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| 1 | STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation显示文摘 | Hazel Tye Catherine L. Kennedy Meri Najdovska Louise McLeod William McCormack Norman Hughes Anouk Dev William Sievert Chia Huey Ooi Tomo-o Ishikawa Hiroko Oshima Prithi S. Bhathal Andrew E. Parker Masanobu Oshima Patrick Tan Brendan J. Jenkins | 2012 | Cancer Cell2012，，4： | 3 |
| 2 | Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of显示文摘Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival(OS) responses, to the use of one such system, implantable macrobeads [RENCA macrobeads(RMBs)], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer(m CRC) are described here.Methods: Forty-eight m CRC patients(30 females; 18 males), who had failed all available, approved treatments,underwent RMB implantation(8 RMB/kg body weight) up to 4 times in phase I and phase IIa open-label trials.Physicals, labs [tumor and inflammation markers, lactate dehydrogenase(LDH)] and positron emission tomography-computed tomography(PET-CT) imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy(as defined by biological responses). PET-CT maximum standard uptake value(SUVmax)(baseline and d 90; SUVmax ≥2.5), LDH,and carcinoembryonic antigen(CEA) and/or cancer antigen 19-9(CA 19-9) response(baseline, d 30 and/or d 60)were assessed and compared to OS.Results: Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose(FDG)-positive lesions(phase I, 39; 2 a, 82) were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV(10) plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders(R)(d 0–60, 290.4–333.9), but increased steadily in Non-responders(NR)(d 0–60, 382.8–1,278.5)(d 60, P=0.050). Responders to RMBs, indicated by the changes in the above markers, correlated with OS(R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006).Conclusions: The correlations of the tumor marker, tumor volume and SUV changes on PET-CT, and LDH levels themselves, and with OS, support the concept of a biological response to RMB implantation and the validity of the biological-systems approach to m CRC. A phase III clinical trial is planned. | Barry H.Smith Lawrence S.Gazda Thomas J.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada Joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson J.Ocean Richard D.Hall David J.Wolf | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 3 | Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction显示文摘 | Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander–Tetri Prithi S. Bhathal John B. Dixon Martin D. Weltman Herbert Tilg Alexander R. Moschen David M. Purdie Anthony J. Demetris Andrew D. Clouston | 2007 | Gastroenterology2007，，1： | 2 |
| 4 | Sympathetic innervation of the liver in man and dog: An immunohistochemical study显示文摘 | Reinier Mann B Appl Sci Prithi S. Bhathal MBBS PhD Christopher Bell | 1991 | Clinical Autonomic Research1991，，2： | 2 |
| 5 | Fine mapping and structural analysis of immuno-dominant Ig E allergenic epitopes in chicken egg ovalbumin显示文摘 | Yoshinori M Prithy R | 2003 | Protein Engineering2003，16，10： | 1 |
| 6 | Expression of bioactive porcine interferon-gammaby recombinant Lactococc uslactis 显示文摘 | Prithy Rupa Vicente Moneero Bruce N Wilkie | 2008 | Veterinary Microbiology2008，129，： | 1 |
| 7 | Nonalcoholicqliver fatty liver disease: predictors of nonalcoholic steatohepatits and liver fibrosis in the severely obese显示文摘 | Prithi SB Paul O | 2001 | Gastroenterology2001，121，： | 1 |
| 8 | Enzyme therapy for management of coeliac disease显示文摘 | Hugh J. Cornell Finlay A. MacRae Joy Melny Catherine J. Pizzey Fiona Cook Sandra Mason Prithi S. Bhathal Teodor Stelmasiak | 2005 | Scandinavian Journal of Gastroenterology2005，，11： | 1 |
| 9 | Heterogeneity of fibrosis patterns in non‐alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways显示文摘 | Richard Skoien Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander‐Tetri Prithi S. Bhathal John B. Dixon Paul E. O’Brien Herbert Tilg Alexander R. Moschen Ulrich Baumann Rachel M. Brown Richard T. Couper Ni | 2013 | Liver Int2013，，4： | 1 |
| 10 | Hepatic steatosis estimated microscopically versus digital image analysis显示文摘 | Andrew R. Hall Amar P. Dhillon Anna C. Green Linda Ferrell James M. Crawford Venancio Alves Charles Balabaud Prithi Bhathal Paulette Bioulac‐Sage Maria Guido Prodromos Hytiroglou Yasuni Nakanuma Valerie Paradis Alberto Quaglia Dale Snover Neil Theise Swan | 2013 | Liver Int2013，，6： | 1 |
| 11 | Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss显示文摘 | John B Prithi S Norman R | 2004 | Hepatology2004，39，6： | 1 |
| 12 | Weight Loss and Non-alcoholic Fatty Liver Disease: Falls In Gamma-Glutamyl Transferase Concentrations are Associated with Histologic Improvement显示文摘 | John B Dixon MBBS PhD FRACGP Prithi S Bhathal MBBS PhD FRCPA Paul E O’Brien MD FRACS | 2006 | Obesity Surgery2006，，10： | 1 |
| 13 | Living with liver disease in the era of COVID-19-the impact of the epidemic and the threat to high-risk populations显示文摘The cardinal symptoms of severe acute respiratory syndrome coronavirus 2 infection as the pandemic began in 2020 were cough,fever,and dyspnea,thus characterizing the virus as a predominantly pulmonary disease.While it is apparent that many patients presenting acutely to the hospital with coronavirus disease 2019(COVID-19)infection have complaints of respiratory symptoms,other vital organs and systems are also being affected.In fact,almost half of COVID-19 hospitalized patients were found to have evidence of some degree of liver injury.Incidence and severity of liver injury in patients with underlying liver disease were even greater.According to the Centers of Disease Control and Prevention,from August 1,2020 to May 31,2022 there have been a total of 4745738 COVID-19 hospital admissions.Considering the gravity of the COVID-19 pandemic and the incidence of liver injury in COVID-19 patients,it is imperative that we as clinicians understand the effects of the virus on the liver and conversely,the effect of underlying hepatobiliary conditions on the severity of the viral course itself.In this article,we review the spectrum of novel studies regarding COVID-19 induced liver injury,compiling data on the effects of the virus in various age and high-risk groups,especially those with preexisting liver disease,in order to obtain a comprehensive understanding of this disease process.We also provide an update of the impact of the new Omicron variant and the changing nature of COVID-19 pathogenesis. | Pranav Barve Prithi Choday Anphong Nguyen Tri Ly Isha Samreen Sukhwinder Jhooty Chukwuemeka A Umeh Sumanta Chaudhuri | 2022 | World Journal of Clinical Cases2022，10，36： | 0 |
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