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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Reservoir architecture patterns of sandy gravel braided distributary channel A case study of Triassic Upper Karamay Formation,Xinjiang oilfield显示文摘The purpose of this study was to discuss shape,scale and superimposed types of sandy gravel bodies in sandy-gravel braided distributary channel.Lithofacies analysis,hierarchy bounding surface analysis and subsurface dense well pattern combining with outcrops method were used to examine reservoir architecture patterns of sandy gravel braided distributary channel based on cores,well logging,and outcrops data,and the reservoir architecture patterns of sandy gravel braided distributary channels in different grades have been established.The study shows:(1)The main reservoir architecture elements for sandy gravel braided channel delta are distributary channel and overbank sand,while reservoir flow barrier elements are interchannel and lacustrine mudstone.(2)The compound sand bodies in the sandy gravel braided delta distributary channel take on three shapes:sheet-like distributary channel sand body,interweave strip distributary channel sand body,single strip distributary channel sand body.(3)Identification marks of single distributary channel include:elevation of sand body top,lateral overlaying,“thick-thin-thick”feature of sand bodies,interchannel mudstone and overbank sand between distributary channels and the differences in well log curve shape of sand bodies.(4)Nine lithofacies types were distinguished in distributary channel unit interior,different channel units have different lithofacies association sequence. | Senlin Yin Zhangming Hu Xiang Ren Xiaojun Wu Yanhui Chen Lijun Zheng Zhibin Jiang | 2016 | Petroleum2016，2，2： | 2 |
| 3 | Controlled self- assembly manipulated by charge - transfer interactions: From tubes to vesicles 显示文摘 | WANG CHAO YIN SHOUCHUN CHEN SENLIN | 2008 | Angewandte Chemic2008，120，47： | 1 |
| 4 | Quantitative Characterization and Genesis Analysis of Complex Modals of Pore Structure in Alluvial-Fan Sandy Conglomerate Reservoirs显示文摘新疆油田冲积扇砂砾岩储层岩石类型多样,颗粒大小混杂,分选极差,储层孔隙结构具有典型的多种模态特征,即单模态、双模态与复模态等。利用铸体薄片、压汞、恒速压汞资料定量表征了七东1区砂砾岩储层复杂模态孔隙特征以及连通特征,利用多元回归分析法建立复杂模态孔隙结构储层的识别模型。以此为基础,分析了冲积扇砂砾岩储层孔隙结构复杂模态成因机制。研究表明:单模态储层主要以Ⅰ类储层为主,双模态储层以Ⅱ、Ⅲ类储层为主,复模态储层以Ⅲ类储层为主。从单模态类型到复模态孔喉组合类型,孔隙发育由好变差,由连通较好的网状到连通较差的星点状,面孔率降低,平均孔径减小,孔喉配位数减小。利用已有147块样品统计发现,七东1区下克拉玛依组储层中单模态储层占19%、双模态储层占48%、复模态储层占33%。由此提出不同模态判断标准,建立了储层孔隙结构预测模型,揭示了储层构型、成岩后作用及注水(聚)开发中后期的系列变化等多因素是导致形成复杂模态的原因。 | Senlin Yin Juan Chen Yukun Chen Xiaoguang Wang Xuzhuang Zhu | 2017 | 石油天然气学报2017，39，3： | 0 |
| 5 | Alternative approaches to target Myc for cancer treatment显示文摘The Myc proto-oncogene family consists of three members,C-MYC,MYCN,and MYCL,which encodes the transcription factor c-Myc(hereafter Myc),N-Myc,and L-Myc,respectively.Myc protein orchestrates diverse physiological processes,including cell proliferation,differentiation,survival,and apoptosis.Myc modulates about 15%of the global transcriptome,and its deregulation rewires the cellular signaling modules inside tumor cells,thereby acquiring selective advantages.The deregulation of Myc occurs in>70%of human cancers,and is related to poor prognosis;hence,hyperactivated Myc oncoprotein has been proposed as an ideal drug target for decades.Nevertheless,no specific drug is currently available to directly target Myc,mainly because of its'undruggable'properties:lack of enzymatic pocket for conventional small molecules to bind;inaccessibility for antibody due to the predominant nucleus localization of Myc.Although the topic of targeting Myc has actively been reviewed in the past decades,exciting new progresses in this field keep emerging.In this review,after a comprehensive summarization of valuable sources for potential druggable targets of Myc-driven cancer,we also peer into the promising future of utilizing macropinocytosis to deliver peptides like Omomyc or antibody agents to intracellular compartment for cancer treatment. | Chen Wang Jiawei Zhang Jie Yin Yichao Gan Senlin Xu Ying Gu Wendong Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 6 | Chinese Named Entity Recognition with Character-Level BLSTM and Soft Attention Model显示文摘Unlike named entity recognition(NER)for English,the absence of word boundaries reduces the final accuracy for Chinese NER.To avoid accumulated error introduced by word segmentation,a deep model extracting character-level features is carefully built and becomes a basis for a new Chinese NER method,which is proposed in this paper.This method converts the raw text to a character vector sequence,extracts global text features with a bidirectional long short-term memory and extracts local text features with a soft attention model.A linear chain conditional random field is also used to label all the characters with the help of the global and local text features.Experiments based on the Microsoft Research Asia(MSRA)dataset are designed and implemented.Results show that the proposed method has good performance compared to other methods,which proves that the global and local text features extracted have a positive influence on Chinese NER.For more variety in the test domains,a resume dataset from Sina Finance is also used to prove the effectiveness of the proposed method. | Jize Yin Senlin Luo Zhouting Wu Limin Pan | 2020 | Journal of Beijing Institute of Technology2020，29，1： | 0 |
| 7 | Architectural Model of a Dryland Gravel Braided River,based on 3D UAV Oblique Photogrammetric Data:A Case Study of West Dalongkou River in Eastern Xinjiang,China显示文摘Three-dimensional unmanned aerial vehicle(UAV)oblique photogrammetric data were used to infer mountainous gravel braided river lithofacies,lithofacies associations and architectural elements.Hierarchical architecture and lithofacies associations with detailed lithofacies characterizations were comprehensively described to document the architectural model,architectural element scale and gravel particle scale.(1)Nine lithofacies(i.e.,Gmm,Gcm,Gcc,Gci,Gcl,Ss,Sm,Fsm and Fl)were identified and classified as gravel,sand and fine matrix deposits.These are typical depositional features of a mountainous dryland gravel-braided river.(2)Three architectural elements were identified,including channel(CH),gravel bar(GB)and overbank(OB).CH can be further divided into flow channel and abandoned channel,while GB consists of Central Gravel bar(CGB)and Margin Gravel bar(MGB).(3)The gravel bar is the key architectural element of the gravel braided river,with its geological attributes.The dimensions of GBs and their particles are various,but exhibit good relationships with each other.The grain size of GB decreases downstream,but the dimensions of GB do not.The bank erosion affects the GB dimensions,whereas channel incision and water flow velocity influence the grain size of GB.The conclusions can be applied to the dryland gravel braided river studies in tectonically active areas. | YIN Senlin ZHU Baiyu GUO Haiping XU Zhenhua LI Xiaoshan WU Xiaojun CHEN Yukun JIANG Zhibin | 2023 | Acta Geologica Sinica(English Edition)2023，97，1： | 0 |
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