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| 1 | Regulation of Pain and Itch by TRP Channels显示文摘Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechanical noxious stimuli to evoke the pain and itch sensations.Among them are the TRPA1 channel, members of the vanilloid subfamily(TRPV1, TRPV3, and TRPV4), and finally members of the melastatin group(TRPM2, TRPM3,and TRPM8). Given that pain and itch are pro-survival,evolutionarily-honed protective mechanisms, care has to be exercised when developing inhibitory/modulatory compounds targeting specific pain/itch-TRPs so that physiological protective mechanisms are not disabled to a degree that stimulus-mediated injury can occur. Such events have impeded the development of safe and effective TRPV1-modulating compounds and have diverted substantial resources. A beneficial outcome can be readily accomplished via simple dosing strategies, and also by incorporating medicinal chemistry design features during compound design and synthesis. Beyond clinical use,where compounds that target more than one channel might have a place and possibly have advantageous features,highly specific and high-potency compounds will be helpful in mechanistic discovery at the structure-function level. | Carlene Moore Rupali Gupta Sven-Eric Jordt Yong Chen Wolfgang B.Liedtke | 2018 | Neuroscience Bulletin2018，34，1： | 39 |
| 2 | Shoot-Specific Down-Regulation of Protein Farnesyltransferase (α-Subunit) for Yield Protection against Drought in Canola显示文摘Canola (Brassica 马来麝 L.) 是在世界和它的种子收益上的最重要的 oilseed 庄稼之一,质量被干旱应力显著地影响。作为对水赤字的天生、适应的回答,陆地植物由植物激素 abscisic 酸(骆驼毛的织物) 的快速的生合成避免潜在的损坏,它触发有气孔的闭合减少 transpirational 水损失。调停骆驼毛的织物的有气孔的反应是一个剂量依赖者过程;因此,为完成干旱回避的一条遗传工程途径能是敏化警卫房间的应答到这荷尔蒙。最近的基因研究作为在警卫房间控制骆驼毛的织物敏感的一个关键否定管理者指出了蛋白质 farnesyltransferase。我们以前证明了编码 farnesyltransferase (ERA1 ) 的 Arabidopsis 子单元的基因的下面规定提高植物的敏感到骆驼毛的织物和干旱忍耐。尽管 farnesyltransferase (AtFTA ) 的子单元也在骆驼毛的织物察觉到被含有,使用如此的一个基因目标在庄稼植物改进干旱忍耐的有效性没被验证。这里,我们报导 Arabidopsis hydroxypyruvate reductase (AtHPR1 ) 的倡导者的鉴定和描述,它在射击并且不在象根那样的非光合的纸巾明确地表示。AtHPR1 的倡导者区域包含元素和我们证实了的很好描绘的脱水应答的行动 cis 的核心主题那 AtHPR1 表情由干旱应力是可诱导的。在用驾驶 RNAi 构造的 AtHPR1 倡导者的 canola 的 FTA 的有条件、特定的下面规定在这块地里对干旱应力导致了收益保护。用这分子的策略,我们在在这重要庄稼种设计干旱忍耐取得了重要进步。 | Yang Wang Michelle Beaith Maryse Chalifoux Jifeng Ying Tina Uchacz Carlene Sarvas Rebecca Griffiths Monika Kuzma Jiangxin Wan Yafan Huang | 2009 | Molecular Plant2009，2，1： | 7 |
| 3 | Propofol enhances the field excitatory postsynaptic potentials in CA1 hippocampal slices of young and aged mice显示文摘 | Yin Yiqing William J Middleton Carlos M. Florez Peter L. Carlen Hossam EI-Beheiry | 2014 | Chinese Medical Journal2014，，1： | 3 |
| 4 | 非晶合金配电变压器最大限度节约能源显示文摘随着全球人口不断增长,能耗需求日益扩大,维系这个电力紧缺的世界需要靠节能产品和可靠电网的支撑。当前节能计划和能效要求的驱动力来自全球性和地区性的CO2减排倡议。谈到配电变压器,作为供电系统的一个重要组成部分,其安装量大,即便是新型变压器,对能源的损耗从总量来看仍然是惊人的。据估计,全球此类能源损耗占总发电量的2.3%,约25 GW。每节约1 GW,大约相当于每年减少500万t的CO2排放量。作为全球领先的变压器制造商,ABB现已开发出油浸式非晶合金配电变压器和EcoDry非晶合金干式配电变压器,相对于传统铁心材料,能够减少70%的空载损耗。 | V.R.Ramanan Martin Carlen | 2014 | 电气制造2014，0，5： | 2 |
| 5 | Principles and applications of electrochemical capacitors显示文摘 | KOTZ R CARLEN M | 2000 | Electrochim Acta2000，45，： | 2 |
| 6 | Blood Pressure and Stroke: An Overview of Published Reviews显示文摘 | Carlene M.M. Lawes Derrick A. Bennett Valery L. Feigin Anthony Rodgers | 2004 | Stroke: Journal of the American Heart Association2004，，3： | 2 |
| 7 | Mediastinoscopy: a method for inspection and tissue biopsy in the superior mediastinum显示文摘 | Carlens E | 1959 | Dis Chest1959，36，： | 1 |
| 8 | Risk factors for chronic graft- versus- host disease after bone marrow transplantion: a retrospective single centre analysis显示文摘 | Carlens S Ringden O Remberger M | 1998 | Bone Marrow Transplant1998，22，： | 1 |
| 9 | Principles and applications of electrochemical capacitors显示文摘 | Kotz R Carlen M | 2000 | Electrochimica Acta2000，45，1516： | 1 |
| 10 | Sourcespecificity of early calcium neurotoxicity in cultured embryonic spinal neurons 显示文摘 | Tymianski M Charhon MP Carlen PL | 1993 | J Neurosci1993，13，5： | 1 |
| 11 | Principle and application of electrochemical capacitors 显示文摘 | KOTZ R CARLEN M | 2000 | Electrochimica Acta2000，54，1516： | 1 |
| 12 | Mediastinoscopy:a method for inspection and tissue biopsy in the superior mediastium显示文摘 | Carlens E | 1959 | Dis Chest1959，36，3： | 1 |
| 13 | Development of affective organi- zational commitment: A cross - sequential examination of change with tenure 显示文摘 | KAREN B CARLENE W | 2000 | Journal of Vocational Behavior2000，56，1： | 1 |
| 14 | Global burden of blood-pressure-related disease, 2001显示文摘 | Carlene MM Lawes Stephen Vander Hoorn Anthony Rodgers | 2008 | The Lancet2008，，9623： | 1 |
| 15 | Principles and applications of electrochemicalcapacitors显示文摘 | K-tz R Carlen M | 2000 | Electrochim Acta2000，45，： | 1 |
| 16 | A new method for in vitro expansion of cytotoxic human CD3^- CD56^+ natural killer cells显示文摘 | Carlens S Gilljam M Chambers BJ | 2001 | Hum Immunol2001，62，10： | 1 |
| 17 | Prinary ciliary dyskinesia显示文摘 | CARLEN R STENRAN U | 2005 | U Itrastruet Pathol2005，29，： | 1 |
| 18 | Effects of variations in hi ppo campal slice preparation protocol on the electrophysiological stability, epilept ogenicity and graded hypoxia responses of CA1 neurons显示文摘 | Weiner J L Carlen P L | 1997 | Brain Research1997，775，： | 1 |
| 19 | Principles and applications of electrochemical capacitors 显示文摘 | Kotz R Carlen M | 2000 | Electrochimica Acta2000，，45： | 1 |
| 20 | Surface Micromachined Paraffin-actuated Microvalve显示文摘 | Carlen E T Mastrangelo C H | 2002 | J Microelectromech Syst2002，11，： | 1 |
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