进一步合作提供新思路。方法选取2013年11—12月中国浙江省人民医院急诊医学科和2013年7—9月美国纽约州立大学上州医科大学急诊医学科两家单位的道路交通伤患者作为调查对象。双方合作设计《MVC Survey Questionare》(中英文版),供两家单位开展问卷调查。调查方法为标准流行病学抽样调查。调查内容包括患者到达急诊医学科的方式、交通工具、损伤类型、影像学检查情况、会诊情况、转归等。结果共发放问卷425份,回收合格问卷399份,有效率为93.9%,其中中国有效问卷155份,美国244份。到达急诊医学科的方式:美国道路交通伤患者救护车使用率高于中国,自备车使用率低于中国(P<0.05)。交通工具:美国自行车、电动车、行人交通事故发生率低于中国,汽车交通事故发生率高于中国(P<0.05)。损伤类型:美国患者颅脑、皮肤软组织损伤发生率低于中国,胸部损伤、骨折发生率高于中国(P<0.05)。影像学检查:美国患者X线、CT检查率均高于中国(P<0.05)。两国住院率、病死率、救治成功出院率、入住ICU比例、急诊手术率比较,差异均无统计学意义(P>0.05)。结论与美国相比,中国较少选择救护车转运道路交通伤患者。中国有更多类型的机动车涉及道路交通伤事故,中国道路交通伤患者中骑电动车、摩托车和行人的比例较高,这在一定程度上导致了中国颅脑损伤的比例远高于美国。另外,中国患者影像学检查率明显低于美国。上述差异为未来双方在道路交通伤临床、教学和科研方面开展进一步合作提供了新思路。 | 涂建锋 张可 周晟昂 陈环 蔡文伟 PaulKo Susan Wojcik Sabine Khan William D. Grant 杨悦 | 2015 | 中国全科医学2015，18，26： | 11 |
| 11 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 12 | Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study显示文摘AIM To analyze liver tests before and following treatment with herbal Traditional Chinese Medicine(TCM) in order to evaluate the frequency of newly detected liver injury.METHODS Patients with normal values of alanine aminotransferase(ALT) as a diagnostic marker for ruling out pre-existing liver disease were enrolled in a prospective study of a safety program carried out at the First German Hospital of TCM from 1994 to 2015. All patients received herbal products, and their ALT values were reassessed 1-3 d prior to discharge. To verify or exclude causality for suspected TCM herbs, the Roussel Uclaf Causality Assessment Method(RUCAM) was used.RESULTS This report presents for the first time liver injury data derived from a prospective, hospital-based and largescale study of 21470 patients who had no liver disease prior to treatment with herbal TCM. Among these, ALT ranged from 1 × to < 5 × upper limit normal(ULN) in 844 patients(3.93%) and suggested mild or moderate liver adaptive abnormalities. However, 26 patients(0.12%) experienced higher ALT values of ≥ 5 × ULN(300.0 ± 172.9 U/L, mean ± SD). Causality for TCM herbs was RUCAM-based probable in 8/26 patients, possible in 16/26, and excluded in 2/26 cases. Bupleuri radix and Scutellariae radix were the two TCM herbs most commonly implicated. CONCLUSION In 26(0.12%) of 21470 patients treated with herbal TCM, liver injury with ALT values of ≥ 5 × ULN was found, which normalized shortly following treatment cessation, also substantiating causality. | Dieter Melchart Stefan Hager Sabine Albrecht Jingzhang Dai Wolfgang Weidenhammer Rolf Teschke | 2017 | World Journal of Hepatology2017，9，29： | 11 |
| 13 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 14 | 降低固井水泥浆密度的新技术显示文摘针对现有低密度固井水泥浆存在的一些问题,介绍了一种有效降低水泥浆密度的新技术,即使用新型密度减轻材料———美国3M公司生产的中空玻璃微球(HGS)作为密度减轻剂。介绍了中空玻璃微球HGS的基本特点,对HGS低密度水泥浆进行了杨氏模量和抗张强度实验、压力和温度循环下的胶结强度实验、钻穿测试实验及现场测试,并与泡沫水泥浆和硅酸钠水泥浆进行了对比。实验及测试结果表明,添加了中空玻璃微球HGS的水泥浆有效地降低了密度,并且其混合、泵送及抗压强度、胶结质量等完全可以满足井下作业的要求。 | Fred Sabins | 2006 | 钻井液与完井液2006，23，4： | 11 |
| 15 | Global kinematics of tectonic plates and subduction zones since the late Paleozoic Era显示文摘Detailed global plate motion models that provide a continuous description of plate boundaries through time are an effective tool for exploring processes both at and below the Earth's surface. A new generation of numerical models of mantle dynamics pre-and post-Pangea timeframes requires global kinematic descriptions with full plate reconstructions extending into the Paleozoic(410 Ma). Current plate models that cover Paleozoic times are characterised by large plate speeds and trench migration rates because they assume that lowermost mantle structures are rigid and fixed through time. When used as a surface boundary constraint in geodynamic models, these plate reconstructions do not accurately reproduce the present-day structure of the lowermost mantle. Building upon previous work, we present a global plate motion model with continuously closing plate boundaries ranging from the early Devonian at 410 Ma to present day.We analyse the model in terms of surface kinematics and predicted lower mantle structure. The magnitude of global plate speeds has been greatly reduced in our reconstruction by modifying the evolution of the synthetic Panthalassa oceanic plates, implementing a Paleozoic reference frame independent of any geodynamic assumptions, and implementing revised models for the Paleozoic evolution of North and South China and the closure of the Rheic Ocean. Paleozoic(410-250 Ma) RMS plate speeds are on average ~8 cm/yr, which is comparable to Mesozoic-Cenozoic rates of ~6 cm/yr on average.Paleozoic global median values of trench migration trend from higher speeds(~2.5 cm/yr) in the late Devonian to rates closer to 0 cm/yr at the end of the Permian(~250 Ma), and during the Mesozoic-Cenozoic(250-0 Ma) generally cluster tightly around ~1.1 cm/yr. Plate motions are best constrained over the past 130 Myr and calculations of global trench convergence rates over this period indicate median rates range between 3.2 cm/yr and 12.4 cm/yr with a present day median rate estimated at~5 cm/yr. For Paleozoic times(410-251 Ma) our model results in median convergence rates largely~5 cm/yr. Globally,~90% of subduction zones modelled in our reconstruction are determined to be in a convergent regime for the period of 120-0 Ma. Over the full span of the model, from 410 Ma to 0 Ma,~93% of subduction zones are calculated to be convergent, and at least 85% of subduction zones are converging for 97% of modelled times. Our changes improve global plate and trench kinematics since the late Paleozoic and our reconstructions of the lowermost mantle structure challenge the proposed fixity of lower mantle structures, suggesting that the eastern margin of the African LLSVP margin has moved by as much as ~1450 km since late Permian times(260 Ma). The model of the plate-mantle system we present suggests that during the Permian Period, South China was proximal to the eastern margin of the African LLSVP and not the western margin of the Pacific LLSVP as previous thought. | Alexander Young Nicolas Flament Kayla Maloney Simon Williams Kara Matthews Sabin Zahirovic R.Dietmar Müller | 2019 | Geoscience Frontiers2019，10，3： | 10 |
| 16 | 青藏高原高山嵩草(Kobresia pygmaea)生态系统的现状与动态显示文摘高山嵩草草场是世界上最大的高山生态系统,本文提供了青藏高原东南部高山嵩草草场的分布、结构和生态学信息。莎草草甸的草皮极其坚硬,具有重要的环境保护作用,能保护黄河、长江、湄公河、怒江和雅鲁藏布江等源头地区的地表免受侵蚀。本文的研究重点是气候驱动演变以及小型哺乳动物和放牧作用下高山草甸系统的动态变化。考虑土壤分析、放射性碳测定地质年代和封育实验的结果,我们假定大多数高山嵩草草甸是由森林、灌木和高草草原在人为因素驱动下形成的。目前载畜量的日益增加以及游牧民定居现象的日益加强正威胁着高山草甸生态系统,尤其是该系统中比较干旱的地区,小型哺乳动物成为家畜强有力的竞争者,草皮一旦消失将难以恢复。本文给出了一些有关恢复措施方面的例子。 | Georg Miehe Sabine Miehe Knut Kaiser 刘健全 赵新全 周华坤(译) 赵新全(译) | 2008 | AMBIO-人类环境杂志2008，37，4： | 10 |
| 17 | Serum levels of soluble Fas, nitric oxide and cytokines in acute decompensated cirrhotic patients显示文摘AIM: To evaluate plasma levels of nitrite/nitrate (NOx), soluble Fas (sFas) antigen, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in patients with com- pensated and acute decompensated cirrhosis and to evaluate mediators causing acute decompensation in liver cirrhosis. METHODS: This prospective study was conducted in the medical intensive care unit of an academic tertiary center. Fifty-five patients with acute decompensation (gastrointestinal hemorrhage, encephalopathy, hydropic decompensation) and twenty-five patients with compen- sated liver cirrhosis were included. Blood samples were taken for analyses of sFas, Nox, IL-6, TNF-α. Liver en- zymes and kidney functions were also tested. RESULTS: In patients with acute decompensation, plas- ma sFas levels were higher than in non-decompensated patients (15 305 ±4646 vs 12 458 ±4322 pg/mL,, P < 0.05). This was also true for the subgroup of patients with alcoholic liver cirrhosis (P < 0.05). The other media- tors were not different and none of the parameters pre- dicted survival, except for ALT (alanine-aminotransfer- ase). In patients with portal-hypertension-induced acute hemorrhage, NOx levels were significantly lower than in patients with other forms of decompensation (70.8 ± 48.3 vs 112.9 ± 74.9 pg/mL, P < 0.05). When NOx lev- els were normalized to creatinine levels, the difference disappeared. IL-6, TNF-α and sFas were not different between bleeders and non-bleeders. In decompensated patients sFas, IL-6 and NOx levels correlated positively with creatinine levels, while IL-6 levels were dependent on Child class. CONCLUSION: In acute decompensated cirrhotic pa- tients sFas is increased, suggesting a role of apoptosis in this process and patients with acute bleeding have lower NOx levels. However, in this acute complex clinical situa-tion, kidney function seems to have a predominant influ- ence on mediator levels. | Christoph Elsing Sabine Harenberg Wolfgang Stremmel Thomas Herrmann | 2007 | World Journal of Gastroenterology2007，13，3： | 10 |
| 18 | 血清乙型肝炎病毒DNA阳性与原发性肝癌危险性关系的前瞻性队列研究显示文摘目的探讨血清HBV DNA阳性与原发性肝癌的关系。方法以分层抽样方法对广西隆安县12个乡镇30~55岁农村居民抽样,采静脉血,酶联免疫吸附试验检测HBsAg,套式聚合酶链反应检测HBV DNA。根据HBsAg和DNA检测结果,将研究对象分为HBsAg(+)/HBvDNA(+)组(A组)和HBsAg(+)/HBVDNA(-)组(B组);根据1:1匹配原则,从本村屯HBsAg(-)者中为前两组观察对象挑选对照,组成HBsAg阴性对照组(C组),对这3组人群进行4年的前瞻性跟踪随访。卡方检验对各组及各因素的发病率进行统计分析,然后用Cox比例风险模型分析与PLC有关的危险因素,用后退法对数值进行迭代分析。结果30~55岁人群HBsAg阳性率为14.52%(3975/27379),HBsAg阳性者HBV DNA阳性率为40.35%(1604/3975)。A、B两组总的肝癌发病率为672.45/10万人年,明显高于C组的17.19/10万人年(P〈0.01),相对危险度为39.123,95%可信因司为9.018~159.146。A组肝癌发病率为984.03/10万人年,显明高于C组的324.38/10万人年(P〈0.01),相对危险度为3.034,95%可信区间为1.795~5.125。对A、B两组进行肝癌危险因素的多因素Cox模型分析,结果表明性别、年龄、血清HBV DNA阳性、肝癌家族史和以玉米为主食均为肝癌的危险因素。结论血清HBV DNA阳性可增加HBsAg阳性者的肝癌危险性。 | 陈钦艳 董柏青 杨进业 韦少超 方孔雄 王学燕 方钟燎 Caroline Sabin Tim J Harrison | 2009 | 中华肝脏病杂志2009，17，12： | 10 |
| 19 | Managing reservoir sedimentation by venting turbidity currents:A review显示文摘Reservoir sedimentation is an issue that dam operators are increasingly facing as dams are aging.Not only does it reduce a reservoir's capacity but it also affects its outlet structures such as bottom outlets and powerhouse intakes.Sedimentation may also impoverish downstream ecosystems.For these reasons,several strategies for sediment management are being investigated and applied worldwide.Among these methods,venting of turbidity currents reaching the dam can be very beneficial and economical.This measure helps in preserving a certain continuity of sediment transport in rivers obstructed by dams.However,several practical but also theoretical challenges hamper this technique,rendering its use less common and its aspects relatively unknown.The present paper aims to gather the actual state-of-the-art concerning turbidity currents venting and to present an outlook for future development and research in this field. | Sabine Chamoun Giovanni De Cesare Anton J.Schleiss | 2016 | International Journal of Sediment Research2016，31，3： | 9 |
| 20 | 为不确定的未来实施洪水风险管理战略:荷兰,与莱茵河洪水共生存显示文摘无论从经济还是从自然保护角度,冲积平原和三角洲的社会压力都很大。随着经济的发展及大坝增高,由于预期的损失上升和更深的洪水,洪水风险在逐渐增加。全球变化,社会需求变化了,人们的观念也变化了,需要修订长期的洪水风险管理战略。而修订洪水风险管理战略应以柔性战略替代过去以加高大坝为主的刚性战略。柔性战略为主的洪水风险管理就意味着允许洪水临时性大面积泛滥,通过改变土地利用方式减少洪水灾害损失。这样的战略是基于风险管理和'与洪水共生存'的理念提出的,完全替代了过去的灾害控制观念。荷兰三角洲地区是世界人口密度最大区域之一,在这里,灵活的柔性洪水风险管理战略水文功能和'可持续的标准'被详细阐述和评估。 | Frans Klijn Michaёl vanBuuren Sabine A.M.vanRooij 石秋池 | 2004 | AMBIO-人类环境杂志2004，33，3： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员