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| 1 | Outcomes after robot-assisted laparoscopic radical prostatectomy显示文摘用 da Vinci 外科的系统的帮助机器人的 laparoscopic 激进分子前列腺切除术(RALRP ) 现在在在经济条件允许这种昂贵的技术的安装的许多国家的普遍使用。自从它首先在 2000 被执行,争吵包围了过程,与加亮支持它的使用的证据的缺乏的许多批评家。尽管有我证实的水平的缺乏,病人的许多大研究不管多么证实了过程可行、安全,与低病态。可得到的长术语的 oncological 数据似乎证明从机器的途径的结果至少传统的开的激进的前列腺切除术匹配那些。功能的结果也似乎令人满意,尽管使随机化控制审判正在缺乏。这份报纸关于 perioperative 数据和复杂并发症和 oncologic 和功能的结果考察 RALRP 的当前的地位。 | Declan G. Murphy Benjamin J. Challacombe Anthony J. Costello | 2009 | Asian Journal of Andrology2009，11，1： | 6 |
| 2 | Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression显示文摘AIM: To establish stable tetracycline-inducible pancreatic cancer cell lines. METHODS: Suit-2, MiaPaca-2, and Panc-1 cells were transfected with a second generation reverse tetracycline-controlled transactivator protein (rtTA2S-M2), under the control of either a cytomegalovirus (CMV) or a chicken β-actin promoter, and the resulting clones were characterised.RESULTS: Use of the chicken (β-actin) promoter proved superior for both the production and maintenance of doxycycline-inducible cell lines. The system proved versatile, enabling transient inducible expression of a variety of genes, including GST-P, CYP2E1, S100A6, and the actin capping protein, CapG. To determine the physiological utility of this system in pancreatic cancer cells, stable inducible CapG expressors were established. Overexpressed CapG was localised to the cytoplasm and the nuclear membrane, but was not observed in the nucleus. High CapG levels were associated with enhanced motility, but not with changes to the cell cycle, or cellular proliferation. In CapG-overexpressing cells, the levels and phosphorylation status of other actin-moduating proteins (Cofilin and Ezrin/Radixin) were not altered. However, preliminary analyses suggest that the levels of other cellular proteins, such as ornithine aminotransferase and enolase, are altered upon CapG induction. CONCLUSION: We have generated pancreatic-cancer derived cell lines in which gene expression is fully controllable. | Sarah Tonack Sabina Patel Mehdi Jalali Taoufik Nedjadi Rosalind E Jenkins Christopher Goldring John Neoptolemos Eithne Costello | 2011 | World Journal of Gastroenterology2011，17，15： | 4 |
| 3 | Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?显示文摘The molecular basis for enhanced chemosensitivity of testicular germ cell tumors(GCT)has been an area of great interest,as it could potentially give us therapeutic leads in other resistant malignancies.Thus far,however,the increased sensitivity of GCT has been variously attributed to multiple factors—an inability to detoxify cisplatin,a lack of export pumps,an inability to repair the DNA damage,an intact apoptotic cascade and lack of p53 mutation;but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive.Herein,we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α(HIF-1α)expression in mediating the general exquisite chemosensitivity of testicular GCT,through the aforementioned processes.This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies. | niraj shenoy roxana dronca fernando quevedo stephen a boorjian john cheville brian costello manish kohli thomas witzig lance pagliaro | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 4 | Dual-energy CT of the heart—Principles and protocols显示文摘 | Florian Schwarz Balazs Ruzsics U. Joseph Schoepf Gorka Bastarrika Salvatore A. Chiaramida Joseph A. Abro Robin L. Brothers Sebastian Vogt Bernhard Schmidt Philip Costello Peter L. Zwerner | 2008 | European Journal of Radiology2008，，3： | 2 |
| 5 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
| 6 | Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience显示文摘 | Balazs Ruzsics Heon Lee Peter L. Zwerner Mulugeta Gebregziabher Philip Costello U. Joseph Schoepf | 2008 | European Radiology2008，，11： | 2 |
| 7 | Automatic-repeat-request error-control schemes显示文摘 | LIN S COSTELLO D J MILLER M J | 1984 | IEEE Commun Mag1984，22，： | 2 |
| 8 | Enforcing Emissions Trading when Emissions Permits are Bankable显示文摘 | John K. Stranlund Christopher Costello Carlos A. Chávez | 2005 | Journal of Regulatory Economics2005，，2： | 2 |
| 9 | Mikhael One Dimensional Comparison of Wiener Filtering and Richardson - Lucy Methods for Sectioned Restoration of Space-Variant Digital Images 显示文摘 | Thomas P Costello Wasfy B | 2002 | IEEE Transactions On Circuits And Systems-I: Fundamental Theory And Applications2002，49，4： | 1 |
| 10 | Increased plasma endothelin - 1 in the early hours of acute myocardial infarction显示文摘 | Sterwart DJ Kubac G Costello KB | 1991 | J Am Coll Cardiol1991，18，： | 1 |
| 11 | A systemic review of the reproductive system effects of mefformin in patients with polycystic ovary syndrome 显示文摘 | COSTELLO M F EDEN J A | 2003 | Fertil Steril2003，79，1： | 1 |
| 12 | A systemic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome显示文摘 | COSTELLO M Eden JA | 2003 | Fertil Steril2003，79，： | 1 |
| 13 | Carotid bifurcation CT angiography:assessment of interactive volumer endering显示文摘 | Costello P Khoo EW | 1999 | J Comput Assist Tomogr1999，23，： | 1 |
| 14 | Unintended biological invasions: Does risk vary by trading partner? 显示文摘 | Costello Christopher Springbom Michael McAusland Carol et al | 2007 | Journal of Environmental Economics and Management2007，54，3： | 1 |
| 15 | CT features of pulmonary alveolar proteinosis显示文摘 | Holbert JM Costello P Li W | 2001 | Am J Roentgenol2001，176，5： | 1 |
| 16 | Model predictive lateral pulse jet control of an atmospheric rocket显示文摘 | Burchett B Costello M | 2002 | Journal of Guidance Control and Dynamics2002，25，5： | 1 |
| 17 | Aprotinin reduces operative closure time and blood product use after pediatric bypass显示文摘 | Costello JM Backer CL de Hoyos A | 2003 | Ann Thorac Surg2003，75，4： | 1 |
| 18 | Glatiramer acetate induces a Th2一biased response and crossreaetivity with myelin basic protein in patients with MS显示文摘 | CHEN M GRAN B COSTELLO K | 2001 | Mult Scler2001，7，4： | 1 |
| 19 | Reliability and Validity of the PAS-ADD Checklist for Detecting Psychiatric Disorders in Adults with Intellectual Disability 显示文摘 | MOSS S PROSSER H COSTELLO H | 1998 | Journal of Intellectual Disability Research1998，42，2： | 1 |
| 20 | Evalution of the airtraq and macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation 显示文摘 | MAHARAJ C H COSTELLO J F HARTE B H | 2008 | Anaesthesia2008，63，2： | 1 |
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