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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension: A Scientific Statement From the American Heart Association显示文摘 | Michael R. Jaff M. Sean McMurtry Stephen L. Archer Mary Cushman Neil Goldenberg Samuel Z. Goldhaber J. Stephen Jenkins Jeffrey A. Kline Andrew D. Michaels Patricia Thistlethwaite Suresh Vedantham R. James White Brenda K. Zierler | 2011 | Circulation2011，，16： | 3 |
| 3 | Facile In Situ Fabrication of Nanostructured Graphene–CuO Hybrid with Hydrogen Sulfide Removal Capacity显示文摘A simple and scalable synthetic approach for one-step synthesis of graphene–Cu O(TRGC) nanocomposite by an in situ thermo-annealing method has been developed.Using graphene oxide(GO) and copper hydroxide as a precursors reagent,the reduction of GO and the uniform deposition of in situ formed Cu O nanoparticles on graphene was simultaneously achieved.The method employed no solvents,toxic-reducing agents,or organic modifiers.The resulting nanostructured hybrid exhibited improved H2 S sorption capacity of 1.5 mmol H2S/g-sorbent(3 g S/100 g-sorbent).Due to its highly dispersed sub-20 nm Cu O nanoparticles and large specific surface area,TRGC nanocomposite exhibits tremendous potential for energy and environment applications. | Sunil P.Lonkar Vishnu V.Pillai Samuel Stephen Ahmed Abdala Vikas Mittal | 2016 | Nano-Micro Letters2016，8，4： | 2 |
| 4 | 笼目超导体CsV_(3)Sb_(5)中的拓扑表面态和平带的光电子谱证据显示文摘具有多种电子序和丰富物态的量子材料中往往蕴含着奇异的量子现象.不同电子序和量子态之间的相互作用也可以产生新的物理现象.本文揭示了笼目超导体CsV_(3)Sb_(5)的独特电子结构.作者在费米能附近发现了拓扑非平庸的表面态,这意味着拓扑物理很可能会参与到超导态中;同时还直接观测到了平带,这表明电子关联作用会在笼目超导体CsV_(3)Sb_(5)中起着重要的作用.这些结果表明笼目晶格CsV_(3)Sb_(5)不仅具有实现马约拉纳零模和奇异超导态的潜力,还是一个独特的可用于探索电荷密度波有序、拓扑量子态、强关联效应和超导性之间的相互作用的研究平台. | 胡勇 Samuel M.L.Teicher Brenden R.Ortiz 罗洋 彭舒婷 淮琳崴 马均章 Nicholas CPlumb Stephen D.Wilson 何俊峰 史明 | 2022 | Science Bulletin2022，67，5： | 2 |
| 5 | Soil Hydraulic Properties: Influence of Tillage and Cover Crops显示文摘Understanding the effects of cover crops and tillage on soil physical properties is important for determining soil productivity. This study was conducted at Lincoln University's Freeman Center, USA to evaluate the effects of tillage and cover crop management on soil hydraulic properties. The field site included three replicate blocks in a randomized complete block design with each plot measuring 21.3 m in length and 12.2 m in width. Treatment factors were tillage at two levels(moldboard plow tillage vs. no tillage) and cover crop at two levels(cereal rye(Secale cereal) cover crop vs. no cover crop). Soil samples were collected in late spring/early summer from each treatment at 10-cm depth increments from the soil surface to a depth of 40 cm using cores(76.2-mm diameter and 76.2-mm length). Soil bulk density was 13% lower with tillage compared with no-tillage. Volumetric water content was significantly higher at 0.0 and -0.4 k Pa pressures with tillage compared with no tillage. Tillage increased the proportion of coarse mesopores by 32% compared with no tillage, resulting in 87% higher saturated hydraulic conductivity(K_(sat)). Cover crop increased the proportion of macropores by 24% compared with no cover crop; this can potentially increase water infiltration and reduce runoff. As a result of higher macroporosity, Ksat was higher under cover crop compared with no cover crop. This study demonstrated that tillage can benefit soil hydraulic properties in the short term, but these effects may not persist over time. Cover crops may slightly improve soil hydraulic properties, but longer term studies are needed to evaluate the long-term effects. | Samuel I. HARUNA Stephen H. ANDERSON Nsalambi V. NKONGOLO Syaharudin ZAIBON | 2018 | Pedosphere2018，28，3： | 2 |
| 6 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 7 | Fibrolamellar Carcinoma: A Review with Focus on Genetics and Comparison to Other Malignant Primary Liver Tumors显示文摘 | Stephen Ward Samuel Waxman | 2011 | Semin Liver Dis2011，，01： | 1 |
| 8 | Critical dialogues with self: developing teacher identities and roles — a case study of South African student teachers显示文摘 | Michael Samuel David Stephens | 2000 | International Journal of Educational Research2000，，5： | 1 |
| 9 | When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii显示文摘 | Talima Pearson Heidie M. Hornstra Jason W. Sahl Sarah Schaack James M. Schupp Stephen M. Beckstrom-Sternberg Matthew W. O’Neill Rachael A. Priestley Mia D. Champion James S. Beckstrom-Sternberg Gilbert J. Kersh James E. Samuel Robert F. Massung Paul Keim | 2013 | Systematic Biology2013，，5： | 1 |
| 10 | Syntheses and structures of bismuth(Ⅲ)complexes with nitrilotriacetic acid,ethylenediaminetetraacetic acid,and diethylenetriaminepentaacetic acid显示文摘 | Stephen P Summers Khalil A Abboud Samuel R Farrah | 1994 | Inorg Chem1994，33，： | 1 |
| 11 | To-ward a Theory of Teacher Community显示文摘 | Pamela Grossman Samuel Wineburg Stephen Woolworth | 2001 | Teachers College Re-cord2001，，6： | 1 |
| 12 | Portal Vein Thrombosis: Should Anticoagulation Be Used?显示文摘 | Stephen E. Congly Samuel S. Lee | 2013 | Current Gastroenterology Reports2013，，2： | 1 |
| 13 | The Effect of Cell Phone Type on Drivers Subjective Workload during Concurrent Driving and Conversing 显示文摘 | Roland Matthews Stephen Legg Samuel Charhon | 2003 | Accident Analysis and Prevention2003，35，5： | 1 |
| 14 | MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a显示文摘 | Sara Toffanin Yujin Hoshida Anja Lachenmayer Augusto Villanueva Laia Cabellos Beatriz Minguez Radoslav Savic Stephen C. Ward Swan Thung Derek Y. Chiang Clara Alsinet Victoria Tovar Sasan Roayaie Myron Schwartz Jordi Bruix Samuel Waxman Scott L. Friedman T | 2011 | Gastroenterology2011，，5： | 1 |
| 15 | Overcoming bioanalytical challenges in an Onglyza<sup>®</sup> intravenous [<sup>14</sup>C]microdose absolute bioavailability study with accelerator MS显示文摘 | Xiaohui (Sophia) Xu Stephen R Dueker Lisa J Christopher Pete N Lohstroh Chi Fung (Anther) Keung Kai (Kevin) Cao Samuel J Bonacorsi Laura Cojocaru Jim X Shen W Griffith Humphreys Bruce Stouffer Mark E Arnold | 2012 | Bioanalysis2012，，15： | 1 |
| 16 | Recent developments in the design and performance of road traffic noise barriers 显示文摘 | Stephen Samuels | 2001 | Acoustics Australia2001，29，： | 1 |
| 17 | Taxxonomy and phylogeny of Gliocladium analyed from nuclear large subunit ribosomal DNA sequences显示文摘 | Samuels GJ | 1994 | Mycological Research1994，98，6： | 1 |
| 18 | A Review of Safety, Efficacy, and Utilization of Erythropoietin, Darbepoetin, and Peginesatide for Patients with Cancer or Chronic Kidney Disease: A Report from the Southern Network on Adverse Reactions (SONAR)显示文摘 | Charles Bennett David Spiegel Iain Macdougall LeAnn Norris Zaina Qureshi Oliver Sartor Stephen Lai Martin Tallman Dennis Raisch Sheila Smith Samuel Silver Alanna Murday James Armitage David Goldsmith | 2012 | Semin Thromb Hemost2012，，08： | 1 |
| 19 | A New Neurologic and Adaptive Capacity Scoring System for: Evaluating Obstetric Medications in Full-term Newborns显示文摘 | Claudine Amiel-Tison Genevieve Barrier Sol M. Shnider Gershon Levinson Samuel C. Hughes Stephen J. Stefani | 1982 | Anesthesiology1982，，5： | 1 |
| 20 | Critical dialogues with self: developing teacher identities and roles — a case study of South African student teachers显示文摘 | Michael Samuel David Stephens | 2000 | International Journal of Educational Research2000，，5： | 1 |
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