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| 1 | Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan显示文摘AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral load.METHODS:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled.Sustained virological response(SVR) and clinical parameters were evaluated.RESULTS:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved SVR.Early virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,respectively.The clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P < 0.0001),adherence to peg-IFN(≥ 80% of planned dose) at week 12(48.1% vs 13.6%,P = 0.00036),adherence to peg-IFN at week 48(54.7% vs 16.2%,P < 0.0001) and adherence to RBV at week 48(56.1% vs 32.1%,P = 0.0102) were determined using univariate analysis,and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis.In the older patient group(> 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR.CONCLUSION:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
| 2 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 3 | Low temperature friction stir welding of P91 steel显示文摘Bead-on-plate friction stir welds were made on P91 alloy with low and high rotational speeds(100 and 1000 RPM) to study their effects on weld microstructural changes and impression creep behavior. Temperatures experienced by the stir zone were recorded at the weld tool tip. Different zones of welds were characterized for their microstructural changes, hardness and creep behavior(by impression creep tests). The results were compared with submerged arc fusion weld. Studies revealed that the stir zone temperature with 100 RPM was well below A_(c1) temperature of P91 steel while it was above A_(c3) with 1000 RPM. The results suggest that the microstructural degradation in P91 welds can be controlled by low temperature friction stir welding technique. | Prasad Rao KALVALA Javed AKRAM Mano MISRA Damodaram RAMACHANDRAN Janaki Ram GABBITA | 2016 | Defence Technology(防务技术)2016，12，4： | 4 |
| 4 | Consequences on the Urban Environment in Greece Related to the Recent Intense Earthquake Activity显示文摘 | George C. Manos | 2011 | Journal of Civil Engineering and Architecture2011，5，12： | 3 |
| 5 | Response of a 2-story test-bed structure for the seismic evaluation of nonstructural systems显示文摘A full-scale,two-story,two-by-one bay,steel braced-frame was subjected to a number of unidirectional ground motions using three shake tables at the UNR-NEES site.The test-bed frame was designed to study the seismic performance of nonstructural systems including steel-framed gypsum partition walls,suspended ceilings and fire sprinkler systems.The frame can be configured to perform as an elastic or inelastic system to generate large floor accelerations or large inter story drift,respectively.In this study,the dynamic performance of the linear and nonlinear test-beds was comprehensively studied.The seismic performance of nonstructural systems installed in the linear and nonlinear test-beds were assessed during extreme excitations.In addition,the dynamic interactions of the test-bed and installed nonstructural systems are investigated. | Siavash Soroushian E. “Manos” Maragakis Arash E. Zaghi Esmaeel Rahmanishamsi Ahmad M. Itani Gokhan Pekcan | 2016 | Earthquake Engineering and Engineering Vibration2016，15，1： | 3 |
| 6 | Predictors of Extrahepatic Recurrence After Curative Hepatectomy for Hepatocellular Carcinoma显示文摘 | Akinobu Taketomi Takeo Toshima Dai Kitagawa Takashi Motomura Kazuki Takeishi Yohei Mano Hiroto Kayashima Keishi Sugimachi Shinichi Aishima Yoichi Yamashita Toru Ikegami Tomonobu Gion Hideaki Uchiyama Yuji Soejima Takashi Maeda Ken Shirabe Yoshihiko Maehar | 2010 | Annals of Surgical Oncology2010，，10： | 2 |
| 7 | The Peculiar Existence of Protein-Bound Unconjugated Bile Acid in the Cytoplasmic Fraction of Rat Brain显示文摘 | MANO Nariyasu GOTO Takaaki GOTO Junichi | 2004 | 色谱2004，22，4： | 2 |
| 8 | Preoperative Neutrophil-to-Lymphocyte Ratio Is a Predictor of Survival After Hepatectomy for Hepatocellular Carcinoma: A Retrospective Analysis显示文摘 | Yohei Mano Ken Shirabe Yo-ichi Yamashita Norifumi Harimoto Eiji Tsujita Kazuki Takeishi Shinichi Aishima Toru Ikegami Tomoharu Yoshizumi Takeharu Yamanaka Yoshihiko Maehara | 2013 | Annals of Surgery2013，，2： | 2 |
| 9 | Tumor-Associated Macrophage Promotes Tumor Progression via STAT3 Signaling in Hepatocellular Carcinoma显示文摘 | Mano Yohei Aishima Shinichi Fujita Nobuhiro Tanaka Yuki Kubo Yuichiro Motomura Takashi Taketomi Akinobu Shirabe Ken Maehara Yoshihiko Oda Yoshinao | 2013 | Pathobiology2013，，3： | 2 |
| 10 | Role of tumor-associated macrophages in the progression of hepatocellular carcinoma显示文摘 | Ken Shirabe Yohei Mano Jun Muto Rumi Matono Takashi Motomura Takeo Toshima Kazuki Takeishi Hidekaki Uchiyama Tomoharu Yoshizumi Akinobu Taketomi Masaru Morita Shunichi Tsujitani Yoshihisa Sakaguchi Yoshihiko Maehara | 2012 | Surgery Today2012，，1： | 2 |
| 11 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 12 | Biomicrofibrilar composites of high density polyethylene reinforced with curauá fibers: Mechanical, interfacial and morphological properties显示文摘 | J.R. Araujo B. Mano G.M. Teixeira M.A.S. Spinacé Marco-A. De Paoli | 2010 | Composites Science and Technology2010，，11： | 2 |
| 13 | Electrohydraulic lithotripsy and rendezvous nasal endoscopic cholangiography for common bile duct stone: A case report显示文摘BACKGROUND In patients with large stones in the common bile duct(CBD),advanced treatment modalities are generally needed.Here,we present an interesting case of a huge CBD stone treated with electrohydraulic lithotripsy(EHL)by the percutaneous approach and rendezvous endoscopic retrograde cholangiography(ERC)using a nasal endoscope.CASE SUMMARY A 91-year-old woman underwent ERC for a symptomatic large CBD stone with a diameter of 50 mm.She was referred to our institution after the failure of lithotomy by ERC,and after undergoing percutaneous transhepatic biliary drainage.We attempted to fragment the stone by transhepatic cholangioscopy using EHL.However,the stones were too large and partly soft clay-like for lithotripsy.Next,we attempted lithotomy with ERC and cholangioscopy by the rendezvous technique using a nasal endoscope and achieved complete lithotomy.No complication was observed at the end of this procedure.CONCLUSION Cholangioscopy by rendezvous technique using a nasal endoscope is a feasible and safe endoscopic method for removing huge CBD stones. | Koichi Kimura Kensuke Kudo Tomoharu Yoshizumi Takeshi Kurihara Shohei Yoshiya Yohei Mano Kazuki Takeishi Shinji Itoh Noboru Harada Toru Ikegami Tetsuo Ikeda | 2019 | World Journal of Clinical Cases2019，7，10： | 2 |
| 14 | Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase显示文摘 | MANO H OHYA K MIYAZATO A | 1998 | Genes Cells1998，3，7： | 1 |
| 15 | Self-Assembly of concentric quantum double rings显示文摘 | TAKAAKI Mano TAKASHI Kuroda STEFANO Sanguinetti | 2005 | Nano letters2005，5，3： | 1 |
| 16 | DNA micro-array analysis ofmyelodysplastic syndrome 显示文摘 | Mano H | 2006 | Leuk Lymphoma2006，47，1： | 1 |
| 17 | Human papillomavirus is a necessary cause of invasive cervical cancer worldwide 显示文摘 | Walboomers JM Jacobs MV Manos MM | 1999 | J Pathol1999，189，1： | 1 |
| 18 | Primary prevention:Why focus on children&young adolescents显示文摘 | MANO S SELVAN ANURA V KURPAD | 2004 | Indian J MedRes2004，120，6： | 1 |
| 19 | A miniature biofuel cell operating in a physiological buffer 显示文摘 | MANO N MAO F HELLER A | 2002 | Journal of the American Chemica Society2002，124，12： | 1 |
| 20 | nventory partial selling quantity model of ameliorating items with linear price dependent demand 显示文摘 | MANDAL BISWAJIT KUMAR BHUNIA ASOKE MAITI MANO RAN JAN | 2005 | Advanced Modeling and Optimization2005，7，1： | 1 |
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