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| 1 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 2 | Effectiveness of UV advanced oxidation for destruction of micro-pollutants 显示文摘 | Swaim Paul Royce Alan Smith Tim | 2008 | Ozone-Science & Engi- neering2008，30，1： | 1 |
| 3 | Chinas steel industry in the WTO era显示文摘 | Tim Smith | 2002 | Steel Times International2002，，2： | 1 |
| 4 | Materials congress 2006 - London 显示文摘 | TIM SMITH | 2006 | Alminium International Today2006，18，3： | 1 |
| 5 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 6 | Nonoperative Management of Cervical Myelopathy: A Systematic Review显示文摘 | John M. Rhee Mohammed F. Shamji W. Mark Erwin Richard J. Bransford S. Tim Yoon Justin S. Smith Han Jo Kim Claire G. Ely Joseph R. Dettori Alpesh A. Patel Sukhvinder Kalsi-Ryan | 2013 | 2013 (22S)2013，，22： | 1 |
| 7 | Greenhouse gas mitigation in agriculture显示文摘 | Smith Pete Martino Daniel Cai Zucong Gwary Daniel Janzen Henry Kumar Pushpam McCarl Bruce Ogle Stephen O&apos Mara Frank Rice Charles Scholes Bob Sirotenko Oleg Howden Mark McAllister Tim Pan Genxing Romanenkov Vladimir Schneider Uwe Towprayoon Sirintornt | 2007 | Philosophical Transactions of The Royal Society B2007，，1492： | 1 |
| 8 | Likelihood of establishment of tree pests and diseases based on their worldwide occurrence as determined by hierarchical cluster analysis显示文摘 | Ren6 Eschen Tim Holmes David Smith | 2014 | Forest Ecology and Management2014，315，1： | 1 |
| 9 | An online library serv- ice for open university MBA alumni-challenges and opportu- nities显示文摘 | Geri Smith Kelvin Street Tim Wales | 2007 | Journal of librarianship and information science2007，，3： | 1 |
| 10 | Greenhouse gas mitigation in agriculture显示文摘 | Smith Pete Martino Daniel Cai Zucong Gwary Daniel Janzen Henry Kumar Pushpam McCarl Bruce Ogle Stephen O&apos Mara Frank Rice Charles Scholes Bob Sirotenko Oleg Howden Mark McAllister Tim Pan Genxing Romanenkov Vladimir Schneider Uwe Towprayoon Sirintorn | 2007 | 2007 (1492)2007，，1492： | 1 |
| 11 | Policy and technological constraints to implementation of greenhouse gas mitigation options in agriculture显示文摘 | Pete Smith Daniel Martino Zucong Cai Daniel Gwary Henry Janzen Pushpam Kumar Bruce McCarl Stephen Ogle Frank O’Mara Charles Rice Bob Scholes Oleg Sirotenko Mark Howden Tim McAllister Genxing Pan Vladimir Romanenkov Uwe Schneider Sirintornthep Towprayoon | 2006 | Agriculture, Ecosystems and Environment2006，，1： | 1 |
| 12 | Estimating rotational iron losses in an induction machine显示文摘 | Carlos A Hernandez-Aramburo Tim C Green Alexander C Smith | 2003 | IEEE Transactions on Magnetics2003，39，6： | 1 |
| 13 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 1 |
| 14 | Guidelines for Colonoscopy Surveillance After Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society显示文摘 | Sidney J. Winawer Ann G. Zauber Robert H. Fletcher Jonathon S. Stillman Michael J. O’Brien Bernard Levin Robert A. Smith David A. Lieberman Randall W. Burt Theodore R. Levin John H. Bond Durado Brooks Tim Byers Neil Hyman Lynne Kirk Alan Thorson Clifford | 2006 | Gastroenterology2006，，6： | 1 |
| 15 | Guidelines for Colonoscopy Surveillance After Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society显示文摘 | Sidney J. Winawer Ann G. Zauber Robert H. Fletcher Jonathon S. Stillman Michael J. O'Brien Bernard Levin Robert A. Smith David A. Lieberman Randall W. Burt Theodore R. Levin John H. Bond Durado Brooks Tim Byers Neil Hyman Lynne Kirk Alan Thorson Clifford | 2006 | Gastroenterology2006，，6： | 1 |
| 16 | K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum显示文摘 | Karl Toischer Stephan E. Lehnart Gero Tenderich Hendrik Milting Reiner K?rfer Jan D. Schmitto Friedrich A. Sch?ndube Noboru Kaneko Christopher M. Loughrey Godfrey L. Smith Gerd Hasenfuss Tim Seidler | 2010 | Basic Research in Cardiology2010，，2： | 1 |
| 17 | Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging显示文摘 | Thomas M. Barber Christopher Alvey Tessa Greenslade Mark Gooding Debbie Barber Rachel Smith Anne Marland John A. H. Wass Tim Child Mark I. McCarthy Stephen Franks Stephen J. Golding | 2010 | European Radiology2010，，5： | 1 |
| 18 | Greenhouse gas mitigation in agriculture显示文摘 | Smith Pete Martino Daniel Cai Zucong Gwary Daniel Janzen Henry Kumar Pushpam McCarl Bruce Ogle Stephen O&apos Mara Frank Rice Charles Scholes Bob Sirotenko Oleg Howden Mark McAllister Tim Pan Genxing Romanenkov Vladimir Schneider Uwe Towprayoon Sirintornt | 2007 | Philosophical Transactions of The Royal Society B2007，，1492： | 1 |
| 19 | DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis显示文摘 | Diane Crighton Simon Wilkinson Jim O’Prey Nelofer Syed Paul Smith Paul R. Harrison Milena Gasco Ornella Garrone Tim Crook Kevin M. Ryan | 2006 | Cell2006，，1： | 1 |
| 20 | An Emerging Chinese Labor Movement显示文摘 | Brendan Smith Jeremy Brecher Tim Costello | 2007 | New Labor Forum2007，，1： | 1 |
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