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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation显示文摘 | Wanqiang Sheng Fan Yang Yi Zhou Henry Yang Pey Yng Low David Michael Kemeny Patrick Tan Akira Moh Mark H Kaplan Yongliang Zhang Xin-Yuan Fu | 2014 | Cell Research2014，24，12： | 7 |
| 3 | STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation显示文摘 | Hazel Tye Catherine L. Kennedy Meri Najdovska Louise McLeod William McCormack Norman Hughes Anouk Dev William Sievert Chia Huey Ooi Tomo-o Ishikawa Hiroko Oshima Prithi S. Bhathal Andrew E. Parker Masanobu Oshima Patrick Tan Brendan J. Jenkins | 2012 | Cancer Cell2012，，4： | 3 |
| 4 | Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3显示文摘 | Yu Wang Yiwei Lu Soo Ting Toh Wing-Kin Sung Patrick Tan Pierce Chow Alexander Y.F. Chung London L.P. Jooi Caroline G.L. Lee | 2010 | Journal of Hepatology2010，，1： | 3 |
| 5 | Preserved T-Cell Function in Children and Young Adults With Immune-Tolerant Chronic Hepatitis B显示文摘 | Patrick T.F. Kennedy Elena Sandalova Juandy Jo Upkar Gill Ines Ushiro–Lumb Anthony T. Tan Sandhia Naik Graham R. Foster Antonio Bertoletti | 2012 | Gastroenterology2012，，3： | 2 |
| 6 | Flow characteristics of liquid with pressure-dependent viscosities in microtubes显示文摘沿着在管子流动的轴的方向的压力坡度根据 Hagen-Poiseuille 方程保持不变,是明显的。然而,最近的实验显示压力的分发在高压力(1-30MPa ) 驾驶的微试管为液体流似乎不再线性。把方程基于 H-P 与滑动边界状况和布里奇曼粘性对静态的压力的关系,沿着轴的方向的压力的非线性的分发在这篇论文被分析。有考虑的压力依赖者粘性的效果的修订标准 Poiseuille 数字与试验性的结果同意很好。因此,压力上的粘性的依赖是在高驾驶的压力下面的统治因素之一,并且被液体的重要性质系数 α
代表。 | Zhanhua Silber-Li Haihang Cui Yuping Tan Patrick Tabeling | 2006 | Acta Mechanica Sinica2006，22，1： | 2 |
| 7 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 8 | Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups显示文摘 | Dong-Hai Xiong Xiao-Gang Liu Yan-Fang Guo Li-Jun Tan Liang Wang Bao-Yong Sha Zi-Hui Tang Feng Pan Tie-Lin Yang Xiang-Ding Chen Shu-Feng Lei Laura M. Yerges Xue-Zen Zhu Victor W. Wheeler Alan L. Patrick ClareAnn H. Bunker Yan Guo Han Yan Yu-Fang Pei Yin-Pi | 2009 | The American Journal of Human Genetics2009，，3： | 1 |
| 9 | Towaros a metalloproteasc - DNA vaccine against piscine cryptobiosis caused by Cryptobia salmositica 显示文摘 | Tan Chung-Wei Jesudhasan Palmy Woo Patrick T K | 2008 | Parasitology Research2008，102，2： | 1 |
| 10 | Long-term follow-up of Asian patients younger than 46 years with acute myeloid leukemia in first complete remission: comparison of allogeneic vs. autologous hematopoietic stem cell transplantation显示文摘 | Yvonne Su Ming Loh Liang Piu Koh Bee Choo Tai William Ying Khee Hwang Yeh Ching Linn Yeow Tee Goh Patrick Huat Chye Tan | 2007 | Leukemia & Lymphoma2007，，1： | 1 |
| 11 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 12 | Singapore Venture Capitalists (VCs) Investment Evaluation Criteria: A Re-Examination显示文摘 | Ravinder K. Zutshi Wee Liang Tan Dattatreya G. Allampalli Patrick G. Gibbons | 1999 | Small Business Economics1999，，1： | 1 |
| 13 | Ureteroscopic management of renal calculi in anomalous kidneys显示文摘 | Alon Z. Weizer W. Patrick Springhart Wesley O. Ekeruo Brian R. Matlaga Yeh H. Tan Dean G. Assimos Glenn M. Preminger | 2005 | Urology2005，，2： | 1 |
| 14 | Placement of self-expanding metal stents for acute malignant large-bowel obstruction: A collective review显示文摘 | Christine E. Dauphine MD Patrick Tan MD Robert W. Beart MD Petar Vukasin MD Hartley Cohen MD Marvin L. Corman MD | 2002 | Annals of Surgical Oncology2002，，6： | 1 |
| 15 | Modification of bisphenol-A based bismaleimide resin (BPA-BMI) with an allyl-terminated hyperbranched polyimide (AT-PAEKI)显示文摘 | Haihu Qin Patrick T. Mather Jong-Beom Baek Loon-Seng Tan | 2006 | Polymer2006，，8： | 1 |
| 16 | Catechol- O -methyltransferase inhibition increases pain sensitivity through activation of both β 2 - and β 3 -adrenergic receptors显示文摘 | Andrea Gail Nackley Kai Soo Tan Karamarie Fecho Patrick Flood Luda Diatchenko William Maixner | 2006 | Pain2006，，3： | 1 |
| 17 | Unmet needs and challenges in gastric cancer: The way forward显示文摘 | Florian Lordick William Allum Fátima Carneiro Emmanuel Mitry Josep Tabernero Patrick Tan Eric Van Cutsem Cornelis van de Velde Andrés Cervantes | 2014 | Cancer Treatment Reviews2014，，： | 1 |
| 18 | Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses显示文摘 | Nicole Joller Ester Lozano Patrick R. Burkett Bonny Patel Sheng Xiao Chen Zhu Junrong Xia Tze G. Tan Esen Sefik Vijay Yajnik Arlene H. Sharpe Francisco J. Quintana Diane Mathis Christophe Benoist David A. Hafler Vijay K. Kuchroo | 2014 | Immunity2014，，4： | 1 |
| 19 | 显示文摘 | Loon-Seng Tan N Venkatasubramanian Patrick T Mather | 1998 | J Polym Sci Part A:Polymer Chemistry1998，36，： | 1 |
| 20 | 地质力学分析新方法显示文摘应力与压力对任何油藏、井筒及完井装置都会产生影响。钻井、开采及注入过程都会使应力和压力发生变化,有时会给作业者带来不利影响。随着地质力学测量、模拟和监测技术的不断发展,在油气田从评价到废弃的整个生命期内,勘探与生产公司都能够预测应力及压力的变化情况,并降低这些变化所造成的不利影响。 | JohnCook ReneA.Frederiksen KlausHasbo Sidney Green Arnis Judzis J.Wesley Martin Roberto Suarez-Rivera Jorg Herwanger Patrick Hooyman Don Lee Sheila Noeth Colin Sayers Nick Koutsabeloulis Robert Marsden Morten G.Stage Chee Phuat Tan | 2009 | 国外测井技术2009，，1： | 1 |
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