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| 1 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 2 | 囊性纤维化:太多NaCl,太少HCO_3^-(英文)显示文摘胰腺囊性纤维化(cystic fibrosis,CF)是一种单基因缺陷导致的致死性遗传疾病,在高加索人种中广泛分布。这种疾病在其它人种的发生率非常低,但据报道大部分人种中发现有该基因的突变。本文对CF发生的分子和病理生理学基本概念进行阐述。首先,阐述了CF的病理学和遗传特征,其基因产物囊性纤维化跨膜电导调节体(cystic fibrosis transmembrane con- ductance regulator,CFTR)的分子结构、特征、功能和调控。其次,由于突变的主要表现是电解质转运失调,其病理学效应和机制在两个典型受累器官中得到了很好的阐明,一个是汗腺,其病理发生是由于分泌过多NaCl,另一个是胰腺,其病理发生是由于分泌太少HCO_3^-。然而,CF的发病率和死亡率主要来自难治性呼吸道感染,其发生机制存存争议,我们推断可能的机制为阴离子转运失调导致CF肺部慢性感染。 | QUINTON Paul M | 2007 | 生理学报2007，59，4： | 5 |
| 3 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 4 | The European soil erosion model (EUROSEM) : A dynamic approach for predicting sediment transport from fields and small catch ments 显示文摘 | Morgan R P C Quinton T N Smith R E | 1998 | Earth Surface Processes and Land forms1998，23，： | 1 |
| 5 | Functions and regulation of NF-kappa B RelA during pneumococcal pneumonia显示文摘 | Quinton LJ Jones MR Simms BT | 2007 | J Immunol2007，178，3： | 1 |
| 6 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 7 | The european soil erosion model (EUROSEM):a dynamic approach for predicting sediment transport from fields and small catchments 显示文摘 | Morgan R P C Quinton J N Smith R E | 1998 | Earth Surf Processed1998，23，： | 1 |
| 8 | The Eu- ropean soil erosion model(EUROSEM) : A dynamic ap- proach for predicting sediment transport from fields and small catchments 显示文摘 | Morgan R P C Quinton J N Smith R E | 1998 | Earth Surface Processes and Landforms1998，23，6： | 1 |
| 9 | Src family kinase- mediated and Erk - mediated thromboxane A2 generation are essential for VWF/GP Ⅰ b - induced fibrinogen receptor activation in human platelets显示文摘 | GARCIA A QUINTON T M DORSAM R T | 2005 | Blood2005，6，： | 1 |
| 10 | Dynamic, distributed simulation of watershed erosion: the KINEROS2 and EUROSEM models 显示文摘 | Smith R E Goodrich D Quinton J N | 1995 | Journal of Soil and Water Conservation1995，50，： | 1 |
| 11 | Assessment of erosion hazard with the USLE and GIS:a case study of the upper Ewaso Ng'iro North Basin of Kenya显示文摘 | Mati B M Morgan R P C Gichuki F N Quinton J N Brewer T R Liniger H P | | 0，，02： | 1 |
| 12 | The effect of cold and dietary energy on right ventricle hypertrophy, right ventricle failure and ascites in meat-type chickens 显示文摘 | Julian R J McMillan I Quinton M | 1989 | Avian Pathology1989，18，： | 1 |
| 13 | Neighbourhood Change: the Impact of the National Reassurance Policing Programme 显示文摘 | Quinton P Tuffin R | 2007 | Policing2007，1，2： | 1 |
| 14 | Ulnar collateral ligament repair of the metacarpo-phalangeal joint of the thumb:a study comparing two methods of repair显示文摘 | Saetta JP Phair IC Quinton DN | 1992 | J Hand Surg Br1992，17，2： | 1 |
| 15 | The European soil erosion model (EUROSEM):a dynamic approach f or predicting sediment transport from fields and small catchments显示文摘 | Morgan R P C Quinton J N | 1998 | Earth Surface Processes and landforms1998，，23： | 1 |
| 16 | Single nucleotide polymorphisms in the leptin receptor gene:studies in anorexia nervosa显示文摘 | Quinton ND Meechan DW Brown K | 2004 | Psychiatr Genet2004，14，： | 1 |
| 17 | The GCTE validation of soil erosion models for global change studies显示文摘 | Favis-Mortlock D T Quinton J N Dickinson W T | 1996 | Journal of Soil and Water Conservatlon1996，51，5： | 1 |
| 18 | Leptin and leptin-binding activity in women with recurrent miscarriage: correlation with pregnancy outcome显示文摘 | Quinton ND Anstie B | 2001 | Hum Reprod2001，16，9： | 1 |
| 19 | The European soil erosion model (EUROSEM): A dynamic approach for predicting sediment transport from fields and small catchments显示文摘 | MORGAN R P C QUINTON J N SMITH R E | 1998 | Earth Surface Processes and Landforms1998，23，： | 1 |
| 20 | The systemic and pulmonaryLPS binding protein response to intratracheal lipopolysaccharide显示文摘 | GAMBLE L BAGBY G J QUINTON L J | 2009 | Shock2009，31，2： | 1 |
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