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| 1 | 亚洲高血压合并左心室肥厚诊治专家共识显示文摘流行病学调查发现,高血压合并左心室肥厚(left ventricular hypertrophy,LVH)的比例很高,由于诊断标准的差异,不同研究LVH的检出率差别也很大。高血压合并LVH显著增加心血管事件的风险,但临床实践中仍关注不足,诊疗欠规范。亚洲高血压合并左心室肥厚诊治专家共识在LVH的诊断流程、治疗策略和患者随访等方面详细地进行了文献回顾和方案推荐,对于规范高血压防治有重要意义。 | 孙宁玲 Jaw-Wen Chen 王继光 谢良地 陈鲁原 牟建军 孙跃民 Chern-En Chiang Cheuk-Man Yu Huay Cheem Tan Razali Omar 霍勇 无 | 2016 | 中华高血压杂志2016，24，7： | 122 |
| 2 | Review:Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism,present strategies and future perspectives of therapies显示文摘Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies. | LUH Shi-ping CHIANG Chi-huei | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，1： | 53 |
| 3 | Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells显示文摘瞄准:在老鼠或人的肝细胞癌(HCC ) 在房间增长和 apoptosis 上调查热提取水的 Lycium 倒刺海芋属植物(LBE ) 和 Rehmannia glutinosa (RGE ) 的效果房间。方法:老鼠(H-4-II-E ) 和 HCC (HA22T/VGH ) 房间衬里的人与热提取水的 LBE 和 RGE 的各种各样的集中(0-10 g/L ) 被孵化。在 6-24 h 孵化以后,房间增长(n = 6 ) 被比色法测量。apoptotic 房间(n = 6 ) 被流动血细胞计数检测。p53 蛋白质的表示(n = 3 ) 被 SDS 页并且西方的弄污决定。结果:粗略的 LBE (2-5 g/L ) 和 RGE (2-10 g/L ) dose-dependently 在 11% 禁止了 H-4-II-E 房间的增长(P <
0.05 ) 到 85%(P <
0.01 ) 在 6-24 h 处理以后。在 5 g/L 的剂量的粗略的 LBE 在 6-24 h 孵化以后比粗略的 RGE 更有效地压制了 H-4-II-E 房间的房间增长(P <
0.01 ) 。粗略的 LBE (2-10 g/L ) 和 RGE (2-5 g/L ) dose-dependently 也由 14%-43% 禁止了 HA22T/VGH 房间的增长(P <
0.01 ) 在 24 h 以后。在 10 g/L 的剂量的粗略的 LBE 比粗略的 RGE 更有效地禁止了 HA22T/VGH 房间的增长(56.8%+/-1.6% 对 70.3%+/-3.1% 控制, P = 0.0003 <
0.01 ) 。apoptotic 房间显著地与粗略的 LBE (2-5 g/L ) 和 RGE (5-10 g/L ) 的更高的剂量在 24 h 处理以后在 H-4-II-E 房间增加了(P <
0.01 ) 。在 H-4-II-E 房间的 p53 蛋白质的表达式是 119% 控制组和 143% 与相比对待 LBE (2, 5 g/L ) 组,和 110% 控制和 132% 组与 RGE 相比对待(5, 10 g/L ) 在 24 h 以后的组。结论:热提取水的粗略的 LBE (2-5 g/L ) 和 RGE (5-10 g/L ) 禁止增长并且在 HCC 房间刺激调停 p53 的 apoptosis。 | Jane C-J Chao Shih-Wen Chiang Ching-Chiung Wang Ya-Hui Tsai Ming-Shun Wu | 2006 | World Journal of Gastroenterology2006，12，28： | 30 |
| 4 | Electro-acupuncture to prevent prolonged postoperative ileus:A randomized clinical trial显示文摘AIM:To examine whether acupuncture can prevent prolonged postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. METHODS:Ninety patients were recruited from the Fudan University Cancer Hospital,Shanghai,China. After surgery,patients were randomized to receive acupuncture(once daily,starting on postoperative day 1, for up to six consecutive days)or usual care.PPOI was defined as an inability to pass flatus or have a bowel movement by 96 h after surgery.The main outcomes were time to first flatus,time to first bowel movement, and electrogastroenterography.Secondary outcomes were quality of life(QOL)measures,including pain, nausea,insomnia,abdominal distension/fullness,and sense of well-being. RESULTS:No significant differences in PPOI on day 4 (P=0.71)or QOL measures were found between the groups.There were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5(P=0.69)or day 6(P= 0.88).No adverse events related to acupuncture were reported. CONCLUSION:Acupuncture did not prevent PPOI andwas not useful for treating PPOI once it had developed in this population. | M Kay Garcia Joseph S Chiang Bob Thornton J Lynn Palmer Jennifer McQuade Lorenzo Cohen | 2010 | World Journal of Gastroenterology2010，16，1： | 27 |
| 5 | Control of hybrid AC/DC microgrid under islanding operational conditions显示文摘This paper presents control methods for hybrid AC/DC microgrid under islanding operation condition.The control schemes for AC sub-microgrid and DC sub-microgrid are investigated according to the power sharing requirement and operational reliability.In addition,the key control schemes of interlinking converter with DC-link capacitor or energy storage,which will devote to the proper power sharing between AC and DC sub-microgrids to maintain AC and DC side voltage stable,is reviewed.Combining the specific control methods developed for AC and DC sub-microgrids with interlinking converter,the whole hybrid AC/DC microgrid can manage the power flow transferred between sub-microgrids for improving on the operational quality and efficiency. | Guangqian DING Feng GAO Song ZHANG Poh Chiang LOH Frede BLAABJERG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，3： | 23 |
| 6 | Biodegradation of nonylphenol in soil显示文摘 | Chang BV Chiang BW Yuan SY | 2007 | 中国生物学文摘2007，21，6： | 21 |
| 7 | 2010年台湾心脏病学会高血压管理指南显示文摘高血压是心血管疾病和心血管死亡的重要危险因素。从2003年美国高血压预防、检测、评价和治疗全国联合委员会第7次报告(the seventh report of the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure,JNC7)和2007年欧洲高血压协会/欧洲心脏病学会高血压防治指南发布以来, | Chern-En Chiang Tzung-Dau Wang Yi-Heng Li Tsung-Hsien Lin Kuo-Liong Chien Hung-I Yeh Kou-Gi Shyu Wei-Chuen Tsai Ting-Hsing Chao Juey-Jen Hwang Fu-Tien Chiang Jyh-Hong Chen | 2011 | 中华高血压杂志2011，19，1： | 20 |
| 8 | Usefulness of serum des-γ-carboxy prothrombin in detection of hepatocellular carcinoma显示文摘AIM: To evaluate whether DCP is better than AFP for differentiating HCC from nonmalignant liver disease and further evaluate the usefulness of DCP in early diagnosis of small HCC.METHODS: Serum DCP and AFP levels were determined in 127 patients. Among these patients, 32 were with noncirrhotic chronic hepatitis, 34 were with compensated cirrhosis, and 61 were with HCC. The cut-off value for the DCP and AFP were set as 40 mAU/mL and 20 ng/mL,respectively. To compare the diagnostic value of DCP and AFP in distinguishing HCC from nonmalignant chronic liver disease, receiver operating characteristic (ROC) curves were constructed for each assay.RESULTS: The accuracy, sensitivity, and specificity of DCP were higher than AFP in detecting HCC (81.9%, 77%,and 86.4% vs 68.5%, 59%, and 77.3%, respectively).The area under the ROC (AUROC) curves revealed that DCP had a better accuracy than AFP in diagnosis of HCC (0.85 [95%CT, 0.78-0.91] vs 0.73 [95%CI, 0.65-0.81],P = 0.013). In 39 patients with solitary HCC, the positive rates of DCP were 100% in patients with tumor size larger than 3 cm, 66.7% in patients with tumor size 2-3 cm and50% in patients with tumor size less than 2 cm. The positive rates of AFP in patients with tumor size larger than 3 cm, 2-3 cm and less than 2 cm were 55.6%, 50%,and 33.3%, respectively. The median level of DCP in HCC patients with tumor size larger than 3 cm was significantly higher than those with tumor size 2-3 cm and those with the size of less than 2 cm.CONCLUSION: Our study indicates that DCP has a better diagnostic value than AFP in differentiating HCC from nonmalignant chronic liver disease. DCP has not only a stronger correlation with HCC than AFP in tumor size but also more effectiveness than AFP in detecting small size of HCC. | Chaur-Shine Wang Chin-Lin Lin Hsi-Chang Lee Kuan-Yang Chen Ming-Feng Chiang Hung-Sheng Chen Tsung-Jung Lin | 2005 | World Journal of Gastroenterology2005，11，39： | 18 |
| 9 | Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function显示文摘Osthole,an active component of Chinese herbal medicines,reportedly possesses various pharmacological properties and has potential therapeutic applications.This study explored the anti-allergic effects of osthole in asthmatic mice and investigated the immunomodulatory actions of osthole on dendritic cells(DCs)and T cells.Herein,we show that oral administration of osthole to BALB/c mice after ovalbumin(OVA)sensitization ameliorated all of the cardinal features of T helper 2(Th2)-mediated allergic asthma;namely,the production of OVA-specific immunoglobulin E,airway hyperresponsiveness,airway inflammation and the production of Th2-type cytokines including interleukin(IL)-4,IL-5 and IL-13.Surprisingly,IL-10 production was not inhibited and was even enhanced by osthole treatment.We observed a significant increase in the percentages of IL-10-producing DCs and forkhead box P3-positive regulatory T(Treg)cells in osthole-treated asthmatic mice.Additionally,in vitro analyses revealed that osthole-treated bone-marrow-derived DCs had a partial maturation phenotype,secreting large amounts of IL-10 and low levels of proinflammatory cytokines,such as IL-12,IL-6 and tumor necrosis factor-α,and displaying reduced levels of MHC class II surface molecules.These DCs displayed immunosuppressive capacity by directly inhibiting effector T-cell responses or inducing Treg cells.In addition,osthole directly inhibited the activated CD4+T-cell proliferation and Th1/Th2-type cytokine production in this system.Collectively,these results suggest that DCs and T cells are potential target cells responsible for the action of osthole against allergic asthma. | Chen-Yuan Chiang Chen-Chen Lee Chia-Kwung Fan Huei-Mei Huang Bor-Luen Chiang Yueh-Lun Lee | 2017 | Cellular & Molecular Immunology2017，14，11： | 15 |
| 10 | Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats显示文摘背景睡觉骚乱在有肺气肿的病人是普通的。这研究试图带着老鼠在肺气肿( SRHIE )开发睡觉相关的血氧不足( SRH )的一个新奇模型,并且在肺探索 SRHIE 的煽动性的地位,肝,胰,七十五只男 Wistar 老鼠根据暴露条件每组与 15 被分到 5 个组的颈动脉动脉和整个 blood.Methods 。协议与组织缺氧暴露的度和肺气肿由香烟烟暴露引起了的先存在的严厉变化了:( 1 ) SRH 控制( SRHCtrl )组,假冒的烟暴露(烟暴露,暴露了每天 15 支香烟吸烟两次, 16 个星期)并且 SRH 暴露(12.5% O2 , 3 个小时, SRH 暴露,均匀地把全部的组织缺氧时间( 1.5 个小时或 3 个小时)划分成 4 个时期( 22.5 分钟或 45 分钟)并且均匀地散布这些组织缺氧时期直到脑电图识别的老鼠的生理的睡觉时间,到星期 16 的星期 9 );(2 ) 肺气肿控制(ECtrl ) 组,烟暴露和假冒的 SRH 暴露(21% O2, 3 个小时) ;(3 ) 在肺气肿(SRHShort ) 的短 SRH 组,烟暴露和短 SRH 暴露(12.5% O2, 1.5 个小时) ;(4 ) 在肺气肿(SRHMild ) 的温和 SRH 组,烟暴露和温和 SRH 暴露(15% O2, 3 个小时) ;(5 ) 在肺气肿(SRHStand ) 的标准 SRH 组,烟暴露和 SRH 暴露(12.5% O2, 3 个小时) 。ECtrl, SRHShort, SRHMild 和 SRHStand 组是有 emphysematous 老鼠的组。在暴露的结束前的二天,在每个组的 5 只老鼠随机为动脉的血气体分析被选择。在在各个的 10 只老鼠组织的剩余的,我们为平淡的测试获得了血样品和 bronchoalveolar lavage 液体(BALF ) 。我们也为病理学的得分和肝的大小获得了肺,肝,胰,和正确颈动脉动脉的织物块氧化应力(测量肝的氧化压力酶, superoxide dismutase (草皮)活动,过氧化氢酶(猫)活动和 malondialdehyde ( MDA )集中) .Results Emphysematous 组有更高的平均数线性拦截( MLI )并且吝啬的牙槽的数字(人)价值比 SRHCtrl 组。在 SRHStand 组的 MLI 价值是最高(生病 P 0.05 ) 。在 SRHStand 老鼠的 O2Sat SRH 暴露是什么时候(83.45 ? 韴 ?( | FENG Jing Ambrose An-Po Chiang WU Qi CHEN Bao-yuan CUI Lin-yang LIANG Dong-chun ZHANG Ze-li YAO Wo | 2010 | Chinese Medical Journal2010，，17： | 15 |
| 11 | Conservation and Diversity of MicroRNA-associated Copper-regulatory Networks in Populus trichocarpa显示文摘Plants develop important regulatory networks to adapt to the frequently-changing availability of copper (Cu). However, little is known about miRNA-associated Cu-regulatory networks in plant species other than Arabidopsis. Here, we report that Cu-responsive miRNAs in Populus trichocarpa (Torr. & Gray) include not only conserved miR397, miR398 and miR408, but also Populus-specific miR1444, suggesting the conservation and diversity of Cu-responsive miRNAs in plants. Copper-associated suppression of mature miRNAs is in company with the up-regulation of their target genes encoding Cu-containing proteins in Populus. The targets include miR397-targeted PtLAC5, PtLAC6 and PtLAC110a, miR398- targeted PtCSD1, PtCSD2a and PtCSD2b, miR408-targeted PtPCL1, PtPCL2, PtPCL3 and PtLAC4, and miR1444-targeted PtPPO3 and PtPPO6. Consistently, P. trichocarpa miR408 promoter-directed GUS gene expression is down-regulated by Cu in transgenic tobacco plants. Cu-response elements (CuREs) are found in the promoters of Cu-responsive miRNA genes. We identified 34 SQUAMOSA-promoter binding protein-like (SPL) genes, of which 17 are full-length PtSPL proteins or partial sequences with at least 300 amino acids. Phylogenetic analysis indicates that PtSPL3 and PtSPL4 are CuRE-binding proteins controlling Cu-responsive gene expression. Cu appears to be not involved in the regulation of these transcription factors because neither PtSPL3 nor PtSPL4 is Cu-regulated and no CuRE exists in their promoters. | Shanfa Lu Chenmin Yang Vincent L. Chiang | 2011 | Journal of Integrative Plant Biology2011，53，11： | 15 |
| 12 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 13 | Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas显示文摘AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome. METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy. RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% conf idence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas. CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas. | Ying-Lung Lin Jui-Kun Chiang Shih-Min Lin Chih-En Tseng | 2010 | World Journal of Gastroenterology2010，16，30： | 13 |
| 14 | 基于CT的数字体散斑法测量物体内部三维变形场显示文摘提出了用于测量物体内部三维变形场的数字体散斑(DVSP)法。利用计算机断层扫描(CT)、磁共振成像(MRI)、激光扫描共焦显微镜(LSCM)或光学相干断层成像术(OCT)获取具有散斑特征的物体变形前后的三维立体图像,将其分别分割成若干具有相同尺寸的子块体,对相对应的子块体进行第一步三维快速傅里叶变换,在频谱域进行数值干涉得到合成谱,对合成谱进行第二步三维快速傅里叶变换,得到含位移信息的扩展脉冲函数,通过求取峰值位置得到子块体的位移矢量,对所有变形前后相对应的子块体逐一进行上述两步三维快速傅里叶变换,就可以求出所有子块体的位移矢量,从而获得物体内部三维变形场。利用模拟生成的三维散斑体图像,通过数字实验,分析了散斑尺寸、数目、子块体尺寸、图像对比度和亮度对DVSP法精度与准确性的影响。利用DVSP法测量了红砂岩单轴压缩内部的三维应变场,由位移场及应变场分布可直观地揭示试件内部变形特征。 | 毛灵涛 Fu-pen Chiang 袁则循 | 2015 | 光学学报2015，35，3： | 13 |
| 15 | Synergistic effect of fatty liver and smoking on metabolic syndrome显示文摘AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its components.METHODS:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005.A total of 3455(1981 men and 1474 women) subjects were included in final analyses.Fatty liver was diagnosed using abdominal ultrasonography by trained gastroenterologists.The modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic syndrome.The associations between smoking,fatty liver and metabolic syndrome were analyzed using multiple logistic regression.RESULTS:Subjects with fatty liver,and who smoked tobacco,had the highest odds ratios(ORs) for high waist circumference [OR,4.5(95% CI:3.3-6.1) ,P < 0.05],hypertriglyceridemia [OR,8.1(95% CI:6.0-10.9) ,P < 0.05],low serum high-density lipoprotein cholesterol(HDL-C) [OR,8.3(95% CI:6.1-11.3) ,P < 0.05],and metabolic syndrome [OR,9.5(95% CI:6.7-13.4) ,P < 0.05] compared to subjects without fatty liver who did not smoke tobacco.We also found that the ORs for hypertriglyceridemia,low serum HDL-C,and metabolic syndrome for subjects with fatty liver who smoked tobacco had greater than the sum of the ORs for subjects with fatty liver who did not smokeplus those who did not have fatty liver and who did smoke.CONCLUSION:Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components,especially for hypertriglyceridemia and low serum HDL-C. | Po-Hsin Chiang Tsui-Yen Chang Jong-Dar Chen | 2009 | World Journal of Gastroenterology2009，15，42： | 12 |
| 16 | Peliosis hepatis complicated by portal hypertension following renal transplantation显示文摘Peliosis hepatis(PH)is a vascular lesion of the liver that mimics a hepatic tumor.PH is often associated with underlying conditions,such as chronic infection and tumor malignancies,or with the use of anabolic steroids,immunosuppressive drugs,and oral contraceptives.Most patients with PH are asymptomatic,but some present with abdominal distension and pain.In some cases,PH may induce intraperitoneal hemorrhage and portal hypertension.This study analyzed a 46-year-old male who received a transplanted kidney nine years prior and had undergone long-term immunosuppressive therapy following the renal transplantation.The patient experienced progressive abdominal distention and pain in the six months prior to this study.Initially,imaging studies revealed multiple liver tumor-like abnormalities,which were determined to be PH by pathological analysis.Because the hepatic lesions were progressively enlarged,the patient suffered from complications related to portal hypertension,such as intense ascites and esophageal varices bleeding.Although the patient was scheduled to undergo liver transplantation,he suffered hepatic failure and died prior to availability of a donor organ. | Chia-Ying Yu Liang-Che Chang Li-Wei Chen Tsung-Shih Lee Rong-Nan Chien Ming-Fang Hsieh Kun-Chun Chiang | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 17 | Percutaneous transgastric computed tomography-guided biopsy of the pancreas using large needles显示文摘AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major organ.The needle passed through the liver in one case(3%).Nine passes(26%)were made through the stomach.These nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this study.Immediate and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all cases.One patient,who had a rare sarco-matoid carcinoma,received a second biopsy.One patient had a complication of transient pneumoperitoneum but no subjective complaints.An immediate imaging study and clinical follow-up detected neither hemorrhage nor peritonitis.No delayed procedure-related complication was seen during the survival period of our patients.CONCLUSION:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding. | Hsiuo-Shan Tseng Chia-Yuen Chen Wing P Chan Jen-Huey Chiang | 2009 | World Journal of Gastroenterology2009，15，47： | 11 |
| 18 | 不平衡负载工况下三相变流器有源功率解耦控制显示文摘三相电压源型变流器(VSC)对于微电网的稳定运行有着重要的作用。然而,孤岛工况下带三相不平衡负载运行时,交流侧产生的二次脉动功率耦合至直流侧,导致系统的工作性能降低并影响系统的寿命。针对该问题,在二次功率脉动分析的基础上,提出了一种基于虚拟三相瞬时功率的解耦控制策略,通过控制虚拟三相瞬时功率脉动分量为0,在不增加开关器件的情况下,利用LCL滤波器中电容提供负载所需二次脉动功率,实现交直流侧二次脉动功率解耦。在此基础上进一步分析了该拓扑结构直流侧所需的最低电压以及电流应力影响因素。最后仿真和实验结果均表明所提控制策略可以较好地实现功率解耦控制,直流侧源电流二次脉动分量大大减小,有利于提高系统控制性能和实现直流侧电容轻量化。 | 许泽富 唐芬 周家宇 辛振 Poh Chiang Loh | 2019 | 电网技术2019，43，3： | 11 |
| 19 | Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells显示文摘Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed. | Eric Wei Chiang Chan Chu Yong Soon Joash Ban Lee Tan Siu Kuin Wong Yew Woh Hui | 2019 | Journal of Integrative Medicine2019，17，3： | 11 |
| 20 | Structure and Potential Application of Konjac Glucomannan Nano Microfibril Aerogel显示文摘An ultra-light and high porosity nano microfibril aerogel was prepared from konjac glucomannan(KGM) by the electrospinning and freeze-drying. The structure of aerogel was analyzed by scanning electron microscopy(SEM) and X-ray diffraction(XRD) while the density and compressive strength of the samples were studied separately. Results reveal that porous network structure of the KGM nano microfibril aerogel is constructed by intermolecular hydrogen bonds in random and interpenetrate way. The nano microfibril structure presents in the KGM aerogel,which is an important reason of its high density and compressive strength. There is a potential application for this unique nano microfibril aerogel in the absorption of biodegradation bacteria to solve problems in marine oil spill pollution. | 陈涵 穆若郡 庞杰 谭小丹 王敏 Chiang Wei-Yin | 2016 | Chinese Journal of Structural Chemistry2016，35，1： | 10 |
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