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| 1 | Abstract from: Pharmacologic treatment of hypertension in adults aged 60 years or older to higher versus lower blood pressure targets: A clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians显示文摘Description: The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure targets for the treatment of hypertension in adults aged 60 years or older. | Amir Qaseem Timothy J. Wilt Robert Rich Linda L. Humphrey Jennifer Frost Mary Ann Forciea | 2017 | Chinese Nursing Research2017，4，4： | 43 |
| 2 | 囊性肾瘤、肾脏混合性上皮和间质肿瘤34例临床病理分析显示文摘 | Turbiner J Amin M B Humphrey P A 刘飞飞(摘译) 张仁亚(审校) | 2007 | 临床与实验病理学杂志2007，23，3： | 29 |
| 3 | Breeding wheat for resistance to Fusarium head blight in the Global North: China, USA, and Canada显示文摘The objective of this paper is to review progress made in wheat breeding for Fusarium head blight(FHB) resistance in China, the United States of America(USA), and Canada. In China,numerous Chinese landraces possessing high levels of FHB resistance were grown before the 1950 s. Later, pyramiding multiple sources of FHB resistance from introduced germplasm such as Mentana and Funo and locally adapted cultivars played a key role in combining satisfactory FHB resistance and high yield potential in commercial cultivars.Sumai 3, a Chinese spring wheat cultivar, became a major source of FHB resistance in the USA and Canada, and contributed to the release of more than 20 modern cultivars used for wheat production, including the leading hard spring wheat cultivars Alsen, Glenn, Barlow and SY Ingmar from North Dakota, Faller and Prosper from Minnesota, and AAC Brandon from Canada. Brazilian wheat cultivar Frontana, T. dicoccoides and other local germplasm provided additional sources of resistance. The FHB resistant cultivars mostly relied on stepwise accumulation of favorable alleles of both genes for FHB resistance and high yield,with marker-assisted selection being a valuable complement to phenotypic selection. With the Chinese Spring reference genome decoded and resistance gene Fhb1 now cloned, new genomic tools such as genomic selection and gene editing will be available to breeders, thus opening new possibilities for development of FHB resistant cultivars. | Zhanwang Zhu Yuanfeng Hao Mohamed Mergoum Guihua Bai Gavin Humphreys Sylvie Cloutier Xianchun Xia Zhonghu He | 2019 | The Crop Journal2019，7，6： | 12 |
| 4 | IN SITU TEM STUDY ON THE R-PHASE TRANSFORMATION IN TiNi ALLOY显示文摘INSITUTEMSTUDYONTHER-PHASETRANSFORMATIONINTiNiALLOYCHENQing;WUXingfangandC.J.Humphreys(DepartmentofMaterialsPhysics,Universit... | CHEN Qing WU Xingfang and C. J. Humphreys(Department of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China)(Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CBZ 3QZ, U. K.) | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，3： | 10 |
| 5 | Oxyphyllones A and B,novel sesquiterpenes with an unusual 4,5-secoeudesmane skeleton from Alpinia oxyphylla显示文摘二新奇 4,5-secoeudesmane sesquiterpenoids, oxyphyllones A (1 ) 和 B (2 ) 从 Alpinia oxyphylla 的水果被孤立。他们的结构被包括 1D 和 2D NMR 系列的分光镜的方法建立。这二混合物是有在 Zingiberaceae 的家庭的一架 4,5-secoeudesmane 骨骼的自然地发生的 sesquiterpenoids 的第一个例子, oxyphyllone A (1 ) 是 13-norsesquiterpenoid 的第一种 4,5-secoeudesmane 类型。1 和 2 展出了的混合物对三个癌症房间的 cytotoxicities 都不在 10 μ 排队; g/mL。 | Jun Ju Xu Ning Hua Tan Jiang Xiong Abiodun Humphrey Adebayo Hong Jin Han Guang Zhi Zeng Chang Jiu Ji Yu Mei Zhang Mei Ju Zhu | 2009 | Chinese Chemical Letters2009，20，8： | 7 |
| 6 | A 1,3-dipolar cycloaddition protocol to porphyrin- functionalized reduced graphene oxide with a push-pull motif显示文摘减少的 graphene 氧化物(RGO ) 是 covalently 有由二个方法的卟啉一半的 functionalized:直接 Prato 反应(即 1,3-dipolar cycloaddition ) 与 sarcosine 和包含甲酰的卟啉,并且用 4-hydroxybenzaldehyde 包含 1,3-dipolar cycloaddition 到 RGO 表面的一个逐步的方法,与适当卟啉由亲核的替换列在后面。到 RGO 表面的卟啉的化学结合被紫外 / 可见的吸收证实了,荧光, Fourier 变换红外线,并且拉曼光谱学, X 光检查粉末衍射和 X 光检查光电子光谱学,传播电子和原子力量显微镜学,和 thermogravimetric 分析;这个化学附件保证在 RGO 和卟啉之间的有效电子 / 精力转移,并且 RGO 先锋和太古的卟啉与那些相比负担得起改进光非线性。 | Aijian Wang Wang Yu Zhengguo Xiao Yinglin Song Lingliang Long Marie P. Cifuentes Mark G. Humphrey Chi Zhang | 2015 | Nano Research2015，8，3： | 7 |
| 7 | 具有复层上皮的前列腺腺癌:易与前列腺高级别上皮内瘤变混淆的癌显示文摘 | Hameed O Humphrey P A 潘敏鸿(摘译) 饶秋(摘译) 周晓军(审校) | 2006 | 临床与实验病理学杂志2006，22，5： | 6 |
| 8 | Efficiency of financial institutions: International survey and directions for future research显示文摘 | Allen N. Berger David B. Humphrey | 1997 | European Journal of Operational Research1997，，2： | 5 |
| 9 | The importance of depression and alcohol use in coronary artery bypass graft surgery patients:risk factors for delirium and poorer quality of life显示文摘ObjectiveTo 调查消沉,焦虑和压力是否增加风险因为谵妄和在冠的动脉以后的生活(QOL ) 的差的质量绕过(CABG ) 180 个 CABG 病人的 surgery.MethodsA 总数(63.5 ± 的吝啬的年龄;10.1 年, 82.2% 男性) 完成了基线和手术后的自我报告问询表估计悲痛和 QOL。事件谵妄与结构化的临床的会见手术后地被诊断,病人们在在 63 个人(35% 样品) 开发的 consciousness.ResultsDelirium 为混乱和骚乱 post-operatively 每天被监视。在为 covariates 的调整以后,谵妄显著地与消沉被联系[机会比率(或) :1.08;95% 信心间隔(CI ) :1.03-1.13, P = 0.003 ] ,焦虑(或:1.07;95% CI:1.02-1.13, P = 0.01 ) 并且应力(或:1.05;95% CI:1.00-1.09, P = 0.03 ) 。外科手术前的消沉分数与更差的 QOL 包括被联系身体疼痛(β=− 0.39, P = 0.013 ) ,活力(β=− 0.32, P = 0.020 ) ,社会工作(β=− 0.51, P ≤0.001 ) ,感情的角色功能(β=− 0.44, P = 0.003 ) 并且一般健康(β=− 0.33, P = 0.038 ) 。在 covariates 之中,白酒使用的有害层次一致地与更差的 QOL.ConclusionsDepression 被联系,而消沉,焦虑和压力与谵妄风险被联系,白酒使用的有害层次一致地与更差的 QOL 被联系。这些调查结果点将推进在经历冠的 revascularization 的冠的心疾病人口检验消沉和白酒使用的有害层次的研究。 | Joanne M Humphreys Linley A Denson Robert A Baker Phillip J Tully | 2016 | Journal of Geriatric Cardiology2016，13，1： | 5 |
| 10 | 自由游动检测仪对大直径PCCP管的现场检测显示文摘遥控领域变压耦合检查法(RFTC),自1997年商业化推出后,已成为条件预应力钢筋混凝土管(PCCP管)行业评估的标准。虽然这种技术几乎适合所有类型的PCCP管,但是在实际中进行许多PCCP输水线路RFEC/TC巡查时,还有一个巨大的挑战,就是其中大部分PCCP管线不能暂停服务和完全脱水。2007年,自由游动检测仪被开发并成功用于小直径PCCP管(24”-48”)领域。它拥有在现场进行PCCP管道线RFTC检查的能力。可以通过小型带压钻孔分接技术将这种新型仪器投入到在用管道中,沿着水流穿越管线的同时收集RFTC数据,然后在下游另一个带压钻孔分接装置中被回收。目前,这个自由游动检测仪正在大口径(60”及以上)应用中扩大规模。本文将介绍其在大直径PCCP管现场检查时的技术要领和操作要求。现场测试结果也将呈现。 | Xiangjie Kong Xinlu Tang Dave Humphrey Brian Mergelas Roberto Mascarenhas 张峰(译) 乌效鸣(校) | 2011 | 非开挖技术2011，，2： | 5 |
| 11 | 共用阿片类和苯二氮类药物与药物过量之间的关系:一项回顾性分析显示文摘目标确定同时使用苯二氮类药物和阿片类药物的趋势,确定这些趋势对阿片类药物过量导致的住院和急诊就诊的影响,提出修改建议。参与者:在研究期间,18~64岁的私人投保人连续参加医疗和药房福利健康计划的病人,并且至少接受过一张阿片类药物的处方。干预:同时使用苯二氮类药物/阿片类药物,定义为每种药物处方所涵盖的时间段内至少有一天重叠。主要观察结局指标:使用苯二氮类药物的阿片类药物使用者的年度百分比;每年发生的急诊就诊和阿片类药物过量住院事件。结果:阿片类药物使用者中在2001年使用苯二氮卓类药物的有9%,2013年增加到17%(相对增加80%)。这种增加主要是间断性阿片类药物使用者的增加,而非长期的阿片类药物使用者。与未使用苯二氮卓类药物的阿片类药物使用者相比,同时使用这两种药物与急诊室留观或阿片类药物过量住院相关的风险增加(校正比值比2.14,95%置信区间2.05-2.24;P<0.001)。间断性阿片类药物使用者的急诊室或住院病人阿片类药物过量的校正比值比为1.42(1.33-1.51;P<0.001),长期阿片类药物使用者为1.81(1.67-1.96;P<0.001)。如果这种关联是因果关系,那么消除同时使用两种药物的情况可以减少阿片类药物使用和阿片类药物过量住院病人因急诊就诊的风险,估计有15%(95%置信区间14-16)。结论:从2001年到2013年,在美国大量私人保险病人样本中,苯二氮类药物和阿片类药物的并用显着增加,并且导致总体人群阿片类药物过量使用的风险。 | Sun EC Dixit A Humphreys K 李楠琦 | 2018 | 中国疼痛医学杂志2018，24，6： | 5 |
| 12 | How does insertion in global value chains affect upgrading in industrial clusters?显示文摘 | John Humphrey Hubert Schmitz | 2002 | Regional Studies2002，，9： | 4 |
| 13 | Photodynamic Therapy Mediated by 5-Aminolevulinic Acid Suppresses Gliomas Growth by Decreasing the Microvessels显示文摘Although 5-aminolevulinic acid(5-ALA)-mediated photodynamic therapy(PDT) has been demonstrated to be a novel and effective therapeutic modality for some human malignancies, its effect and mechanism on glioma are still controversial. Previous studies have reported that 5-ALA-PDT induced necrosis of C6 rat glioma cells in vitro. The aim of this study was to further investigate the effect and mechanism of 5-ALA-PDT on C6 gliomas implanted in rats in vivo. Twenty-four rats bearing similar size of subcutaneously implanted C6 rat glioma were randomly divided into 3 groups: receiving 5-ALA-PDT(group A), laser irradiation(group B), and mock procedures but without any treatment(group C), respectively. The growth, histology, microvessel density(MVD), and apoptosis of the grafts in each group were determined after the treatments. As compared with groups B and C, the volume of tumor grafts was significantly reduced(P<0.05), MVD was significantly decreased(P<0.001), and the cellular necrosis was obviously increased in group A. There was no significant difference in apoptosis among the three groups. The in vivo studies confirmed that 5-ALA-PDT may be an effective treatment for gliomas by inhibiting the tumor growth. The mechanism underlying may involve increasing the cellular necrosis but not inducing the cellular apoptosis, which may result from the destruction of the tumor microvessels. | 易伟 徐海涛 田道锋 吴立权 张申起 王龙 冀保卫 朱晓楠 Humphrey Okechi 刘刚 陈谦学 | 2015 | Journal of Huazhong University of Science and Technology(Medical Sciences)2015，35，2： | 4 |
| 14 | VMD: Visual molecular dynamics显示文摘 | William Humphrey Andrew Dalke Klaus Schulten | 1996 | Journal of Molecular Graphics1996，，1： | 4 |
| 15 | Integration of meta-QTL discovery with omics: Towards a molecular breeding platform for improving wheat resistance to Fusarium head blight显示文摘Fusarium head blight(FHB) is a global wheat disease that devastates wheat production. Resistance to FHB spread within a wheat spike(type Ⅱ resistance) and to mycotoxin accumulation in infected kernel(type Ⅲ resistance) are the two main types of resistance. Of hundreds of QTL that have been reported, only a few can be used in wheat breeding because most show minor and/or inconsistent effects in different genetic backgrounds. We describe a new strategy for identifying robust and reliable meta-QTL(mQTL)that can be used for improvement of wheat FHB resistance. It involves integration of mQTL analysis with mQTL physical mapping and identification of single-copy markers and candidate genes. Using metaanalysis, we consolidated 625 original QTL from 113 publications into 118 genetic map-based mQTL(gmQTL). These gmQTL were further located on the Chinese Spring reference sequence map. Finally, 77 high-confidence mQTL(hcmQTL) were selected from the reference sequence-based mQTL(smQTL).Locus-specific single nucleotide polymorphism(SNP) and simple sequence repeat(SSR) markers and17 genes responsive to FHB were then identified in the hcmQTL intervals by combined analysis of transcriptomic and proteomic data. This work may lead to a comprehensive molecular breeding platform for improving wheat resistance to FHB. | Tong Zheng Chen Hua Lei Li Zhengxi Sun Minmin Yuan Guihua Bai Gavin Humphreys Tao Li | 2021 | The Crop Journal2021，9，4： | 4 |
| 16 | Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines显示文摘In the present study, total membrane proteins from tumor cell lines including HepG2, Hep3 B2,H226, Ovcar3 and N87 were extracted and digested with γLys C and trypsin. The resulting peptide lysate were pre-fractionated and subjected to untargeted quantitative proteomics analysis using a high resolution mass spectrometer. The mass spectra were processed by the Max Quant and the protein abundances were estimated using total peak area(TPA) method. A total of 6037 proteins were identified, and the analysis resulted in the identification of 2647 membrane proteins. Of those, tumor antigens and absorption,metabolism, disposition and elimination(ADME) proteins including UDP-glucuronosyltransferase,cytochrome P450, solute carriers and ATP-binding cassette transporters were detected and disclosed significant variations among the cell lines. The principal component analysis was performed for the cluster of cell lines. The results demonstrated that H226 is closely related with N87, while Hep3 B2 aligned with HepG2. The protein cluster of Ovcar3 was apart from that of other cell lines investigated. By providing for the first time quantitative untargeted proteomics analysis, the results delineated the expression profiles of membrane proteins. These findings provided a useful resource for selecting targets of choice for anticancer therapy through advancing data obtained from preclinical tumor cell line models to clinical outcomes. | Xiaomei Gu Qing Xiao Qian Ruan Yuezhong Shu Ashok Dongre Ramaswamy Iyer W.Griffith Humphreys Yurong Lai | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 17 | Global distribution and prevalence of hepatitis C virus genotypes显示文摘 | Jane P. Messina Isla Humphreys Abraham Flaxman Anthony Brown Graham S. Cooke Oliver G. Pybus Eleanor Barnes | 2015 | Hepatology2015，，1： | 3 |
| 18 | Current issues in recrystallization: a review显示文摘 | R.D. Doherty D.A. Hughes F.J. Humphreys J.J. Jonas D.Juul Jensen M.E. Kassner W.E. King T.R. McNelley H.J. McQueen A.D. Rollett | 1997 | Materials Science & Engineering A1997，，2： | 3 |
| 19 | Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration显示文摘To assess targeting of an epothilone folate conjugate(BMS-753493) to the folate receptor(FR)-overexpressed tumor in mice bearing both FRt and FR– tumors,a series of experiments were conducted by quantitative whole-body autoradiography(QWBA) and LC–MS/MS following i.v.administration of BMS-753493 or its active moiety,BMS-748285 in mice bearing FRt(98M109) and FR–(M109) tumors.QWBA showed [3H]BMS-753493–derived radioactivity was extensively distributed to various tissues.The FR over-expressing 98M109 tumors showed consistently higher level of radioactivity than FR-negative tumors(i.e.,M109 tumors) up to 48 h post dose of [3H]BMS-753493,despite the magnitude of difference between the tumors is relatively small(generally 3 5-fold).The radioactivity level in 98M109 tumors was 2 12-fold of normal tissues except intestine/content at 48 h post dose.No selective radioactivity uptake into 98M109 tumors over M109 or normal tissues was observed after i.v.administration of the active epothilone,[3H]BMS-748285.LC–MS/MS measurements demonstrated that the concentrations of BMS-748285,presumably from hydrolysis of the folate conjugate,in 98M109 tumors were greater than those in M109 tumors after i.v.administration of BMS-753493(2–3-fold) whereas no differential uptake in the tumors following BMS-748285 administration.Those data were consistent with radioactivity determinations.Those results demonstrated that the folate conjugation in BMS-753493 enabled moderately preferential distribution of the active epothilone to FR overexpressing 98M109 tumors,thereby supporting targeted delivery of cytotoxics through the folate receptor. | Hong Shen Lifei Wang Weiqi Chen Krista Menard Yang Hong Yuan Tian Samuel J.Bonacorsi W.Griffith Humphreys Francis Y.Lee Jinping Gan | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 20 | 北极、南极和西藏有壳虫区系与分布显示文摘有壳虫(Testacea)是一类常见的自由生活的原生动物,在生态系统物质循环和能量流动中发挥重要作用。作者在分析地球三极(北极、南极、西藏)地区有壳虫种类名录(62属315种)基础上,对有壳虫区系特征、地理分布及其影响因素进行了研究。结果显示,北极地区已记录25科51属232种;南极地区20科30属131种;西藏地区22科42属173种。三个地区物种丰富度最高的属均为砂壳虫属(Difflugia)、匣壳虫属(Centropyxis)、梨壳虫属(Nebela)、鳞壳虫属(Euglypha)和表壳虫属(Arcella);5个属的种数分别占北极、南极、西藏总种数的51.3%、63.4%和60.1%。此外,3个地区共有种数是73(23.2%),共有属数是24(38.7%);仅在1个地区记录的种数是167种(53.0%)。在三极地区40个亚区域,苔藓鳞盖虫(Assulina muscorum)和旋匣壳虫(Centropyxis aerophila)的分布最广泛,出现频率均高达90%。聚类分析显示,三个地区种水平相似性系数为51.3-56.3%,属于中等相似,北极和西藏相似系数最大。相似性分析表明,虽然有壳虫具有较强的长距离被动扩散能力,但是一些大于100μm的种类不是全球性分布。有壳虫的地理分布格局与个体大小、生境类型、地质历史事件等密切相关,分析结果受物种鉴定标准、样品数量、空间尺度大小等因素影响。 | 杨军 Humphrey G.Smith David M.Wilkinson | 2010 | 生物多样性2010，18，4： | 3 |
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