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| 1 | 循环荷载作用下饱和黏性土的弹塑性双面模型显示文摘基于作者新近提出的一种混合塑性硬化准则和临界状态土力学理论建立了一个三维形式表述的适于饱和黏性土的弹塑性双面模型,此硬化准则是著名的M asing方法在三维应力空间中的推广。该模型的二维形式已采用饱和黏性土样室内动态三轴不排水剪切试验的结果进行了验证并已在另文发表。本文所建的三维弹塑性动本构模型与一个半经验的孔隙水压力增长模式相结合,通过有限元程序ABAQUS*对一个循环荷载作用下的条形基础下部地基土层内的位移、应力分布和超孔隙水压力随时间的变化进行了分析,计算结果表明模型预测的地基土的力学响应是符合实际的。 | 李涛 H. Meissner | 2006 | 土木工程学报2006，39，1： | 16 |
| 2 | Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis显示文摘A robust animal model for 'hypothesis-testing/mechanistic' research in human immunology and immuno-pathology should meet the following criteria.First,it has well-studied hemato-lymphoid organs and target cells similar to those of humans.Second,the human pathogens establish infection and lead to relevant diseases.Third,it is genetically inbred and can be manipulated via genetic,immunological and pharmacological means.Many human-tropic pathogens such as HIV-1 fail to infect murine cells due to the blocks at multiple steps of their life cycle.The mouse with a reconstituted human immune system and other human target organs is a good candidate.A number of human-mouse chimeric models with human immune cells have been developed in the past 20 years,but most with only limited success due to the selective engraftment of xeno-reactive human T cells in hu-PBL-SCID mice or the lack of significant human immune responses in the SCID-hu Thy/Liv mouse.This review summarizes the current understanding of HIV-1 immuno-pathogenesis in human patients and in SIV-infected primate models.It also reviews the recent progress in the development of humanized mouse models with a functional human immune system,especially the recent progress in the immunodeficient mice that carry a defective gammaC gene.NOD/SCID/gammaC-/(NOG or NSG) or the Rag2-/-/gammaC-/double knockout (DKO) mice,which lack NK as well as T and B cells (NTB-null mice),have been used to reconstitute a functional human immune system in central and peripheral lymphoid organs with human CD34+ HSC.These NTB-hu HSC humanized models have been used to investigate HIV-1 infection,immuno-pathogenesis and therapeutic interventions.Such models,with further improvements,will contribute to study human immunology,human-tropic pathogens as well as human stem cell biology in the tissue development and function in vivo. | MEISSNER Eric | 2010 | Science China(Life Sciences)2010，53，2： | 11 |
| 3 | Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation显示文摘AIM:To investigate the effects of intravenous administration of the antioxidant glutathione (GSH) on reperfusion injury following liver transplantation.METHODS:Livers of male Lewis rats were transplanted after 24 h of hypothermic preservation in University of Wisconsin solution in a syngeneic setting. During a 2-h reperfusion period either saline (controls,n=8) or GSH (50 or 100μmol/(h·kg),n=5 each) was continuously administered via the jugular vein.RESULTS:Two hours after starting reperfusion plasma ALT increased to 1 457±281U/L (mean±SE) in controls but to only 908_+187 U/L (P<0.05) in animals treated with 100μmol GSH/(h·kg).No protection was conveyed by 50μmol GSH/(h·kg).Cytoprotection was confirmed by morphological findings on electron microscopy:GSH treatment prevented detachment of sinusoidal endothelial cells (SECs) as well as loss of microvilli and mitochondrial swelling of hepatocytes. Accordingly, postischemic bile flow increased 2-fold. Intravital fluorescence microscopy revealed a nearly complete restoration of sinusoidal blood flow and a significant reduction of leukocyte adherence to sinusoids and postsinusoidal venules. Following infusion of 50μmol and 100 μmol GSH/(h·kg),plasma GSH increased to 65±7mol/L and 97±18μmol/L,but to only 20±3mol/L in untreated recipients.Furthermore, plasma glutathione disulfide (GSSG) increased to 7.5±1.0mol/L in animals treated with 100μmol/(h·kg) GSH but infusion of 50μmol GSH/(h·kg) did not raise levels of untreated controls (1.8±0.5mol/L vs 2.2±0.2mol/L).CONCLUSION:Plasma GSH levels above a critical level may act as a “sink” for ROS produced in the hepatic vasculature during reperfusion of liver grafts.Therefore, GSH can be considered a candidate antioxidant for the prevention of reperfusion injury after liver transplantation, in particular since it has a low toxicity in humans. | RolfJ.Schauer SinanKalmuk Alexander L.Gerbes Rosemarie Leiderer Herbert Meissner Friedrich W.Schildberg Konrad Messmer Manfred Bilzer | 2004 | World Journal of Gastroenterology2004，10，6： | 9 |
| 4 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 5 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 6 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 7 | Partial Splenectomy in the Management of Nonparasitic Splenic Cysts显示文摘 | Andrzej B. Szczepanik Alfred J. Meissner | 2009 | World Journal of Surgery2009，，4： | 2 |
| 8 | The Mammalian Epigenome显示文摘 | Bradley E. Bernstein Alexander Meissner Eric S. Lander | 2007 | Cell2007，，4： | 2 |
| 9 | Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction显示文摘 | Tobias Reichlin Affan Irfan Raphael Twerenbold Miriam Reiter Willibald Hochholzer Hanna Burkhalter Stefano Bassetti Stephan Steuer Katrin Winkler Federico Peter Julia Meissner Philip Haaf Mihael Potocki Beatrice Drexler Stefan Osswald Christian Mueller | 2011 | Circulation2011，，2： | 2 |
| 10 | Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17~92 Family of miRNA Clusters显示文摘 | Andrea Ventura Amanda G. Young Monte M. Winslow Laura Lintault Alex Meissner Stefan J. Erkeland Jamie Newman Roderick T. Bronson Denise Crowley James R. Stone Rudolf Jaenisch Phillip A. Sharp Tyler Jacks | 2008 | Cell2008，，5： | 2 |
| 11 | Activation of the cardiac calcium release channel (ryanodine receptor) by poly -S - nitrosylation 显示文摘 | Xu L Eu JP Meissner G | 1998 | Science1998，279，5348： | 1 |
| 12 | Clinical findings and diagnostic tests in Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease显示文摘 | Krasnianski A Meissner B Heinemann U | 2004 | Folia Neuropathol2004，42，： | 1 |
| 13 | Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy:long term follow up of the first series of 25 patients 显示文摘 | Meissner A Ziemssen P | 2000 | Heart2000，83，： | 1 |
| 14 | Cement leakage into the posterior spinal canal during balloon kyphoplasty:a case report显示文摘 | Becker S Meissner J Tuschel A | 2007 | J Orthopaed Surg2007，15，： | 1 |
| 15 | Superoxide dismutase 1 regulates caspase-1 and endotoxic shock显示文摘 | Meissner F Molawi K Zychlinsky A | 2008 | Nat Immunol2008，9，： | 1 |
| 16 | Isolation and charactefisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs显示文摘 | MEISSNER R MICHAEL A J | 1997 | Plant Mol Bio1997，33，4： | 1 |
| 17 | Percutaneous transluminal septal myocardial ablation for hypertrophic obstruction cardiomyopathy:long term follow up of the first series of 25 patients显示文摘 | Faber L Meissner A Ziemssen P et al | 2000 | Heart2000，83，3： | 1 |
| 18 | Diffusion Bonded Composite of YAG Single Crystals显示文摘 | Lee H C Brownlie P L Meissner H E | 1991 | SPIE1991，1624，： | 1 |
| 19 | A new elongational rheometer for polymer melts and other viscoelastic liquids显示文摘 | MEISSNER J and HOSETTLER J | 1994 | J Rheol Acta1994，33，： | 1 |
| 20 | Effects of pasteurization and storage temperature on vacuum-packaged Vienna sausage shelf life显示文摘 | VON HOLY A MEISSNER D HOLZAPFEL W H | 1991 | S Aft J Sci1991，87，： | 1 |
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