|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sensing for advancing mining automation capability:A review of underground automation technology development显示文摘This paper highlights the role of automation technologies for improving the safety, productivity, and environmental sustainability of underground coal mining processes. This is accomplished by reviewing the impact that the introduction of automation technology has made through the longwall shearer automation research program of Longwall Automation Steering Committee(LASC). This result has been achieved through close integration of sensing, processing, and control technologies into the longwall mining process. Key to the success of the automation solution has been the development of new sensing methods to accurately measure the location of longwall equipment and the spatial configuration of coal seam geology. The relevance of system interoperability and open communications standards for facilitating effective automation is also discussed. Importantly, the insights gained through the longwall automation development process are now leading to new technology transfer activity to benefit other underground mining processes. | Ralston Jonathon Reid David Hargrave Chad Hainsworth David | 2014 | International Journal of Mining Science and Technology2014，24，3： | 37 |
| 2 | Infrastructure-based localisation of automated coal mining equipment显示文摘 | Chad O. Hargrave Craig A. James Jonathon C. Ralston | 2017 | International Journal of Coal Science & Technology2017，4，3： | 30 |
| 3 | Longwall automation: Delivering enabling technology to achieve safer and more productive underground mining显示文摘The ongoing need to deliver improved safety, productivity and environmental benefit in coal mining presents an open challenge as well as a powerful incentive to develop new and improved solutions.This paper assesses the critical role that enabling technologies have played in the delivery of remote and automated capability for longwall mining. A brief historical account is given to highlight key technical contributions which have influenced the direction and development of present-day longwall technology. The current state of longwall automation is discussed with particular attention drawn to the technologies that enable automated capability. Outcomes are presented from an independently conducted case study that assessed the impact that CSIRO's LASC longwall automation research has made to the longwall mining industry in Australia. Importantly, this study reveals how uptake of this innovative technology has significantly benefitted coal mine productivity, improved working conditions for personnel and enhanced environmental outcomes. These benefits have been widely adopted with CSIRO automation technology being used in 60 per cent of all Australian underground operations.International deployment of the technology is also emerging. The paper concludes with future challenges and opportunities to highlight the ongoing scope for longwall automation research and development. | Ralston Jonathon C. Reid David C. Dunn Mark T. Hainsworth David W. | 2015 | International Journal of Mining Science and Technology2015，25，6： | 27 |
| 4 | Developing selective mining capability for longwall shearers using thermal infrared-based seam tracking显示文摘Longwall mining continues to remain the most efficient method for underground coal recovery. A key aspect in achieving safe and productive longwall mining is to ensure that the shearer is always correctly positioned within the coal seam. At present, this machine positioning task is the role of longwall personnel who must simultaneously monitor the longwall coal face and the shearer's cutting drum position to infer the geological trends of the coal seam. This is a labour intensive task which has negative impacts on the consistency and quality of coal production. As a solution to this problem, this paper presents a sensing method to automatically track geological coal seam features on the longwall face, known as marker bands, using thermal infrared imaging. These non-visible marker bands are geological features that link strongly to the horizontal trends present in layered coal seams. Tracking these line-like features allows the generation of a vertical datum that can be used to maintain the shearer in a position for optimal coal extraction. Details on the theory of thermal infrared imaging are given, as well as practical aspects associated with machine-based implementation underground. The feature detection and tracking tasks are given with real measurements to demonstrate the efficacy of the approach. The outcome is important as it represents a new selective mining capability to help address a long-standing limitation in longwall mining operations. | Jonathon C. Ralston Andrew D. Strange | 2013 | International Journal of Mining Science and Technology2013，23，1： | 13 |
| 5 | Ablation techniques for primary and metastatic liver tumors显示文摘Ablative treatment methods have emerged as safe and effective therapies for patients with primary and secondary liver tumors who are not surgical candidates at the time of diagnosis.This article reviews the current literature and describes the techniques,complications and results for radiofrequency ablation,microwave ablation,cryoablation,and irreversible electroporation. | Michael J Ryan Jonathon Willatt Bill S Majdalany Ania Z Kielar Suzanne Chong Julie A Ruma Amit Pandya | 2016 | World Journal of Hepatology2016，8，3： | 13 |
| 6 | Longwall automation:trends,challenges and opportunities显示文摘This paper explores the ongoing development and implementation of longwall automation technology to achieve greater levels of underground coal mining performance. The primary driver behind the research and development effort is to increase the safety, productivity and efficiency of longwall mining operations to enhance the underlying mining business. A brief review of major longwall automation challenges is given followed by a review of the insights and benefits associated with the LASC longwall shearer automation solution. Areas of technical challenge in sensing, decision support, autonomy and human interaction are then highlighted, with specific attention given to remote operating centres, proximity detection and systems-level architectures in order to motivate further automation system development.The vision for a fully integrated coal mining ecosystem is discussed with the goal of delivering a highperformance, zero-exposure and environmentally coherent mining operations. | Jonathon C.Ralston Chad O.Hargrave Mark T.Dunn | 2017 | International Journal of Mining Science and Technology2017，27，5： | 11 |
| 7 | Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis显示文摘Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone sclerosis.However,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain unclear.In knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte function.Suppression of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular matrix.As a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 promoter.Not only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised cartilage.Even in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early OA.Thus,in humans and mice,defects in PLR coincide with cartilage defects.Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on PLR.Together,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis. | Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston | 2019 | Bone Research2019，7，4： | 10 |
| 8 | Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells显示文摘瞄准:在类型 5 phosphodiesterase (PDE5 ) 上学习人半胱氨酸和铜的效果在 cavernosal 的表示脉管的光滑的肌肉房间(CVSMC ) 并且调查超级氧化物(当人半胱氨酸和铜产生 O 2 · −, 和 O 2 · − 在上面, O 2 · −) 源于菸碱腺嘌 dinucleotide 磷酸盐 oxidase 调整 PDE5 表示。方法:从兔子阴茎导出的 CVSMC 与人半胱氨酸或铜氯化物被孵化与或没有超级氧化物为 16 h 的 dismutase (草皮)( 菸碱腺嘌 dinucleotide 磷酸盐禁止者) ,过氧化氢酶, sildenafil 柠檬酸盐,或 apocynin。PDE5 并且 glyceraldehyde-3-phosphate 脱氢酶(内部标准) 的表示用西方的污点分析被估计。在平行, O 2 · − spectrophotometrically 被测量。结果:CuCl 2 独自一个(多达 10 μmol/L ) 并且(多达 100 μmol/L ) 人半胱氨酸独自没与控制相比在 CVSMC 在 O 2 · − 形成上有效果。然而,当在一样的时间功课上共同孵化时,在联合,人半胱氨酸和 CuCl 2 显著地增加了 O 2 · − 形成,草皮堵住的效果,过氧化氢酶, apocynin,和 sildenafil (1 μmol/L ) 。PDE5 表示显著地也在与控制相比与人半胱氨酸和 CuCl 2, 孵化的 CVSMC 被增加。这效果被 16-h 合作孵化也与草皮,过氧化氢酶, apocynin 和 sildenafil 否定。结论:这代表位于编辑下面的新奇病原的机制,并且显示延长 sildenafil 使用的治疗学的行动通过这条小径的抑制部分地被调停。 | Matthew Hotston Jamie Y. Jeremy Jonathon Bloor Nick S. Greaves Raj Persad Gianni Angelini Nilima Shukla | 2008 | Asian Journal of Andrology2008，10，6： | 7 |
| 9 | 联合应用沙利度胺和脂质体阿霉素治疗复发性卵巢上皮性癌和腹膜癌的初步研究显示文摘目的:评价联合应用沙利度胺与脂质体阿霉素治疗复发性卵巢上皮性癌和腹膜癌的疗效和毒副作用。方法:将9例经手术和术后泰素+卡铂化疗后复发患者纳入本研究。每4周予以脂质体阿霉素30~50mg/m^2化疗,共3~8个疗程;同时每日予以沙利度胺100~300mg,其剂量从100mg/d开始,此后每2周增加50~100mg。通过体检、影像学检查和测定CA125水平评价治疗效果。结果:9例患者的中位年龄为56岁(35~81岁),FIGO分期为ⅢB~Ⅳ期。本次化疗的中位疗程数是6个疗程。中位随访时间为18.5个月。最常见的不良反应为疲劳(55.6%)和神经系统症状(55.6%)。3例患者出现Ⅲ度副反应,1例为无力、1例过敏性皮疹和1例末梢神经感觉异常。根据RECIST标准评价有病灶的6例患者疗效,2例部分缓解,2例治疗中疾病无进展,1例病情进展,1例失访。另有2例CA125升高的患者,在联合化疗3~4个疗程后CA125水平降低50%以上。1例二次肿瘤细胞减灭术后化疗的患者治疗后随访36个月无肿瘤复发迹象。在随访的8例患者中,中位疾病无进展时间为6.5个月(0~36个月);中位总的生存时间为20.5个月(8~36个月)。结论:联合应用沙利度胺与脂质体阿霉素治疗复发性卵巢上皮性癌具有可接受的毒副作用,同时具有一定的治疗效果。 | 郭红燕 Nelson N. Teng John K. Chan Amreen Husain Deirdre Stieglitz Jonathon S Bereck | 2008 | 现代妇产科进展2008，17，2： | 5 |
| 10 | Regulator of myeloid differentiation and function:The secret life of Ikaros显示文摘Ikaros (also known as Lyf-1) was initially described as a lymphoid-specific transcription factor.Although Ikaros has been shown to regulate hematopoietic stem cell renewal,as well as the development and function of cells from multiple hematopoietic lineages,including the myeloid lineage,Ikaros has primarily been studied in context of lymphoid development and malignancy.This review focuses on the role of Ikaros in myeloid cells.We address the importance of post-transcriptional regulation of Ikaros function;the emerging role of Ikaros in myeloid malignancy;Ikaros as a regulator of myeloid differentiation and function;and the selective expression of Ikaros isoform-x in cells with myeloid potential.We highlight the challenges of dissecting Ikaros function in lineage commitment decisions among lymphoidmyeloid progenitors that have emerged as a major myeloid differentiation pathway in recent studies,which leads to reconstruction of the traditional map of murine and human hematopoiesis. | Olivia L Francis Jonathon L Payne Kimberly J Payne | 2011 | World Journal of Biological Chemistry2011，2，6： | 4 |
| 11 | Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management显示文摘Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using 'top-down' care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. | Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 4 |
| 12 | 钙离子激活性氯通道在犬心力衰竭心肌功能重塑的观察显示文摘目的观察 I_(to)第2个成分 I_(to2)即钙离子激活性氯通道(CLCA)是否参与心力衰竭(心衰)心脏的功能重塑。方法快速起搏犬右心室,诱发心衰,酶学法分离心肌细胞,以经典膜片钳全细胞记录法评价心衰时 I_(to2)电流密度的变化、I_(to2)与 L-型钙通道电流(I_(Ca-L))的关系和在恒定的细胞内钙浓度条件下 I_(to2)与膜电压的关系。用氯通道阻断剂4,4′diisothiocyanostilbene-2,2′-disulfonic acid(DIDS)200μmol 筛选出 I_(to2)。结果 I_(to2)电压-电流关系呈倒钟型,与 I_(Ca-L)的曲线成镜影关系但右移10 mV_oI_(Ca-L)密度在心衰和对照组之间差异无统计学意义。在膜电压0~40 mV 之间,I_(to2)密度在心衰组明显减小。例如膜电压为20 mV 时,对照组与心衰组 I_(to2)分别为(3.02±0.55)pA/pF(n=7)和(1.31±0.25)pA/pF(n=8),P<0.05。I_(to2)电流的衰退时间常数在两组间差异无统计学意义。当细胞内钙浓度锁定在100μmol 时,I_(to2)密度在心衰组反而比对照组增大,提示 CLCA 功能上调。结论心衰时 I_(to2)密度下降,这可能与心衰细胞兴奋释放钙浓度下降有关。I(to2)密度下降可能参与心衰时的动作电位时程延长和晚期后除极的发生,可能是心衰时心律失常的发生机制之一。 | 浦介麟 李宁 马克娟 王洪涛 腾思勇 Jonathon C.Makielski | 2006 | 中华心血管病杂志2006，34，9： | 3 |
| 13 | Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse显示文摘Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the brain.While increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely explored.In this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein EGFP.The results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and oligodendrocytes.Colocalization of P2X7-EGFP with cell type-specific markers was not detected in neurons or astrocytes.These data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy. | James Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon Smith Annette Nicke Tobias Engel | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 14 | Salmonella typhimurium myopericarditis: A case report and review of literature显示文摘BACKGROUND Non-typhoidal salmonella(NTS)is a rare,but well-established cause of myopericarditis.Presenting symptoms may be varied,however often revolve around the dual presentation of both myopericarditis and infectious diarrhoea.Given the rarity of NTS related myopericarditis,we conducted a systematic review of the literature,identifying 41 previously reported cases.CASE SUMMARY We present the case of an otherwise healthy 39-year old male,presenting with chest pain in the setting of documented Salmonella typhimurium infection.After further investigation with echocardiogram and laboratory blood tests,a diagnosis of NTS associated myopericarditis was made,and the patient received antibiotic treatment with an excellent clinical outcome.Overall,myopericarditis is rare in NTS.Although treatment for myopericarditis has not been well established,there are guidelines for the treatment of NTS infection.In our review,we found that the majority of NTS cases has been pericarditis(27/42,64.3%),with an average age of 48.3 years,and 71.4%being male.The average mortality across all cases was 31%.CONCLUSION Myopericarditis is a rare,but potentially serious complication of NTS infection,associated with an increased morbidity and mortality. | David Jin Chien-Ying Kao Jonathon Darby Sonny Palmer | 2020 | World Journal of Cardiology2020，12，1： | 3 |
| 15 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 16 | A Practical Guide to Multimodality Imaging of Transcatheter Aortic Valve Replacement显示文摘 | Gerald S. Bloomfield Linda D. Gillam Rebecca T. Hahn Samir Kapadia Jonathon Leipsic Stamatios Lerakis Murat Tuzcu Pamela S. Douglas | 2012 | JACC: Cardiovascular Imaging2012，，4： | 2 |
| 17 | SCCT guidelines for the interpretation and reporting of coronary CT angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee显示文摘 | Jonathon Leipsic Suhny Abbara Stephan Achenbach Ricardo Cury James P. Earls GB John Mancini Koen Nieman Gianluca Pontone Gilbert L. Raff | 2014 | Journal of Cardiovascular Computed Tomography2014，，5： | 2 |
| 18 | Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support显示文摘 | Paul A. Harris Robert Taylor Robert Thielke Jonathon Payne Nathaniel Gonzalez Jose G. Conde | 2008 | Journal of Biomedical Informatics2008，，2： | 2 |
| 19 | Improving cirrhosis care: The potential for telemedicine and mobile health technologies显示文摘Decompensated cirrhosis is a condition associated with significant morbidity and mortality. While there have been significant efforts to develop quality metrics that ensure high-value care of these patients, wide variations in clinical practice exist. In this opinion review, we discuss the quality gap in the care of patients with cirrhosis, including low levels of compliance with recommended cancer screening and other clinical outcome and patient-reported outcome measures. We posit that innovations in telemedicine and mobile health (mHealth) should play a key role in closing the quality gaps in liver disease management. We highlight interventions that have been performed to date in liver disease and heart failurefrom successful teleconsultation interventions in the care of veterans with cirrhosis to the use of telemonitoring to reduce hospital readmissions and decrease mortality rates in heart failure. Telemedicine and mHealth can effectively address unmet needs in the care of patients with cirrhosis by increasing preventative care, expanding outreach to rural communities, and increasing high-value care. We aim to highlight the benefits of investing in innovative solutions in telemedicine and mHealth to improve care for patients with cirrhosis and create downstream cost savings. | Matthew Jonathon Stotts Justin Alexander Grischkan Vandana Khungar | 2019 | World Journal of Gastroenterology2019，25，29： | 2 |
| 20 | Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria显示文摘 | Sandra C. Kim Susan L. Tonkonogy Carol A. Albright Julia Tsang Edward J. Balish Jonathon Braun Mark M. Huycke R. Balfour Sartor | 2005 | Gastroenterology2005，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员