|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 西藏及其周围地区地壳、地幔地震层析成像——印度板块大规模俯冲于西藏高原之下的证据显示文摘文中介绍有关西藏—喜马拉雅碰撞带的一项地震层析成像研究。根据一个用天然地震数据产生的全球波速模型 ,印度板块有可能以近水平状俯冲于整个西藏高原之下至 16 5~ 2 6 0km深度。西藏岩石圈具有低波速地壳和高波速下岩石圈 (75~ 12 0km深 )。在 12 0~ 16 5km深度范围 ,西藏岩石圈与俯冲的印度板块之间有一层低速软流圈物质。高原中部从地表到 310km深处有一低速体 ,说明地幔物质有可能穿过俯冲板块的脆弱部位上隆。这些结果以及野外实测的地壳缩短值说明高原的抬升得助于印度板块的近水平俯冲。我们推论俯冲印度板块的升温上浮以及上覆软流层的存在是造成西藏高原高海拔抬升以及内部地表仍相对平坦的主要原因。2 0 0 1年 1月 2 6日在印度西部发生的毁灭性大地震有可能是俯冲应力在印度板块后缘薄弱处引发的岩石圈大断裂。 | 周华伟 Michael A. MURPHY 林清良 | 2002 | 地学前缘2002，9，4： | 32 |
| 2 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 3 | Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial显示文摘 | Michael Miller Christopher P. Cannon Sabina A. Murphy Jie Qin Kausik K. Ray Eugene Braunwald | 2008 | Journal of the American College of Cardiology2008，，7： | 2 |
| 4 | Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice显示文摘 | Rachel A. Gioscia‐Ryan Thomas J. LaRocca Amy L. Sindler Melanie C. Zigler Michael P. Murphy Douglas R. Seals | 2014 | J Physiol2014，，12： | 1 |
| 5 | A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic显示文摘 | Geoffrey F. Kelso Andrej Maroz Helena M. Cochemé Angela Logan Tracy A. Prime Alexander V. Peskin Christine C. Winterbourn Andrew M. James Meredith F. Ross Sally Brooker Carolyn M. Porteous Robert F. Anderson Michael P. Murphy Robin A.J. Smith | 2012 | Chemistry & Biology2012，，10： | 1 |
| 6 | Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic显示文摘 | C. Ellie Wilson Nicola Gillan Deborah Spain Dene Robertson Gedeon Roberts Clodagh M. Murphy Stefanos Maltezos Janneke Zinkstok Katie Johnston Christina Dardani Chris Ohlsen P. Quinton Deeley Michael Craig Maria A. Mendez Francesca Happé Declan G. M. Murph | 2013 | Journal of Autism and Developmental Disorders2013，，11： | 1 |
| 7 | Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy显示文摘 | Delyth Graham Ngan N. Huynh Carlene A. Hamilton Elisabeth Beattie Robin A.J. Smith Helena M. Cochemé Michael P. Murphy Anna F. Dominiczak | 2009 | Hypertension2009，，2： | 1 |
| 8 | Relationship of TIMI Myocardial Perfusion Grade to Mortality After Administration of Thrombolytic Drugs显示文摘 | C. Michael Gibson Christopher P. Cannon Sabina A. Murphy Kathryn A. Ryan Rebecca Mesley Susan J. Marble Carolyn H. McCabe Frans Van de Werf Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，2： | 1 |
| 9 | Direct Activation of Cytosolic Ca 2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells显示文摘 | John A. Murphy David N. Criddle Mark Sherwood Michael Chvanov Rajarshi Mukherjee Euan McLaughlin David Booth Julia V. Gerasimenko Michael G.T. Raraty Paula Ghaneh John P. Neoptolemos Oleg V. Gerasimenko Alexei V. Tepikin Gary M. Green Joseph R. Reeve Ole | 2008 | Gastroenterology2008，，2： | 1 |
| 10 | Abciximab Improves Both Epicardial Flow and Myocardial Reperfusion in ST-Elevation Myocardial Infarction: Observations from the TIMI 14 Trial显示文摘 | James A. de Lemos Elliott M. Antman C. Michael Gibson Carolyn H. McCabe Robert P. Giugliano Sabina A. Murphy Stephanie A. Coulter Keaven Anderson Joel Scherer Martin J. Frey R. Van der Wieken Frans Van de Werf Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，3： | 1 |
| 11 | Early initiation of eptifibatide in the emergency department before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Results of the Time to Integrilin Therapy in Acute Myocardial Infarction (TITAN)-TIMI 34 trial显示文摘 | C. Michael Gibson Ajay J. Kirtane Sabina A. Murphy Steve Rohrbeck Venu Menon Jeffrey Lins Samer Kazziha Ivan Rokos Nicolas W. Shammas Theresa M. Palabrica Polly Fish Carolyn H. McCabe Eugene Braunwald | 2006 | American Heart Journal2006，，4： | 1 |
| 12 | Association of Impaired Thrombolysis In Myocardial Infarction Myocardial Perfusion Grade With Ventricular Tachycardia and Ventricular Fibrillation Following Fibrinolytic Therapy for ST-Segment Elevation Myocardial Infarction显示文摘 | C. Michael Gibson Yuri B. Pride Jacqueline L. Buros Erin Lord Amy Shui Sabina A. Murphy Duane S. Pinto Peter J. Zimetbaum Marc S. Sabatine Christopher P. Cannon Mark E. Josephson | 2008 | Journal of the American College of Cardiology2008，，5： | 1 |
| 13 | Clinical Features, Use of Evidence‐Based Therapies, and Cardiovascular Outcomes Among Patients With Chronic Kidney Disease Following Non– ST ‐Elevation Acute Coronary Syndrome显示文摘 | June‐Wha Rhee Stephen D. Wiviott Benjamin M. Scirica C. Michael Gibson Sabina A. Murphy Marc P. Bonaca David A. Morrow Jessica L. Mega | 2014 | Clin Cardiol2014，，6： | 1 |
| 14 | Relationship of TIMI Myocardial Perfusion Grade to Mortality After Administration of Thrombolytic Drugs显示文摘 | C. Michael Gibson Christopher P. Cannon Sabina A. Murphy Kathryn A. Ryan Rebecca Mesley Susan J. Marble Carolyn H. McCabe Frans Van de Werf Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，2： | 1 |
| 15 | Effect of Intensive Lipid-Lowering Therapy on Mortality After Acute Coronary Syndrome (a Patient-Level Analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis In Myocardial Infarction 22 Trials)显示文摘 | Sabina A. Murphy Christopher P. Cannon Stephen D. Wiviott James A. de Lemos Michael A. Blazing Carolyn H. McCabe Robert M. Califf Eugene Braunwald | 2007 | The American Journal of Cardiology2007，，： | 1 |
| 16 | Is the glass half full or half empty?: An examination of user and provider perspectives towards third-party logistics relationships显示文摘 | A. Michael Knemeyer Paul R. Murphy | 2005 | International Journal of Physical Distribution & Logistics Management2005，，10： | 1 |
| 17 | Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells显示文摘 | Dmitry O. Traktuev Daniel N. Prater Stephanie Merfeld-Clauss Aravind Raj Sanjeevaiah M Reza Saadatzadeh Michael Murphy Brian H. Johnstone David A. Ingram Keith L. March | 2009 | Circulation Research2009，，12： | 1 |
| 18 | Association of Platelet Counts on Presentation and Clinical Outcomes in ST-Elevation Myocardial Infarction (from the TIMI Trials)显示文摘 | Hung Q. Ly Ajay J. Kirtane Sabina A. Murphy Jacki Buros Christopher P. Cannon Eugene Braunwald C. Michael Gibson | 2006 | The American Journal of Cardiology2006，，1： | 1 |
| 19 | Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 in patients with cirrhosis显示文摘 | Bashar A. Aqel Surakit Pungpapong Michael Leise K. Tuesday Werner Amy E. Chervenak Kymberly D. Watt Jennifer L. Murphy Kristen Ryland Andrew P. Keaveny Ryan McLemore Hugo E. Vargas | 2015 | Hepatology2015，，4： | 1 |
| 20 | A Phase II Study of AT-101 (Gossypol) in Chemotherapy-Sensitive Recurrent Extensive-Stage Small Cell Lung Cancer显示文摘 | Maria Q. Baggstrom Yingwei Qi Marianna Koczywas Athanassios Argiris Elizabeth A. Johnson Michael J. Millward Sara C. Murphy Charles Erlichman Charles M. Rudin Ramaswamy Govindan | 2011 | Journal of Thoracic Oncology2011，，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员