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| 1 | Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss显示文摘Diabetic retinopathy(DR) is one of the most common retinal diseases world-wide. It has a complex pathology that involves the vasculature of the inner retina and breakdown of the blood-retinal barrier. Extensive research has determined that DR is not only a vascular disease but also has a neurodegenerative component and that essentially all types of cells in the retina are affected, leading to chronic loss of visual function. A great deal of work using animal models of DR has established the loss of neurons and pathology of other cell types, including supporting glial cells. There has also been an increased emphasis on measuring retinal function in the models, as well as further validation and extension of the animal studies by clinical and translational research. This article will attempt to summarize the more recent developments in research towards understanding the complexities of retinal neurodegeneration and functional vision loss in DR. | BARBER Alistair J. | 2015 | Science China(Life Sciences)2015，58，6： | 19 |
| 2 | Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome显示文摘AIM: To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome (HPS).METHODS: Seven patients, three of them with advanced HPS, in whom detailed pulmonary function tests were performed before and after TIPS placementat the University of Alabama Hospital and at the Hospital Clinic, Barcelona, were considered.RESULTS: TIPS patency was confirmed by hemodynamic evaluation. No changes in arterial blood gases were observed in the overall subset of patients. Transient arterial oxygenation improvement was observed in only one HPS patient, early after TIPS, but this was not sustained 4 mo later.CONCLUSION: TIPS neither improved nor worsened pulmonary gas exchange in patients with portal hypertension. This data does not support the use of TIPS as a specific treatment for HPS. However, it does reinforce the view that TIPS can be safely performed for the treatment of other complications of portal hypertension in patients with HPS. | Graciela Martínez-Pallí Britt B Drake Joan-Carles García-Pagán Joan-Albert Barberà Miguel R Arguedas Robert Rodriguez-Roisin Jaume Bosch Michael B Fallon | 2005 | World Journal of Gastroenterology2005，11，43： | 11 |
| 3 | Astaxanthin Accumulation in the Green Alga Haematococcus pluvialis: Effects of Cultivation Parameters显示文摘绿水藻, Haematococcus 雨在鱼水产业为申请被用作 theketocarotenoid astaxanthin 的来源,药品、化妆的工业。绿水藻的房间被不同的光的申请导致,在 astaxanthin 评估效果的饥饿条件积累。为正式就职使用的条件高光强(170 微摩尔 m-2 s-1 ) ,铁饥饿,硫饥饿和磷酸盐饥饿。在文化使用的压力,防碍细胞分裂,触发 astaxanthin 的累积。尤其是,硫饥饿导致这商业地重要的类胡萝卜素的巨大的累积…… | Ping He James Duncan James Barber | 2007 | Journal of Integrative Plant Biology2007，49，4： | 10 |
| 4 | Record Low Sea-Ice Concentration in the Central Arctic during Summer 2010显示文摘The Arctic sea-ice extent has shown a declining trend over the past 30 years. Ice coverage reached historic minima in 2007 and again in 2012. This trend has recently been assessed to be unique over at least the last 1450 years. In the summer of 2010, a very low sea-ice concentration(SIC) appeared at high Arctic latitudes—even lower than that of surrounding pack ice at lower latitudes. This striking low ice concentration—referred to here as a record low ice concentration in the central Arctic(CARLIC)—is unique in our analysis period of 2003–15, and has not been previously reported in the literature. The CARLIC was not the result of ice melt, because sea ice was still quite thick based on in-situ ice thickness measurements.Instead, divergent ice drift appears to have been responsible for the CARLIC. A high correlation between SIC and wind stress curl suggests that the sea ice drift during the summer of 2010 responded strongly to the regional wind forcing. The drift trajectories of ice buoys exhibited a transpolar drift in the Atlantic sector and an eastward drift in the Pacific sector,which appeared to benefit the CARLIC in 2010. Under these conditions, more solar energy can penetrate into the open water,increasing melt through increased heat flux to the ocean. We speculate that this divergence of sea ice could occur more often in the coming decades, and impact on hemispheric SIC and feed back to the climate. | JinpingZHAO David BARBER Shugang ZHANG Qinghua YANG Xiaoyu WANG Hongjie XIE | 2018 | Advances in Atmospheric Sciences2018，35，1： | 7 |
| 5 | Sustained low diffusing capacity in hepatopulmonary syndrome after liver transplantation显示文摘AIM: To study the presence of sustained low diffusing capacity (DLCO) after liver transplantation (LT) in patients with hepatopulmonary syndrome (HPS).METHODS: Six patients with mild-to-severe HPS and 24 without HPS who underwent LT were prospectively followed before and after LT at mid-term (median, 15 mo). HPS patients were also assessed at long-tem (median, 86 mo).RESULTS: Before LT, HPS patients showed lower PaO2 (71 ± 8 mmHg), higher AaPO2 (43 ± 10 mmHg) and lower DLCO (54% ± 9% predicted), due to a combination of moderate-to-severe ventilation-perfusion (VA/Q) imbalance, mild shunt and diffusion limitation, than non-HPS patients (94 ± 4 mmHg and 19 ± 3 mmHg, and 85% ± 3% predicted, respectively) (P < 0.05 each). Seven non-HPS patients had also reduced DLCO (70% ± 4% predicted).At mid- and long-term after LT, compared to pre-LT, HPS patients normalized PaO2 (91 ± 3 mmHg and 87 ± 5 mmHg), AaPO2 (14 ± 3 mmHg and 23 ± 5 mmHg) and all VA/Q descriptors (P < 0.05 each) without changes in DLCO (53% ± 8% and 56% ± 7% predicted, respectively). Post-LT DLCO in non-HPS patients with pre-LT low DLCO was unchanged (75% ± 6% predicted).CONCLUSION: While complete VA/Q resolution in HPS indicates a reversible functional disturbance, sustained low DLCO after LT also present in some non-HPS patients, points to persistence of sub-clinical liver-induced pulmonary vascular changes. | Graciela Martínez-Pallí Federico P Gómez Joan A Barberà Miquel Navasa Josep Roca Robert Rodríguez-Roisin Felip Burgos Conchi Gistau | 2006 | World Journal of Gastroenterology2006，12，36： | 6 |
| 6 | 中国基本药物改革:为实现最佳健康产出的选择显示文摘2009年4月,中国政府发布了《关于深化医药卫生体制改革的意见》,提出到2020年实现全民享有基本医疗卫生服务的目标。改革的重点任务之一是建立基本药物制度。在全球范围内,基本药物这一概念自1975年首次被世界卫生大会提出以来,一直具有非常重要的意义。这一概念最初强调药物的可及性和基本药物目录。但随时间推移,这一概念的内涵逐渐演变。现在各国引入基本药物概念,主要是为了确保药物可及性与可支付性、合理用药以及药物的质量和安全性。瑞典、挪威以及经合组织国家的经验表明,基本药物的概念可灵活适用于多种情形。在中国,基本药物制度的改革已取得良好成果,在非常短的时间内使公众更多获益,继续贯彻基本药物制度将有利于在中国实现最佳健康产出。 | Saral L Barber 黄宝斌 Budiono Santoso Richard Laing | 2012 | 中国卫生政策研究2012，5，7： | 3 |
| 7 | Response of grease film at low speeds under pure rolling reciprocating motion显示文摘Using an optical interferometric technique,the grease film distribution under a pure rolling reciprocating motion is observed on a ball‐disk test rig,to explore the transient response of grease,which is expected to fill the contact with thickener fiber and run for a long time under steady‐state conditions.It is found that the reciprocating motion reduces the accumulation of the thickener fiber gradually with time.The maximum film thickness forms around the stroke ends.After 1,000 working cycles,very severe starvation occurs so that either the central or minimum film thickness becomes nearly constant over one working period.Thus,the life of grease lubrication under a transient condition is far below that under steady‐state conditions.However,it is also found that by selecting a smaller stroke length,the thickener fiber spreads out in the contact instead of being removed from the contact at the 1,000th working period.When increasing the maximum entraining speed of the reciprocating motion to a certain value,during which the thickener fiber is not expected to accumulate under a steady‐state condition,severe starvation occurs very quickly,causing surface damage. | Yiming HAN Jing WANG Shanshan WANG Qian ZOU Gary BARBER | 2020 | Friction2020，8，1： | 3 |
| 8 | 热带西太平洋海洋事件与初级生产力的关系显示文摘本文依据“中、美热带西太平洋联合调查研究”资料,分析了正常年份,El Ni(?)o及La-Nina事件热带西太平洋165°E断面(10°N~6°S)的初级生产力。结果发现,El Ni(?)o及La-Nina期间热带西太平洋165°E断面的海洋初级生产力较正常年份分别增加50%和70%左右。 | 王桂云 R. T. Barber | 1991 | 黄渤海海洋1991，9，3： | 2 |
| 9 | A calcineurin homologous protein inhibits GTPasestimulated Na-H exchange 显示文摘 | Lin X Barber DL | 1996 | Pro Natl Acad Sci USA1996，93，12： | 2 |
| 10 | 当代英语的变化显示文摘本世纪内,英语似乎已进入一个重大的变化时期。一个鼓舞人心的特点是,过去几个世纪里英语发生明显的分离趋向似乎有所缓滞,或甚至发生相反的变化。随着十七世纪以来英语在世界上传播开来,不可避免地出现了许多变体,这些变体主要出现在北美洲、澳大利亚等地。但是,新交通工具的出现和交际的日益频繁,以及大规模的宣传工具的普遍使用,使英语的不同地区变体互相影响,从而缩小它们之间的差别。当前在说英语的国家和地区。 | Charles Barber 王宁 | 1981 | 当代语言学1981，，2： | 2 |
| 11 | The use of the anaerobic baffled reactor (ABR) for wastewater treatment: a review显示文摘 | William P. Barber David C. Stuckey | 1999 | Water Research1999，，7： | 2 |
| 12 | HITEMP, the high-temperature molecular spectroscopic database显示文摘 | L.S. Rothman I.E. Gordon R.J. Barber H. Dothe R.R. Gamache A. Goldman V.I. Perevalov S.A. Tashkun J. Tennyson | 2010 | Journal of Quantitative Spectroscopy and Radiative Transfer2010，，15： | 2 |
| 13 | Diabetic Retinopathy显示文摘 | Thomas W Gardner David A Antonetti Alistair J Barber Kathryn F LaNoue Steven W Levison | 2002 | Survey of Ophthalmology2002，，： | 2 |
| 14 | Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease显示文摘 | Alevtina Gall Piper Treuting Keith B. Elkon Yueh-Ming Loo Michael Gale Glen N. Barber Daniel B. Stetson | 2012 | Immunity2012，，1： | 2 |
| 15 | Microsatellite instability in human solid tumors显示文摘 | Arzimanoglou I Gilbert F Barber HRK | | 0，，： | 2 |
| 16 | 赤道太平洋初级生产力对El Nio事件响应的综合分析显示文摘本文依据热带海洋全球大气研究(TOGA),东太平洋海洋环流研究(EPOCS)、西赤道太平洋海洋环流研究(WEPOCS)、表层热带太平洋观测(SURTROPAC)以及太平洋区域观察)PROPPAC)等计划,对1980~1990年期间在赤道太平洋(141.5°E~85°W,10°N~10°S)所调查的生物化学资料进行了分析和比较。所得结果是:东赤道太平洋正常年份初级生产力为500~800mg/(m^2·d),El Ni(?)o期间约为150mg/(m^2·d);西赤道太平洋正常年份初级生产力为200~250rag/(m^2·d),El Ni(?)o期间约为300mg/(m^2·d)。研究结论是:El Ni(?)o期间东赤道太平洋初级生产力较正常年份显著降低,西赤道太平洋初级生产力较正常年份明显增加,生物响应均较显著。 | 王桂云 Barber R. T. | 1991 | 黄渤海海洋1991，9，2： | 2 |
| 17 | Effect of lycopene on androgen receptor and prostate-specific antigen velocity显示文摘背景在前列腺 cancer.This 学习的发展和行为在饮食的因素的角色正在增加兴趣被执行在 DNA 上评估饮食的因素 lycopene 的影响合成,在前列腺 LnCaP 房间并且到我们在一个 year.Methods LnCaP 房间上在前列腺特定的抗原速度上调查它的效果的飞行员阶段学习被成长与或没有 lycopene o 的不同集中的报告的雄激素受体基因元素的活动和表示然而,这不是统计上重要的(P=0.18 ) 作为一种抗氧化剂,饮食的因素能显著地禁止的 .Conclusions Lycopene 在一个剂量依赖者模式的 DNA 合成;结果表明 lycopene 可能禁止雄激素受体基因元素活动, expression.Dietary lycopene 可以在前列腺癌症房间增长起一个重要作用并且进一步在恶意的前列腺疾病支持大使随机化的研究进 lycopene 补充的角色。 | ZHANG Xin WANG Qi Barber Neil CHEN Xiao | 2010 | Chinese Medical Journal2010，，16： | 2 |
| 18 | 重度盆腔脏器脱垂治疗的妇女体型及生活质量显示文摘Objective: Women who seek treatment for pelvic organ prolapse strive for an improvement in quality of life. Body image has been shown to be an important component of differences in quality of life. To date, there are no data on body image in patients with advanced pelvic organ prolapse. Our objective was to compare body image and quality of life in women with advanced pelvic organ prolapse with normal controls. Studydesign: We used a case-control study design. Cases were defined as subjects who presented to a tertiary urogynecology clinic with advanced pelvic organ prolapse (stage 3 or 4). Controls were defined as subjects who presented to a tertiary care gynecology or women s health clinic for an annual visit with normal pelvic floor support (stage 0 or 1) and without urinary incontinence. All patients completed a valid and reliable bodyimage scale and a generalized (Short Form Health Survey) and condition-specific (Pelvic Floor Distress Inventory- 20) quality- of- life scale. Linear and logistic regression analyses were performed to adjust for possible confounding variables. Results:Forty-seven case and 51 control subjects were enrolled.After controlling for age, race, parity, previous hysterectomy,and medical comorbidities, subjects with advanced pelvic organ prolapse were more likely to feel self-conscious (adjusted oddsratio 4.7; 95% confidence interval 1.4 to 18, P = .02), less likely to feel physically attractive (adjusted odds ratio 11; 95% confidence interval 2.9 to 51, P < .001), less likely to feel feminine(adjusted odds ratio 4.0; 95% confidence interval 1.2 to 15, P = .03), and less likely to feel sexually attractive (adjusted odds ratio 4.6; 95% confidence interval 1.4 to 17, P = .02) than normal controls. The groups were similar in their feeling of dissatisfaction with appearance when dressed, difficulty looking at themselves naked, avoiding people because of appearance, and overall dissatisfaction with their body. Subjects with advanced pelvic organ prolapse suffered significantly lower quality of life on the physical scale of the SF- 12 (mean 42; 95% confidence interval 39 to 45 versus mean 50; 95% confidence interval 47 to 53, P < .009). However, no differences between groups were noted on the mental scale of the SF- 12 (mean 51; 95% confidence interval 50 to 54 versus mean 50; 95% confidence interva l47 to 52, P = .56). Additionally, subjects with advanced pelvic organ prolapse scored significantly worse on the prolapse, urinary,and colorectal scales and overall summary score of Pelvic Floor Distress Inventory- 20 than normal controls (mean summary score 104; 95% confidence interval 90 to 118 versus mean 29; 95% confidence interval 16 to 43, P < .0001), indicating a decrease in condition-specific quality of life. Worsening body image correlated with lower quality of life on both the physical and mental scales of the SF- 12 as well as the prolapse, urinary,and colorectal scales and overall summary score of Pelvic Floor Distress Inventory- 20 in subjects with advanced pelvic organ prolapse. Conclusion: Women seeking treatment for advanced pelvic organ prolapse have decreased body image and overall quality of life. Body image may be a key determinant for quality of life in patients with advanced prolapse and may be an important outcome measure for treatment evaluation in clinical trials. | Jelovsek J.E. Barber M.D. 柳蕴 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，9： | 1 |
| 19 | Lateralization of motor imagery following stroke 显示文摘 | Stinear CM Fleming MK Barber PA | 2007 | Clinical Neurophysiology2007，118，8： | 1 |
| 20 | Incorporating a priori anatomical information into image reconstruction in electrical impedance tomography 显示文摘 | DEHGHANI H BARBER D C BASARAB-HORWATH I | 1999 | Physiol Meas1999，20，： | 1 |
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