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| 1 | 童年中期同伴关系与孤独感的中介变量检验显示文摘以571名小学三、四、五、六年级的儿童为被试,考察了儿童社会喜好、友谊质量、社交自我知觉与孤独感的关系,检验了社交自我知觉在同伴关系变量与孤独感间的中介作用。结果表明,社会喜好、友谊质量、社交自我知觉和孤独感间相关显著,并且存在显著的性别差异;社交自我知觉在同伴关系变量与孤独感间存在中介的作用;独立的中介效应检验中,社会喜好、友谊质量均通过社交自我知觉的中介作用与孤独感发生联系,同时,也存在直接的联系;综合模型中,社会喜好只通过社交自我知觉的中介作用与孤独感产生联系,不存在直接效应,而友谊质量与孤独感既存在中介的联系,同时也存在直接联系。 | 周宗奎 孙晓军 赵冬梅 Hsueh Yeh | 2005 | 心理学报2005，37，6： | 58 |
| 2 | Renminbi Internationalization: Progress, Prospect and Comparison显示文摘<正>Using principal component analyses,this paper constructs two internationalization indices for the renminbi(RMB) and 32 other major currencies.We find that the RMB’s currency internationalization degree index(CIDI) is still low,and far behind the 4 most important international currencies.In 2009,it was ranked 18th among all important international currencies.However,in terms of the currency internationalization prospect index(CIPI), the RMB has remained the world’s fifth highest since 2006.Although it is still far behind the US dollar and the euro,surpassing the ranking of the yen and the pound is possible in the near future.The dramatic difference in the ranking between the CIDI and the CIPI is a result of China’s tight capital account control,the usage continuity of international currency due to network externalities,and the narrow foreign exchange and imperfect financial markets.Hence,to a large degree,the RMB’s potential as an international currency depends on China’s capital account liberalization. | Chen-yuan Tung Guo-chen Wang Jason Yeh | 2012 | China & World Economy2012，20，5： | 39 |
| 3 | Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation显示文摘AIM: To build up the research models of hepatic fibrosis in mice.METHODS: Inbred wild-type FVB/N mice were either treated with alpha-naphthyl-isothiocyanate (ANIT), allyl alcohol (AA),carbon tetrachloride (CCl4), 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), and silica, or subjected to common bile duct ligation (CBDL) to induce hepatic injury. Liver biopsies were performed every 4 wk to evaluate hepatic fibrosis over a period of 6 mo. Cumulative cirrhosis and survival curves were constructed by life table method and compared with Wilcoxon test.RESULTS: Under the dosages used, there was neither mortality nor cirrhosis in AA and silica-treated groups. DDC and ANIT caused cirrhosis within 4-12 and 12-24 wk, respectively.Both showed significantly faster cirrhosis induction at high dosages without significant alteration of survival. The duration for cirrhosis induction by CCl4 ranged from 4 to 20 wk, mainly dependent upon the dosage. However, the increase in CCl4dosage significantly worsened survival. Intraperitoneal CCl4administration resulted in better survival in comparison with gavage administration at high dosage, but not at medium and low dosages. After CBDL, all the mice developed liver cirrhosis within 4-8 wk and then died by the end of 16 wk.CONCLUSION: CBDL and administrations of ANIT, CCl4, and DDC ensured liver cirrhosis. CBDL required the least amount of time in cirrhosis induction, but caused shortened lives of mice. It was followed by DDC and ANIT administration with favorable survival. As for CCl4, the speed of cirrhosis induction and the mouse survival depended upon the dosages and the administration route. | Ming-Ling Chang Chau-Ting Yeh Pei-Yeh Chang Jeng-Chang Chen | 2005 | World Journal of Gastroenterology2005，11，27： | 33 |
| 4 | Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding显示文摘Bacterial infections are common in cirrhotic patients with acute variceal bleeding,occurring in 20%within48 h.Outcomes including early rebleeding and failure to control bleeding are strongly associated with bacterial infection.However,mortality from variceal bleeding is largely determined by the severity of liver disease.Besides a higher Child-Pugh score,patients with hepatocellular carcinoma are particularly susceptible to infections.Despite several hypotheses that include increased use of instruments,greater risk of aspiration pneumonia and higher bacterial translocation,it remains debatable whether variceal bleeding results in infection or vice versa but studies suggest that antibiotic prophylaxis prior to endoscopy and up to 8 h is useful in reducing bacteremia and spontaneous bacterial peritonitis.Aerobic gram negative bacilli of enteric origin are most commonly isolated from cultures,but more recently,gram positives and quinolone-resistant organisms are increasingly seen,even though their clinical significance is unclear.Fluoroquinolones(including ciprofloxacin and norfloxacin)used for short term(7 d)have the most robust evidence and are recommended in most expert guidelines.Short term intravenous cephalosporin(especially ceftriaxone),given in a hospital setting with prevalent quinolone-resistant organisms,has been shown in studies to be beneficial,particularly in high risk patients with advanced cirrhosis. | Yeong Yeh Lee Hoi-Poh Tee Sanjiv Mahadeva | 2014 | World Journal of Gastroenterology2014，20，7： | 31 |
| 5 | The UCR Time Series Archive显示文摘The UCR time series archive–introduced in 2002,has become an important resource in the time series data mining community,with at least one thousand published papers making use of at least one data set from the archive.The original incarnation of the archive had sixteen data sets but since that time,it has gone through periodic expansions.The last expansion took place in the summer of 2015 when the archive grew from 45 to 85 data sets.This paper introduces and will focus on the new data expansion from 85 to 128 data sets.Beyond expanding this valuable resource,this paper offers pragmatic advice to anyone who may wish to evaluate a new algorithm on the archive.Finally,this paper makes a novel and yet actionable claim:of the hundreds of papers that show an improvement over the standard baseline(1-nearest neighbor classification),a fraction might be mis-attributing the reasons for their improvement.Moreover,the improvements claimed by these papers might have been achievable with a much simpler modification,requiring just a few lines of code. | Hoang Anh Dau Anthony Bagnall Kaveh Kamgar Chin-Chia Michael Yeh Yan Zhu Shaghayegh Gharghabi Chotirat Ann Ratanamahatana Eamonn Keogh | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 26 |
| 6 | Clinicopathological study of solid and pseudopapillary tumor of pancreas: Emphasis on magnetic resonance imaging findings显示文摘AIM: To report the clinicopathological features and magnetic resonance imaging (MRI) findings of solid and pseudopapillary tumor (SPT) of pancreas.METHODS: From 1981 to 2005, 26 surgically treated cases of SPT were retrospectively reviewed. MRI findings of the latest 11 consecutive SPT cases were investigated.RESULTS: There were 25 women and one man having SPT (median age: 23 year) with a median tumor size of 7.5 cm. Among them, nine patients developed solid pseudopapillary carcinoma. During the median follow-up period of 66 mo, the 5-year survival rate of the 26 SPT patients was 96.2%. Three MRI features were proposed including Type 1 image, displaying SPT with completely solid part. All SPT patients with type 1 image were detected incidentally. Type 2 image displays of SPT with solid mass hemorrhage and type 3 image with massive hemorrhage. All the eight SPT patients with type 2 and 3 images suffered abdominal pain due to hemorrhage from SPT.CONCLUSION: SPT had a favorable survival rate irrespective of surgical procedures, malignancy, and MRI findings, however, MRI could reliably correlate with its clinicopathological features. | Chi-Chang Yu Jeng-Hwei Tseng Chun-Nan Yeh Tsann-Long Hwang Yi-Yin Jan | 2007 | World Journal of Gastroenterology2007，13，12： | 21 |
| 7 | 小学儿童互选友谊的发展趋势及攻击行为的影响:3年追踪研究显示文摘对小学3、4年级的285名儿童进行了3年追踪调查,分析了儿童分别与男、女生互选友谊数的变化趋势及其在个体间的差异,探讨了外部攻击和关系攻击分别对两类互选友谊数的影响。结果表明:(1)儿童的男、女生互选友谊数在3年时间内都有显著的增加趋势,并表现出显著的性别差异,儿童与同性互选友谊数显著多于他们与异性的互选友谊数,男生与女生互选友谊数的增加速度比女生与女生互选友谊数增加速度慢,儿童与男生的互选友谊数越多,他/她与女生的互选友谊数就越少,表明了性别疏离现象的存在。(2)在控制了关系攻击的影响后,儿童的外部攻击对他们在各时间点测得的与女生的互选友谊数有显著的消极影响,而对他们与男生的互选友谊数影响不显著;在控制了外部攻击的影响后,儿童的关系攻击对他们在各时间点测得的与女生的互选友谊数有显著的积极影响,而对他们与男生的互选友谊数影响不显著。这说明外部攻击和关系攻击对儿童互选友谊数的影响存在性别差异。 | 赵冬梅 周宗奎 孙晓军 Yeh Hsueh Robert Cohen | 2008 | 心理学报2008，40，12： | 21 |
| 8 | Timing of mortality in severe acute pancreatitis:Experience from 643 patients显示文摘AIM: To determine the timing of mortality after onset of severe acute pancreatitis (SAP) and the course of the disease in a large series of patients. METHODS: From July 1996 to June 2005, all patients diagnosed with acute pancreatitis at Chang Gung Memorial Hospital, Taipei, Taiwan were retrospectively studied. Three thousand two hundred and fifty episodes of acute pancreatitis were recorded in 2248 patients (1431 males and 817 females; median age, 55.6 years; range, 18-97 years). Mortality was divided into two groups: early death (≤ 14 d after admission), and late death (> 14 d after admission). The clinical features of patients in these two groups were compared. RESULTS: Although the overall mortality rate of acute pancreatitis was 3.8% (123/3250), mortality rate of SAP was as high as 16.3% (105/643). Of those 105 SAP mortalities, 44 (41.9%) deaths occurred within the first 14 d after admission and 61 (58.1%) occurred after14 d. Incidence of early death did not significantly differ from that of late death. The co-morbidities did not contribute to the timing of death. Early deaths mainly resulted from multiple organ failure. Late deaths were mainly caused by secondary complication of infected necrosis. Intra- abdominal bleeding significantly caused higher mortality in late death. CONCLUSION: Approximately half (42%) of SAP deaths occur within 14 d and most were due to multiple organ failure. The late deaths of SAP were mostly due to infected necrosis. | Chih-Yuan Fu Chun-Nan Yeh Jun-Te Hsu Yi-Yin Jan Tsann- Long Hwang | 2007 | World Journal of Gastroenterology2007，13，13： | 21 |
| 9 | 2010年台湾心脏病学会高血压管理指南显示文摘高血压是心血管疾病和心血管死亡的重要危险因素。从2003年美国高血压预防、检测、评价和治疗全国联合委员会第7次报告(the seventh report of the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure,JNC7)和2007年欧洲高血压协会/欧洲心脏病学会高血压防治指南发布以来, | Chern-En Chiang Tzung-Dau Wang Yi-Heng Li Tsung-Hsien Lin Kuo-Liong Chien Hung-I Yeh Kou-Gi Shyu Wei-Chuen Tsai Ting-Hsing Chao Juey-Jen Hwang Fu-Tien Chiang Jyh-Hong Chen | 2011 | 中华高血压杂志2011，19，1： | 20 |
| 10 | Risk factors and therapeutic response in Chinese patients with peptic ulcer disease显示文摘AIM:To assess the risk factors and the eff icacy of medications of patients with gastric and duodenal ulcers among Chinese patients in Taiwan.METHODS:Patients with peptic ulcers,diagnosed by upper endoscopy,were retrospectively collected between January 2008 and December 2008.The differences were compared.RESULTS:Among all 448 cases,254(56.6%) and 194(43.4%) patients had gastric ulcers and duodenal ulcers respectively.Patients with gastric ulcers were younger than those with duodenal ulcers.Although more men existed,there was a female predominance in middle-aged cases.Patients with duodenal ulcers had a higher rate of Helicobacter pylori(H.pylori) infection(62.4% vs 43.3%,P = 0.001),and those with gastric ulcers owned a significantly higher amount of aspirin and nonsteroidal anti-inflammatory drug(NSAID) use(7.5% vs 1.5%,6.7% vs 2.1%,P = 0.001).Tobacco smoking and alcohol drinking had no different impact between these two groups.Proton-pump inhibitors and H2-receptor antagonists(H2RA) were effective,but significantly less so in cases with duodenal ulcers receiving H2RAs,or in those with H.pylori infection and a history of NSAID use.CONCLUSION:Patients with gastric ulcers had lower H.pylori infection but more aspirin or NSAID use.Antisecretory therapy was ineffective in gastric ulcers underwent H2RA treatment,and cases combined H.pylori infection and NSAID use. | Shou-Wu Lee Teng-Yu Lee Hong-Zen Yeh Chun-Fang Tung Yen-Chun Peng | 2010 | World Journal of Gastroenterology2010，16，16： | 19 |
| 11 | Clinical outcome of intersphincteric resection for ultra-low rectal cancer显示文摘瞄准:与节省 colostoma 的目的在极端低的直肠的癌症分析 intersphincteric 切除术(ISR ) 的 oncological 结果。方法:从 1995 ~ 1998,有没有远转移,在齿状线上面在 1-3 厘米保存更低的边缘的非修理的直肠的腺癌(肿瘤阶段 T2 ) 的病人被注册(时期我) 。ISR 在八个病人被练习,并且他们的手术后的后续是至少 5 年。另外从 1999 ~ 2003,另一作为时期有一样的肿瘤地点的 10 个病人我经历了 ISR (时期 II ) 。在那些之中,有 T3-4-staged 肿瘤的 6 个病人收到了外科手术前的 chemoradiotherapy。结果:所有病人与药品意愿和没有手术后的死亡收到了 ISR。在在时期的这些情况系列我,本地再发率是 12.5% 和转移率 25.0% ;5 年的幸存率是 87.5% 和没有疾病的幸存率 75.0% 。在有 30 的中部的后续的 10 个病人没有本地复发或远转移(范围, 18-47 ) 在时期 II 的瞬间。结论:至于极端低的直肠的癌症, intersphincteric 切除术能在早阶段的肿瘤(肿瘤阶段 T2 ) 没有永久气孔提供可接受的本地控制和癌症相关的幸存;而且,外科手术前的并发的 chemoradiotherapy 将在更先进的肿瘤(肿瘤阶段 T3-4 ) 与外科的药品目的使 ISR 可行。 | Chih-ChienChin Wen-ShihHuang Jeng-YiWang Chien-Yuh Yeh | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 12 | Surgical management of gallbladder sarcomatoid carcinoma显示文摘AIM:To study the behavior as well as optimal treatment of gallbladder sarcomatoid carcinoma, we reviewed the results of treatment of gallbladder sarcomatoid carcinoma from Chang Gung Memorial Hospital. METHODS:From 1987 to 2005,six patients were diagnosed with gallbladder sarcomatoid carcinoma and treated at our institution.Tumor staging was based on 2002 revised tumor-node-metastasis(TNM)staging for gall bladder cancer from the American Joint Committee on Cancer.The clinical presentation,laboratory data and preoperative workup were reviewed retrospectively. RESULTS:Five patients were female and one was male.The age ranged from 51 to 66 years(median, 58 years).Surgical procedures included three curative resections,two palliative resections and one biopsy. There were two surgical complications(33.3%)and one case of surgical mortality(16.7%).The followup time ranged from 30 d to 5 mo.The median survival was 2.5 mo.The prognosis was extremely poor,even after curative resection and postoperative chemotherapy. CONCLUSION:The prognosis of gallbladder sarcomatoid carcinoma was not dependent on TNM stage and was always dismal.The clinicopathological features were different from those of gall bladder cancer. | Keng-Hao Liu Ta-Sen Yeh Tsann-Long Hwang Yi-Yin Jan Miin-Fu Chen | 2009 | World Journal of Gastroenterology2009，15，15： | 18 |
| 13 | Prognostic analysis of surgical treatment of peripheral cholangiocarcinoma: Two decades of experience at Chang Gung Memorial Hospital显示文摘AIM: To analyze the prognostic factors influencing the overall survival of peripheral cholangiocarcinoma (PCC)patients undergoing surgical treatment during 25 years at a single institution.METHODS: This study retrospectively reviewed prospectively collecting data about 373 patients with histologically proven PCC who underwent surgical treatment between 1977 and 2001.RESULTS: Three hundred and seventy-three PCC patients (159 men and 214 women) underwent surgical treatment from 1977 to 2001. Among them, 187 PCC patients underwent hepatectomy and 135 had curative resection (curative resectability rate: 36.2%). The follow-up duration ranged from 1.05 to 167.6 mo (mean/median = 14.1/7.2 mo).Overall cumulative survival rates at 1, 3, and 5 years were 32.5%, 9.2%, and 4.1%, respectively. Univariate log-rank analysis identified the following as adverse influences on overall survival: presence of symptoms, absence of mucobilia, elevated CEA and CA 19-9 levels, non-papillary tumor type, receiving non-hepatectomy, advanced tumor staging, lack of post-operative chemotherapy, and radiotherapy. Meanwhile, multivariate Cox's proportional hazard analysis demonstrated that absence of mucobilia,non-papillary tumor type, advanced tumor staging, nonhepatectomy, and lack of post-operative chemotherapy were the five independent prognostic factors that adversely affected overall survival.CONCLUSION: Favorable overall survival of PCC patients undergoing surgical treatment depends on early tumor stage, presence of mucobilia, papillary tumor type, hepatic resection, and post-operative chemotherapy. | Yi-Yin Jan Chun-Nan Yeh Ta-Sen Yeh Tse-Ching Chen | 2005 | World Journal of Gastroenterology2005，11，12： | 17 |
| 14 | Predictive factors for lymph node metastasis in early gastric cancer显示文摘AIM: To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC). METHODS: Data from patients surgically treated for gastric cancers between January 1994 and December 2007 were retrospectively collected. Clinicopathological factors were analyzed to identify predictive factors for LNM. RESULTS: Of the 2936 patients who underwent gas-trectomy and lymph node dissection, 556 were diag-nosed with EGC and included in this study. Among these, 4.1% of patients had mucosal tumors (T1a) with LNM while 24.3% of patients had submucosal tumorswith LNM. Univariate analysis found that female gen-der, tumors ≥ 2 cm, tumor invasion to the submucosa, vascular and lymphatic involvement were significantly associated with a higher rate of LNM. On multivariate analysis, tumor size, lymphatic involvement, and tumor with submucosal invasion were associated with LNM. CONCLUSION: Tumor with submucosal invasion, size ≥ 2 cm, and presence of lymphatic involvement are predictive factors for LNM in EGC. | Chang-Mu Sung Chen-Ming Hsu Jun-Te Hsu Ta-Sen Yeh Chun-Jung Lin Tse-Ching Chen Cheng-Tang Chiu | 2010 | World Journal of Gastroenterology2010，16，41： | 15 |
| 15 | Successful laparoscopic management for cholecystoenteric fistula显示文摘瞄准:自从 1987, laparoscopic 胆囊炎(LC ) 广泛地为胆囊损害被用作赞成治疗。Cholecystoenteric 管(CF ) 是胆囊疾病的不平常的复杂并发症,它是为从 LC 的变换的原因之一到开的胆囊炎。这里,我们报导了没有变换, laparoscopic 成功地管理的 CF 的四个案例来临打开胆囊炎。方法:在从 2000 ~ 2004 的 4 年的时期期间,有在 Chang Gung 纪念的医院台北与 laparoscopic 管理成功地对待的 CF 的四个病人的医药记录回顾地被考察。结果:学习包括了二男性和二个女病人,年龄从 36 ~ 74 年(中部:53.5 年) 。所有四个病人有恰好上面的象限疼痛。四个病人中的二个被腹的 ultrasonography 与 pneumobilia 检测。一个病人正确地外科手术前地与 cholecystocolic 管被诊断由内视镜后退 cholangiopancreatography 和另一个被磁性的回声 cholangiopancreatography 作为胆囊十二指肠管诊断。CF 的正确外科手术前的诊断与 50% 外科手术前的诊断的率在四个病人中的二个被做。所有四个病人经历了 LC,管的闭合被与平静手术后的功课成功地使用 Endo-GIA 执行。四个病人的医院停留从 7 ~ 10 d (中部, 8 d ) 。结论:CF 是传统地被看作禁止徵候到 LC 的长期的胆囊疾病的已知的复杂并发症。CF 的正确外科手术前的诊断要求怀疑的高索引并且为病人的子集决定 laparoscopic 管理的成功。困难的 laparoscopic 修理在 laparoscopic 外科医生的富有经验的手里安全、有效。 | Chun-Nan Yeh Yi-Yin Jan | 2006 | World Journal of Gastroenterology2006，12，5： | 15 |
| 16 | 小学儿童的尊重观念与同伴关系显示文摘采用开放式尊重观念问卷考察了502名三到六年级小学生的尊重观念,探讨儿童的尊重观念与其友伴关系的联系。结果表明,双向尊重的儿童比单向尊重的儿童具有更多的友伴数和更好的友谊质量,但双向尊重的儿童不一定是受欢迎儿童;在不同社交地位的儿童中,被拒绝儿童比其他类型的儿童在一般尊重观念和对朋友的尊重观念上更多地具有单向尊重观念(主要是自我取向尊重观念)。因此,同伴关系的不同侧面———友谊关系和群体社交地位与儿童尊重观念具有不同的联系。 | 周宗奎 张春妹 Yeh H sueh | 2006 | 心理学报2006，38，2： | 13 |
| 17 | 中药甘松挥发油对HEK细胞Na_v1.5电流电压及电导电压的影响显示文摘目的应用膜片钳技术研究HEK细胞Nav1.5电流电压依赖性Na+电流失活与激活曲线,甘松挥发油对电流-电压关系(I-V),电导-电压关系(G-V)曲线的影响,以及对快Na+通道失活(H-I)的影响。方法应用膜片钳技术研究HEK细胞Nav1.5电压依赖性Na+电流失活曲线,I-V和H-I曲线。结果正常自然依赖性失活曲线向超极化移位,移动速度10 min内是4 mV。甘松挥发油能降低I-V曲线Na电流的峰电位,但不能改变其Na电位(ENa)从内流向外流的反转电位的方向。G-V曲线明显向超极化方面移动,Vg1/2=(-59.8±4.22)mV是对照自然失活曲线;Vg1/2=(-58.8±5.69)mV是10 PPM甘松挥发油;Vg1/2=(-68.0±4.36)mV是药物被洗脱后失活曲线(P<0.01,n=6)。在除去自然移动值后10 PPM甘松挥发油的Na电位失活作用明显。甘松挥发油应用前,应用10 PPM甘松挥发油以及药物洗脱后H-I曲线与自然失活曲线比较,校正自然失活因素后10 PPM甘松挥发油实际移动Vg1/2是(18.0±4.50)mV(P<0.01,n=5),洗脱40min后接近对照状态。结论甘松挥发油对I-V,G-V曲线有向超极化移位的影响。对快Na+通道有加速失活与抑制激活的作用,然而电压依赖性Na失活是可逆性的。这一作用奠定了甘松挥发油抗心律失常的作用机制。 | 葛郁芝 吴志婷 胡朗吉 Yeh Jay Z | 2009 | 时珍国医国药2009，20，1： | 13 |
| 18 | A light-weight high-entropy alloy Al_(20)Be_(20)Fe_(10)Si_(15)Ti_(35)显示文摘A light-weight high-entropy alloy(LWHEA) Al_(20)Be_(20)Fe_(10)Si_(15)Ti_(35) has been developed to have unique mechanical properties and oxidation resistance. One major and two minor phases are observed in the as-cast microstructure. The density of the alloy is3.91 g cm^(-3), and its hardness is HV 911, which is higher than quartz. The hardness and hardness to density ratio are the highest of all light-weight alloys reported before. In addition, it has excellent oxidation resistance at 700℃ and 900℃, which far exceeds that of Ti-6 A1-4 V. Thus, the combination of properties is promising for high-temperature applications, which require light weight,wear-resistant and oxidation-resistant components. | tseng kokai yang yachu juan chienchang chin tsungshune tsai chewei yeh jienwei | 2018 | Science China(Technological Sciences)2018，61，2： | 12 |
| 19 | 推荐以“EBV相关肺癌”术语替代和扩展肺淋巴上皮瘤样癌的组织学谱系显示文摘肺淋巴上皮瘤样癌(LELC)是一种罕见的EBV相关性癌,其组织学特征为癌细胞呈合体细胞样生长,伴显著的淋巴细胞浸润,组织学上与未分化型鼻咽癌难以区分。研究发现LELC亦可显示非经典组织学形态且缺乏显著的淋巴细胞浸润。作者选取61例肺LELC病例进行全面临床病理分析,并使用免疫组化分析软件对浸润淋巴细胞进行自动定量分析,发现肺LELC形态学上存在连续性谱系,呈现从富于淋巴细胞浸润的经典型未分化LELC至极少淋巴细胞浸润的非经典型组织学形态。 | Yeh Y C Kao H L Lee K L | 2019 | 临床与实验病理学杂志2019，35，5： | 12 |
| 20 | Prevalence of advanced colonic polyps in asymptomatic Chinese显示文摘AIM: To investigate the prevalence of advanced polyps in asymptomatic Chinese and to determine the risk of proximal advanced colonic polyps in subjects with and without polyps in the distal colon.METHODS: Data were collected prospectively during colonoscopic examinations performed in 5 973 subjects as part of health evaluation at our unit from December 1997 to December 2003. Polyps were considered advanced, if they were larger than 10 mm or were tubovillous, villous or malignant. Proximal colon was defined as the splenic flexure and more proximal portions of the colon.RESULTS: Colon polyps were detected in 971 (16.3%)subjects (613 males and 358 females) with their mean age being 56.6±10.7 years. Advanced polyps were noted in 199 (3.3%) individuals. Subjects were sub-classified according to the location of polyps into three groups: distal (569, 58.6%), proximal (284, 29.2%), and combined proximal and distal (118, 12.2%) groups. Subjects with advanced polyps in these three groups were 95 (9.8%),56 (5.8%), and 48 (4.9%) respectively. In the 48 subjects with advanced combined polyps, 13 advanced polyps were distributed at the distal colon, 17 at the proximal colon,and 18 at both. Eighteen colon cancers including 12 at sigmoid and 6 at ascending colon were confirmed by final pathology. The relative risk for advanced proximal polyp according to distal findings was 3.1 (95%CI: 1.3-7.4) for hyperplastic polyp, 2.7 (95%CI: 1.4-5.3) for tubular polyp and 13.5 (95%CI: 5.1-35.4) for advanced polyp as compared to that for no polyp. However, 56 (28.2%) of 199 subjects with advanced polyps had no index polyps at the distal colon and might go undetected under sigmoidoscopic screening.CONCLUSION: Although distal lesions can predict the risk of advanced proximal polyps, a substantial portion of Chinese with advanced proximal polyps is not associated with any distal sentinel lesions. These data have implications for screening policy of colon cancers in Taiwan Residents Chinese. | Hui-Hsiung Liu Meng-Chen Wu Yeh Peng Ming-Shiang Wu | 2005 | World Journal of Gastroenterology2005，11，30： | 11 |
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