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| 1 | Autophagy and human diseases显示文摘Autophagy 是为降级把细胞质的材料送到 lysosome 的一个主要细胞内部的 degradative 过程。自从发现 autophagy 相关(Atg ) 在 1990 年代的基因,有在许多 autophagy 大美人模型的 autophagy 的生理、病理学的角色上的研究的增长。然而,指导疾病仅仅最近出现了的在 ATG 基因机能障碍和人之间的连接的证据。有越来越多的报告,证明在 ATG 基因的变化在象 neurodegenerative 疾病,传染疾病,和癌症那样的各种各样的人的疾病被识别。这里,我们在人的疾病在变化的鉴定或 ATG 基因的多型性考察主要进展。在临床的审判的当前的模块化 autophagy 混合物也被总结。 | Peidu Jiang | 2014 | Cell Research2014，24，1： | 75 |
| 2 | Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats显示文摘AIM: To study the regulatory mechanisms of sinusoidal regeneration after partial hepatectomy.METHODS: We investigated the expression of angiopoietin (Ang)-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in regenerating liver tissue by quantitative reverse-transcription polymerase chain reaction (RT-PCR) using a LightCycler (Roche Diagnostics) and also immunohistochemical staining after 70% hepatectomy in rats. In the next step, we isolated liver cells (hepatocytes,sinusoidal endothelial cell (SEC), Kupffer cell, and hepatic stellate cells (HSC)) from regenerating liver tissue by in situ collagenase perfusion and counterflow elutriation,to determine potential cellular sources of these angiogenic factors after hepatectomy. Proliferation and apoptosis of SECs were also evaluated by proliferating cell nuclear antigen (PCNA) staining and the terminal deoxynucleotidyl transferase d-uridine triphosphate nick end labeling (TUNEL) assay, respectively.RESULTS: VEGF mRNA expression increased with a peak at 72 h after hepatectomy, decreasing thereafter.The expression of Ang-1 mRNA was present at detectable levels before hepatectomy and increased slowly with a peak at 96 h. Meanwhile, Ang-2 mRNA was hardly detected before hepatectomy, but was remarkably induced at 120 and 144 h. In isolated cells, VEGF mRNA expression was found mainly in the hepatocyte fraction.Meanwhile, mRNA for Ang-1 and Ang-2 was foundin the SEC and HSC fractions, but was more prominent in the latter. The PCNA labeling index of SECs increased slowly,reaching a peak at 72 h, whereas apoptotic SECs were detected between 120 h and 144 h.CONCLUSION: Ang-Tie system, together with VEGF,plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy. However, the VEGF system plays a more important role in the early phase of sinusoidal regeneration than angiopoietin/Tie system. | Hiroaki Shimizu Noboru Mitsuhashi Masayuki Ohtsuka Hiroshi Ito Fumio Kimura Satoshi Ambiru Akira Togawa Hiroyuki Yoshidome Atsushi Kato Masaru Miyazaki | 2005 | World Journal of Gastroenterology2005，11，46： | 17 |
| 3 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 4 | Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding显示文摘AIM: To investigate the early upper gastrointestinal endoscopy(endoscopy) significantly reduces mortality resulting from upper gastrointestinal(GI) bleeding. METHODS: Upper GI bleeding was defined as 1a, 1b, 2a, and 2b according to the Forrest classification. The hemoglobin(Hb), and C-reactive protein(CRP) were examined at around the day of endoscopy and 3 mo prior to endoscopy. The rate of change was calculated as follows:(the result of blood examination on the day of endoscopy- the results of blood examination 3 mo prior to endoscopy)/(results of blood examination 3 mo prior to endoscopy). Receiver operating characteristic curves were created to determine threshold values. RESULTS: Seventy-nine men and 77 women were enrolled. There were 17 patients with upper GI bleeding: 12 with a gastric ulcer, 3 with a duodenal ulcer, 1 with an acute gastric mucosal lesion, and 1 with gastric cancer. The area under the curve(AUC), threshold, sensitivity, and specificity of Hb around the day of endoscopy were 0.902, 11.7 g/dL, 94.1%, and 77.1%, respectively, while those of CRP were 0.722, 0.5 mg/dL, 70.5%, and 73%, respectively. The AUC, threshold, sensitivity, and specificity of the rate of change of Hb were 0.851,-21.3%, 76.4%, and 82.6%, respectively, while those of CRP were 0.901, 100%, 100%, and 82.5%, respectively. CONCLUSION: Predictors for upper GI bleeding were Hb < 11.7 g/dL, reduction rate in the Hb > 21.3% and an increase in the CRP > 100%, 3 mo before endoscopy. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Akira Togawa Yoshinori Shirai Noboru Ichiki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Makoto Sueishi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 5 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 6 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 7 | 车用柴油机未来展望显示文摘在全球,车辆作为载客和运货的作用将显得日益重要。以石油为燃料的往复式发动机将继续被需求作为未来最实用的车辆发动机。考虑到能源有限和CO_2排放使地球变暖的威胁日益加重,柴油机因其在所有发动机中热效率最高而变得更加重要。因此,柴油机技术必然是未来最重要的技术领域之一。文中概述了车用柴油机的性能、燃油经济性和排放的现状并讨论了在技术上进一步提高的可能性。在讨论的各种技术中,考察重点放在在燃烧过程中同时降低燃油耗和排放以及提高循环效率方面,制造了几台采用一系列新技术的轿车用直喷式柴油机样机并进行了试验,取得了非常低的燃油耗和排放。这些试验研究结果表明,柴油机具有进一步改进燃油经济性和排放的潜力,可以满足全世界社会的需求。 | Noboru Hikosaka 杜任方 | 1999 | 国外内燃机1999，31，4： | 9 |
| 8 | Outcomes of locally advanced prostate cancer:a single institution study of 209 patients in Japan显示文摘瞄准:为了与局部地先进 / 临床的阶段 III 为亚洲人口调查结果,前列腺癌症(PCa ) 与当前占优势的形式对待。方法:我们考察了在在 1992 和 2003 之间的 Niigata 癌症中心医院被对待的有临床的阶段 III PCa 的 209 个病人的记录。治疗选择包括了荷尔蒙联合治疗的激进的前列腺切除术(RP+HT ) ,荷尔蒙联合治疗的外部横梁照耀(EBRT+HT ) 和主要荷尔蒙治疗(PHT ) 。结果:5 年、 10 年的全面幸存率分别地在所有队是 80.3% 和 46.1% 。幸存率在 RP+HT 组,是 87.3% 和 66.5%94.9% 和 70.0% 在 EBRT+HT 组织, 66.1% 和 17.2% 分别地在 PHT 组织。重要幸存优点在 PHT 与那相比在 EBRT+HT 组被发现的 A 组织(P <
0.0001 ) 。另外, RP+HT 组织幸存最好比 PHT 组织(P = 0.0107 ) 。为所有情况的 5 年、 10 年的疾病特定的幸存率分别地是 92.5% 和 80.0% 。他们在 RP+HT 组,是 93.8% 和 71.4%96.6% 和 93.6% 在 EBRT+HT 组织, 88.6% 和 62.3% 分别地在 PHT 组织。一个幸存优点与 PHT 组相比在 EBRT+HT 组被发现(P = 0.029 ) 。没有有效差量在在 EBRT+HT 和 RP+HT 组之间或在 RP+HT 和 PHT 组之间的疾病特定的幸存被发现。结论:尽管我们的调查结果显示那放射疗法,正 HT 在 PCa 的这个阶段有一个幸存优点,我们推荐与临床的阶段 III PCa 为亚洲人考虑 patients'social 和医药条件的治疗。 | ToshihiroSaito YasuoKitamura ShuichiKomatsubara YasuoMatsumoto TadashiSugita Noboru Hara | 2006 | Asian Journal of Andrology2006，8，5： | 8 |
| 9 | Diagnostic utility of narrow-band imaging endoscopy for pharyngeal superfi cial carcinoma显示文摘AIM: To investigate the endoscopic features of pharyngeal superfi cial carcinoma and evaluate the utility of narrow-band imaging (NBI) for this disease. METHODS: In the present prospective study, 335 patients underwent conventional white light (CWL) en-doscopy and non-magnifi ed/magnifi ed NBI endoscopy, followed by an endoscopic biopsy, for 445 superfi cial lesions in the oropharynx and hypopharynx. The macroscopic appearance of superfi cial lesions was categorized as either elevated (< 5 mm in height), flat, or depressed (not ulcerous). Superficial carcinoma (SC) was defi ned as a superfi cial lesion showing high-grade dysplasia or squamous cell carcinoma on histology. The color, delineation, and macroscopic appearances of the lesions were evaluated by CWL endoscopy. The ratio of the brownish area/intervascular brownish epithelium (IBE), as well as microvascular proliferation, dilation, and irregularities, was determined by non-magnifi ed/ magnifi ed NBI endoscopy. An experienced pathologist who was unaware of the endoscopic fi ndings made the histological diagnoses. By comparing endoscopic fi ndings with histology, we determined the endoscopic features of SC and evaluated the diagnostic utility of NBI. RESULTS: The 445 lesions were divided histologically into two groups: a non-SC group, including non-neoplasia and low-grade dysplasia cases, and an SC group. Of the 445 lesions examined, 333 were classified as non-SC and 112 were classif ied as SC. There were no significant differences in age, gender, or the location of the lesions between the patients in the two groups. The mean diameter of the SC lesions was signif icantly greater than that of non-SC lesions (11.0 ± 7.6 mm vs 4.6 ± 3.6 mm, respectively, P < 0.001). Comparisons of CWL endoscopy fi ndings for SC and non-SC lesions by univariate analysis revealed that the incidence of redness (72% vs 41%, respectively, P < 0.001) and a flat or depressed type of lesion (58% vs 44%, respectively, P = 0.013) was significantly higher in the SC group. Using non-magnifi ed NBI endoscopy, the incidence of a brownish area was signifi cantly higher for SC lesions (79% vs 57%, respectively, P < 0.001). On magnifi ed NBI endoscopy, the incidence of IBE (68% vs 33%, P < 0.001) and microvascular proliferation (82% vs 51%, P < 0.001), dilation (90% vs 76%, P =0.002), and irregularity (82% vs 31%, P < 0.001) was also signifi cantly higher for the SC compared with the non-SC lesions. Multivariate analysis revealed that the incidence of redness (P = 0.022) on CWL endoscopy and IBE (P < 0.001) and microvascular irregularities (P < 0.001) on magnif ied NBI endoscopy was signif icantly higher in SC than non-SC lesions. Redness alone exhibited signifi cantly higher sensitivity and signifi cantly lower specifi city for the diagnosis of SC compared with redness plus IBE and microvascular irregularities (72% vs 52%, P = 0.002; and 59% vs 92%, P < 0.001, respectively). The accuracy of redness plus IBE and irregularities for the diagnosis of SC was signifi cantly greater than using redness alone (82% vs 62%, respectively, P < 0.001). CONCLUSION: Redness, IBE, and microvascular irregularities appear to be closely related to SC lesions. Magnifi ed NBI endoscopy may increase the diagnostic accuracy of CWL endoscopy for SC. | Noboru Yoshimura Kenichi Goda Hisao Tajiri Yukinaga Yoshida Takakuni Kato Yoichi Seino Masahiro Ikegami Mitsuyoshi Urashima | 2011 | World Journal of Gastroenterology2011，17，45： | 7 |
| 10 | Development and evaluation of a general-purpose electric off-road robot based on agricultural navigation显示文摘The aim of this study was to develop a general-purpose electric off-road robot vehicle by using automatic control technologies.The vehicle prototype used in this study was a commercially-purchased electricity utility vehicle that was designed originally for manual operations.A manipulating unit,an automatic steering system and a speed control system were developed and integrated into a CAN-bus network for operating on functions(forward,reverse,park or stop),realizing desired steering angles and maintaining a constant speed,respectively,in the mode of automation.An autonomous navigation system based on RTK-GPS and IMU was used to evaluate the performance of the newly developed off-road robot.Field tests showed that the maximum error in speed control was 0.29 m/s and 0.22 m/s for speed tests and autonomous runs,respectively.The lateral offset was less than 10 cm in terms of straight paths,indicating that the automatic steering control system was of good performance. | Yin Xiang Noboru Noguchi | 2014 | International Journal of Agricultural and Biological Engineering2014，7，5： | 6 |
| 11 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 12 | Development of autonomous navigation system for rice transplanter显示文摘Rice transplanting requires the operator to manipulate the rice transplanter in straight trajectories.Various markers are proposed to help experienced drivers in keeping straightforward and parallel to the previous path,which are extremely boring in terms of large-scale fields.The objective of this research was to develop an autonomous navigation system that automatically guided a rice transplanter working along predetermined paths in the field.The rice transplanter used in this research was commercially available and originally manually-operated.An automatic manipulating system was developed instead of manual functions including steering,stop,going forward and reverse.A sensor fusion algorithm was adopted to integrate measurements of the Real-Time Kinematic Global Navigation Satellite System(RTK-GNSS)and Inertial Measurement Unit(IMU),and calculate the absolute moving direction under the UTM coordinate system.A headland turning control method was proposed to ensure a robust turning process considering that the rice transplanter featured a small turning radius and a relatively large slip rate at extreme steering angles.Experiments were designed and conducted to verify the performance of the newly developed autonomous navigation system.Results showed that both lateral and heading errors were less than 8 cm and 3 degrees,respectively,in terms of following straight paths.And headland turns were robustly executed according to the required pattern. | Xiang Yin Juan Du Noboru Noguchi Tengxiang Yang Chengqian Jin | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 6 |
| 13 | SECI, Ba and Leadership: a Unified Model of Dynamic Knowledge Creation显示文摘 | Ikujiro Nonaka Ryoko Toyama Noboru Konno | 2000 | Long Range Planning2000，，1： | 5 |
| 14 | 混合导电体型氧透膜材料的研究显示文摘研究了具有氧离子导电性和电子导电性的钴系钙钛矿型复合氧化物混合导电体材料中氧的选择性透过能力,考察了该体系中 A 位低价金属离子置换量、置换金属离子的种类及 B 位置换金属离子的种类对氧的透过率的影响.结果表明:改变钙钛矿型复合氧化物的组成,提高材料中氧空位浓度和氧离子导电率,有利于提高氧离子的扩散速度,即提高氧的透过率和降低氧透过的起始温度.将钙钛矿型复合氧化物混合导电体氧透膜与固体电解质氧透膜进行了比较,前者具有结构简单的优点,有希望成为一种新型高温氧分离膜介质材料. | 张华民 Yasutake Teraoka Noboru Yamazoe | 1993 | 无机材料学报1993，8，4： | 5 |
| 15 | Development of uncut crop edge detection system based on laser rangefinder for combine harvesters显示文摘The objective of this research was to develop an uncut crop edge detection system for a combine harvester.A laser rangefinder(LF)was selected as a primary sensor,combined with a pan-tilt unit(PTU)and an inertial measurement unit(IMU).Three-dimensional field information can be obtained when the PTU rotates the laser rangefinder in the vertical plane.A field profile was modeled by analyzing range data.Otsu’s method was used to detect the crop edge position on each scanning profile,and the least squares method was applied to fit the uncut crop edge.Fundamental performance of the system was first evaluated under laboratory conditions.Then,validation experiments were conducted under both static and dynamic conditions in a wheat field during harvesting season.To verify the error of the detection system,the real position of the edge was measured by GPS for accuracy evaluation.The results showed an average lateral error of±12 cm,with a Root-Mean-Square Error(RMSE)of 3.01 cm for the static test,and an average lateral error of±25 cm,with an RMSE of 10.15 cm for the dynamic test.The proposed laser rangefinder-based uncut crop edge detection system exhibited a satisfactory performance for edge detection under different conditions in the field,and can provide reliable information for further study. | Zhao Teng Noboru Noguchi Yang Liangliang Kazunobu Ishii Chen Jun | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 5 |
| 16 | 向净化和高效柴油机提出的挑战显示文摘为了开发未来净化和高效的柴油机,目前的重要任务是改善经济性和进一步降低排放。叙述一台总排量为2L的涡轮增压轿车用柴油机有效地采用以下新技术;4气门;喷油器垂直布置于气缸中心;直喷式燃烧系统;高压喷油系统;优化匹配的涡轮增压器;冷却的废气再循环;计算机优化控制系统和氧化催化转换器。结果使发动机达到良好的经济性--燃油耗4.5L/100km,排放性能已经达到Euro3标准。 | Noboru,H 杨寿藏 | 1997 | 国外内燃机1997，29，5： | 4 |
| 17 | Retroperitoneal disorders associated with Ig G4-related autoimmune pancreatitis显示文摘Ig G4-related autoimmune pancreatitis is frequently accompanied by relevant lesions in the genitourinary tract and retroperitoneal organs, which cause various clinical problems, ranging from non-specific back pain or bladder outlet obstruction to renal failure. The diagnosis of Ig G4-related retroperitoneal fibrosis requires a multidisciplinary approach, including serological tests, histological examination, imaging analysis, and susceptibility to steroid therapy. Radiological examinations are helpful to diagnose this condition, but surgical resection is occasionally unavoidable to exclude malignancy, particularly for patients with isolated retroperitoneal involvement. Steroid therapy is the treatment of choice for this condition, the same as for other manifestationsof Ig G4-related disease.For patients with severe ureteral obstruction,additional ureteral stenting needs to be considered prior to steroid therapy to preserve the renal function.Some papers have suggested that Ig G4-related disease can affect male reproductive organs including the prostate and testis.Ig G4-related prostatitis usually causes lower urinary tract symptoms,such as dysuria and pollakisuria.Patients sometimes state that corticosteroids given for Ig G4-related disease at other sites relieve their lower urinary tract symptoms,which leads us to suspect prostatic involvement in this condition.Because of the limited number of publications available,further studies are warranted to better characterize Ig G4-related disease in male reproductive organs. | Noboru Hara Makoto Kawaguchi Keisuke Takeda Yoh Zen | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 18 | Development and evaluation of a low-cost precision seeding control system for a corn drill显示文摘Precision seeding requires that the corn drill drop seeds into the soil by a specific in-row spacing while its travelling speed fluctuates due to unevenness of the field ground.This paper presents a low-cost precision seeding control system for a conventional corn drill with mechanical metering devices of finger-pickup type.A median filtering method was implemented in the control system to process measurements from a rotary encoder in order to acquire stable values of the corn drill travelling speed.The metering unit was driven by an electric motor controlled by the metering ECU according to the actual travelling speed and the desired in-row spacing in real-time.A user interface was programmed to communicate with ECUs for configuring parameters and displaying operating information during working.The newly-developed precision seeding control system was first calibrated in terms of speed measurement and control for two ECUs.Experiments were conducted on a seeding test platform in the laboratory for evaluating its accuracy in dropping seeds by giving different in-row spacing under different travelling speeds of the conveyor sticky belt.Results showed that the average spacing error was less than 2 cm and the maximum RMS error was 0.78 cm for all spacing values including 25 cm,30 cm and 35 cm under the travelling speed of 1.0-8.0 km/h.These indicated that the low-cost precision seeding control system worked in a both accurate and stable way. | Xiang Yin Noboru Noguchi Tengxiang Yang Chengqian Jin | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 3 |
| 19 | 精细农业机械化作物生产计算机集成技术(英文)显示文摘介绍了一项适用于精细农业机械化的新技术计算机集成作物生产技术(CCP)。该技术融合信息采集、网络通讯、数据处理、过程决策、自动执行等功能,能有效地完成作物生产的精确机械化作业。计算机集成作物生产技术的3个主要功能是先根据需要实时采集传感数据,然后根据传感信息构建合理的行动决策,最后将传递上述决策并付诸实施。为了说明CCP的工作原理和结构设计,介绍了由伊利诺依大学机械电子系统实验室设计开发的CCP技术系统的关键功能。研究结果表明,在车辆自动导航,主从机械控制,在线式变量作业等利用农业机械实施田间作物生产作业的领域,有必要在农业机械上集成CCP技术,使机械自动地完成各项最优化项目作业。最后,根据以往工作中的经验,简要讨论了目前CPP技术发展所面临的问题和挑战。 | 何勇 张勤 Alan Hansen Noboru Noguchi Beom-soo Shin | 2006 | 农业工程学报2006，22，11： | 3 |
| 20 | Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas显示文摘AIM: To investigate the accuracy of endoscopic or biopsy diagnoses of superficial nonampullary duodenal epithelial tumors(NADETs).METHODS:Clinicopathological data were reviewed for84 superficial NADETs from 74 patients who underwent surgery or endoscopic resection between September2002 and August 2014 at a single prefectural cancer center.Superficial NADETs were defined as lesions confined to the mucosa or submucosa.Demographic and clinicopathological data were retrieved from charts,endoscopic and pathologic reports.Endoscopic reports included endoscopic diagnosis,location,gross type,diameter,color,and presence or absence of biopsy.Endoscopic diagnoses were made by an endoscopist in charge of the examination before biopsy specimens were obtained.Endoscopic images were obtained using routine,front-view,high-resolution video endoscopy,and chromoendoscopy with indigocarmine was performed for all lesions.Endoscopic images were reviewed by at least two endoscopists to assess endoscopic findings indicative of carcinoma.Preoperative diagnoses based on endoscopy and biopsy findings were compared with histological diagnoses of resected specimens.Sensitivity,specificity,and accuracy were assessed for endoscopic diagnosis and biopsy diagnosis.RESULTS:The majority(81%)of the lesions were located in the second portion of the duodenum.The median lesion diameter was 14.5 mm according to final histology.Surgery was performed for 49 lesions from 39 patients,and 35 lesions from 35 patients were endoscopically resected.Final histology confirmed 65carcinomas,15 adenomas,and 3 hyperplasias.A finaldiagnosis of duodenal carcinoma was made for 91%(52/57)of the lesions diagnosed as carcinoma by endoscopy and 93%(42/45)of the lesions diagnosed as carcinoma by biopsy.The sensitivity,specificity,and accuracy of endoscopic diagnoses were 80%,72%,and 78%,respectively,whereas those of biopsy diagnoses were 72%,80%,and 74%,respectively.Preoperative diagnoses of carcinomas were made in88%(57/65)of the carcinoma lesions via endoscopy or biopsy.Endoscopic findings associated with carcinoma were red color,depression,and mixed-type morphology.CONCLUSION:Preoperative endoscopy and biopsy showed similar accuracies in the diagnosis of carcinoma in patients with superficial NADETs. | Naomi Kakushima Hideyuki Kanemoto Keiko Sasaki Noboru Kawata Masaki Tanaka Kohei Takizawa Kenichiro Imai Kinichi Hotta Hiroyuki Matsubayashi Hiroyuki Ono | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
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