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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives显示文摘Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health concern.Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis.The deregulation of epigenetic mechanisms,which maintain heritable gene expression changes and chromatin organization,is implicated in the development of multiple cancers,including HCC.This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC,with an emphasis on HCC mediated by chronic hepatitis B virus infection.This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers,and highlights the future potential of similar therapies in the treatment of HCC. | Li Ma Mei-Sze Chua Ourania Andrisani Samuel So | 2014 | World Journal of Gastroenterology2014，20，2： | 12 |
| 3 | 青海省不同地区乙型肝炎病毒母婴阻断以及婴儿免疫后血清检测研究显示文摘目的评价青海省乙肝母婴阻断工作现况,掌握乙肝病毒表面抗原(hepatitis B surface antigen,HBsAg)阳性母亲所生婴儿乙肝疫苗免疫后血清学检测情况.方法对2016年5月1日至2017年4月30日期间在青海省内住院分娩的所有孕妇开展乙肝表面抗原筛查,乙肝表面抗原阳性的孕妇所生新生儿,出生后12 h内免费注射乙肝免疫球蛋白,并按照0、1、6月免疫程序接种3剂次乙肝疫苗(10μg重组汉逊酵母),全程免疫后1~3个月采集指尖血快速筛查,乙型肝炎病毒表面抗原阳性者,采集静脉血进行乙肝抗原定量检测.结果 60027名孕妇参与HBsAg筛查,其中乙肝表面抗原阳性孕妇1912名,阳性率为3.19%.调查活产儿57557名,24 h乙肝疫苗接种率为97.11%.HBsAg阳性产妇的活产儿12 h乙肝疫苗接种率94.78%,乙型肝炎免疫球蛋白注射率97.15%.864名新生儿完成随访,45名HBsAg(+),阳性率为5.21%.结论青海省育龄期妇女仍有一定比例乙肝感染者,乙肝疫苗和乙肝免疫球蛋白联合阻断效果好,对于阳性产妇和儿童仍需加强乙肝疫苗以及乙肝免疫球蛋白注射. | 马小军 巴文生 郝增平 李溥仁 赵建海 阿克忠 李忠玖 杨雪琴 马艳梅 Samuel So 张建敏 | 2019 | 国际病毒学杂志2019，26，4： | 8 |
| 4 | Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains显示文摘The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion injury.The current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli(ST36)and Fengchi(GB20) stimulation.Rats were divided into five groups:uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes(3 times or 18 times)of electro-acupuncture stimulation before experimental cerebral ischemia was induced.Bcl-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments(P<0.05).The production was higher with 18 electro-acupuncture treatments in the ST36 groups(P<0.05).In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments(P<0.05).No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint groups.However,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups(P<0.05).The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon Mason CP Leung | 2012 | Neural Regeneration Research2012，7，24： | 3 |
| 5 | Medical training fails to prepare providers to care for patients with chronic hepatitis B infection显示文摘AIM: To investigate physicians' knowledge including chronic hepatitis B(CHB) diagnosis, screening, and management in various stages of their training.METHODS: A voluntary 20-question survey was administered in Santa Clara County, CA where Asian and Pacific Islanders(API) account for a third of the population. Among the 219 physician participants,there were 63 interns, 60 second-year residents, 26 chief residents and 70 attending physicians. The survey asked questions regarding respondents' demographics,general hepatitis B virus knowledge questions(i.e.,transmission, prevalence, diagnostic testing, prevention,and treatment options), as well as, self-reported practice behavior and confidence in knowledge.RESULTS: Knowledge about screening and managing patients with CHB was poor: only 24% identified the correct tests to screen for CHB, 13% knew the next steps for patients testing positive for CHB, 18% knew the high prevalence rate among API, and 31% knew how to screen for liver cancer. Wald chi-square analysis determined the effect of training level on knowledge; in all cases except for knowledge of liver cancer screening(p = 0.0032), knowledge did not significantly increase with length in residency training or completion of residency.CONCLUSION: Even in a high-risk region, both medical school and residency training have not adequatelyprepared physicians in the screening and management of CHB. | Stephanie D Chao Bing-Mei Wang Ellen T Chang Li Ma Samuel K So | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 6 | Prevalence of bacterial and candida albicans infection mongst women attending irrua specialist teaching hospital, irrua, nigeria 显示文摘 | ISIBOR JO SAMUEL SO NWAHAM CI | 2011 | Aft J Microbiol Res2011，5，20： | 1 |
| 7 | Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer显示文摘 | Suet Yi Leung Siu Tsan Yuen Kent-Man Chu Jonathan A. Mathy Rui Li Annie S.Y. Chan Simon Law John Wong Xin Chen Samuel So | 2004 | Gastroenterology2004，，2： | 1 |
| 8 | Hepatitis B and liver cancer knowledge and practices among healthcare and public health professionals in china:a cross-sectional study显示文摘 | Jonathan Chao Ellen T Chang Samuel KS So | 2010 | BMC Public Health2010，10，3： | 1 |
| 9 | Perinatal transmission in infants of mothers with chronic hepatitis B in California显示文摘AIM To evaluate maternal hepatitis B virus(HBV) DNA as risk for perinatal HBV infection among infants of HBVinfected women in California.METHODS Retrospective analysis among infants born to hepatitis B surface antigen(HBs Ag)-positive mothers who received post vaccination serologic testing(PVST) between 2005 and 2011 in California. Demographic information was collected from the California Department of Public Health Perinatal Hepatitis B Program databaseand matched to birth certificate records. HBV DNA level and hepatitis B e antigen(HBe Ag) status were obtained from three large commercial laboratories in California and provider records if available and matched to mother infant pairs. Univariate analysis compared infected and uninfected infants. Multivariate analysis was restricted to infected infants and controls with complete maternal HBV DNA results using a predefined high HBV DNA level of > 2 × 107 IU/ml,a 5:1 ratio of cases to controls and a two-sided confidence level of 95%.RESULTS A total of 17687 infants were born to HBs Ag positive mothers in California between Jan 1 2005 and Dec 31,2011. Among 11473 infants with PVST,only 125(1.1%) were found to be HBV infected. Among these infected infants,lapses in Advisory Committee on Immunization Practices recommended post exposure prophylaxis(PEP) occurred in only 9 infants. However,PEP errors were not significantly different between infected and uninfected infants. Among the 347 uninfected and infected infants who had maternal HBe Ag and HBV DNA level,case-control analysis found HBe Ag positivity(70.4% vs 28.9%,OR = 46.76,95%CI: 6.05-361.32,P < 0.001) and a maternal HBV DNA level ≥ 2 × 107 IU/ml(92.6% vs 18.5%,OR = 54.5,95%CI: 12.22-247.55,P < 0.001) were associated with perinatal HBV infection. In multivariate logistic regression,maternal HBV DNA level ≥ 2 × 107 IU/ml was the only significant independent predictor of perinatal HBV infection. CONCLUSION In California,transmission is low and most infected infants receive appropriate PEP and vaccination. Maternal HBV DNA ≥ 2 × 107 IU/ml is associated with high risk of perinatal infection. | Jennifer C Burgis Darryl Kong Catheryn Salibay Jennifer Zipprich Kathleen Harriman Samuel So | 2017 | World Journal of Gastroenterology2017，23，27： | 1 |
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