|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA显示文摘Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.Much of the newly-discovered transcriptome appears to represent long non-coding RNA(lncRNA),a heterogeneous group of largely uncharacterised transcripts.Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date.One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA(miRNA) pathways.lnc RNA has been shown to act as both a source and an inhibitory regulator of mi RNA.At the transcriptional level,a model is emerging whereby lnc RNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes.Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping,as well as conferring specificity on histone modifying complexes by directing them to specific loci. | Iain M.Dykes Costanza Emanueli | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 71 |
| 2 | 考虑风电出力波动性的发电调度(英文)显示文摘提出了一种基于混合整数线性规划(MILP)的随机优化方法,来求解考虑风电出力不确定性、以总运行成本最小化为目标的机组组合优化问题。为计及风电的波动性,采用时间序列分析自回归滑动平均(ARMA)模型和拉丁立方采样(LHS),将随机优化模型转化为确定性模型,通过场景削减技术来解决场景数量很多时的计算量庞大问题。采用10机组和100机组系统对所提出的方法进行了模拟测试。仿真结果表明:计及风电出力不确定性后,系统总的运行成本趋于增加;非风电机组的爬坡速度和风电预测精度对所提出的算法的计算效率有明显的影响;将风电作为旋转备用资源可以明显降低系统总的运行成本。 | 颜拥 文福拴 杨首晖 Iain MACGILL | 2010 | 电力系统自动化2010，34，6： | 53 |
| 3 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 4 | 鄂西的硒资源及其开发战略研究显示文摘湖北省西南部有二叠系茅口组富硒碳质硅质岩和碳质页岩广泛出露。岩石、土壤和富硒土壤上生长的玉米含硒量最高分别达到8.390、354和40(mg/kg)。作者对这一硒资源的价值进行了评估,并对其开发战略进行了探讨。 | 郑宝山 严良荣 毛大钧 苏宏灿 周怀阳 夏卫平 洪业汤 赵伟 陈福 朱笑清 Iain Thornton | 1993 | 自然资源学报1993，8，3： | 27 |
| 5 | 多孔泡沫材料的声吸收特性显示文摘为了结合泡沫金属兼有的高吸声和高热传导两种特性以进一步提高其吸声性能,回顾了泡沫金属材料的应用和声学建模;通过对泡沫金属和用于制造泡沫金属的高分子基体材料的实验,比较了作者提出的声波通过泡沫金属传播的3种黏滞模型的预测结果,结果表明所有模型在泡沫金属典型胞元尺寸所对应的低雷诺数范围内是有效的(假定声波为线性,幅值低于160dB). | 卢天健 Iain D. J. Dupère Ann P. Dowling | 2007 | 西安交通大学学报2007，41，7： | 18 |
| 6 | 声学多孔材料的孔结构优化显示文摘介绍了一种基于微结构的声学模型,可用来对多孔材料的微组织结构进行优化,从而使多孔材料具备最佳的声学性能.该模型是一种适用于低雷诺数的非稳态线性声学模型,主要微结构考虑平行排列的柱形杆件或圆球列阵,包括3个子模型:①声波传播方向平行于圆柱形杆件的子模型;②声波传播方向垂直于圆柱形杆件的子模型;③声波在圆球列阵中传播和吸收的子模型.前2个子模型通过考虑多边形周期边界条件的影响,计及了相邻圆柱形杆件间的交互作用.由于模型是线性的,因此可以结合起来描述任意角度入射声波的传播特性.第3个子模型可用于描述胞状多孔材料中节点处的情形.文中利用这3个子模型来扩大吸声材料的设计空间,根据不同用途所要求的声学特性计算最优的胞元结构,并对这种模型的应用领域进行了分析讨论. | Iain D.J.Dupère 卢天健 Ann P.Dowling | 2007 | 西安交通大学学报2007，41，11： | 15 |
| 7 | 多环芳烃污染区域氧化多环芳烃的来源、迁移转化和毒性危害显示文摘本文阐明了在对高浓度多环芳烃污染区域进行风险评估和修复过程中,氧化多环芳烃是不容忽视的重要污染物。我们通过对自己的研究成果和公开发表资料的综合分析,发现在这些地方氧化多环芳烃的量较大,但并未受到足够重视。这些氧化多环芳烃是通过多环芳烃转化而来的,滞留时间也较长。许多修复方法会加速多环芳烃的降解,从而导致在环境中的氧化多环芳烃浓度升高。此外,我们发现尽管氧化多环芳烃与通过诱变和致癌等多环芳烃常见的毒害有区别的方式产生毒性,但他们对人类和环境也是有害的。我们还有数据支持以下假说:在环境中,具有极性的氧化多环芳烃比多环芳烃稳定性差,更易通过受污染地区的地表水和地下水扩散。因此在受多环芳烃污染区域,氧化多环芳烃应该纳入监测项目当中,而其它毒性相关成分如带硝基的多环芳烃和氮杂环芳烃等则不必纳入监洲项目当中。因为氧化多环芳烃有可能在多环芳烃发生降解的时候形成,而且它们的环境行为是完全不同的,也很难通过多环芳烃浓度来预测氧化多环芳烃的含量。 | Staffan Lundstedt Paul A.White Christine L.Lemieux Krista D.Lynes Iain B.Lambert Larsberg Peter Haglund Mats Tysklind 王丽平 | 2007 | AMBIO-人类环境杂志2007，36，6： | 11 |
| 8 | Reducing the oxidative stress mediates the cardioprotection of bicyclol against ischemia-reperfusion injury in rats显示文摘Objective:To investigate the beneficial effect of bicyclol on rat hearts subjected to ischemia-reperfusion(IR) injuries and its possible mechanism.Methods:Male Sprague-Dawley rats were intragastrically administered with bicyclol(25,50 or 100 mg/(kg·d)) for 3 d.Myocardial IR was produced by occlusion of the coronary artery for 1 h and reperfusion for 3 h.Left ventricular hemodynamics was continuously monitored.At the end of reperfusion,myocardial infarct was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining,and serum lactate dehydrogenase(LDH) level and myocardial superoxide dismutase(SOD) activity were determined by spectrophotometry.Isolated ventricular myocytes from adult rats were exposed to 60 min anoxia and 30 min reoxygenation to simulate IR injuries.After reperfusion,cell viability was determined with trypan blue;reactive oxygen species(ROS) and mitochondrial membrane potential of the cardiomyocytes were measured with the fluorescent probe.The mitochondrial permeability transition pore(mPTP) opening induced by Ca2+(200 μmol/L) was measured with the absorbance at 520 nm in the isolated myocardial mitochondria.Results:Low dose of bicyclol(25 mg/(kg·d)) had no significant improving effect on all cardiac parameters,whereas pretreatment with high bicyclol markedly reduced the myocardial infarct and improved the left ventricular contractility in the myocardium exposed to IR(P<0.05).Medium dose of bicyclol(50 mg/(kg·d)) markedly improved the myocardial contractility,left ventricular myocyte viability,and SOD activity,as well decreased infarct size,serum LDH level,ROS production,and mitochondrial membrane potential in rat myocardium exposed to IR.The reduction of ventricular myocyte viability in IR group was inhibited by pretreatment with 50 and 100 mg/(kg·d) bicyclol(P<0.05 vs.IR),but not by 25 mg/(kg·d) bicyclol.The opening of mPTP evoked by Ca2+ was significantly inhibited by medium bicyclol.Conclusions:Bicyclol exerts cardioprotection against IR injury,at least,via reducing oxidative stress and its subsequent mPTP opening. | Jie CUI Zhi LI Ling-bo QIAN Qin GAO Jue WANG Meng XUE Xiao-e LOU Iain C.BRUCE Qiang XIA Hui-ping WANG | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，6： | 8 |
| 9 | 对人文科学所遭受抨击的回应显示文摘长期以来,不少人站在功利角度,对人文科学进行了颇多抨击。本文意欲对此做出有理有据的反击。首先,文章概述了人文科学在政界、民间和实践领域所遭受的非议,并寻找出主要的批评者及其拥护者。其次,作为申辩内容的一部分,本文详细阐述了人文学科的核心优势。这些优势涵盖了哲学和实用科学领域,包括为知识创造提供批判性视角,使生活丰富多彩,培养应对未来不确定性和复杂性的技能,以及增强理性和维持大学机构的收入和信誉度。最后,本文提出人文学者不仅要开展相关学科里非常重要的理论和实证研究,还必须将捍卫和保护人文科学纳入到专业活动中来。 | Iain HAY | 2018 | 地理科学进展2018，37，3： | 7 |
| 10 | Targeting collagen expression in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is a leading cause of liver disease and liver-related deaths globally,particularly in developed nations.Liver fibrosis is a consequence of ALD and other chronic liver insults,which can progress to cirrhosis and hepatocellular carcinoma if left un-treated.Liver fibrosis is characterized by accumulation of excess extracellular matrix components,including typeⅠcollagen,which disrupts liver microcirculation and leads to injury.To date,there is no therapy for the treatment of liver fibrosis;thus treatments that either prevent the accumulation of typeⅠcollagen or hasten its degradation are desirable.The focus of this review is to examine the regulation of typeⅠcollagen in fibrogenic cells of the liver and to discuss current advances in therapeutics to eliminate excessive collagen deposition. | Kyle J Thompson Iain H McKillop Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 7 |
| 11 | “Anti-HBc alone” in human immunodefi ciency virus-positive and immuno-suppressed lymphoma patients显示文摘Hepatitis B virus (HBV) infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen (anti-HBc), which could produce protective antibody to hepatitis B surface antigen (anti-HBs). With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or 'anti-HBc alone'. In the context of immunodef icient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in 'anti-HBc alone' patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management. | Yu Xuan Koo Daniel SW Tan Iain BH Tan Richard Quek Miriam Tao Soon Thye Lim | 2009 | World Journal of Gastroenterology2009，15，30： | 5 |
| 12 | 慢性肾脏病患者铁剂应用的争议:来自改善全球肾脏病预后组织(KDIGO)会议的结论显示文摘慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使用的利和弊,并且提供合理使用方案以减轻急性反应及其他毒副作用。 | Iain C.Macdougall Andreas J.Bircher Kai-Uwe Eckardt Gregorio T.Obrador Carol A.Pollock Peter Stenvinkel Dorine W.Swinkels Christoph Wanner Gü nter Weiss Glenn M.Chertow 陈佩玲(翻译) 龚德华(审校) | 2016 | 肾脏病与透析肾移植杂志2016，，4： | 5 |
| 13 | 定量光导荧光技术评价含氟牙膏抑制早期龋损效果的临床研究显示文摘目的评价定量光导荧光技术(QLF)用于纵向监测光滑面早期龋损矿物质含量变化的能力及用于评价不同氟化物抑制早期龋损效果差异的可能性。方法选取305名11~14岁上颌前牙有早期光滑面龋的中小学生,随机分为NaF组、MFP组和不含氟组,分别采用含NaF的牙膏、含Na2PO3F的牙膏(氟浓度均为1450mg/L)和不含氟的牙膏刷牙。拍摄受检者上颌前牙光滑面早期龋损基线、刷牙后3个月和6个月时的QLF照片并保存。使用软件QLF2.00g对病损进行分析,界定病损范围,得出每次检查的△F(荧光损失)、Area(病损面积)和△Q(总荧光损失量)。结果296名(97.05%)受检者完成了整个研究。QLF检查结果显示,3个月时,296名受检者上颌前牙光滑面早期龋损均出现不同程度的好转,3组光滑面早期龋损Area、△F和lg△Q的变化均无统计学差异(P>0.05);6个月时,296名受检者上颌前牙光滑面早期龋损均较基线时出现明显的好转,NaF组、MFP组光滑面早期龋损Area、△F和lg△Q的变化有统计学差异(P<0.05),而NaF组与MFP组之间无统计学差异(P>0.05)。结论QLF作为一种定量诊断方法,能够用于纵向病变跟踪监测和评价不同龋病干预措施效果。 | 冯岩 尹伟 胡德渝 Yunpo Zhang Iain A. Pretty Roger P. Ellwood | 2008 | 华西口腔医学杂志2008，26，6： | 5 |
| 14 | Evolution of stereoscopic imaging in surgery and recent advances显示文摘In the late 1980s the first laparoscopic cholecystectomies were performed prompting a sudden rise in technological innovations as the benefits and feasibility of minimal access surgery became recognised.Monocular laparoscopes provided only two-dimensional(2D) viewing with reduced depth perception and contributed to an extended learning curve.Attention turned to producing a usable three-dimensional(3D) endoscopic view for surgeons;utilising different technologies for image capture and image projection.These evolving visual systems have been assessed in various research environments with conflicting outcomes of success and usability,and no overall consensus to their benefit.This review article aims to provide an explanation of the different types of technologies,summarise the published literature evaluating 3D vs 2D laparoscopy,to explain the conflicting outcomes,and discuss the current consensus view. | Katie Schwab Ralph Smith Vanessa Brown Martin Whyte Iain Jourdan | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 4 |
| 15 | 多孔泡沫材料的声吸收特性显示文摘为了结合泡沫金属兼有的高吸声和高热传导两种特性以进一步提高其吸声性能,回顾了泡沫金属材料的应用和声学建模;通过对泡沫金属和用于制造泡沫金属的高分子基体材料的实验,比较了作者提出的声波通过泡沫金属传播的3种黏滞模型的预测结果,表明所有模型在泡沫金属典型胞元尺寸所对应的低雷诺数范围内是有效的(假定声波为线性,幅值低于160 dB).第一种模型考虑了声波沿平行于刚性圆柱束轴线方向传播时所受到的空气曳力,第二种模型考虑了声波沿垂直于刚性圆柱束轴线方向的传播,第三种模型考虑了声波通过球形节点的传播.结合这3种模型,提出了一种泡沫金属声学性能的综合模型,可以用来预测泡沫金属的声吸收特性.此外,还介绍了一种用于泡沫金属材料基本声传播特性实验的后处理技术. | 卢天健 Iain D. J. Dupère Ann P. Dowling | 2007 | 西安交通大学学报2007，41，9： | 4 |
| 16 | 儿童语言中的递归领属结构显示文摘语言的递归性一直是当代语言学界关注的一个重要问题。近年来“递归性是否是人类语言的本质属性”这个问题成为语言学界争论的焦点。有研究者提出儿童对递归结构掌握较晚,在6岁前对递归结构的理解和产出都存在问题。本文通过“基于真值判断的诱发性产出任务”考察了30名4岁的汉语普通话儿童对表领属的递归结构的习得。实验结果显示,4岁的汉语普通话儿童在缺乏足够外界语言输入的情况下,仍能正确理解并产出递归结构。实验结果为“递归性是人类语言的本质属性”这一论点提供了儿童语言的实证支持。 | 施嘉伟 周鹏 Iain Giblin Stephen Crain | 2019 | 外语教学与研究2019，51，3： | 4 |
| 17 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 18 | Deciphering the epitranscriptome: A green perspective显示文摘The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation the epitranscriptome. With over 100 known RNA modifications, understanding the repertoire of RNA modifications is a huge undertaking. This review summarizes what is known about RNA modifications with an emphasis on discoveries in plants. RNA ribose modifications, base methylations and pseudouridylation are required for normal development in Arabidopsis, as mutations in the enzymes modifying them have diverse effects on plant development and stress responses. These modifications can regulate RNA structure,turnover and translation. Transfer RNA and ribosomal RNA modifications have been mapped extensively and theirfunctions investigated in many organisms, including plants.Recent work exploring the locations, functions and targeting of N^6-methyladenosine(m^6A), 5-methylcytosine(m^5C), pseudouridine(Ψ), and additional modifications in mRNAs and nc RNAs are highlighted, as well as those previously known on t RNAs and r RNAs. Many questions remain as to the exact mechanisms of targeting and functions of specific modified sites and whether these modifications have distinct functions in the different classes of RNAs. | Alice Burgess | 2016 | Journal of Integrative Plant Biology2016，58，10： | 4 |
| 19 | A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteria显示文摘Bacterial lipoproteins are proteins that are post-trans-lationally modified with a diacylglyceride at an N-terminal cysteine,which serves to tether these proteins to the outer face of the plasma membrane or to the outer membrane.This paper reviews recent insights into the enzymology of bacterial lipoprotein biosynthe-sis and localization.Moreover,we use bioinformatic analyses of bacterial lipoprotein signal peptide features and of the key biosynthetic enzymes to consider the distribution of lipoprotein biosynthesis at the phylum level. | Iain C.Sutcliffe Dean J.Harrington Matthew I.Hutchings | 2012 | Protein & Cell2012，3，3： | 3 |
| 20 | A sting in the tail: the N-terminal domain of the androgen receptor as a drug target显示文摘在前列腺癌症(PCa ) 的开始和前进的雄激素受体(AR ) 的角色很好被建立。AR ligand 有约束力的领域(LBD ) 的竞争抑制是采用在最近的年里与疾病作斗争的 antiandrogen 治疗的主食。然而,他们的功效被抵抗的出现经常限制了,通过点变化,和受体截断调停了。作为结果,为病人与的预后恶意阉割抵抗疾病遗体穷人。AR 的氨基终端的域(NTD ) 被显示了为 AR 功能批评。它的模块化的激活功能(AF-1 ) 在蛋白质蛋白质相互作用为基因规定和参予是重要的。由于领域的内在地混乱的结构,然而,它的潜力在过去被斥为治疗学的干预的一个候选人。小分子 EPI-001 的最近的出现提供了 AR-NTD 能治疗学地被指向的证据,独立于 LBD。AR-NTD 指向有潜力破坏在 AR 和它的 coregulatory 绑定搭挡之间的多重分子间的相互作用,除了在 AR 的领域之间的 intramolecular 串音。直接指向这些蛋白质蛋白质相互作用或 NTD 的治疗学应该也对新兴的 AR 有功效拼接可以在 PCa 起一个作用的变体前进。这评论将在 AR 功能讨论内在的混乱的角色并且说明新兴的治疗怎么可能在 PCa 指向 NTD。 | Amy E Monaghan Iain J McEwan | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员