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| 1 | NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection显示文摘AIM: To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Hellcobacter pylori (Hpylon) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type Ⅳ secretion system and the two pathways, nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression. METHODS: Gene expression profiles induced by H pylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4 600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted capE (△cagE) was used to elucidate the role of capPAI-encoding type Ⅳ secretion system in the gene expression profile. RESULTS: According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes (476/566) was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI- positive H pylori was analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% (367/566) or 76% (429/566) of the genes whose activation appealed to depend on cagPAI. CONCLUSION: These results suggest that more than half of the genes induced by cagPAI-positive H pylori depend on NF-κB and ERK signaling activation, and these pathways may play a role in the gene expression induced by host-bacterial interaction which may associate with H pylori-related gastro-duodenal diseases. | Wataru Shibata Yoshihiro Hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，39： | 12 |
| 2 | 10 生活方式及环境因素在鼻NK/T细胞淋巴瘤发生中的作用:一组东亚病例对照研究结果显示文摘鼻NK/T细胞淋巴瘤多发生于亚洲和拉丁美洲,而西方国家发生率很低,该文旨在研究生活方式及环境因素与鼻NK/T细胞淋巴瘤发生的关系。2000—2005年间,日本5所、韩国和中国各1所大学医院参与此项研究,试验组88例。对照组305例。对年龄、性别和国家因素调整后。鼻NK/T细胞淋巴瘤的比值比(OR值)为:农场主4.15,农民2.81,杀虫剂使用者4.01,垃圾焚烧场附近居民11.65,先前饮酒者2.95,当前吸烟者0.49。工作期间对杀虫剂采取戴手套、口罩、顺风喷洒防护措施的农民OR值分别为3.30、1.18、2.20,远低于未采取防护措施者。结论:杀虫剂和化学溶剂是鼻NK/T细胞淋巴瘤的病因,生活方式及环境是鼻NK/T细胞淋巴瘤发病的危险因素。 | Xu JX Hoshida Y Yang WI 王延安 | 2007 | 中国口腔颌面外科杂志2007，5，2： | 3 |
| 3 | Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection显示文摘 | Yue Wang Naoya Kato Yujin Hoshida Hideo Yoshida Hiroyoshi Taniguchi Tadashi Goto Masaru Moriyama Motoyuki Otsuka Shuichiro Shiina Yasushi Shiratori Yoichi Ito Masao Omata | 2003 | Hepatology2003，，： | 3 |
| 4 | Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Yujin Hoshida Carlo Battiston Victoria Tovar Daniela Sia Clara Alsinet Helena Cornella Arthur Liberzon Masahiro Kobayashi Hiromitsu Kumada Swan N. Thung Jordi Bruix Philippa Newell Craig April Jian–Bing Fan Sasan Roayaie Vincenzo Mazzaf | 2011 | Gastroenterology2011，，5： | 3 |
| 5 | Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients显示文摘AIM: To determine fibrosis progression and hepatocellular carcinoma (HCC), using simultaneous gene expression analysis.METHODS: Total RNA samples were extracted from liver biopsies from 19 patients with hepatitis C virus (HCV)infection and 3 patients without HCV infection. Among the 19 HCV-infected patients, 7 and 12 patients had grade F1-2 and F3-4 fibrosis, respectively. Of the 12 patients with F3-4 fibrosis, 8 had HCC. Gene expression in the liver samples was determined using an oligonucleotide microarray. The following comparisons were performed:normal livers vs HCV-infected livers; F1-2 vs F3-4; and F3-4 with HCC vs F3-4 without HCC. Genes that were differentially expressed between these groups were identified based on signal-to-noise ratios.RESULTS: In the HCV-infected livers, genes involved in immune responses were highly expressed. Expression levels of genes for plasma proteins and drug-metabolizing enzymes were decreased and those of genes involved in the cell cycle and oncogenesis were increased in the F3-4 cases as compared to the F1-2 cases. Among the F3-4 cases, genes involved in carbohydrate metabolism tended to be more highly expressed in patients with HCC than in patients without HCC.CONCLUSION: We identified genes that are associated with fibrosis progression and hepatocarcinogenesis. This information may be used to detect increased carcinogenic potential in the livers of patients with HCV infection. | Yujin Hoshida Motoyuki Otsuka Naoya Kato Ryosuke Tateishi Takuma Teratani Shuichiro Shiina Hiroyoshi Taniguchi Masaru Moriyama Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 6 | Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements显示文摘 | Yujin Hoshida Sara Toffanin Anja Lachenmayer Augusto Villanueva Beatriz Minguez Josep Llovet | 2010 | Semin Liver Dis2010，，01： | 2 |
| 7 | Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib显示文摘 | Anja Lachenmayer Clara Alsinet Radoslav Savic Laia Cabellos Sara Toffanin Yujin Hoshida Augusto Villanueva Beatriz Minguez Philippa Newell Hung-Wen Tsai Jordi Barretina Swan Thung Stephen C. Ward Jordi Bruix Vincenzo Mazzaferro Myron Schwartz Scott L. Fri | 2012 | Clinical Cancer Research2012，，18： | 2 |
| 8 | p53, K-ras, c-kit and β-catenin gene mutations in sinonasal NK/T-celllymphoma in Korea and Japan显示文摘 | Tadashi Hongyo Yoshihiko Hoshida Shin-ichi Nakatsuka Mukh Syaifudin Shizuo Kojya Woo-Ick Yang Yoo-Hong Min Heekyung Chan Chan Kim Yasuaki Harabuchi Tetsuo Himi Masao Inuyama Katsuyuki Aozasa Taisei Nomura | 2005 | Oncology Reports2005，，2： | 2 |
| 9 | Relationship between time interval from preconditioning to sustained isebemie and its offects on limiting infarct size显示文摘 | Yamashita N Kuzuyaa T Hoshida S | 1992 | J Mol Coll Cardiac1992，24，1： | 1 |
| 10 | Exercise provides dI/Rect biphasic cardioprotection via manganese supcroxide dismutase activation 显示文摘 | Yamashita N Hoshida S Otsu K | 1999 | J Exp Med1999，189，11： | 1 |
| 11 | Preprocedural statin adminis- tration can reduce thrombotic reaction after stent implantation 显示文摘 | NishinoM Hoshida S KatoH | 2008 | Circ J2008，72，2： | 1 |
| 12 | Heat shock-induced manganese superoxide dismutase enhances the tolerance of cardiac myocytes to hypoxia-reoxyegnation injury显示文摘 | Yamashita N Hoshida S | 1997 | J Mol Cell Cardiol1997，29，7： | 1 |
| 13 | Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis显示文摘 | Yamamoto S Tomita Y Hoshida Y | 2004 | Clin Cancer Res2004，10，2： | 1 |
| 14 | Topological and functional discovery in a gene coexpression meta - network of gastric cancer 显示文摘 | Aggarwal A Guo DL Hoshida Y | 2006 | Cancer Res2006，66，1： | 1 |
| 15 | Estrogen dependent signaling in a molecularly distinct subclass of aggressive prostate cancer显示文摘 | Setlur S R Mertz K D Hoshida Y | 2008 | J Natl Cancer Inst2008，100，11： | 1 |
| 16 | Wholebody hyperthermia provides biphasic cardioprotection against ischemia/reperfusion injury in rats 显示文摘 | Yamashita N Hoshida S Taniguchi N | 1998 | Circulation1998，98，： | 1 |
| 17 | Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma显示文摘 | Yamamoto S Tomita Y Hoshida Y | 2003 | J Clin Oncol2003，21，13： | 1 |
| 18 | Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Derek Y. Chiang Pippa Newell Judit Peix Swan Thung Clara Alsinet Victoria Tovar Sasan Roayaie Beatriz Minguez Manel Sole Carlo Battiston Stijn van Laarhoven Maria I. Fiel Analisa Di Feo Yujin Hoshida Steven Yea Sara Toffanin Alex Ramos | 2008 | Gastroenterology2008，，6： | 1 |
| 19 | Gene-expression sig- nature of vascular invasion in hepatocellular carcinoma显示文摘 | Minguez B Hoshida Y Villanueva A | 2011 | J He- patol2011，55，6： | 1 |
| 20 | Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma显示文摘 | Yamamoto S Tomita Y Hoshida Y | 2004 | Clin Cancer Res2004，10，8： | 1 |
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