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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Trends in reperfusion strategies,door-to-needle and door-to-balloon times, and in?hospital mortality among patients with ST -segment elevation myocardial infarction enrolled in the National Registry of Myocardial Infarction from 1990 to 2006显示文摘 | Gibson CM Pride YB Frederick PO | 2008 | Am Heart J2008，156，6： | 1 |
| 4 | Critical role for Gab2 in transformation by BCR/ABL显示文摘 | Sattler M Mohi M G Pride Y B | | 0，，05： | 1 |
| 5 | The Impact of Channel Leadership Behavior on Intrachannel Conflict 显示文摘 | Patrick L Schul William M Pride and Taylor L Little | 1983 | Journal of Marketing1983，47，3： | 1 |
| 6 | A TAT-Frataxin fusion protein increases lifespan and cardiac func-tion in a conditional Friedreich’s ataxia mouse model显示文摘 | Vyas PM Tomamichel WJ Pride PM | 2012 | Hum Mol Genet2012，12，6： | 1 |
| 7 | Stent-coil treatment of a distal internal carotid artery dissecting pseudoaneurysm on a redundant loop by use of a flexible,dedicated nitinol intracranial stent显示文摘 | Pride GL Jr Replogle RE Rappard G | 2004 | AJNR2004，25，2： | 1 |
| 8 | Electrophysiological mechanisms in a canine model of erythromycin-associated long QT syndrome 显示文摘 | Rubart M Pressler ML Pride HP | 1993 | Circulation1993，88，4： | 1 |
| 9 | Inhaled croticosteroids with/without long-acting β-agonists reduce the risk of rehospitallization and death in COPD patients显示文摘 | Soriano B Kiri VA Pride NB | 2003 | Am J Respir Crit Care Med2003，2，1： | 1 |
| 10 | Percutaneous translum- bar spinal cord compression injury in a dog model that uses angioplasty halloons: MR imaging and histopatho- logic findings显示文摘 | Purdy P D Duong R T White C L 3rd Baer D L Rei- chard R R Pride G L Jr | 2003 | AJNR Am J Neuroradiol2003，24，： | 1 |
| 11 | Allelic Variation within Helicobacter pylori babA and babB显示文摘 | Meinersmann RJ Blaser MJ | 2001 | Infection and Immunity2001，69，2： | 1 |
| 12 | Percutaneous trans- lumbar spinal cord compression injury in dogs from an angioplasty balloon: MR and histopathologic changes with balloon sizes and compression times显示文摘 | Purdy P D White C L 3rd Baer D L Frawley W H Reiehard R R Pride G L Jr | 2004 | AJNR Am J Neuroradiol2004，25，： | 1 |
| 13 | Tumour necrosis factor- a gene promoter polymorphism in chronic obstructive pulmonaryd- isease显示文摘 | Higham MA Pride NB Alikhan A | 2000 | Eur Respir J2000，15，2： | 1 |
| 14 | Tumour necrosis factor- c gene promoter polymorphism in chronic obstructive pulmonary disease 显示文摘 | Higham M A Pride N B Alikhan A | 2000 | Eur Respir J2000，15，2： | 1 |
| 15 | Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD 显示文摘 | Lofdahl C G Postma D S Pride N B | 2007 | Eur Respir J2007，29，6： | 1 |
| 16 | Tumor necrosis factor-α gone promoter polymorphism in chronic obstructive pulmonary disease显示文摘 | Higham MA Pride NB Alikhan A | 2000 | Eur Respir J2000，15，： | 1 |
| 17 | Optimal assessment and management of chronic obstructive pulmonary disease (COPD) 显示文摘 | Siafakas NM Vermeire P Pride NB | 1995 | Eur Respir J1995，8，8： | 1 |
| 18 | Inhaled corticosteroids in chronic obstructive pulmonary disease:results from two observational designs free of immortal time bias显示文摘 | Kiri VA Pride NB Soriano JB | 2005 | American Journal of Respiratory and Critical Care Medicine2005，172，4： | 1 |
| 19 | Radiofrequency catheter ablation of the atria reduces inducibility and duration of atrial fibrillation in dogs显示文摘 | Elvan A Pride HP Ehle JN | 1995 | Circulation1995，91，8： | 1 |
| 20 | Interleukin-12 redirects murine immune responses to soluble or aluminum phosphate adsorbed HSV-2 glycoprotein D towards Thl and CD4 + CTL responses 显示文摘 | Cooper D Pride M W Guo M | 2004 | Vaccine2004，23，2： | 1 |
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