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| 1 | Metastatic gastric cancer treatment: Second line and beyond显示文摘Advanced gastric cancer(a GC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve survival and tumor related symptoms in the frontline setting, second-line therapy(SLT) is subject to much debate in the scientific community, mainly because of the debilitating effects of GC, which would impede the administration of cytotoxic therapy. Recent data has provided sufficient evidence for the safe use of SLT in patients with an adequate performance status. Taxanes, Irinotecan and even some Fluoropyrimidine analogs were found to provide a survival advantage in this subset of patients. Most importantly, quality of life measures were also improved through the use of adequate therapy. Even more pertinent were the findings involving antiangiogenic agents, which would add measurable improvements without significantly jeopardizing the patients' well-being. Further lines of therapy are cause for much more debate nowadays, but specific targeted agents have shown considerable promise in this context. We herein review noteworthy published data involving the use of additional lines of the therapy after failure of standard frontline therapies in patients with a GC. | Marwan Ghosn Samer Tabchi Hampig Raphael Kourie Mustapha Tehfe | 2016 | World Journal of Gastroenterology2016，22，11： | 10 |
| 2 | Resistin is not an appropriate biochemical marker to predict severity of acute pancreatitis:A case-controlled study显示文摘AIM:To assess levels of serum resistin upon hospital admission as a predictor of acute pancreatitis(AP) severity.METHODS:AP is both a common and serious disease,with severe cases resulting in a high mortality rate.Several predictive inflammatory markers have been used clinically to assess severity.This prospective study collected data from 102 patients who were diagnosed with an initial acute biliary pancreatitis between March 2010 and February 2013.Measurements of body mass index(BMI) and waist circumference(WC) were obtained and serum resistin levels were analyzed at the time of hospital admission using enzyme-linked immunosorbent assay.Additionally,resistin levels were measured from a control group after matching gender,BMI and age.RESULTS:A total of 102 patients(60 females and 42 males) were diagnosed with acute gallstone-induced pancreatitis.The mean age was 45 years,and mean BMI value was 30.5 kg/m2(Obese,class?Ⅰ).Twentytwo patients(21.6%) had severe AP,while eighty-eight patients had mild pancreatitis(78.4%).Our results showed that BMI significantly correlated with pancreatitis severity(P = 0.007).Serum resistin did not correlate with BMI,weight or WC.Furthermore,serum resistin was significantly higher in patients with AP compared to control subjects(P < 0.0001).The mean resistin values upon admission were 17.5 ng/mL in the severe acute biliary pancreatitis group and 16.82 ng/mL in the mild AP group(P = 0.188),indicating that resistin is not an appropriate predictive marker of clinical severity.CONCLUSION:We demonstrate that obesity is a risk factor for developing severe AP.Further,although there is a correlation between serum resistin levels and AP at the time of hospital admission,resistin does not adequately serve as a predictive marker of clinical severity. | Hamdi Al-Maramhy Abdelrahman I Abdelrahman Samer Sawalhi | 2014 | World Journal of Gastroenterology2014，20，41： | 10 |
| 3 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 4 | 基于钻柱正弦屈曲的套管磨损预测模型显示文摘在复杂井况油气勘探开发的钻井过程中,巨大的摩阻扭矩和严重的狗腿度使钻柱和套管不可避免地发生接触,导致严重的套管磨损。基于能量耗散原理和新的复杂几何关系,建立一种考虑钻柱正弦屈曲的套管磨损预测模型,并利用套管磨损因子反演的方法校正并预测具有相似结构和井眼轨迹的井的套管磨损情况。该模型应用于涪陵页岩气套管磨损预测,通过井X1现场井径测试数据对具有相似结构和井眼轨迹的井X2进行磨损预测。结果表明:当测深达到2 700 m时,如果不考虑钻柱的正弦屈曲会导致磨损深度预测误差超过23.9%;对于位于1989 m钻柱接头与套管的目标磨损位置,若考虑正弦屈曲情况,实际位于1 794 m处,预测误差达到9.8%;忽略钻柱正弦屈曲对套管磨损的影响会导致套管磨损预测不准确。 | 谭雷川 高德利 ADEEB Samer 陶红 陶冶 王正旭 任韶然 庞琬滢 张馨方 | 2019 | 中国石油大学学报(自然科学版)2019，43，4： | 8 |
| 5 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 6 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 7 | Ileal lipoma-a rare cause of ileocolic intussusception in adults:Case report and literature review显示文摘The occurrence of intussusception in adults is rare,accounting for less than 5% of all cases of intussusceptions and almost 1%-5% of bowel obstruction.The condition is found in less than 1 in 1300 abdominal operations and 1 in 100 patients operated for intestinal obstruction.The child to adult ratio is more than 20:1.We report a rare case of ileocolic intussusception in an adult secondary to an ileal lipoma. | Hany Balamoun Samer Doughan | 2011 | World Journal of Gastrointestinal Surgery2011，3，1： | 5 |
| 8 | Randomized study comparing incidence of radial artery occlusion post-percutaneous coronary intervention between two conventional compression devices using a novel airinflation technique显示文摘AIM To compare post-percutaneous coronary intervention(PCI) radial artery occlusion(RAO) incidence between two conventional radial artery compression devices using a novel air-inflation technique.METHODS One hundred consecutive patients post-PCI were randomized 1:1 to Safeguard or TR band compression devices. Post-radial sheath removal, each compression device was inflated with additional 2 m L of air above index bleeding point during air-filled device application and gradually down-titrated accordingly. RAO was defined as absence of Doppler flow signal performed at 24 h and at 6 wk post-PCI. Patients with missing data were excluded. Statistical significance was defined as P < 0.05.RESULTS All patients had 6 F radial sheath inserted. No significant differences were observed between Safeguard Radial(n = 42) vs TR band(n = 42) in terms of age(63 ± 11 years vs 67 ± 11 years), clinical presentation(electives, n = 18 vs n = 16; acute coronary syndrome, n = 24 vs n = 26) and total procedural heparin(7778 ± 2704 IU vs 7825 ± 2450 IU). RAO incidence was not significantly different between groups at 24 h(2% vs 0%, P = 0.32) and 6 wk(0%, both).CONCLUSION Safeguard Radial and TR band did not demonstrate significant between-group differences in short-term RAO incidence. Lack of evidence of RAO in all postPCI patients at 6 wk follow-up, regardless of radial compression device indicate advantage of using the novel and pragmatic air-inflation technique. Further work is required to more accurately confirm these findings. | Victor Voon Muhammad Ayyaz Ul Haq Ciara Cahill Kirsten Mannix Catriona Ahern Terence Hennessy Samer Arnous Thomas Kiernan | 2017 | World Journal of Cardiology2017，9，11： | 5 |
| 9 | Nonalcoholic fatty liver disease is associated with benign gastrointestinal disorders显示文摘AIM:To explore associations between nonalcoholic fatty liver disease(NAFLD)and benign gastrointestinal and pancreato-biliary disorders.METHODS:Patient demographics,diagnoses,and hospital outcomes from the 2010 Nationwide Inpatient Sample were analyzed.Chronic liver diseases were identified using International Classification of Diseases,the 9thRevision,Clinical Modification codes.Patients with NAFLD were compared to those with other chronic liver diseases for the endpoints of total hospital charges,disease severity,and hospital mortality.Multivariable stepwise logistic regression analyses to assess for the independent association of demographic,comorbidity,and diagnosis variables with the event of NAFLD(vs other chronic liver diseases)were also performed.RESULTS:Of 7800441 discharge records,32347(0.4%)and 271049(3.5%)included diagnoses of NAFLD and other chronic liver diseases,respectively.NAFLD patients were younger(average 52.3 years vs55.3 years),more often female(58.8%vs 41.6%),less often black(9.6%vs 18.6%),and were from higher income areas(23.7%vs 17.7%)compared to counterparts with other chronic liver diseases(all P<0.0001).Diabetes mellitus(43.4%vs 28.9%),hypertension(56.9%vs 47.6%),morbid obesity(36.9%vs 8.0%),dyslipidemia(37.9%vs 15.6%),and the metabolic syndrome(28.75%vs 8.8%)were all more common among NAFLD patients(all P<0.0001).The average total hospital charge($39607 vs$51665),disease severity scores,and intra-hospital mortality(0.9%vs6.0%)were lower among NALFD patients compared to those with other chronic liver diseases(all P<0.0001).Compared with other chronic liver diseases,NAFLD was significantly associated with diverticular disorders[OR=4.26(3.89-4.67)],inflammatory bowel diseases[OR=3.64(3.10-4.28)],gallstone related diseases[OR=3.59(3.40-3.79)],and benign pancreatitis[OR=2.95(2.79-3.12)]on multivariable logistic regression(all P<0.0001)when the latter disorders were the principal diagnoses on hospital discharge.Similar relationships were observed when the latter disorders were associated diagnoses on hospital discharge.CONCLUSION:NAFLD is associated with diverticular,inflammatory bowel,gallstone,and benign pancreatitis disorders.Compared with other liver diseases,patients with NAFLD have lower hospital charges and mortality. | Srinevas K Reddy Min Zhan H Richard Alexander Samer S El-Kamary | 2013 | World Journal of Gastroenterology2013，19，45： | 4 |
| 10 | Pharmacological Management of Type 2 Diabetes Mellitus: An Update显示文摘 | Samer El-Kaissi Suphia Sherbeeni | 2011 | Current Diabetes Reviews2011，，6： | 3 |
| 11 | Gastrointestinal and hepatic complications of hematopoietic stem cell transplantation显示文摘Recognition and management of gastrointestinal and hepatic complications of hematopoietic stem cell transplantation has gained increasing importance as indications and techniques of transplantation have expanded in the last few years.The transplant recipient is at risk for several complications including conditioning chemotherapy related toxicities,infections,bleeding,sinusoidal obstruction syndrome,acute and chronic graftversus-host disease(GVHD) as well as other long-term problems.The severity and the incidence of many complications have improved in the past several years as the intensity of conditioning regimens has diminished and better supportive care and GVHD prevention strategies have been implemented.Transplant clinicians,however,continue to be challenged with problems arising from human leukocyte antigen-mismatched and unrelated donor transplants,expanding transplant indications and age-limit.This review describes the most commonly seen transplant related complications,focusing on their pathogenesis,differential diagnosis and management. | Hande H Tuncer Naveed Rana Cannon Milani Angela Darko Samer A AlHomsi | 2012 | World Journal of Gastroenterology2012，18，16： | 3 |
| 12 | Simpli?ed point-of-care ultrasound protocol to con?rm central venous catheter placement:A prospective study显示文摘BACKGROUND: The current standard for con? rmation of correct supra-diaphragmatic central venous catheter(CVC) placement is with plain ? lm chest radiography(CXR). We hypothesized that a simple point-of-care ultrasound(POCUS) protocol could effectively con? rm placement and reduce time to con? rmation.METHODS: We prospectively enrolled a convenience sample of patients in the emergency department and intensive care unit who required CVC placement. Correct positioning was considered if turbulent flow was visualized in the right atrium on sub-xiphoid, parasternal or apical cardiac ultrasound after injecting 5 cc of sterile, non-agitated, normal saline through the CVC.RESULTS: Seventy-eight patients were enrolled. POCUS had a sensitivity of 86.8%(95%CI 77.1%–93.5%) and speci? city of 100%(95%CI 15.8%–100.0%) for identifying correct central venous catheter placement. Median POCUS and CXR completion were 16 minutes(IQR 10–29) and 32 minutes(IQR 19–45), respectively.CONCLUSION: Ultrasound may be an effective tool to confirm central venous catheter placement in instances where there is a delay in obtaining a con? rmatory CXR. | Scan P.Wilson Samer Assaf Shadi Lahham Mohammad Subeh Alan Chiem Craig Anderson Samantha Shwe Ryan Nguyen John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，1： | 2 |
| 13 | Central retinal artery resistive index and optical coherence tomography in assessment of glaucoma progression显示文摘AIM: To assess the relation between central retinal artery(CRA) resistive index(RI) and retinal nerve fiber thickness measured by optical coherence tomography(OCT) in assessment of disease progress in cases of open angle glaucoma.METHODS: Twenty-three patients with diagnosed open angle glaucoma were included in this study. They were examined by colored duplex ultrasonography of CRA with estimation of RI of CRA and ophthalmic artery(OA)with estimation of CRA/OA RI ratio as well as OCT measurement of the average retinal nerve fiber layer(RNFL) thickness in order to assess the disease progress.RESULTS: There was strong inverse relation between the increased RI in CRA as well as the increased CRA/OA RI ratio and the decrease in average RNFL thickness in cases of open angle glaucoma.CONCLUSION: Assessment of CRA RI can indirectly assess the vascular changes associated with glaucoma and can assess the degree of retinal atrophy helping in evaluating prognosis thus guiding the choice of treatment. | Ahmed F.Abdel Ghany Samer M.Botros Tamer M.El-Raggal | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 2 |
| 14 | CFD based extraction column design-Chances and challenges显示文摘This paper shows that one-dimensional(1-D) [and three-dimensional(3-D) computational fluid dynamics(CFD)] simulations can replace the state-of-the-art usage of pseudo-homogeneous dispersion or back mixing models.This is based on standardized lab-scale cell experiments for the determination of droplet rise,breakage,coalescence and mass transfer parameters in addition to a limited number of additional mini-plant experiments with original fluids.Alternatively,the hydrodynamic parameters can also be derived using more sophisticated 3-D CFD simulations.Computational 1-D modeling served as a basis to replace pilot-plant experiments in any column geometry.The combination of 3-D CFD simulations with droplet population balance models(DPBM)increased the accuracy of the hydrodynamic simulations and gave information about the local droplet size.The high computational costs can be reduced by open source CFD codes when using a flexible mesh generation.First combined simulations using a three way coupled CFD/DPBM/mass-transfer solver pave the way for a safer design of industrial-sized columns,where no correlations are available. | Mark W.Hlawitschka Menwer M.Attarakilh Samer S.Alzyod Hans-Jorg Bart | 2016 | Chinese Journal of Chemical Engineering2016，24，2： | 2 |
| 15 | Combination of low vascular endothelial growth factor A (VEGF‐A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer显示文摘 | TomDonnem KhalidAl‐Shibli SigveAndersen SamerAl‐Saad Lill‐ToveBusund Roy M.Bremnes | 2010 | Cancer2010，，18： | 2 |
| 16 | Information Technology and the Changing Fabric of Organization显示文摘 | Raymond F. Zammuto Terri L. Griffith Ann Majchrzak Deborah J. Dougherty Samer Faraj | 2007 | Organization Science2007，，5： | 2 |
| 17 | 第一跖趾关节硅胶人工关节置换的远期预后:108足术后的回顾性研究显示文摘硅胶人工跖趾关节置换(MTPJ)的短期预后是十分令人满意的,但对其远期预后的研究仍相对缺乏,此次研究目的就是对硅胶人工跖趾关节置换治疗野外翻的长期疗效进行回顾性研究。这次研究对83例108足进行回顾性的研究。平均年龄为55岁(方差8.1),每例病例都作了平均8.5年的回访。用美国足踝外科协会评分系统(AOFAS)对足踝主动、被动活动度的测量、患者的主观满意度、测定患者的骨质疏松程度。 | Samer Morgan Aaron Ng Tim Clough 吴亘彬 俞光荣 | 2012 | 中国矫形外科杂志2012，20，24： | 2 |
| 18 | Similar long-term results of mitral valve repair for anterior compared with posterior leaflet prolapse显示文摘 | Michele De Bonis Roberto Lorusso Elisabetta Lapenna Samer Kassem Giuseppe De Cicco Lucia Torracca Francesco Maisano Giovanni La Canna Ottavio Alfieri | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，2： | 2 |
| 19 | Mental health in the post-COVID-19 era:challenges and the way forward显示文摘The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management. | Ramyadarshni Vadivel Sheikh Shoib Sarah El Halabi Samer El Hayek LamiaàEssam Drita Gashi Bytyçi Ruta Karaliuniene Andre Luiz Schuh Teixeira Sachin Nagendrappa Rodrigo Ramalho Ramdas Ransing Victor Pereira-Sanchez Chonnakarn Jatchavala Frances Nkechi Adiukwu Ganesh Kudva Kundadak | 2021 | General Psychiatry2021，34，1： | 2 |
| 20 | 高度近视合并青光眼患者黄斑区脉络膜厚度的多元回归分析(英文)显示文摘目的:探讨高度近视合并原发性开角型青光眼(POAG)患者的黄斑区脉络膜厚度分布特征及影响黄斑区脉络膜厚度的相关因素。方法:研究共纳入高度近视合并POAG患者18例32眼,POAG患者20例36眼,以及高度近视患者21例33眼。采用频域OCT增强深度扫描测定中心凹下(SFCT)、距中心凹1mm和3mm处上、下、鼻、颞四个方位的脉络膜厚度(S1CT、S3CT、I1CT、I3CT、N1CT、N3CT、T1CT、T3CT)。比较三组间黄斑区脉络膜厚度的差异,并利用多元回归分析对POAG患者的诊断、屈光度、年龄、眼压、角膜厚度、视野缺损等对黄斑区脉络膜厚度的影响进行分析。结果:高度近视合并POAG患者的黄斑区脉络膜厚度较POAG患者在各测量位置均明显变薄(均P<0.05),但与高度近视患者在各测量点的脉络膜厚度差异均无统计学意义(均P>0.05)。屈光度是POAG患者黄斑区各测量点脉络膜厚度的主要影响因素,颞侧距中心凹3mm处的脉络膜厚度(S3CT)受年龄的影响,而诊断、视野缺损、眼压及角膜厚度不是脉络膜厚度的影响因素。结论:高度近视合并POAG患者黄斑区脉络膜厚度比单纯POAG患者薄,但与高度近视患者无统计学差异,黄斑区脉络膜厚度与青光眼性视神经损伤程度无明显关联。 | 栗改云 陈威 Samer abdo Al-wesabi 王莉 张虹 | 2016 | 国际眼科杂志2016，16，8： | 2 |
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