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| 1 | Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding显示文摘Bacterial infections are common in cirrhotic patients with acute variceal bleeding,occurring in 20%within48 h.Outcomes including early rebleeding and failure to control bleeding are strongly associated with bacterial infection.However,mortality from variceal bleeding is largely determined by the severity of liver disease.Besides a higher Child-Pugh score,patients with hepatocellular carcinoma are particularly susceptible to infections.Despite several hypotheses that include increased use of instruments,greater risk of aspiration pneumonia and higher bacterial translocation,it remains debatable whether variceal bleeding results in infection or vice versa but studies suggest that antibiotic prophylaxis prior to endoscopy and up to 8 h is useful in reducing bacteremia and spontaneous bacterial peritonitis.Aerobic gram negative bacilli of enteric origin are most commonly isolated from cultures,but more recently,gram positives and quinolone-resistant organisms are increasingly seen,even though their clinical significance is unclear.Fluoroquinolones(including ciprofloxacin and norfloxacin)used for short term(7 d)have the most robust evidence and are recommended in most expert guidelines.Short term intravenous cephalosporin(especially ceftriaxone),given in a hospital setting with prevalent quinolone-resistant organisms,has been shown in studies to be beneficial,particularly in high risk patients with advanced cirrhosis. | Yeong Yeh Lee Hoi-Poh Tee Sanjiv Mahadeva | 2014 | World Journal of Gastroenterology2014，20，7： | 31 |
| 2 | Non-small-bowel lesions encountered during double-balloon enteroscopy performed for obscure gastrointestinal bleeding显示文摘AIM:To report the incidence of non-small-bowel bleeding pathologies encountered during double-balloon enteroscopy (DBE) procedures and to analyse their significance.METHODS: A retrospective study of a prospective DBE database conducted in a tertiary-referral center was conducted. A total of 179 patients with obscure gastrointestinal bleeding (OGIB) referred for DBE from June 2004 to November 2008 were analysed looking for the incidence of non-small-bowel lesions (NSBLs; all and newly diagnosed) encountered during DBE.RESULTS: There were 228 (150 antegrade and 78 retrograde) DBE procedures performed in 179 patients. The mean number of DBE procedures was 1.27 per patient. The mean age (SD) of the patients was 62 ± 16 years old. There were 94 females (52.5%). The positive yield for a bleeding lesion was 65.9%. Of the 179 patients, 44 (24.6%) had NSBLs (19 of them had dual pathology with small-bowel lesions and NSBLs); 27 (15.1%) had lesions not detected by previous endoscopies. The most common type of missed lesions were vascular lesions.CONCLUSION: A significant proportion of patients (24.6%) had lesions within reach of conventional endoscopy. Careful repeat examination with gastroscopy and colonoscopy might be required. | Hoi-Poh Tee Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，15： | 21 |
| 3 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 4 | 澳门护理专业本科生逆境商的调查研究显示文摘目的调查澳门特别行政区护理专业本科生的逆境商,并分析其影响因素。方法采用便利抽样方法从澳门某高等院校中选取护理专业本科生158名。调查问卷包括基本人口社会学问卷、逆境商量表、情绪智力量表、简化应对方式问卷及父母教养方式量表。结果本组护理专业本科生的逆境商得分为(116.72±11.39)分。他们的逆境商得分与消极应对方式和母亲管教风格(过度干预、过度保护)呈负相关(r=-0.332,P<0.001;r=-0.167,P=0.036)。多元回归分析结果,仅消极应对方式进入回归方程(F=19.154,P<0.001)。女生的逆境商得分高于男生(31.98±3.26比29.21±3.08,t=-4.442,P<0.001)。结论澳门护理专业本科生平均逆境商得分处于中等水平,女生更有可能将逆境归因于自己,这可能与其社会心理和文化背景有关。澳门护理专业本科生有必要提高自身克服挫折的能力。教育者应恃別注意培养学生积极的应对方式。 | 王新 刘明 Stephen Tee 戴红霞 | 2021 | International Journal of Nursing Sciences2021，8，2： | 17 |
| 5 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 6 | Placement of removable metal biliary stent in post-orthotopic liver transplantation anastomotic stricture显示文摘Postoperative biliary strictures are the most common cause of benign biliary stricture in Western countries, secondary to either operative injury or bile duct anastomotic stricture following orthotopic liver transplantation(OLT).Surgery or endoscopic interventions are the mainstay of treatment for benign biliary strictures.We aim to report the outcome of 2 patients with refractory anastomotic biliary stricture post-OLT,who had successful temporary placement of a prototype removable covered self-expandable metal stent(RCSEMS).These 2 patients(both men,aged 44 and 53 years)were given temporary placement of a prototype RCSEMS (8.5 Fr gauge delivery system,8 mm×40 mm stent dimensions)in the common bile duct across the biliary stricture.There was no morbidity associated with stent placement and removal in these 2 cases.Clinical parameters improved after the RCSEMS placement.Longterm biliary patency was achieved in both the patients. No further biliary intervention was required within 14 and 18 mo follow-up after stent removal. | Hoi-Poh Tee Martin W James Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，28： | 4 |
| 7 | HIV/AIDS in Asia:The Shape of Epidemics and Their Molecular Epidemiology显示文摘The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS annually in Asia,becoming the second largest epicenter of global AIDS epidemic. Molecular epidemiology has been useful tool to track a course of HIV spread. In-depth knowledge from the studies on molecular epidemiology elucidates the dynamics of HIV spread and the interrelationship of epidemics in the different regions in Asia. | Rie Uenishi Saiki Hase Tee Kok Keng Shigeru Kusagawa Yutaka Takebe | 2007 | Virologica Sinica2007，22，6： | 4 |
| 8 | Antibiotic Resistance and Heavy Metals Tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia显示文摘A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog (Rana catesbeiana) cultured in Malaysia. The most frequently isolated bacteria was Edwardsiella spp. (46 isolates) followed by Aeromonas spp. (33 isolates), Flavobacterium spp. (31 isolates), and Vibrio spp. (30 isolates). Majority of the bacterial isolates were found sensitive to furazolidone (85.0%), chloramphenicol (85.0%), oxolinic acid (90.0%), florfenicol (95.0%), and flumequine (97.5%). On the other hand, most of the bacterial isolates were resistant to oleandomycin (77.5%) and lincomycin (87.5%). Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance (MAR) index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. These results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals. | M Najiah S W Lee W Wendy L W Tee M Nadirah S H Faizah | 2009 | Agricultural Sciences in China2009，8，10： | 4 |
| 9 | Structural finite element model updating using incomplete ambient vibration modal data显示文摘This paper presents an effective approach for updating finite element dynamic model from incomplete modal data identified from ambient vibration measurements.The proposed method is based on the relationship between the perturbation of structural parameters such as stiffness and mass changes and the modal data measurements of the tested structure such as measured mode shape readings.Structural updating parameters including both stiffness and mass parameters are employed to represent the differences in structural parameters between the finite element model and the associated tested structure.These updating parameters are then evaluated by an iterative solution procedure,giving optimised solutions in the least squares sense without requiring an optimisation technique.In order to reduce the influence of modal measurement uncertainty,the truncated singular value decomposition regularization method incorporating the quasi-optimality criterion is employed to produce reliable solutions for the structural updating parameters.Finally,the numerical investigations of a space frame structure and the practical applications to the Canton Tower benchmark problem demonstrate that the proposed method can correctly update the given finite element model using the incomplete modal data identified from the recorded ambient vibration measurements. | CHEN HuaPeng TEE KongFah | 2014 | Science China(Technological Sciences)2014，57，9： | 4 |
| 10 | 为双汽球 enteroscopy 的学习曲线: 从 282 过程的分析的调查结果显示文摘 AIM: To determine the learning curves for antegrade double-balloon enteroscopy (aDBE) and retrograde DBE (rDBE) by analyzing the technical success rates. METHODS: A retrospective analysis in a tertiary referral center. This study reviewed all cases from June 2006 to April 2011 with a target lesion in the small-bowel identified by either capsule endoscopy or computed tomography scan posted for DBE examinations. Main outcome measurements were: (1) Technical success of aDBE def ined by f inding or excluding a target lesion after achieving suff icient length of small bowel intubation; and (2) Technical success for rDBE was def ined by either f inding the target lesion or achieving stable overtube placement in the ileum. RESULTS: Two hundred and eighty two procedures fulf illed the inclusion criteria and were analyzed. These procedures were analyzed by blocks of 30 cases. Therewas no distinct learning curve for aDBE. Technical success rates for rDBE continued to rise over time, although on logistic regression analysis testing for trend, there was no signif icance (P = 0.09). The odds of success increased by a factor of 1.73 (95% CI: 0.93-3.22) for rDBE. For these data, it was estimated that at least 30-35 cases of rDBE under supervision were needed to achieve a good technical success of more than 75%. CONCLUSION: There was no learning curve for aDBE. Technical success continued to increase over time for rDBE, although a learning curve could not be proven statistically. Approximately 30-35 cases of rDBE will be required for stable overtube intubation in ileum. | Hoi-Poh Tee Soon-Hin How Arthur J Kaffes | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 4 |
| 11 | Ophthalmology simulation for undergraduate and postgraduate clinical education显示文摘This is a review education paper on the current ophthalmology simulators utilized worldwide for undergraduate and postgraduate training. At present,various simulators such as the EYE Exam Simulator(Kyoto Kagaku Co. Ltd., Kyoto, Japan), Eyesi direct ophthalmoscope simulator(VRmagic, Gmb H, Mannheim,Germany), Eyesi indirect ophthalmoscope simulator(VRmagic, Gmb H, Mannheim, Germany) and Eyesi cataract simulators(VRmagic, Gmb H, Mannheim,Germany). These simulators are thought to be able to reduce the initial learning curve for the ophthalmology training but further research will need to be conducted to assess the effectiveness of the simulation-assisted ophthalmology training. Future research will be of great value to assess the medical students and residents' responses and performance regarding the usefulness of the individual eye simulator. | Daniel Shu Wei Ting Shaun Sebastian Khung Peng Sim Christine Wen Leng Yau Mohamad Rosman Ai Tee Aw Ian Yew San Yeo | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 3 |
| 12 | 中医药在马来西亚的发展现状与分析显示文摘马来西亚是位于东南亚的一个多民族、多元文化的君主立宪联邦制国家。导致民众死亡前3位的疾病是缺血性心脏病、下呼吸道感染、脑卒中,近年来下呼吸道感染、结肠直肠癌、AD发病率明显增加。马来西亚医保体系公私互补,传统医学包括马来医学、中医学、印度医学、顺势疗法及伊斯兰医学等。尽管中医药、针灸尚未纳入医保,但在华人的带动下应用较为广泛。目前马来西亚民众对中医药接受度有待提高,中医药教育体系有待完善,科研有待拓展和深入。希望未来通过推动中医立法,提高民众认知度,着重教育与培训、开展国际科研合作等,更好地推动中医药在马来西亚的发展。 | 崔鑫 Eow Gaik Bee Tee Bee Ching 胥静 魏竞竞 石晗 王智博 刘奕清 徐玉芹 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，6： | 3 |
| 13 | Anti-hypercholesterolemic effect of kenaf(Hibiscus cannabinus L.)seed on high-fat diet Sprague dawley rats显示文摘Objective:To determine? the anlihypercholesterolemic effects of kenaf seed samples and compare with the commercial hypocholesterolemic drug on serum lipids profiles and malondialdehyde(MDA) level in the rat.Methods:Kenaf seed oil(KSO),microencapsulated kenaf seed oil(MKSO),kenaf seed extract(KSE) and defatted kenaf seed meal(DKSM) were prepared and phytocHemicals screening on these samples were done prior in viro study.Phenolic compounds in KSF.were quantified using high performance liquid chromatography.There were 40(divided in eight diet groups of 5) male Sprague dawley rats adapted lo normal standard diet or hypercholesterolemic diet(HD) with or without the treatment of these kenaf samples for 32 days.Results:All the kenaf samples exhibited to contain most of the major phytocliemicals.KSE possessed gallic acid,tannic acid,catechin.benzaldehyde.benzoic acid,syringic acid,sinapic acid,ferulic acid,naringin acid,and protocatechuic acid.The significant higher(P<0.05) serum total cholesterol,low density lipoprotein cholesterol and MDA levels in HD group without treatment than the normal control group suggested the hypercholesterolemia was induced by the Incorporation of cholesterol into diet.KSE exhibited higher cholesterol-lowering properties due to the significant lower(P<0.05)in serum triglycerides,total cholesterol and MDA levels.KSF showed the highest efficiency of cholesterol-lowering activity,followed by KSO.MKSO and DKSM.Conclusions:DKSM.MKSO.KSO and KSE appeared lo have comparable anti-hypercholesterolemic effect with the commercial hypocholesterolemic drug.Hence,kenaf seed could be used as an alternative natural source lo replace the synthetic hypocholosterolemic drugs. | Ng Shy Kai Tee Ai Nee Elaine Lai Chia Ling Tan Chin Ping Long Kamariah Nyam Kar Lin | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，1： | 2 |
| 14 | Beta-blocker use and risk of symptomatic bradyarrhythmias: a hospital-based case-control study显示文摘在与 -blockers use.MethodsA 的关系调查征兆的 bradyarrhythmias 的风险因素基于医院的盒子控制学习[228 个病人:108 与征兆的 bradyarrhythmias (案例) 和 120 控制] 在 Sultanah Aminah 医院,在 2011 年 1 月之间的马来西亚和 2014 年 1 月 .ResultsThe 平均数年龄里被进行是 61.1 ?? 業牴敩歮?? 呑 ? | Hou Tee Lu Jiyen Kam Rusli Bin Nordin Surinder Kaur Khelae Jing Mein Wang Chun Ngok Choy Chuey Yan Lee | 2016 | Journal of Geriatric Cardiology2016，13，9： | 2 |
| 15 | Quality indicators in pediatric colonoscopy in a low-volume center:Implications for training显示文摘AIM To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training center.METHODS We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years(January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as benchmarks.RESULTS Median(± SD) age of 121 children [males = 74(61.2%)] who had 177 colonoscopies was 7.0(± 4.6) years. On average, 30 colonoscopies were performed each year(range: 19-58). Except for investigations of abdominal pain(21/177, 17%), indications for colonoscopies were appropriate in the remaining 83%. Bowel preparation was good in 87%. One patient(0.6%) with severe Crohn's disease had bowel perforation. Cecum examination and ileal intubation rate was 95% and 68.1%. Ileal intubation rate was significantly higher in diagnosing or assessing inflammatory bowel disease(IBD) than non-IBD(72.9% vs 50.0%; P = 0.016). Performance of four trainees was consistent throughout the study period. Average cecum and ileal examination rate among trainees were 97% and 77%.CONCLUSION Benchmarking against established guidelines helps units with a low-volume of colonoscopies to identify area for further improvement. | Way-Seah Lee Chun-Wei Tee Zhong-Lin Koay Tat-Seng Wong Fatimah Zahraq Hee-Wei Foo Sik-Yong Ong Shin-Yee Wong Ruey-Terng Ng | 2018 | World Journal of Gastroenterology2018，24，9： | 2 |
| 16 | Hepatitis B virus reactivation in B-cell lymphoma patients treated with rituximab: Analysis from the Asia Lymphoma Study Group显示文摘 | Seok Jin Kim Chiun Hsu Yu-Qin Song Kevin Tay Xiao-Nan Hong Junning Cao Jin Seok Kim Hyeon Seok Eom Joon Hyeok Lee Jun Zhu Kian-Meng Chang Arry Harryanto Reksodiputro Daryl Tan Yeow Tee Goh Jejung Lee Tanin Intragumtornchai Wee-Joo Chng Ann-Lii Cheng Soon | 2013 | European Journal of Cancer2013，，： | 2 |
| 17 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Paul Gissen Louise Tee Colin A. Johnson Emmanuelle Genin Almuth Caliebe David Chitayat Carol Clericuzio Jonas Denecke Maja Rocco Bj?rn Fischler David FitzPatrick Angeles García-Cazorla Delphine Guyot Sebastien Jacquemont Sibylle Koletzko Bruno Leheup Hann | 2006 | Human Genetics2006，，3： | 2 |
| 18 | SINGLE-01: a randomized, controlled trial comparing the efficacy and depth of insertion of single- and double-balloon enteroscopy by using a novel method to determine insertion depth显示文摘 | Marios Efthymiou Paul V. Desmond Gregor Brown Richard La Nauze Arthur Kaffes Tee Joo Chua Andrew C.F. Taylor | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 19 | Passive harmonic mode locking of gain-guided solitons in erbium-doped fiber lasers显示文摘We report the experimental observation of passive harmonic mode locking of gain-guided solitons in erbium-doped fiber lasers either made of purely normal dispersion fibers or operating in the net normal cavity dispersion regime. Harmonic-2 and harmonic-3 mode locking states of the gain-guided solitons with supermode suppression larger than 35 dB have been obtained. | ZHAO LuMing TANG DingYuan CHENG Tee Hiang TAM Hwa-Yaw LU Chao | 2008 | Chinese Science Bulletin2008，53，5： | 2 |
| 20 | The Paradoxes of Student Well-being in Singapore显示文摘Purpose:Singapore’s education system is known for its robust curriculum and excellent results.It is also a system of keen competitiveness and high pressure.This article addresses how such an education system responds to the issue of student well-being.Design/Approach/Methods:This article analyses the recent initiatives and shift in education philosophy in Singapore’s education system,which have a bearing on the issue of student wellbeing.Findings:This article argues that while there are direct efforts to address student well-being,the direction Singapore is taking is to pursue a holistic education paradigm,in which education is engaging,joyful,meaningful,and values-based.This article also argues that such a paradigm goes beyond the current well-being agenda and is aligned with a view that education should be about wholeness and purpose.While there are challenges associated with these changes,the Singapore experience suggests that the more we focus on holistic education,rather than interpret student well-being narrowly,the more wellness the students may actually and eventually experience.Originality/Value:This article brings to readers learning points from Singapore regarding student well-being,as the country grapples with change to develop a generation of young people,whose beings are and will continue to be well. | Pak Tee Ng | 2020 | ECNU Review of Education2020，3，3： | 2 |
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