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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 3 | The Flavivirus Protease As a Target for Drug Discovery显示文摘Many flaviviruses are significant human pathogens causing considerable disease burdens,including encephalitis and hemorrhagic fever,in the regions in which they are endemic.A paucity of treatments for flaviviral infections has driven interest in drug development targeting proteins essential to flavivirus replication,such as the viral protease.During viral replication,the flavivirus genome is translated as a single polyprotein precursor,which must be cleaved into individual proteins by a complex of the viral protease,NS3,and its cofactor,NS2B.Because this cleavage is an obligate step of the viral life-cycle,the flavivirus protease is an attractive target for antiviral drug development.In this review,we will survey recent drug development studies targeting the NS3 active site,as well as studies targeting an NS2B/NS3interaction site determined from flavivirus protease crystal structures. | Matthew Brecher Jing Zhang Hongmin Li | 2013 | Virologica Sinica2013，28，6： | 3 |
| 4 | Characterization and amino acid sequence of a fatty acid-binding protein from human heart显示文摘 | Offner GD Brecher P Sawlivich WB | 1988 | Biochem J1988，252，1： | 1 |
| 5 | Infrared Spectroscopy of LuAlO3:Ce a Useful Tool to Determine Ce Concentration显示文摘 | Zych E Brecher C Lempicki A | 1998 | Spectro Acta A1998，54，11： | 1 |
| 6 | Machine tool spindle units 显示文摘 | Abele E Altintas Y Brecher C | 2010 | CIRP Annals-Manufacturing Technology2010，59，2： | 1 |
| 7 | Desmoplastic small round cell tumor in the abdomen and pelvis: report of CT findings in 11 aftected children and young adults显示文摘 | Bellah R Suzuki-Bordalo L Brecher E | 2005 | AJR2005，184，6： | 1 |
| 8 | Compact design for high precision machine tools 显示文摘 | BRECHER C UTSCH P KLAR R | 2010 | International Journal of Machine Tools & Manufacture2010，50，4： | 1 |
| 9 | Transmission lossers in aprotic liquid lasers显示文摘 | Brecher C French K | 1970 | J Appl Phys1970，41，： | 1 |
| 10 | Transfusion medicine:looking to the future显示文摘 | Goodnough LT Shander A Brecher ME | 2003 | Lancet2003，361，9352： | 1 |
| 11 | Development of a dermal cancer slope factor for benzopyrene显示文摘 | Knafla A Phillipps K A Brecher R W | 2006 | Regul Toxicol Pharmacol2006，45，2： | 1 |
| 12 | Virtual Machine Tool显示文摘 | Altintas Y Brecher C Weck M | 2005 | CIRP Annals-Manufacturing Technology2005，54，2： | 1 |
| 13 | Angiomyolipoma with regional lymph node involvement and long-term follow-up study显示文摘 | Brecher ME Cill WB Straus FH | 1986 | Hum Pathol1986，17，3： | 1 |
| 14 | Machine tool spindle units显示文摘 | ABELEE ALTINTAS Y BRECHER C | 2010 | CIRP Annals-Manufacturing Technology2010，59，2： | 1 |
| 15 | Limits for controller settings with electric linear direct drives显示文摘 | WECK M KRUGER P BRECHER C | 2001 | International Journal of Machine Tools & Manufacture2001，41，1： | 1 |
| 16 | Temperature dependence of host-associated luminescence from YAG transparent ceramic material显示文摘 | E Zych C Brecher | 2000 | Journal of Luminescence2000，，3： | 1 |
| 17 | Carotenoids of com and sorghum V显示文摘 | C W B lessin J D Brecher R J Dimler | | 0，，40： | 1 |
| 18 | Multicenter survey and retrospectiveanalysis of current efficacy of therapeutic plasma exchange显示文摘 | Bandarenko N Brecher M E | | 0，，： | 1 |
| 19 | Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme显示文摘 | White J M Delos S E Brecher M | 2008 | Crit Rev Biochem Mol Biol2008，43，3： | 1 |
| 20 | The importance of long axis ventricular fun-ction 显示文摘 | Brecher S J Stephen J D | 2000 | Heart2000，8，4： | 1 |
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