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| 1 | 文献快报(8):美国儿科学会颁布新版儿童青少年高血压筛查与管理临床实践指南显示文摘美国儿科学会于2017年8月重新颁布了《儿童青少年高血压筛查与管理临床实践指南》(以下简称《新指南》),主要涉及了新的规范血压图表、筛查方案修订和启动药物降压治疗的推荐,此外指南还对儿童血压偏高和高血压筛查时间及动态血压监测进行了推荐。为促进儿科临床诊疗中血压偏高的早期发现,《新指南》纳入了简化表格用于筛查。以舒张压和收缩压的第90百分位值作为筛查阳性标准,需要进一步开展听诊器袖套方法确诊。 | FLYNN J T KAELBER D C BAKER-SMITH C M 孙莹 | 2017 | 中国学校卫生2017，38，10： | 57 |
| 2 | 3D打印碳纤维增强PLA试件的力学性能分析显示文摘以300目短切碳纤维(CF)和聚乳酸(PLA)为实验原料,分别配制CF质量分数为5%、10%、15%和20%的CF/PLA混合料,再经双螺杆挤出机挤出造粒后得到CF/PLA复合材料。分别以纯PLA和不同组分的CF/PLA复合材料为实验材料,在粒料3D打印机上制备抗拉伸、压缩、弯曲和冲击试样,并做力学性能测试。实验结果表明,随着CF含量的增加,材料最大拉伸强度呈先增大后减小的趋势,当CF含量为5%时,材料的平均拉伸强度最大,为48.45 MPa。材料的平均弯曲和压缩强度随CF含量的增加均呈先减小后增大再减小的趋势,且无CF填充时,二者的强度值最大,分别为114.77 MPa和103.94 MPa。材料的抗冲击强度随着CF含量的增大呈先增大后减小的趋势,当CF含量为5%时,材料的抗冲击强度最大,为14.49 kJ/m^2。 | 刘晓军 Liam Dillon Flynn Lachendro James 杨卫民 焦志伟 | 2017 | 塑料2017，46，3： | 12 |
| 3 | NICE指南概要:共病状态的临床评估和管理显示文摘大多数慢性疾病患者患有一种或多种慢性疾病,共病状态在老年人中十分常见(图1和图2)。共病状态的重要性在于其与降低生活质量、高死亡率、多重用药、更高药物不良事件几率、更多计划外医疗服务耗费均相关。共病患者需要频繁前往初级医疗保健机构和各个专科就诊,这些机构的医师之间可能缺乏有效沟通交流。 | Caroline Farmer Elisabetta Fenu Norma O'Flynn Bruce Guthrie 符天旭 | 2017 | 中国医院院长2017，13，5： | 8 |
| 4 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 5 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 6 | GE公司GEVO柴油机的开发显示文摘 美国GE公司运输分部开发了一种新型柴油机以满足下一阶段的排放和燃油经济性要求。该型发动机的开发始于1998年,其包括GE公司现有发动机的最佳特性以及新发动机技术的最新发展。它将首先应用于自2005年起新造的符合美国环保局2级排放标准的内燃机车。GEVO12缸发动机在1050 r/min下的标定功率达到3360 kW,这相当于原来的一台7FDL 16缸发动机所达到的功率水平。发动机的缸径为250 mm,行程为320 mm。这导致了采用约2 0 MPa的较保守的平均有效压力。美国机车的2级排放标准较之0级和1级排放标准在降低NOx和颗粒物质排放方面具有特殊要求。为了达到NOx排放标准而对现有发动机作进一步调整势必造成燃油经济性的巨大损失。为此,GE公司运输分部正通过开发一种新型发动机来满足2级排放标准要求,新型发动机将不仅能满足排放要求,而且在燃油经济性方面较之现有发动机亦将有较大改进。发动机的性能开发包括燃烧模拟、系统模拟和优化。应用统计学方法对燃油喷射系统进行了优化设计以保证高效和可靠的运行。涡轮增压器设计采用了先进的空气动力学和结构模拟以获得高的效率和安全性。单缸机和多缸机的性能试验进一步改进了燃烧系统。采用一个严格的可靠性设计(DFR)程序对每个系统和部件的可靠性进行了评估。通过将? | Paul Flynn Patrick Hupperich 王庆宇 | 2005 | 国外内燃机车2005，，1： | 5 |
| 7 | Data clustering显示文摘 | A. K. Jain M. N. Murty P. J. Flynn | 1999 | ACM Computing Surveys (CSUR)1999，，3： | 5 |
| 8 | The impact of supply chain integration on performance: A contingency and configuration approach显示文摘 | Barbara B. Flynn Baofeng Huo Xiande Zhao | 2009 | Journal of Operations Management2009，，1： | 5 |
| 9 | Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement显示文摘 | J. Esquivel R. Sticca P. Sugarbaker E. Levine T. D. Yan R. Alexander D. Baratti D. Bartlett R. Barone P. Barrios S. Bieligk P. Bretcha-Boix C. K. Chang F. Chu Q. Chu S. Daniel E. Bree M. Deraco L. Dominguez-Parra D. Elias R. Flynn J. Foster A. Garofalo F. | 2007 | Annals of Surgical Oncology2007，，1： | 4 |
| 10 | 北极臭氧年际变化特征及其与极涡的关系显示文摘利用风云三号卫星搭载的紫外臭氧总量探测仪(TOU)和国际同类卫星的臭氧总量数据对1979年—2011年北半球春季臭氧特征进行了分析,发现北极臭氧年际变化显著,它与平流层温度变化一致(相关系数为0.75)。北极臭氧损耗异常强弱年的月均和日变化特征有明显差异,春季北极臭氧损耗强年有明显的化学损耗过程(1997年和2011年),而弱年化学作用影响不明显(1999年和2010年)。损耗弱年的日变化型在不同年份特征不同,它的臭氧变化可能更多受天气过程的影响。综合分析北极涛动、极涡和平流层温度等大气环流背景场的变化,表明春季北极臭氧损耗强弱受大气环流变化影响。北极涛动指数正位相,极涡偏强偏冷,北极臭氧损耗异常偏高。北极涛动指数负位相,极涡偏弱偏暖,北极臭氧损耗异常偏低。 | 张艳 王维和 张兴赢 LAWRENCE Flynn | 2013 | 遥感学报2013，17，3： | 4 |
| 11 | Towards a Wireless Sensor Platform for Energy Efficient Building Operation显示文摘Currently, the IT-support for energy performance rating of buildings is insufficient. So-called IT-platforms often 'built' of an ad-hoc, inconsistent combination of off-the-shelf building management compo-nents, distributed data metering equipment and several monitoring software tools. A promising approach to achieve consistent, holistic performance data management is the implementation of an integrated, modular wireless sensor platform. This paper presents an approach of how wireless sensors can be seamlessly integrated into existing and future intelligent building management systems supporting improved building performance and diagnostics with an emphasis on energy management. | Karsten Menzel Dirk Pesch Brendan O'Flynn Marcus Keane Cian O'Mathuna | 2008 | Tsinghua Science and Technology2008，13，S1： | 4 |
| 12 | The impact of power and relationship commitment on the integration between manufacturers and customers in a supply chain显示文摘 | Xiande Zhao Baofeng Huo Barbara B. Flynn Jeff Hoi Yan Yeung | 2007 | Journal of Operations Management2007，，3： | 3 |
| 13 | An Optical Coherence Tomography-Guided, Variable Dosing Regimen with Intravitreal Ranibizumab (Lucentis) for Neovascular Age-related Macular Degeneration显示文摘 | Anne E. Fung Geeta A. Lalwani Philip J. Rosenfeld Sander R. Dubovy Stephan Michels William J. Feuer Carmen A. Puliafito Janet L. Davis Harry W. Flynn Maria Esquiabro | 2007 | American Journal of Ophthalmology2007，，4： | 3 |
| 14 | Efficacy of telemedicine on glycaemic control in patients with type 2 diabetes:A meta-analysis显示文摘BACKGROUND Telemedicine is defined as the delivery of health services via remote communication and technology.It is a convenient and cost-effective method of intervention,which has shown to be successful in improving glyceamic control for type 2 diabetes patients.The utility of a successful diabetes intervention is vital to reduce disease complications,hospital admissions and associated economic costs.AIM To evaluate the effects of telemedicine interventions on hemoglobin A1c(HbA1c),systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),post-prandial glucose(PPG),fasting plasma glucose(FPG),weight,cholesterol,mental and physical quality of life(QoL)in patients with type 2 diabetes.The secondary aim of this study is to determine the effect of the following subgroups on HbA1c post-telemedicine intervention;telemedicine characteristics,patient characteristics and self-care outcomes.METHODS PubMed Central,Cochrane Library,Embase and Scopus databases were searched from inception until 18th of June 2020.The quality of the 43 included studies were assessed using the PEDro scale,and the random effects model was used to estimate outcomes and I2 for heterogeneity testing.The mean difference and standard deviation data were extracted for analysis.RESULTS We found a significant reduction in HbA1c[-0.486%;95%confidence interval(CI)-0.561 to-0.410,P<0.001],DBP(-0.875 mmHg;95%CI-1.429 to-0.321,P<0.01),PPG(-1.458 mmol/L;95%CI-2.648 to-0.268,P<0.01),FPG(-0.577 mmol/L;95%CI-0.710 to-0.443,P<0.001),weight(-0.243 kg;95%CI-0.442 to-0.045,P<0.05),BMI(-0.304;95%CI-0.563 to-0.045,P<0.05),mental QoL(2.210;95%CI 0.053 to 4.367,P<0.05)and physical QoL(-1.312;95%CI 0.545 to 2.080,P<0.001)for patients following telemedicine interventions in comparison to control groups.The results of the meta-analysis did not show any significant reductions in SBP and cholesterol in the telemedicine interventions compared to the control groups.The telemedicine characteristic subgroup analysis revealed that clinical treatment models of intervention,as well as those involving telemonitoring,and those provided via modes of videoconference or interactive telephone had the greatest effect on HbA1c reduction.In addition,interventions delivered at a less than weekly frequency,as well as those given for a duration of 6 mo,and those lead by allied health resulted in better HbA1c outcomes.Furthermore,interventions with a focus on biomedical parameters,as well as those with an engagement level>70%and those with a drop-out rate of 10%-19.9%showed greatest HbA1c reduction.The patient characteristics investigation reported that Hispanic patients with T2DM had a greater HbA1c reduction post telemedicine intervention.For self-care outcomes,telemedicine interventions that resulted in higher postintervention glucose monitoring and self-efficacy were shown to have better HbA1c reduction.CONCLUSION The findings indicate that telemedicine is effective for improving HbA1c and thus,glycemic control in patients with type 2 diabetes.In addition,telemedicine interventions were also found to significantly improved other health outcomes as well as QoL scores.The results of the subgroup analysis emphasized that interventions in the form of telemonitoring,via a clinical treatment model and with a focus on biomedical parameters,delivered at a less than weekly frequency and 6 mo duration would have the largest effect on HbA1c reduction.This is in addition to being led by allied health,through modes such as video conference and interactive telephone,with an intervention engagement level>70%and a drop-out rate between 10%-19.9%.Due to the high heterogeneity of included studies and limitations,further studies with a larger sample size is needed to confirm our findings. | Julia De Groot Dongjun Wu Declan Flynn Dylan Robertson Gary Grant Jing Sun | 2021 | World Journal of Diabetes2021，12，2： | 3 |
| 15 | Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia显示文摘 | Hiroto Inaba Aditya H. Gaur Xueyuan Cao Patricia M. Flynn Stanley B. Pounds Viswatej Avutu Lindsay N. Marszal Scott C. Howard Ching‐Hon Pui Raul C. Ribeiro Randall T. Hayden Jeffrey E. Rubnitz | 2014 | Cancer2014，，13： | 3 |
| 16 | Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth显示文摘 | Michael S O’Reilly Thomas Boehm Yuen Shing Naomi Fukai George Vasios William S Lane Evelyn Flynn James R Birkhead Bjorn R Olsen Judah Folkman | 1997 | Cell1997，，2： | 3 |
| 17 | GE公司PowerHaul柴油机的开发显示文摘GE运输装备公司开发了一种新系列柴油机以接受轻型机车高功率、低重量和新排放要求的挑战。该系列柴油机的第一个成员为16缸机,该机在1500r/min下标定功率为2750kW。未来的机型包括一种标定功率为2060kW的12缸发动机,其用于船舶发电。PowerHaul发动机由成功的6系列Jenbacher气体燃料发动机演变而来。它保持了后者的强度,同时应用了最新的燃料喷射、涡轮增压和燃烧系统技术。高压共轨系统可以灵活地优化NOx排放与燃油消耗之间的折衷效果,同时使颗粒物的排放降至最低。发动机采用高压比、单级增压器供应空气以支持一种适度的Miller循环燃烧系统。利用一适度的Miller循环进气门关闭来保持涡轮增压器和一种传统的气门机构简单匹配,与此同时保持良好的加速和低功率性能。在一台单缸试验机上对燃烧过程进行了模拟与校准,以评估几种活塞头、气门定时、增压比和燃油喷嘴几何形状的组合效果。这使得只需制造一套多缸硬件并直接达到功率、排放和燃油消耗的目标。该16缸发动机已被证明达到欧盟EUIIIa排放标准。发动机的基本结构经过修改以与机车主发电机紧密配合,并驱动机车冷却系统所需的机油泵和冷却水泵。发动机弹性地安装在机车内,除了抵抗在机车应用中遇到的冲击负荷外,还可以减少振动传递。通过广泛的部件和发动机耐久性试验,整个发动机及其主要零部件已被证实可以用于机车运营。发动机允许超速10%,超载20%。此外,还对发动机做了一项特殊的负荷循环试验,以使其能够胜任高循环机车运营。16缸PowerHaul发动机的首次应用将是安装在为英国货运铁路公司提供的PH37ACmi型机车上。在轻型机车市场上,该发动机代表了功率、排放、牵引力和燃油消耗的新标准。 | Paul Flynn 李臣 | 2011 | 国外内燃机车2011，，1： | 3 |
| 18 | Management of infected pancreatic necrosis in the setting of concomitant rectal cancer:A case report and review of literature显示文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant treatment and resection for his concomitant colorectal cancer. | Kihoon Choi David E Flynn Anitha Karunairajah Andrew Hughes Ambika Bhasin Benedict Devereaux Manju D Chandrasegaram | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 2 |
| 19 | The impact of supply chain integration on performance: A contingency and configuration approach显示文摘 | Barbara B. Flynn Baofeng Huo Xiande Zhao | 2009 | Journal of Operations Management2009，，1： | 2 |
| 20 | Data clustering:a review显示文摘 | JAIN A K MURTY M N FLYNN P J | 1999 | AGM Computing Surveys1999，31，3： | 2 |
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